CN110368608A - A kind of neuromodulation device and method - Google Patents
A kind of neuromodulation device and method Download PDFInfo
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- CN110368608A CN110368608A CN201910665447.3A CN201910665447A CN110368608A CN 110368608 A CN110368608 A CN 110368608A CN 201910665447 A CN201910665447 A CN 201910665447A CN 110368608 A CN110368608 A CN 110368608A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
Abstract
A kind of neuromodulation device and method is used for stimulation target nerve nucleus.The device is generated and transmitted by ultrasonic wave by ultrasonic generation module, is conducted by the first conduction module, the parameter information of position and rea adjusting ultrasonic wave that orientation guided wave module is rolled into a ball according to target nerve core, to change the conduction orientation of ultrasonic wave and be oriented conduction；Orientation guided wave module includes multiple artificial structures that replacement uses, the corresponding one group of target nerve core group of an artificial structure.Second conduction module transmits the ultrasonic wave of orientation conduction, so that the ultrasonic focal spot of focusing ultrasonic wave is projeced into target nerve core group.Above-mentioned neuromodulation device and method, the position and area rolled into a ball according to one group of target nerve core to be stimulated accordingly select artificial structure to work, so that ultrasonic wave is after artificial structure's adjusting parameter information, ultrasonic focal spot is projeced into this group of target nerve core group, realization is intervened and treated to cerebral dysfunction disease.
Description
Technical field
The invention belongs to neuromodulation technical field more particularly to a kind of neuromodulation device and methods.
Background technique
Cerebral dysfunction disease such as Parkinson, epilepsy, depression etc., main reason is brain deep nerve loop, and there are functions
Obstacle, multiple nerve nucleus in neural circuitry can not cooperate.The principle of neuromodulation technology be by and meanwhile stimulation it is more
A nerve nucleus, improves the function of neural circuitry, to achieve the effect that treatment.
Currently, traditional neuromodulation technology carries out nerve nucleus by using electronically phased array sound field modulating device
Stimulation, the device are generated and transmitted by multi beam ultrasonic wave using multiple more array element ultrasonic transducers, pierce to one group of nerve nucleus
Swash.The electronically phased array sound field regulation device at high cost therefore traditional of more array element ultrasonic transducers involves great expense, and controls multiple
The circuit of more array element ultrasonic transducers is complicated, and trivial operations, practicability are low.
Therefore, there is need to carry out work using multiple more element transducers for traditional electronically phased array sound field modulating device
Make, trivial operations, cost be high and the problem that can not popularize.
Summary of the invention
In view of this, the embodiment of the invention provides a kind of neuromodulation device and methods, it is intended to solve traditional technology
It needs to work using multiple more element transducers present in scheme, trivial operations, cost are high and can not popularize
Problem.
The first aspect of the embodiment of the present invention provides a kind of neuromodulation device, is used for stimulation target nerve nucleus, institute
Stating neuromodulation device includes:
Ultrasonic generation module, for being generated and transmitted by ultrasonic wave；
First conduction module is connect with the ultrasonic generation module, and the first conduction module is for conducting the ultrasound
Wave；
Guided wave module is oriented, is connect with the first conduction module, the orientation guided wave module is used for according to one group
The parameter information of ultrasonic wave described in the position of target nerve core group and rea adjusting, to change the conduction orientation of the ultrasonic wave simultaneously
It is oriented conduction；Wherein, the orientation guided wave module includes multiple artificial structures that replacement uses, an artificial structure
Target nerve core group described in one group corresponding；And
Second conduction module, connect with the orientation guided wave module, and the second conduction module is used for orientation conduction
The ultrasonic wave is transmitted, so that the ultrasonic focal spot of the focusing ultrasonic wave is projeced into the target nerve core group.
The second aspect of the embodiment of the present invention provides a kind of neuromodulation method, is used for stimulation target nerve nucleus, institute
Stating neuromodulation method includes:
It is generated and transmitted by ultrasonic wave；
Conduct the ultrasonic wave；
The parameter information of ultrasonic wave described in the position rolled into a ball according to the different target nerve core and rea adjusting, to change
The conduction orientation of the ultrasonic wave is simultaneously oriented conduction；
The ultrasonic wave of orientation conduction is transmitted so that the ultrasonic focal spot of the focusing ultrasonic wave be projeced into it is described
In target nerve core group.
