CN103097356A - 13-环己基-3-甲氧基-6-[甲基-(2-{2-[甲基-(氨磺酰基)-氨基]-乙氧基}-乙基)-氨基甲酰基]-7H-吲哚并-[2,1-a]-[2]-苯并氮杂*-10-羧酸的制备 - Google Patents
13-环己基-3-甲氧基-6-[甲基-(2-{2-[甲基-(氨磺酰基)-氨基]-乙氧基}-乙基)-氨基甲酰基]-7H-吲哚并-[2,1-a]-[2]-苯并氮杂*-10-羧酸的制备 Download PDFInfo
- Publication number
- CN103097356A CN103097356A CN2011800309490A CN201180030949A CN103097356A CN 103097356 A CN103097356 A CN 103097356A CN 2011800309490 A CN2011800309490 A CN 2011800309490A CN 201180030949 A CN201180030949 A CN 201180030949A CN 103097356 A CN103097356 A CN 103097356A
- Authority
- CN
- China
- Prior art keywords
- acid
- methyl
- ethyl
- compound
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IMVJDMJXJLKARD-UHFFFAOYSA-N CNCC[IH]CCNC Chemical compound CNCC[IH]CCNC IMVJDMJXJLKARD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims (8)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10167221.0 | 2010-06-24 | ||
EP10167221 | 2010-06-24 | ||
PCT/EP2011/060606 WO2011161232A1 (en) | 2010-06-24 | 2011-06-24 | PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2-{2-[METHYL-(SULPHAMOYL)-AMINO]-ETHOXY}-ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103097356A true CN103097356A (zh) | 2013-05-08 |
CN103097356B CN103097356B (zh) | 2016-01-13 |
Family
ID=43216626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180030949.0A Expired - Fee Related CN103097356B (zh) | 2010-06-24 | 2011-06-24 | 13-环己基-3-甲氧基-6-[甲基-(2-{2-[甲基-(氨磺酰基)-氨基]-乙氧基}-乙基)-氨基甲酰基]-7H-吲哚并-[2,1-a]-[2]-苯并氮杂*-10-羧酸的制备 |
Country Status (11)
Country | Link |
---|---|
US (2) | US9127010B2 (zh) |
EP (1) | EP2585438B1 (zh) |
JP (1) | JP5870098B2 (zh) |
CN (1) | CN103097356B (zh) |
AU (1) | AU2011268922B2 (zh) |
BR (1) | BR112012032889A2 (zh) |
CA (1) | CA2801517C (zh) |
IL (1) | IL223427A (zh) |
MX (1) | MX2012015198A (zh) |
RU (1) | RU2559886C2 (zh) |
WO (1) | WO2011161232A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI454476B (zh) | 2008-07-08 | 2014-10-01 | Tibotec Pharm Ltd | 用作c型肝炎病毒抑制劑之巨環吲哚衍生物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007140200A2 (en) * | 2006-05-25 | 2007-12-06 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors |
WO2010003658A1 (en) * | 2008-07-08 | 2010-01-14 | Tibotec Pharmaceuticals | Macrocyclic indole derivatives useful as hepatitis c virus inhibitors |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
CZ298463B6 (cs) | 1996-04-23 | 2007-10-10 | Vertex Pharmaceuticals Incorporated | Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují |
DK0966465T3 (da) | 1997-03-14 | 2003-10-20 | Vertex Pharma | Inhibitorer af IMPDH-enzymer |
ES2405316T3 (es) | 1999-03-19 | 2013-05-30 | Vertex Pharmaceuticals Incorporated | Inhibidores de la enzima IMPDH |
WO2002019369A1 (fr) | 2000-08-30 | 2002-03-07 | Matsushita Electric Industrial Co., Ltd. | Unite d'affichage a plasma et son procede de fabrication |
US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
KR20080040032A (ko) | 2005-09-02 | 2008-05-07 | 티보텍 파마슈티칼즈 리미티드 | Hcv 저해제로서의 벤조디아제핀 |
US7399758B2 (en) | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
GB0522881D0 (en) | 2005-11-10 | 2005-12-21 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2007092000A1 (en) | 2006-02-06 | 2007-08-16 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
US7456166B2 (en) | 2006-05-17 | 2008-11-25 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7521443B2 (en) | 2006-05-17 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7521441B2 (en) | 2006-05-22 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US8101595B2 (en) | 2006-12-20 | 2012-01-24 | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA | Antiviral indoles |
AU2008277440A1 (en) | 2007-07-17 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic indole derivatives for the treatment of hepatitis C infections |
-
2011
- 2011-06-24 MX MX2012015198A patent/MX2012015198A/es active IP Right Grant
- 2011-06-24 US US13/805,607 patent/US9127010B2/en not_active Expired - Fee Related
- 2011-06-24 CA CA2801517A patent/CA2801517C/en not_active Expired - Fee Related
- 2011-06-24 RU RU2013103004/04A patent/RU2559886C2/ru not_active IP Right Cessation
- 2011-06-24 CN CN201180030949.0A patent/CN103097356B/zh not_active Expired - Fee Related
- 2011-06-24 EP EP11727184.1A patent/EP2585438B1/en not_active Not-in-force
- 2011-06-24 WO PCT/EP2011/060606 patent/WO2011161232A1/en active Application Filing
- 2011-06-24 JP JP2013515907A patent/JP5870098B2/ja not_active Expired - Fee Related
- 2011-06-24 AU AU2011268922A patent/AU2011268922B2/en not_active Ceased
- 2011-06-24 BR BR112012032889A patent/BR112012032889A2/pt not_active IP Right Cessation
-
2012
- 2012-12-04 IL IL223427A patent/IL223427A/en active IP Right Grant
-
2015
- 2015-07-28 US US14/810,783 patent/US20150329482A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007140200A2 (en) * | 2006-05-25 | 2007-12-06 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors |
WO2010003658A1 (en) * | 2008-07-08 | 2010-01-14 | Tibotec Pharmaceuticals | Macrocyclic indole derivatives useful as hepatitis c virus inhibitors |
Also Published As
Publication number | Publication date |
---|---|
BR112012032889A2 (pt) | 2015-09-15 |
EP2585438B1 (en) | 2014-08-20 |
MX2012015198A (es) | 2013-02-11 |
US20130102777A1 (en) | 2013-04-25 |
WO2011161232A1 (en) | 2011-12-29 |
RU2013103004A (ru) | 2014-07-27 |
JP2013530976A (ja) | 2013-08-01 |
AU2011268922A1 (en) | 2013-01-10 |
CN103097356B (zh) | 2016-01-13 |
RU2559886C2 (ru) | 2015-08-20 |
US20150329482A1 (en) | 2015-11-19 |
US9127010B2 (en) | 2015-09-08 |
CA2801517C (en) | 2017-12-12 |
IL223427A (en) | 2015-04-30 |
CA2801517A1 (en) | 2011-12-29 |
JP5870098B2 (ja) | 2016-02-24 |
AU2011268922B2 (en) | 2014-06-12 |
EP2585438A1 (en) | 2013-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: IRELAND JANSSEN R + D COMPANY Free format text: FORMER OWNER: JANSSEN R + D IRELAND Effective date: 20150728 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20150728 Address after: The Irish Village Applicant after: Ireland Jansen scientific company Address before: Kirk County, Ireland Applicant before: Tibotec Pharm Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160113 Termination date: 20190624 |