CN103028202A - Transcranial ultrasound stimulation cranial-nerve-function-repairing device and method - Google Patents
Transcranial ultrasound stimulation cranial-nerve-function-repairing device and method Download PDFInfo
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Abstract
The invention discloses a transcranial ultrasound stimulation cranial-nerve-function-repairing device and a method. The device comprises a function signal generator, a power amplifier, and an ultrasonic transducer, wherein after the function signal generator produces stimulation signals needed by stimulation, the stimulation signals are amplified though the power amplifier to high voltage pulse signals needed by the ultrasonic transducer and then ultrasonic stimulation signals are obtained through the ultrasonic transducer to stimulate brain tissue. The transcranial ultrasound stimulation cranial-nerve-function-repairing device and the method can achieve the purposes of low-power, high-resolution, and non-invasive neural restoration treatment.
Description
Technical field
The present invention is about a kind of cortex stimulating technology, and particularly relating to a kind of TCD,transcranial Doppler stimulates the device and method of repairing cranial nerve function.
Background technology
Treat ultrasonic be divided into low-power treatment ultrasonic (usually less than 0.5W/cm2) and high power treatment ultrasonic (greater than 100W/cm2).Ultrasonicly can import human multiple tissue (comprising skeleton) into by the form of continuous wave or pulse.Intensity is lower than that the treatment of 0.5W/cm2 is ultrasonic then mainly to reach therapeutic effect by comprising that the non-thermal effects such as mechanical force occur to interact with tissue.The low intensity ultrasound that ultrasonic diagnosis is adopted then can regularly and professionally be examined the safety of tissue.Medical ultrasonic extensive use has clinically also confirmed the safety of low intensity ultrasound to biological tissue substantially.
At present existing various wounds or atraumatic cerebral cortex stimulating technology apply to laboratory and clinical, but these technology respectively have its limitation.Pharmacology and chemical method lack the specificity of target tissue, and spatial resolution is low, and disturb organizing metabolism to exist.Electrical stimulus patterns, for example deep brain stimulation is then passed through direct implant electrode in cerebral tissue, have higher spatial resolution, but the wound that the operation of opening cranium in the implantation process causes is larger.Photostimulation based on photogene directly acts on ion channel and transport protein, has impayable spatial resolution, processes but need to carry out transgenic to tested object, only is used at present laboratory research, is difficult to clinical practice.Atraumatic cortex stimulating technology commonly used has transcranial magnetic stimulation and stimulates through the cranium Direct Current at present.These two kinds of technology utilize respectively magnetic field and electric current through skull cortex to be stimulated, and need not carry out operation of opening cranium and other preprocessing means.But the spatial resolution of such technology relatively poor (greater than 1cm) has limited the scope of its application.
Summary of the invention
For overcoming above-mentioned the deficiencies in the prior art, the present invention's purpose is that a kind of TCD,transcranial Doppler stimulates the device and method of repairing cranial nerve function, and it has realized low-power, high-resolution, noninvasive neural repairing and treating purpose.
For reaching above-mentioned and other purpose, the invention provides a kind of TCD,transcranial Doppler and stimulate the device of repairing cranial nerve function, this device comprises function signal generator, power amplifier and ultrasonic transducer, wherein, after this function signal generator produces and stimulates required stimulus signal, be amplified to the required high-voltage pulse signal of this ultrasonic transducer by this power amplifier, then obtain the ultrasound stimulation signal by this ultrasonic transducer, so that cerebral tissue is stimulated.
Further, this device also comprises a wave filter, and the stimulus signal that this function signal generator produces amplifies by this power amplifier behind this filter filtering again.
Further, this function signal generator produces the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz.
Further, the parameter of this function signal generator configuration is as follows: fundamental frequency is 0.35MHz～0.7MHz, the primitive period number that individual pulse comprises is 70～250, and pulse recurrence frequency is 1K～3KHZ, and the individual pulse number that boost pulse comprises is 100～300.
Further, on this ultrasonic transducer, be equipped with the different-diameter collimator to realize precise positioning.
Further, this ultrasonic transducer is the ultrasonic transducer of self-focusing.
For reaching above-mentioned and other purpose, the present invention also provides a kind of TCD,transcranial Doppler to stimulate the method for repairing cranial nerve function, comprises the steps:
Step 1, configuration function signal generator produce stimulates required stimulus signal;
Step 2, the stimulus signal that function signal generator produces is amplified to the required high-voltage pulse signal of ultrasonic transducer by power amplifier; And
Step 3, this ultrasonic transducer obtain the ultrasound stimulation signal under the driving of this high-voltage pulse signal, so that cerebral tissue is stimulated.
Further, before step 2, comprise that also this stimulus signal carries out the step of filtering through a wave filter.
Further, this function signal generator produces the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz.