A kind of above-mentioned neuromodulation device and method, position roll into a ball according to target nerve core by orientation guided wave module with
The parameter information of rea adjusting ultrasonic wave, to change the conduction orientation of ultrasonic wave and be oriented conduction.For different brain minds
Through property disease, the applicable artificial structure in the position and area selection that need to be only rolled into a ball according to corresponding one group of target nerve core is replaced
After come into operation, can realize and the ultrasonic focal spot of ultrasonic wave is projeced on this group of nerve nucleus, this group of nerve nucleus is carried out
Stimulation, to be intervened cerebral dysfunction disease and be treated.Adaptability selects artificial structure, it can be achieved that fixed point stimulation applications letter
Single, maintenance cost is low, cheap.
Detailed description of the invention
It to describe the technical solutions in the embodiments of the present invention more clearly, below will be to embodiment or description of the prior art
Needed in attached drawing be briefly described, it should be apparent that, the accompanying drawings in the following description is only of the invention some
Embodiment for those of ordinary skill in the art without any creative labor, can also be according to these
Attached drawing obtains other attached drawings.
Fig. 1 is a kind of modular structure schematic diagram for neuromodulation device that one embodiment of the invention provides；
Fig. 2 is the composition schematic diagram of neuromodulation device shown in FIG. 1；
Fig. 3 be another embodiment of the present invention provides a kind of neuromodulation method specific flow chart；
Fig. 4 is a kind of specific flow chart for neuromodulation method that further embodiment of this invention provides.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Cerebral dysfunction disease such as Parkinson's disease, epileptics and depression etc., the mainly neural circuitry due to patient's brain
There is obstacle, neural circuitry is made of at least one nerve nucleus, when the nerve nucleus in a neural circuitry can not cooperate with work
When making, it will lead to and specific cerebral dysfunction disease occur.The present invention is intended to provide a kind of neuromodulation device and method, for piercing
Target nerve core group, such as one group of target nerve core group corresponding to stimulation Parkinson's disease are swashed, so that this group of target nerve core group
It cooperates, so that the cranial nerve disease is intervened and be treated.
Fig. 1 is a kind of modular structure schematic diagram for neuromodulation device that one embodiment of the invention provides, for the ease of saying
Bright, only the parts related to this embodiment are shown, and details are as follows:
A kind of neuromodulation device is used for stimulation target nerve nucleus.The neuromodulation device includes ultrasonic generation module
10, the first conduction module 20, orientation guided wave module 30 and the second conduction module 40.
Ultrasonic first conduction of the connection of generation module 10 module 20, the first conduction connection orientation guided wave module 30 of module 20 are fixed
To the connection of guided wave module 30 second conduction module 40, the skin contact of the second conduction module 40 and organism.
Wherein, ultrasonic generation module 10 is for being generated and transmitted by ultrasonic wave.First conduction module 20 is used for conduct ultrasound.
The parameter for orienting position and rea adjusting ultrasonic wave that guided wave module 30 is used to roll into a ball according to one group of target nerve core is believed
Breath, to change the conduction orientation of ultrasonic wave and be oriented conduction；Wherein, orientation guided wave module 30 uses multiple including replacement
Artificial structure 301, the corresponding one group of target nerve core group of an artificial structure 301.Neuromodulation device provided in this embodiment,
Only an artificial structure 301 is selected to come into operation according to actual needs in single use.
Optionally, the connection type between ultrasonic generation module 10 and the artificial structure 301 come into operation includes but unlimited
In key connection, pin connection or threaded connection.Certainly, it is adopted between ultrasonic generation module 10 and the artificial structure 301 come into operation
Neuromodulation device provided in an embodiment of the present invention is had no effect on to the therapeutic effect of disease with for which kind of connection type.
Second conduction module 40 is used to transmit the ultrasonic wave of orientation conduction, so that the ultrasonic focal spot of focusing ultrasonic wave
It is projeced into target nerve core group.
