CN103071246B - The neuroactive prosthetic device of near infrared light - Google Patents
The neuroactive prosthetic device of near infrared light Download PDFInfo
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- CN103071246B CN103071246B CN201310052800.3A CN201310052800A CN103071246B CN 103071246 B CN103071246 B CN 103071246B CN 201310052800 A CN201310052800 A CN 201310052800A CN 103071246 B CN103071246 B CN 103071246B
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Abstract
The invention discloses the neuroactive prosthetic device of a kind of near infrared light and method, optical fiber is connected with laser instrument, is sent to by the near-infrared laser that laser instrument produces in pre-nervous tissue of repairing; Microelectrode array inserts in pre-nervous tissue of repairing, and be connected with multichannel collecting instrument by electrode converting interface, lead-in wire, this multichannel collecting instrument is connected with computer by transmission cable, the Evoked ptential amplification that microelectrode array collects by multichannel collecting instrument, filtering and digitized processing, and by computer disposal, display and storage, the optical fiber major axis of optical fiber is 0 ~ 45 ° with the axis angle of record microelectrode; The near infrared wave-length coverage that laser instrument produces is 780 ~ 2526nm.Device and method of the present invention, effectively can activate nervous tissue and make it to induce neural impulse, and to realize the reparation of function of nervous system, and artefact time-histories is shorter, resolution is higher, directly do not contact with nervous tissue.
Description
Technical field
The invention belongs to the device and method that function of nervous system repairs, be specifically related to the neuroactive prosthetic device of a kind of near infrared light and method.
Background technology
The impaired meeting of function of nervous system brings great pain to patient, and is difficult at present utilize biological method to cure the nervous system injury of the overwhelming majority.From the angle of function of nervous system's Information Conduction path, function of nervous system repairs and can launch at levels such as sensor, nervus centripetalis, nerve centre, nervus centrifugalis and effectors.Cerebral cortex is five-star nerve centre, and be the best nerve prosthesis method of restoration effect, its stimulating method comprises electricity irritation, Neural stem cell and photostimulation etc.
Along with raising that is scientific and technical and clinical level, nerve electric stimulation reparation once became study hotspot, it mainly utilizes nerve microelectrode and functional rehabilitation integrated circuit is fully-integrated or hybrid integrated, System on Chip/SoC in human implantable, to realize the reparation of function of nervous system.But along with the raising of resolution, the carrying out of nerve electric stimulation clinical practice are repaired in electricity irritation, traditional electricity irritation exposes following limitation gradually:
(1) there is artefact in electrical stimulation method, need vibration just can disappear, and the time is longer in tissue fluid;
(2) because microelectrode size is by the restriction of processing technique, and microelectrode is understood by immersion corrosion in tissue fluid, therefore the raising of electricity irritation resolution can be subject to the constraint of microelectrode array;
(3) realization of electricity irritation is flow of charge form, it is ion flow form in biological tissue, need the conversion of two kinds of form of energy, therefore the transmission in biological tissues of electricity irritation energy and conversion need be considered, and electricity irritation needs the power supply supply problem considering implantation circuit and implantation circuit.
Summary of the invention
The object of this invention is to provide the neuroactive prosthetic device of a kind of near infrared light and method, effectively can activate nervous tissue and make it to induce neural impulse, to realize the reparation of function of nervous system, and artefact time-histories is shorter, resolution is higher, directly do not contact with nervous tissue.
The neuroactive prosthetic device of near infrared light of the present invention, comprises laser instrument, optical fiber, microelectrode array, electrode converting interface, lead-in wire, multichannel collecting instrument, transmission cable and computer;
Described optical fiber is connected with laser instrument, and laser instrument produces near-infrared laser, for being sent to pre-nervous tissue of repairing;
Described microelectrode array is for being inserted in pre-nervous tissue of repairing, and be connected with multichannel collecting instrument by electrode converting interface, lead-in wire, this multichannel collecting instrument is connected with computer by transmission cable, the Evoked ptential amplification that microelectrode array collects by multichannel collecting instrument, filtering and digitized processing, and by computer disposal, display and storage;
The optical fiber major axis of described optical fiber is 0 ~ 45 ° with the axis angle of record microelectrode;
The near infrared wave-length coverage that described laser instrument produces is 780 ~ 2526nm.