Further, in step 3, this ultrasonic transducer is equipped with the ultrasonic transducer of different-diameter collimator or employing self-focusing to realize precise positioning.
Compared with prior art, a kind of TCD,transcranial Doppler of the present invention stimulates the device and method of repairing cranial nerve function to produce the voltage signal of pulsed by function signal generator, be amplified to the required high-voltage pulse signal of ultrasonic transducer by power amplifier, then obtain the ultrasound stimulation signal by ultrasonic transducer, cerebral tissue is stimulated, have following advantage: 1) have millimetre-sized high spatial resolution; 2) the low stimulation power of use mW/cm2 level; 3) select easily penetrate skull, the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz; 4) but the present invention's noinvasive ground cerebral tissue is stimulated targetedly, repair the damaged portion in the cerebral tissue.
Description of drawings
Fig. 1 is the Organization Chart that a kind of TCD,transcranial Doppler of the present invention stimulates the device of repairing cranial nerve function;
Fig. 2 is the structure chart that a kind of TCD,transcranial Doppler of the present invention stimulates the preferred embodiment of the device of repairing cranial nerve function;
Fig. 3 is the flow chart of steps that a kind of TCD,transcranial Doppler of the present invention stimulates the method for repairing cranial nerve function.
The specific embodiment
Below by specific instantiation and accompanying drawings embodiments of the present invention, those skilled in the art can understand other advantage of the present invention and effect easily by content disclosed in the present specification.The present invention also can be implemented or be used by other different instantiation, and the every details in this description also can be based on different viewpoints and application, carries out various modifications and change under the spirit of the present invention not deviating from.
Fig. 1 is the Organization Chart that a kind of TCD,transcranial Doppler of the present invention stimulates the device of repairing cranial nerve function.As shown in Figure 1, a kind of TCD,transcranial Doppler of the present invention stimulates the device of repairing cranial nerve function, comprises at least: function signal generator 10, power amplifier 11 and ultrasonic transducer 12
Wherein, function signal generator 10 produces through configuration stimulates required signal, in preferred embodiment of the present invention, produce easily penetrate skull, the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz; The signal that power amplifier 11 produces function signal generator 10 is amplified to stimulates required high-voltage pulse signal, in order to drive ultrasonic transducer 12, better, the signal that function signal generator 10 produces amplifies through power amplifier 11 behind a filter filtering again; Ultrasonic transducer 12 obtains the ultrasound stimulation signal under the driving of high-voltage pulse signal, so that cerebral tissue is stimulated.
Fig. 2 is the structure chart that a kind of TCD,transcranial Doppler of the present invention stimulates the preferred embodiment of the device of repairing cranial nerve function.In preferred embodiment of the present invention, function signal generator 10 is by Single-chip Controlling, it selects the stimulus signal of pulsed, design parameter is as follows: fundamental frequency is 0.35MHz～0.7MHz, in preferred embodiment of the present invention, fundamental frequency is 0.5MHZ, selecting the frequency in this scope is because this scope belongs to ultrasonic frequency range optimum in the noinvasive TCD,transcranial Doppler, ultrasonic signal in this frequency range can be passed to cerebral tissue in the situation that minimum decay sees through skull effectively, Stimulation of The Brain is neural, the excitement of exciting motion cortex; The primitive period number that individual pulse comprises is 70～200, pulse recurrence frequency is 1K～2.5KHZ, the individual pulse number that boost pulse comprises is 100～300, random wave functional generator (shown in the 2-1 of Fig. 2) is by configuring as above parameter, and can send the signal that meets anticipation is required stimulus modelity.
After signal is sent by functional generator 2-1, filtering clutter via wave filter, by power amplifier (shown in the 2-2 of Fig. 2), is that the stimulus signal linear amplification of 5V is to stimulating required magnitude of voltage with peak value, send with pulse mode, low-power directly drives ultrasonic transducer.As shown in Figure 2, be coated with couplant on its surface and contact with the brain specific region, thereby target tissue is produced stimulation, repair tissue neural and domination, the contact table is not produced any damage.
For realizing high-resolution ultrasound stimulation, the stimulus signal that ultrasonic transducer generating can be focused on, can be at the fixing collimator of ultrasonic transducer, or the ultrasonic transducer of direct self-focusing, in preferred embodiment of the present invention, ultrasonic transducer (shown in the 2-3 among Fig. 2) is equipped with different-diameter collimator (shown in the 2-4 among Fig. 2) can the different brain area of precise positioning (spatial resolution can reach 2mm), improve the spatial resolution that stimulates.High-resolution stimulation can stimulate targetedly by ultrasonic different zone to cerebral tissue, thereby realizes specific brain region is stimulated rehabilitation.