Specifically, the first conduction module 20 and the second conduction module 40 only carry out indifference supplementary biography to the ultrasonic wave received
It leads, does not change the Energy distribution form of ultrasonic wave.It orients guided wave module 30 to realize using multiple artificial structures 301, for one
Group target nerve core group to be stimulated selects a corresponding artificial structure 301 and comes into operation, with the parameter letter to ultrasonic wave
Breath is adjusted, so that the Energy distribution form of ultrasonic wave changes；Finally, ultrasonic focal spot projects this group of nerve nucleus
On, this group of nerve nucleus is stimulated simultaneously, corresponding cerebral dysfunction disease is intervened and be treated.
Artificial structure 301 is a kind of composite material as made of its stereoeffect of artificial special designing, usually by one
Kind or a variety of elastic materials are by periodic arrangement or by lattice similar in no periodic array composition size and ultrasonic wavelength
Arrangement architecture.
There are vocal cords gap in the lattice arrangement structure of artificial structure 301, the ultrasound propagated in such lattice arrangement structure
Wave can show some special properties, lead so that acoustic filter, orientation guided wave, fixed point may be implemented in artificial structure 301
The functions such as wave.Ultrasonic wave conducts after 301 adjusting parameter information of artificial structure, can realize that single-point pierces according to actual needs
Swash, multiple spot stimulation, the position of stimulation and area are adjustable.
It, can by introducing special microstructure unit when the lattice dimensions in artificial structure 301 are much smaller than ultrasonic wavelength
To realize acoustic characteristic that some natural materials cannot achieve.Such as described by equivalent parameters, including density anisotropy,
Negative mass density, negative elasticity modulus etc..
In embodiments of the present invention, for different cerebral dysfunction diseases, different artificial structures 301 is designed, is used for
Stimulate corresponding one group of nerve nucleus；Meanwhile it can also be directed to the concrete condition of patient, design the artificial structure of the exclusive patient
301, to carry out personalized treatment to patient, therapeutic effect is more preferably.In practical application, artificial knot can be set according to actual needs
The concrete composition of structure 301 and the scale of lattice arrangement structure, the specific present invention are without restriction.
The lattice arrangement structure of each artificial structure 301 determines that it imitates the effect of the Energy distribution form of ultrasonic wave
Fruit.Multiple artificial structures 301 are adjusted the parameter information of ultrasonic wave according to respective lattice arrangement structure, super to determine
The position of sound focal spot and size.
For example, an artificial structure 301 can realize the Energy distribution modality conversion of ultrasonic wave are as follows: be with an area
1.01mm2Ultrasonic focal spot, and the ultrasound focal spot be projeced into target nerve core group A on；For another example, another artificial structure 301 can
Realize the Energy distribution modality conversion of ultrasonic wave are as follows: tool is respectively 0.21mm there are three area2、1.00mm2And 1.11mm2It is super
Sound focal spot, and three ultrasonic focal spots are projeced into respectively on target nerve core group B, target nerve core group C and target nerve core group D.
In an alternative embodiment, artificial structure 301 presses predetermined material and preset thickness using at least one elastic material
It is made.
In an alternative embodiment, artificial structure 301 uses at least one of epoxy resin and silica gel, and by default material
Material proportion and preset thickness are made.Epoxy resin and silica gel belong to the good elastic material of sound transparency, by changing asphalt mixtures modified by epoxy resin
The thickness of the proportion and artificial structure 301 of rouge and silica gel can prepare the different multiple artificial structures of lattice arrangement structure
301。
Neuromodulation device provided in an embodiment of the present invention is led by using the orientation being made of multiple artificial structures 301
The parameter information of position and rea adjusting ultrasonic wave that wave module 30 is rolled into a ball according to target nerve core, to change the conduction side of ultrasonic wave
To and be oriented conduction, that is, change the Energy distribution form of ultrasonic wave.Therefore, the ultrasonic wave meeting that ultrasonic generation module 10 emits
According to preset direction and position to organism skin conductance after artificial structure 301 so that ultrasonic focal spot be projeced into it is to be stimulated
In one group of target nerve core group, while multiple target nerve cores groups different to depth, area is different stimulates.
In an alternative embodiment, ultrasonic generation module 10 is realized using single-element ultrasound transducer 02, specially plane
Single-element ultrasound transducer.
Specifically, single-element ultrasound transducer 02 only generates a branch of ultrasonic wave, after which passes through artificial structure 301, ginseng
Number information changes, and is transmitted by specific direction, and be consequently focused on one group of target corresponding with the artificial structure 301
On nerve nucleus.