Also comprise locating rack, this locating rack comprises bracing frame, the first hold-down bars, the second hold-down bars, angle adjusting mechanism and height adjustment mechanism, described first hold-down bars is connected with bracing frame by angle adjusting mechanism, the outfan of optical fiber is fixed on the first hold-down bars, and the locus of fiber-optic output is regulated by angle adjusting mechanism, described microelectrode array is fixed on the second hold-down bars, and regulates the locus of microelectrode array by height adjustment mechanism.
Described angle adjusting mechanism is made up of the first screw, the second screw, connector and metal ball, metal ball is fixed on bracing frame, one end of connector is connected with the first hold-down bars, and by the first screw lock between the first hold-down bars and connector, the other end of connector is connected with metal ball, and by the second screw lock between connector and metal ball; Described height adjustment mechanism is the 3rd screw.
Described laser instrument is pulsed laser, its pulsewidth < 10ms, frequency < 100Hz, and drive current amplitudes is < 4A, and threshold current is < 999mA, and step-length is 10mA.
Described microelectrode array can gather pre-repairs the local field potentials and SPIKE signal that nervous tissue brings out under near-infrared laser irradiates.
The neuroactive restorative procedure of near infrared light of the present invention, its step is as follows:
Step one, optical fiber to be connected with laser instrument, multichannel collecting instrument is connected with microelectrode array by electrode converting interface, lead-in wire, and is connected with computer by transmission cable by multichannel collecting instrument;
Step 2, microelectrode array to be fixed on locating rack, and microelectrode array to be inserted in pre-nervous tissue region of repairing;
Step 3, to be fixed on locating rack by the outfan of optical fiber, and pre-nervous tissue region of repairing aimed at by the outfan of optical fiber, the near-infrared laser that laser instrument is exported can be radiated on the nervous tissue region of pre-reparation;
Step 4, the drive current regulating laser instrument, pulsewidth, frequency parameter control the laser that laser instrument exports different wave length, the Evoked ptential of nervous tissue under near-infrared laser irradiates that microelectrode array collection is repaired in advance, and by electrode converting interface, lead-in wire input multichannel collecting instrument, the Evoked ptential amplification that microelectrode array collects by multichannel collecting instrument, filtering and digitized processing, and undertaken processing, show and storing by transmission cable input computer.
In described step 2, described microelectrode array is fixed on the second hold-down bars of locating rack, and regulates the locus of microelectrode array by the 3rd screw.
In described step 3, the outfan of described optical fiber is fixed on the first hold-down bars of locating rack, and regulates the locus of fiber-optic output by the first screw, the second screw and metal ball.
The method of nervous tissue being repaired with near infrared light neuroactive prosthetic device described above,
(1) absorption due to light energy is very fast, therefore artefact time-histories is shorter;
(2) owing to can not be subject to the restriction of microelectrode processing technique, microelectrode materials biocompatibility, therefore the resolution of photostimulation function of nervous system recovery technique is higher;
(3) because near infrared light penetration depth in the tissue can reach more than 5cm, skin, hypodermic blood vessel, lymphatic vessel, teleneuron can be applied directly to, therefore adopt near-infrared laser stimulating method without the need to directly contacting, without the need to settling circuit in biological tissue's body, without the need to considering the power issue of implantation circuit with tissue.