Fig. 3 is the flow chart of steps that a kind of TCD,transcranial Doppler of the present invention stimulates the method for repairing cranial nerve function.As shown in Figure 3, a kind of TCD,transcranial Doppler of the present invention stimulates the method for repairing cranial nerve function, comprises the steps:
In preferred embodiment of the present invention, function signal generator is by Single-chip Controlling, its design parameter is as follows: fundamental frequency is 0.35MHz～0.7MHz, in preferred embodiment of the present invention, fundamental frequency is 0.5MHZ, selecting the frequency in this scope is because this scope belongs to ultrasonic frequency range optimum in the noinvasive TCD,transcranial Doppler, ultrasonic signal in this frequency range can be passed to cerebral tissue in the situation that minimum decay sees through skull effectively, Stimulation of The Brain is neural, the excitement of exciting motion cortex; The primitive period number that individual pulse comprises is 70～250, pulse recurrence frequency is 1K～3KHZ, the individual pulse number that boost pulse comprises is 100～300, and the random wave functional generator is by configuring as above parameter, and can send the signal that meets anticipation is required stimulus modelity.
After stimulus signal is sent by functional generator, filter clutter via wave filter, by power amplifier, with peak value be the stimulus signal linear amplification of 5V to stimulating required magnitude of voltage, send with pulse mode, low-power directly drives ultrasonic transducer.
In preferred embodiment of the present invention, ultrasonic transducer is equipped with the different-diameter collimator, can the different brain area of precise positioning (spatial resolution can reach 2mm), improve the spatial resolution that stimulates.High-resolution stimulation can stimulate targetedly by ultrasonic different zone to cerebral tissue, thereby realizes specific brain region is stimulated rehabilitation.
In sum, a kind of TCD,transcranial Doppler of the present invention stimulates the device and method of repairing cranial nerve function to produce the voltage signal of pulsed by function signal generator, be amplified to the required high-voltage pulse signal of ultrasonic transducer by power amplifier, then obtain the ultrasound stimulation signal by ultrasonic transducer, cerebral tissue is stimulated, have following advantage: 1) have millimetre-sized high spatial resolution; 2) the low stimulation power of use mW/cm2 level; 3) select easily penetrate skull, the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz; 4) but the present invention's noinvasive ground cerebral tissue is stimulated targetedly, repair the damaged portion in the cerebral tissue.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not is used for restriction the present invention.Any those skilled in the art all can be under spirit of the present invention and category, and above-described embodiment is modified and changed.Therefore, the scope of the present invention should be listed such as claims.
Claims (10)
1. a TCD,transcranial Doppler stimulates the device of repairing cranial nerve function, it is characterized in that: this device comprises function signal generator, power amplifier and ultrasonic transducer, wherein, after this function signal generator produces and stimulates required stimulus signal, be amplified to the required high-voltage pulse signal of this ultrasonic transducer by this power amplifier, then obtain the ultrasound stimulation signal by this ultrasonic transducer, so that cerebral tissue is stimulated.
2. a kind of TCD,transcranial Doppler as claimed in claim 1 stimulates the device of repairing cranial nerve function, it is characterized in that: this device also comprises a wave filter, and the stimulus signal that this function signal generator produces amplifies by this power amplifier behind this filter filtering again.
3. a kind of TCD,transcranial Doppler as claimed in claim 2 stimulates the device of repairing cranial nerve function: this function signal generator produces the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz.
4. a kind of TCD,transcranial Doppler as claimed in claim 2 stimulates the device of repairing cranial nerve function, it is characterized in that, the parameter of this function signal generator configuration is as follows: fundamental frequency is 0.35MHz～0.7MHz, the primitive period number that individual pulse comprises is 70～250, pulse recurrence frequency is 1K～3KHZ, and the individual pulse number that boost pulse comprises is 100～300.
5. a kind of TCD,transcranial Doppler as claimed in claim 2 stimulates the device of repairing cranial nerve function, it is characterized in that: be equipped with the different-diameter collimator to realize precise positioning on this ultrasonic transducer.
6. a kind of TCD,transcranial Doppler as claimed in claim 2 stimulates the device of repairing cranial nerve function, and it is characterized in that: this ultrasonic transducer can be the ultrasonic transducer of self-focusing.
7. a TCD,transcranial Doppler stimulates the method for repairing cranial nerve function, comprises the steps:
Step 1, configuration function signal generator produce stimulates required stimulus signal;
Step 2, the stimulus signal that function signal generator produces is amplified to the required high-voltage pulse signal of ultrasonic transducer by power amplifier;
Step 3, this ultrasonic transducer obtain the ultrasound stimulation signal under the driving of this high-voltage pulse signal, so that cerebral tissue is stimulated.
8. a kind of TCD,transcranial Doppler as claimed in claim 7 stimulates the method for repairing cranial nerve function, it is characterized in that: before step 2, comprise that also this stimulus signal carries out the step of filtering through a wave filter.