The low manufacture cost of artificial structure 301, compared to the more array element ultrasonic transducers to involve great expense, the present invention is using single
A single-element ultrasound transducer 02 emits ultrasonic wave, is realized by replacement using artificial structure 301 and is carried out to target nerve core group
Stimulation, the cost of device is low, and universality is high；Also, artificial structure 301 changes the Energy distribution form of ultrasonic wave, so that super
Sound focal spot is accurately projeced into target nerve core group to be stimulated, and specific aim is stronger, realizes personalized treatment, therapeutic effect
It greatly promotes.
In the present embodiment, the shape of artificial structure 301 include but is not limited to cuboid, square, cylindrical body, round estrade or
Person's prismoid.
Emit ultrasonic wave using multiple more array element ultrasonic transducers compared to traditional, so that nerve nucleus is stimulated,
Neuromodulation device accuracy provided in this embodiment is high, with strong points.In addition, the multiple more array element ultrasonic transducers of control carry out
The control circuit and program of work are extremely complex, and the maintenance difficulty of control circuit is big, and neuromodulation provided in this embodiment fills
Setting only need to select the artificial structure 301 come into operation according to the cerebral dysfunction disease of patient, control single single array element ultrasonic transduction
The control circuit and program that device 02 works are simple, and maintenance difficulty is low.Thus, neuromodulation device provided in this embodiment exists
Greatly reduced while improving therapeutic effect Medical Devices Material Cost, research and development cost, cost of manufacture, use cost and
Maintenance cost.
Fig. 2 is that the composition schematic diagram of neuromodulation device shown in FIG. 1 illustrates only and this implementation for ease of description
The relevant part of example, details are as follows:
The appended drawing reference of Fig. 2 respectively indicates:
01: conducting wire；02: single-element ultrasound transducer；301: artificial structure；04: fixator；05: deionized water；06: the
One clamper；07: the second water pocket 07；08: deionized water；09: the second clamper；010: skull；011: ultrasonic wave propagation path；
012: target nerve core group；013: target nerve core group；014: target nerve core group；015: target nerve core group.
In an alternative embodiment, the first above-mentioned conduction module 20 and the second conduction module 40 are all made of deionized water reality
Existing, deionized water is installed in water pocket, and water pocket is bonded with artificial structure 301.
Specifically, the first conduction module 20 is placed in the first water pocket, the outer surface of the first water pocket and single array element ultrasonic transduction
Device 02 is bonded, and the area for the outer surface that the first water pocket is bonded with single-element ultrasound transducer 02 is more than or equal to single array element ultrasound
Ultrasonic wave is carried out indifference transmission by the area of the ultrasonic emission port of energy converter 02.Optionally, the first water pocket is ultrasonic water
First conduction module 20 both can be that deionized water 05 is loaded on inner space by capsule, itself can also be with indifference conduct ultrasound.
In an alternative embodiment, the first water pocket is imitated body material using tissue and is made, and organizes imitative body material that can carry out ultrasound
It propagates.
In another embodiment, the first water pocket, which can cover couplant, is applied to outer surface, to enhance the energy of transmission ultrasonic wave
Power.
Meanwhile first the outer surface of water pocket be bonded with the artificial structure 301 come into operation, ultrasonic wave is transferred to artificial knot
Structure 301.It can be adhesively fixed by nylon tape between first water pocket and single-element ultrasound transducer 02, the first water pocket and artificial
It can also be adhesively fixed by nylon tape between structure 301.
The outer surface that second conduction module 40 is placed in the second water pocket 07 is bonded with artificial structure 301, the second water pocket 07 and people
The area for the outer surface that work structure 301 is bonded is more than or equal to the surface of artificial structure 301 being bonded with the second water pocket 07
The ultrasonic wave that second water pocket 07 conducts is completely transferred to artificial structure 301 by area.
Optionally, the second water pocket 07 is ultrasonic water pocket, both can be deionized water 08 loaded on interior by the second conduction module 40
Portion space, itself can be with indifference conduct ultrasound.
In an alternative embodiment, the second water pocket 07 is imitated body material using tissue and is made, and organizes imitative body material that can be surpassed
Acoustic propagation.
In another embodiment, the second water pocket 07, which can cover couplant, is applied to outer surface, to enhance transmission ultrasonic wave
Ability.