In sum, the present invention utilizes near infrared light nervous tissue, effectively can activate nervous tissue and make it to induce neural impulse, thus reach the object of function of nervous system's reparation, have that artefact time-histories is shorter, resolution is higher, direction of stimulation is better, and the advantage directly do not contacted with nervous tissue.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described:
The neuroactive prosthetic device of near infrared light as shown in Figure 1, comprises laser instrument 1, optical fiber 2, microelectrode array 10, electrode converting interface 8, lead-in wire 4, multichannel collecting instrument 5, transmission cable 6 and computer 7; Optical fiber 2 is connected with laser instrument 1, and laser instrument 1 produces near-infrared laser, for being sent to pre-nervous tissue 9 of repairing; Microelectrode array 10 is for being inserted in pre-nervous tissue 9 of repairing, and be connected with multichannel collecting instrument 5 by electrode converting interface 8, lead-in wire 4, this multichannel collecting instrument 5 is connected with computer 7 by transmission cable 6, the Evoked ptential amplification that microelectrode array 10 collects by multichannel collecting instrument 5, filtering and digitized processing, and process by computer 7, show and store; The optical fiber major axis of optical fiber 2 is 0 ~ 45 ° with the axis angle of record microelectrode 10.
The neuroactive prosthetic device of this near infrared light replaces the electrode in electricity irritation by optical fiber 2, the stimulus signal occurring source in electricity irritation is replaced by laser, optical fiber 2 is placed in above the pre-neurocyte repaired, transmission laser irradiates neurocyte and activates or suppress neural impulse, thus repairs function of nervous system corresponding to cortex target region.
Also comprise locating rack 3, this locating rack 3 comprises bracing frame 3h, first hold-down bars 3a, second hold-down bars 3f, angle adjusting mechanism and height adjustment mechanism, described first hold-down bars 3a is connected with bracing frame 3h by angle adjusting mechanism, the outfan of optical fiber 2 by medical adhesive tape looping on the first hold-down bars 3a, and carry out fine adjustment (that is: regulating optical fiber 2 major axis to repair the angle of nervous tissue 9 horizontal plane and the distance of optical fiber 2 outfan and pre-nervous tissue 9 of repairing with pre-) by the locus of angle adjusting mechanism adjustment optical fiber 2 outfan, to guarantee that the near-infrared laser that laser instrument 1 exports can be radiated on pre-nervous tissue 9 region of repairing preferably, described microelectrode array 10 uses medical adhesive tape looping on the second hold-down bars 3f by lead-in wire 4, and regulate the locus of microelectrode array 10 to carry out fine adjustment by height adjustment mechanism, to guarantee to regulate microelectrode array 10 vertically to insert pre-reparation nervous tissue 9, and the insertion depth of accurate position the record microelectrode.
Further, angle adjusting mechanism is made up of the first screw 3b, the second screw 3c, connector 3g and metal ball 3d, metal ball 3d is fixed on bracing frame 3h, one end of connector 3g is connected with the first hold-down bars 3a, and locked by the first screw 3b between the first hold-down bars 3a and connector 3g, the other end of connector 3g is connected with metal ball 3d, and is locked by the second screw 3c between connector 3g and metal ball 3d; Described height adjustment mechanism is the 3rd screw 3e.
Described laser instrument 1 is pulsed laser, comprises laser diode, power supply and drive circuit, light path system, optical fiber interface.Drive circuit is made up of timing circuit, pulse generator, electrical switch and power supply.By regulate drive current, pulsewidth, frequency parameter control laser instrument 1 send different wave length low-energy laser (continuously or distinct pulse widths, different frequency pulse signal), the pulsewidth < 10ms of this laser instrument 1, frequency < 100Hz, drive current amplitudes is < 4A, threshold current is < 999mA, and step-length is 10mA.The near infrared wave-length coverage that this laser instrument 1 produces is 780 ~ 2526nm.
Described microelectrode array 10 can gather pre-repairs the local field potentials and SPIKE signal that nervous tissue 9 brings out under near-infrared laser irradiates.