9. a kind of TCD,transcranial Doppler as claimed in claim 8 stimulates the method for repairing cranial nerve function, it is characterized in that: this function signal generator produces the stimulus signal of fundamental frequency between 0.35MHz～0.7MHz.
10. a kind of TCD,transcranial Doppler as claimed in claim 8 stimulates the method for repairing cranial nerve function, it is characterized in that: in step 3, this ultrasonic transducer is equipped with the ultrasonic transducer of different-diameter collimator or employing self-focusing to realize precise positioning.
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Cited By (14)
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| CN103432691A (en) * | 2013-08-13 | 2013-12-11 | 北京师范大学 | Transcranial ultrasonic brain regulating and controlling method and device |
| CN104548390A (en) * | 2014-12-26 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Ultrasound deep brain stimulation method and system |
| CN104548392A (en) * | 2015-01-16 | 2015-04-29 | 上海理工大学 | Transcranial ultrasonic stimulation device and stimulation method |
| CN104857640A (en) * | 2015-04-22 | 2015-08-26 | 燕山大学 | Closed-loop type transcranial ultrasonic brain stimulation apparatus |
| CN105536156A (en) * | 2015-12-25 | 2016-05-04 | 中国科学院深圳先进技术研究院 | Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof |
| WO2016184116A1 (en) * | 2015-05-15 | 2016-11-24 | 深圳先进技术研究院 | Ultrasonic stimulation device for neural tissue |
| WO2017035767A1 (en) * | 2015-09-01 | 2017-03-09 | 中国科学院深圳先进技术研究院 | Method and system for genetic manipulation of sound-sensitive ion channels |
| CN106861061A (en) * | 2017-03-09 | 2017-06-20 | 中国科学院深圳先进技术研究院 | Sobering animal ultrasound neuromodulation device |
| CN107510900A (en) * | 2017-10-20 | 2017-12-26 | 上海交通大学 | A kind of TCD,transcranial Doppler stimulates the device and method of increase neurotrophic factor expression |
| CN109011225A (en) * | 2018-07-02 | 2018-12-18 | 华中科技大学 | A kind of Biologic analgesia device based on ultrasonic nerve stimulation |
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| CN103432691A (en) * | 2013-08-13 | 2013-12-11 | 北京师范大学 | Transcranial ultrasonic brain regulating and controlling method and device |
| CN104548390A (en) * | 2014-12-26 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Ultrasound deep brain stimulation method and system |
| US11253730B2 (en) | 2014-12-26 | 2022-02-22 | Greenvalley Braintech (Shenzhen) Medical Technology Co., Ltd. | Ultrasound deep brain stimulation method and system |
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| CN104548390B (en) * | 2014-12-26 | 2018-03-23 | 中国科学院深圳先进技术研究院 | It is a kind of to obtain the method and system that the ultrasound emission sequence that cranium focuses on ultrasound is worn for launching |
| CN104548392B (en) * | 2015-01-16 | 2017-12-05 | 上海理工大学 | TCD,transcranial Doppler stimulating apparatus and stimulating method |
| CN104548392A (en) * | 2015-01-16 | 2015-04-29 | 上海理工大学 | Transcranial ultrasonic stimulation device and stimulation method |
| CN104857640A (en) * | 2015-04-22 | 2015-08-26 | 燕山大学 | Closed-loop type transcranial ultrasonic brain stimulation apparatus |
| WO2016184116A1 (en) * | 2015-05-15 | 2016-11-24 | 深圳先进技术研究院 | Ultrasonic stimulation device for neural tissue |
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| CN105536156A (en) * | 2015-12-25 | 2016-05-04 | 中国科学院深圳先进技术研究院 | Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof |
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| CN107510900A (en) * | 2017-10-20 | 2017-12-26 | 上海交通大学 | A kind of TCD,transcranial Doppler stimulates the device and method of increase neurotrophic factor expression |
| CN109718481A (en) * | 2017-10-31 | 2019-05-07 | 深圳先进技术研究院 | Ultrasonic neuromodulation system, method and the storage medium for treating addictive disorders |
| CN109011225A (en) * | 2018-07-02 | 2018-12-18 | 华中科技大学 | A kind of Biologic analgesia device based on ultrasonic nerve stimulation |
| CN110368608A (en) * | 2019-07-23 | 2019-10-25 | 深圳先进技术研究院 | A kind of neuromodulation device and method |
| CN110368608B (en) * | 2019-07-23 | 2021-04-30 | 深圳先进技术研究院 | Nerve regulation and control device |
| CN110478632A (en) * | 2019-08-30 | 2019-11-22 | 深圳先进技术研究院 | Ultrasonic acupuncture device |
| WO2021087960A1 (en) * | 2019-11-08 | 2021-05-14 | 中国科学院深圳先进技术研究院 | Closed-loop ultrasonic neuromodulation system and method |
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