Optionally, the first water pocket is bonded by nylon tape with artificial structure 301 and single-element ultrasound transducer 02, the
Two water pockets 07 are bonded by nylon tape with artificial structure 301.Nylon tape can be dismantled and be may be reused, convenient
Replace artificial structure 301, single-element ultrasound transducer 02, the first water pocket or the first conduction module 20.Nylon tape is set to
The outer surface of the outer surface of one water pocket, the outer surface of single-element ultrasound transducer 02 and artificial structure 301 is specifically set to
Position other than the contact surface and the first water pocket of one water pocket and single-element ultrasound transducer 02 and the contact surface of artificial structure 301,
The conductive process of ultrasonic wave is influenced to avoid nylon tape.
Certainly, the first water pocket can also be by other dismountable fixed devices and single-element ultrasound transducer 02 and artificial
Structure 301 is posted and fixed.How first water pocket is bonded with single-element ultrasound transducer 02 and artificial structure 301,
Have no effect on the performance of the neuromodulation device of the present embodiment.
For example, in the embodiment shown in Figure 2, single-element ultrasound transducer 02 and artificial structure 301 pass through fixator 04
It is fixed, and deionized water 05 is held between single-element ultrasound transducer 02 and artificial structure 301.Certainly, deionization
Water 05 is set in the first water pocket.First water pocket is held between single-element ultrasound transducer 02 and artificial structure 301.
Optionally, fixator 04 is to single-element ultrasound transducer 02 and 301 company of being fixed of artificial structure come into operation
When connecing, the modes such as key connection, pin connection or threaded connection can be used.
Optionally, the second water pocket 07 is bonded by nylon tape with artificial structure 301.Nylon tape can carry out disassembly and
It may be reused, be convenient for changing artificial structure 301, the second water pocket 07 or deionized water 08.Nylon tape is set to the second water
The outer surface of capsule 07 and the outer surface of artificial structure 301, be specifically set to the contact surface of the second water pocket 07 and artificial structure 301 with
Outer position influences the conductive process of ultrasonic wave to avoid nylon tape.
Certainly, the second water pocket 07 can also be by other dismountable fixed device single-element ultrasound transducers 02 and artificial
Structure 301 is posted and fixed.How first water pocket is bonded with single-element ultrasound transducer 02 and artificial structure 301,
Have no effect on the performance of the neuromodulation device of the present embodiment.
For example, in the embodiment shown in Figure 2, the upper surface of the second water pocket 07 is equipped with concave surface, the people come into operation
Work structure 301 is placed in the concave surface, is fitted closely with the concave surface.Under the premise of not influencing ultrasonic transmission, nylon can be used
Patch or adhesive bond artificial structure 301 and the concave surface.
Deionized water 08 is set in the second water pocket 07, can periodically be replaced.Second water pocket 07 is using flexible material system
At the skin of the outer surface fitting organism of the second water pocket 07.For example, Fig. 2 shows the skulls 010 of the second water pocket 07 and human body
The situation of fitting, the second water pocket 07 accordingly adjust the shape of itself, final fitting completely with the fluctuating situation of the skin of its contact
In on the skin of organism.
Certainly, neuromodulation device provided in this embodiment is not only disposed only on the skull 010 of human body, only to human body
Brain neuroblastoma is stimulated；According to actual needs, which may also be placed in the other positions of organism, to organism
Peripheral organ and peripheral nerve stimulate, to reach therapeutic effect.Above-mentioned organism is not limited only to the mankind, can be with
For other animals.
Optionally, the first conduction module 20 and the second conduction module 40 can be used the good substance of other sound transparencies and realize.
Neuromodulation device provided in this embodiment is placed in by the first clamper 06 and the second clamper 09 with a pedestal
On the ground, the external support equipment connection on wall or in other fixed objects.Wherein, the first clamper 06 is for clamping single array element
Ultrasonic transducer 02, the second clamper 09 is for clamping artificial structure 301；First clamper 06 is nested with the second clamper 09 to be made
With.When needing replacing artificial structure 301, single-element ultrasound transducer 02 need to only be separated in the first water pocket, and will be artificial
Fixator 04 between structure 301 and single-element ultrasound transducer 02, which releases, to be fixed, and will need to put into make by fixator 04
Artificial structure 301 is fixed with single-element ultrasound transducer 02.