Pre-reparation nervous tissue 9 of the present invention comprises the nervous tissues such as visual cortex, motor cortex and cochlea.
The neuroactive restorative procedure of near infrared light of the present invention, its step is as follows:
Step one, optical fiber 2 to be connected with laser instrument 1, multichannel collecting instrument 5 is connected with microelectrode array 10 by electrode converting interface 8, lead-in wire 4, and is connected with computer 7 by transmission cable 6 by multichannel collecting instrument 5;
Step 2, microelectrode array 10 to be fixed on the second hold-down bars 3f of locating rack 3, and to regulate the 3rd locus of screw 3e to microelectrode array 10 accurately to locate, and microelectrode array 10 is inserted into pre-nervous tissue 9 region of repairing;
Step 3, the outfan of optical fiber 2 is fixed on the first hold-down bars 3a of locating rack 3, and the locus of optical fiber 2 outfan is regulated by the first screw 3b, the second screw 3c and metal ball 3d, to guarantee that pre-nervous tissue 9 region of repairing aimed at by the outfan of optical fiber 2, to guarantee that the near-infrared laser that laser instrument 1 exports can be radiated on pre-nervous tissue 9 region of repairing preferably;
Step 4, regulate the drive current of laser instrument 1, pulsewidth, frequency parameter controls low-energy laser (the continuous or distinct pulse widths that laser instrument 1 exports different wave length, the pulse signal of different frequency), when near-infrared laser irradiates pre-nervous tissue 9 of repairing, near-infrared laser can make the nervous tissue 9 in this region excited, to reach the object of repairing different function of nervous system, microelectrode array 10 gathers the Evoked ptential of pre-nervous tissue 9 of repairing under near-infrared laser irradiates, and by electrode converting interface 8, lead-in wire 4 input multichannel collecting instrument 5, the Evoked ptential that microelectrode array 10 collects by multichannel collecting instrument 5 amplifies, filtering and digitized processing, and input computer 7 by transmission cable 6 and process, display and storage, the neural response that photostimulation induces is observed by computer 7.
Neural for visual cortex below, restorative procedure of the present invention is described further:
Cut off animal head skin, expose skull, visual cortex region, accurate location, thus orient the on position of microelectrode array 10, bone window is outputed in this region of tailing edge, after cerebral dura mater exposes completely, microelectrode array 10 is inserted into visual cortex neurological region, and optical fiber major axis and the axis angle of record microelectrode are adjusted to 20 °, and the vertical dimension of the outfan of optical fiber 2 and visual cortex nervous tissue is 1 ~ 2mm, regulate the drive current of laser instrument 1, pulsewidth, frequency parameter controls low-energy laser (the continuous or distinct pulse widths that laser instrument 1 exports specific wavelength, the pulse signal of different frequency), the Evoked ptential collected is observed by computer 7, and record and storage are for follow-up labor.
Claims (4)
1. the neuroactive prosthetic device of near infrared light, is characterized in that: comprise laser instrument (1), optical fiber (2), microelectrode array (10), electrode converting interface (8), lead-in wire (4), multichannel collecting instrument (5), transmission cable (6) and computer (7);
Described optical fiber (2) is connected with laser instrument (1), and laser instrument (1) produces near-infrared laser, for being sent to pre-nervous tissue (9) of repairing;
Described microelectrode array (10) is for being inserted in pre-nervous tissue (9) of repairing, and be connected with multichannel collecting instrument (5) by electrode converting interface (8), lead-in wire (4), this multichannel collecting instrument (5) is connected with computer (7) by transmission cable (6), the Evoked ptential amplification that microelectrode array (10) collects by multichannel collecting instrument (5), filtering and digitized processing, and by computer (7) process, display and storage;
The optical fiber major axis of described optical fiber (2) and the axis angle of microelectrode array (10) are 0 ~ 45 °;
The near infrared wave-length coverage that described laser instrument (1) produces is 780 ~ 2526nm;
The neuroactive prosthetic device of described near infrared light also comprises locating rack (3), this locating rack (3) comprises bracing frame (3h), first hold-down bars (3a), second hold-down bars (3f), angle adjusting mechanism and height adjustment mechanism, described first hold-down bars (3a) is connected with bracing frame (3h) by angle adjusting mechanism, the outfan of optical fiber (2) is fixed on the first hold-down bars (3a), and the locus of optical fiber (2) outfan is regulated by angle adjusting mechanism, described microelectrode array (10) is fixed on the second hold-down bars (3f), and the locus of microelectrode array (10) is regulated by height adjustment mechanism.