As shown in Fig. 2, the ultrasonic wave that single-element ultrasound transducer 02 is generated and transmitted by passes through the first water pocket and deionized water
05 conduction adjusts its parameter information by artificial structure 301 to artificial structure 301.Ultrasonic wave after parameter information is adjusted, macro
The variation that the change of ultrasonic wave propagation path 011, the position of ultrasonic focal spot and area change is embodied in sight.For example, through shown in Fig. 2
Artificial structure 301 adjustment after, ultrasonic wave is conducted along ultrasonic wave propagation path 011, and pass through 07 He of the second water pocket
After deionized water 08, it is transmitted to the skull 010 of human body, the ultrasonic focal spot point of three of formation is projeced into target nerve core and rolls into a ball 012, mesh
It marks in nerve nucleus 013, target nerve core group 014 and target nerve core group 015.Specifically, target nerve core shown in Fig. 2 group
13 be subthalamic nuclei, and target nerve core group 14 is pallidal inside.
The neuromodulation device provided through this embodiment, only need to be according in neural circuitry to be stimulated, target nerve core
The position of group and area, it is corresponding that artificial structure 301 is selected to come into operation, it can be by ultrasonic projection in loop nerve to be stimulated
In each target nerve core group, cerebral dysfunction disease is intervened and is treated, the state of an illness of patient is improved, it is easy to use, and
It is cheap.It is reformed by Energy distribution form of the different artificial structures 301 to ultrasonic wave, modulates specific ultrasound
Sound field, multiple ultrasonic focal spots that depth is different so that ultrasonic wave can produce, field stimulation is different.According to patient individual or brain
The case where functional disease itself, designs different artificial structures 301 and devotes oneself to work, and modulates personalized ultrasonic sound field point
Cloth state, i.e. energy distributional pattern, to achieve the effect that precisely treatment, personalized treatment.
Neuromodulation device provided in this embodiment is generated and transmitted by super using single plane single-element ultrasound transducer 02
Sound wave, by replace artificial structure 301 realize accurate treatment, abandoned it is traditional using multiple more array element ultrasonic transducers to mind
The method stimulated through core group, it is cheap, and the accuracy of stimulation sites greatly improves, and has more preferably treatment effect
Fruit.
In an alternative embodiment, above-mentioned neuromodulation device further includes power supply module, passes through conducting wire 01 and single array element
Ultrasonic transducer 02 connects, for being powered to single-element ultrasound transducer 02.Power supply module passes through 01 pair of conducting wire single array element
Ultrasonic transducer 02 provides electric energy, to motivate single-element ultrasound transducer 02 to generate ultrasonic wave and be emitted.Specifically, it supplies
Electric module realizes that the electric energy that the power supply circuit provides is transferred to Dan Zhen in the form of ac signal using existing power supply circuit
The frequency of first ultrasonic transducer 02, the ac signal is within the scope of predeterminated frequency.
In an alternative embodiment, above-mentioned neuromodulation device further includes adjustment module, adjustment module and power supply ground mould
Block connection, for adjusting the frequency, amplitude and phase of ac signal, to increase or reduce the frequency of ultrasonic wave, to increase
The stimulation degree that target nerve core is rolled into a ball in big or reduction.
Fig. 3 be another embodiment of the present invention provides a kind of neuromodulation method specific flow chart, for ease of description,
Only the parts related to this embodiment are shown, and details are as follows:
A kind of neuromodulation method is used for stimulation target nerve nucleus, includes the following steps:
S01: it is generated and transmitted by ultrasonic wave；
S02: conduct ultrasound；
S03: the parameter information of the position and rea adjusting ultrasonic wave rolled into a ball according to different target nerve core, to change ultrasound
The conduction orientation of wave is simultaneously oriented conduction；
S04: the ultrasonic wave of orientation conduction is transmitted, so that the ultrasonic focal spot of focusing ultrasonic wave is projeced into target nerve
In core group.
Specifically, step S01 is generated and transmitted by ultrasonic wave using ultrasonic generation module 10, and ultrasonic generation module 10 is using single
Array element ultrasonic transducer 02 is realized.Step S02 is using the first conduction 20 conduct ultrasound of module.First conduction module 20, which uses, goes
Ionized water realizes that deionized water is set in the first water pocket, and the first water pocket and single-element ultrasound transducer 02 and artificial structure 301 paste
It closes.
Position and rea adjusting ultrasonic wave of the step S03 using orientation guided wave module 30 according to different target nerve core groups
Parameter information, to change the conduction orientation of ultrasonic wave and be oriented conduction.Orientation guided wave module 30 includes what replacement used
Multiple artificial structures 301, the corresponding one group of target nerve core group of an artificial structure 301, one group of target nerve core group are corresponding a kind of
The disease of cerebral dysfunction disease or peripheral organ and peripheral nerve.
Step S04 is transmitted using the ultrasonic wave of 40 pairs of module orientation conduction of the second conduction.Second conduction module 40 is adopted
It is realized with the deionized water being set in the second water pocket 07.Second water pocket 07 is bonded with artificial structure 301, and the skin with organism
Skin fitting.
It is worth noting that the deionized water in step S02 and step S04 can be replaced.
Fig. 4 is a kind of specific flow chart for neuromodulation method that further embodiment of this invention provides, for ease of description,
Only the parts related to this embodiment are shown, and details are as follows:
In an alternative embodiment, above-mentioned step S03 is specially step S031: replacement uses artificial structure 301, and root
The parameter information of the position and rea adjusting ultrasonic wave rolled into a ball according to one group of target nerve core, is gone forward side by side with changing the conduction orientation of ultrasonic wave
Row orientation conduction；Wherein, the corresponding one group of target nerve core group of an artificial structure 301.
Specifically, it when replacing artificial structure 301, can also be replaced by mechanical device by replacing manually.Replacement
Process specifically:
Fixation of the fixator to single-element ultrasound transducer 02 and artificial structure 301 is released, artificial structure 301 is replaced, adopts
Poor social function energy converter and artificial structure 301 are retightened with fixator.
Further include following steps before executing step S031 in an alternative embodiment:
The material composition of artificial structure 301 is derived according to the position of target nerve core group and area, and calculates material composition
Proportion and calculate artificial structure 301 thickness；Prepare corresponding artificial structure 301.
Ultrasonic wave conducts after 301 adjusting parameter information of artificial structure, can realize according to actual needs punctual stimulation,
Multiple spot stimulation, the position of stimulation and area are adjustable.For different cerebral dysfunction diseases, different artificial structures is designed
301, for stimulating corresponding one group of nerve nucleus；Meanwhile it can also be directed to the concrete condition of patient, design the people of the exclusive patient
Work structure 301, to carry out personalized treatment to patient, therapeutic effect is more preferably.In practical application, it can be set according to actual needs
The concrete composition of artificial structure 301 and the scale of lattice arrangement structure, the specific present invention are without restriction.
Further include following steps before executing step S01 in an alternative embodiment:
Export ac signal.
Specifically, using power supply module to provide form is the electric energy of ac signal to single-element ultrasound transducer 02, single
Array element ultrasonic transducer 02 is emitted after converting electrical energy into ultrasonic wave.
In conclusion the embodiment of the invention provides a kind of neuromodulation device and method, according to one group of mesh to be stimulated
The position and area for marking nerve nucleus accordingly select artificial structure 301 to work, so that ultrasonic wave is adjusted through artificial structure 301
After parameter information, ultrasonic focal spot is projeced into this group of target nerve core group, cerebral dysfunction disease is intervened to realize
And treatment.Only the artificial structure 301 come into operation need to be selected according to the cerebral dysfunction disease of patient, control single single array element ultrasound
The control circuit and program that energy converter 02 works are simple, and maintenance difficulty is low, drops significantly while improving therapeutic effect
The low Material Cost of Medical Devices, research and development cost, cost of manufacture, use cost and maintenance cost.
Various embodiments are described to various device and method herein.Many specific details are elaborated to provide pair
The thorough understanding of the general construction, function, manufacture and use of the embodiment that sum as described in the description is shown in the accompanying drawings.
However it will be understood by those skilled in the art that embodiment can be carried out in the case where not such specific detail.?
In other examples, well known operation, component and element is described in detail, in order to avoid embodiment in the description is made to be difficult to manage
Solution.It will be understood by those skilled in the art that being non-limited example in the embodiment with shown in herein, and therefore will be recognized that
It arrives, can be model representative and that embodiment might not be limited in specific structure and function details disclosed herein
It encloses.