2. the neuroactive prosthetic device of near infrared light according to claim 1, it is characterized in that: described angle adjusting mechanism is by the first screw (3b), second screw (3c), connector (3g) and metal ball (3d) composition, metal ball (3d) is fixed on bracing frame (3h), one end of connector (3g) is connected with the first hold-down bars (3a), and locked by the first screw (3b) between the first hold-down bars (3a) and connector (3g), the other end of connector (3g) is connected with metal ball (3d), and locked by the second screw (3c) between connector (3g) and metal ball (3d), described height adjustment mechanism is the 3rd screw (3e).
3. the neuroactive prosthetic device of near infrared light according to claim 1 and 2, it is characterized in that: described laser instrument (1) is pulsed laser, its pulsewidth < 10ms, frequency < 100Hz, drive current amplitudes is < 4A, threshold current is < 999mA, and step-length is 10mA.
4. the neuroactive prosthetic device of near infrared light according to claim 1 and 2, is characterized in that: described microelectrode array (10) can gather repairs nervous tissue (9) local field potentials of bringing out and SPIKE signal under near-infrared laser irradiates in advance.
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| CN201310052800.3A CN103071246B (en) | 2013-02-19 | 2013-02-19 | The neuroactive prosthetic device of near infrared light |
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| CN103405291B (en) * | 2013-08-23 | 2016-01-06 | 重庆大学 | Transmission-type multicenter near-infrared pulse nervus cochleae stimulating apparatus |
| CN110058004A (en) * | 2019-04-11 | 2019-07-26 | 高权 | A kind of experimental provision of laser co-focusing detection electro photoluminescence safety |
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| CN101705184A (en) * | 2009-11-26 | 2010-05-12 | 浙江大学 | Full-automatic cell physiological parameter analyzer based on multi-parameter detection integrated chip |
| US20110127405A1 (en) * | 2008-05-16 | 2011-06-02 | Nir Grossman | Optical stimulation of photosensitized cells |
| CN102283742A (en) * | 2011-08-15 | 2011-12-21 | 重庆大学 | Light stimulation based retinal prosthesis repairing device and repairing method |
| CN102793973A (en) * | 2012-08-03 | 2012-11-28 | 中国科学院深圳先进技术研究院 | Device for treating Parkinson's disease |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110127405A1 (en) * | 2008-05-16 | 2011-06-02 | Nir Grossman | Optical stimulation of photosensitized cells |
| CN101705184A (en) * | 2009-11-26 | 2010-05-12 | 浙江大学 | Full-automatic cell physiological parameter analyzer based on multi-parameter detection integrated chip |
| CN102283742A (en) * | 2011-08-15 | 2011-12-21 | 重庆大学 | Light stimulation based retinal prosthesis repairing device and repairing method |
| CN102793973A (en) * | 2012-08-03 | 2012-11-28 | 中国科学院深圳先进技术研究院 | Device for treating Parkinson's disease |
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Effective date of registration: 20230731 Address after: 400030 Floor 3, Chengjiao 5th Apartment, Chongqing University, Shazhong Road, Shapingba District, Chongqing Patentee after: Chongqing University Science and Technology Park Co.,Ltd. Address before: 400030 No. 174 Sha Jie street, Shapingba District, Chongqing Patentee before: Chongqing University |