In the above-described embodiments, it all emphasizes particularly on different fields to the description of each embodiment, is not described in detail or remembers in some embodiment
The part of load may refer to the associated description of other embodiments.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.It can select some or all of unit therein according to the actual needs to realize the mesh of this embodiment scheme
's.
It, can also be in addition, the functional units in various embodiments of the present invention may be integrated into one processing unit
It is that each unit physically exists alone, can also be integrated in one unit with two or more units.Above-mentioned integrated list
Member both can take the form of hardware realization, can also realize in the form of software functional units.
Claims (10)
1. a kind of neuromodulation device, it to be used for stimulation target nerve nucleus, which is characterized in that the neuromodulation device includes:
Ultrasonic generation module, for being generated and transmitted by ultrasonic wave；
First conduction module is connect with the ultrasonic generation module, and the first conduction module is for conducting the ultrasonic wave；
Guided wave module is oriented, is connect with the first conduction module, the orientation guided wave module is used for the target according to one group
The parameter information of ultrasonic wave described in the position of nerve nucleus and rea adjusting, to change conduction orientation and the progress of the ultrasonic wave
Orientation conduction；Wherein, the orientation guided wave module includes multiple artificial structures that replacement uses, and an artificial structure is corresponding
Target nerve core group described in one group；And
Second conduction module, connect with the orientation guided wave module, and the second conduction module is used for described in orientation conduction
Ultrasonic wave is transmitted, so that the ultrasonic focal spot of the focusing ultrasonic wave is projeced into the target nerve core group.
2. neuromodulation device as described in claim 1, which is characterized in that each artificial structure is all made of epoxy resin
At least one of with silica gel, and it is made by predetermined material proportion and preset thickness.
3. neuromodulation device as described in claim 1, which is characterized in that the ultrasound generation module is using single array element ultrasound
Energy converter is realized.
4. neuromodulation device as described in claim 1, which is characterized in that the first conduction module and second conduction
Module is all made of deionized water realization；The deionized water is installed in water pocket, and the water pocket is bonded with the artificial structure.
5. neuromodulation device as described in claim 1, which is characterized in that the ultrasound generation module and the artificial structure
Between connection type include key connection, pin connection or threaded connection.
6. neuromodulation device as described in claim 1, which is characterized in that multiple artificial structures are according to respective lattice
Arrangement architecture is adjusted the parameter information of the ultrasonic wave, with the position of the determination ultrasonic focal spot and size.
7. a kind of neuromodulation method, it to be used for stimulation target nerve nucleus, which is characterized in that the neuromodulation method includes:
It is generated and transmitted by ultrasonic wave；
Conduct the ultrasonic wave；
The parameter information of ultrasonic wave described in the position rolled into a ball according to the different target nerve core and rea adjusting, described in changing
The conduction orientation of ultrasonic wave is simultaneously oriented conduction；
The ultrasonic wave of orientation conduction is transmitted, so that the ultrasonic focal spot of the focusing ultrasonic wave is projeced into the target
On nerve nucleus.
8. neuromodulation method as claimed in claim 7, which is characterized in that the position rolled into a ball according to different target nerve core and
The parameter information of ultrasonic wave described in rea adjusting, to change the conduction orientation of the ultrasonic wave and be oriented conduction, specifically:
Replacement uses artificial structure, and the ginseng of ultrasonic wave described in the position of the group of the target nerve core according to one group and rea adjusting
Number information, to change the conduction orientation of the ultrasonic wave and be oriented conduction；Wherein, an artificial structure is one group corresponding
Target nerve core group.
9. neuromodulation method as claimed in claim 8, which is characterized in that replacement uses artificial structure, and according to one group of institute
The parameter information of ultrasonic wave described in the position and rea adjusting that target nerve core is rolled into a ball is stated, to change the conduction orientation of the ultrasonic wave
And it is oriented before conduction, further includes:
The material composition of the artificial structure is derived according to the position of target nerve core group and area, and calculates the material
The proportion of ingredient and the thickness for calculating the artificial structure；
Prepare the corresponding artificial structure.
10. neuromodulation method as claimed in claim 8, which is characterized in that replacement uses the artificial structure specifically:
It replaces manually or the artificial structure is replaced by mechanical device.
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