WO2021012178A1

WO2021012178A1 - Nerve regulation device and method

Info

Publication number: WO2021012178A1
Application number: PCT/CN2019/097256
Authority: WO
Inventors: 郑海荣; 周慧; 牛丽丽; 孟龙; 蔡飞燕; 夏向向
Original assignee: 深圳先进技术研究院
Priority date: 2019-07-23
Filing date: 2019-07-23
Publication date: 2021-01-28

Abstract

A nerve regulation device and method, used for stimulating target nerve nuclei. The device generates and emits ultrasonic waves by means of an ultrasound generation module (10) and performs conduction by means of a first conduction module (20), and a directional wave guide module (30) adjusts parameter information of the ultrasonic waves according to positions and areas of the target nerve nuclei so as to change the conduction direction of the ultrasonic waves and perform directional conduction; the directional wave guide module comprises multiple artificial structures (301) used for replacement, and each artificial structure corresponds to one target nerve nuclei group. A second conduction module (40) transmits the directionally conducted ultrasonic waves to enable ultrasonic focal spots focused by the ultrasonic waves to be projected onto target nerve nuclei. According to the position and the area of the target nerve nuclei group to be stimulated, the nerve regulation device and method accordingly select artificial structures to work, and enable the ultrasonic focal spots to be projected onto the target nerve nuclei group after the parameter information of the ultrasonic waves is adjusted by the artificial structure, thereby implementing intervention and treatment of brain functional diseases.

Description

Nerve control device and method

Technical field

This application belongs to the technical field of neuromodulation, and in particular relates to a neuromodulation device and method.

Background technique

Functional brain diseases such as Parkinson's, epilepsy, depression, etc., are mainly caused by dysfunction of the deep brain neural circuits, and multiple nerve nuclei in the neural circuits cannot work together. The principle of neuromodulation technology is to improve the function of the neural circuit by stimulating multiple nerve nuclei at the same time to achieve the therapeutic effect.

At present, the traditional neuromodulation technology uses an electronic phased array sound field modulation device to stimulate nerve nuclei. The device uses multiple multi-element ultrasonic transducers to generate and emit multiple ultrasound beams to perform treatment on a group of nerve nuclei. stimulate. The cost of the multi-element ultrasonic transducer is high, so the traditional electronic phased array sound field control device is expensive, the circuit for controlling multiple multi-element ultrasonic transducers is complicated, and the operation is complicated, and the practicability is low.

technical problem

This application aims to solve the problems of traditional electronic phased array sound field modulation devices that require multiple multi-element transducers to work, complicated operations, high cost, and unpopularization.

Technical solutions

The first aspect of the present application provides a neuromodulation device for stimulating a target nerve nucleus. The neuromodulation device includes: an ultrasound generating module for generating and transmitting ultrasound; a first conduction module and the ultrasound generating module Connected, the first conduction module is used to conduct the ultrasound; a directed wave module is connected to the first conduction module, and the directed wave module is used according to the position and area of a group of the target nerve nuclei Adjust the parameter information of the ultrasonic wave to change the conduction direction of the ultrasonic wave and conduct directional conduction; wherein, the directional guide wave module includes a plurality of artificial structures to be replaced, and one artificial structure corresponds to a group of the target nerves Nucleus; and a second conduction module connected to the directed wave module, and the second conduction module is used to transmit the directionally conducted ultrasonic wave so that the ultrasonic focal spot focused by the ultrasonic wave is projected on the On the target nerve nucleus.

Preferably, each artificial structure is made of at least one of epoxy resin and silica gel, and is made according to a preset material ratio and a preset thickness.

Preferably, the ultrasonic generation module is realized by a single-element ultrasonic transducer.

Preferably, both the first conduction module and the second conduction module are realized by using deionized water; the deionized water is installed in a water bladder, and the water bladder is attached to the artificial structure.

Preferably, the connection mode between the ultrasonic generation module and the artificial structure includes key connection, pin connection or thread connection.

Preferably, the nerve regulation device is connected to an external support device through a first clamp and a second clamp; wherein, the first clamp is used to clamp the ultrasonic generation module, and the second clamp The device is used to clamp the artificial structure, and the first clamp and the second clamp are used in nesting.

Preferably, the plurality of artificial structures adjust the parameter information of the ultrasonic waves according to their respective lattice arrangement structures to determine the position and size of the ultrasonic focal spot.

Preferably, it further includes a power supply module connected to the ultrasonic generating module through a wire, and configured to output an alternating current signal in a preset frequency range to the ultrasonic generating module to excite the ultrasonic generating module to generate the ultrasonic wave.

Preferably, it further includes an adjustment module connected to the power supply module for adjusting the frequency, amplitude and phase of the alternating current signal to increase or decrease the frequency of the ultrasonic wave.

The second aspect of the present application provides a neuromodulation method for stimulating a target nerve nucleus, and the neuromodulation method includes:

Generate and emit ultrasonic waves;

Conduct the ultrasound;

Adjusting the parameter information of the ultrasonic wave according to different positions and areas of the target nerve nucleus to change the conduction direction of the ultrasonic wave and conduct directional conduction;

The directionally conducted ultrasonic waves are transmitted, so that an ultrasonic focal spot focused by the ultrasonic waves is projected on the target nerve nucleus.

Preferably, the parameter information of the ultrasound is adjusted according to the position and area of different target nerve nuclei to change the conduction direction of the ultrasound and conduct directional conduction, specifically:

Replace the artificial structure, and adjust the parameter information of the ultrasonic wave according to the position and area of a group of the target nerve nucleus to change the transmission direction of the ultrasonic wave and conduct directional conduction; wherein, one artificial structure corresponds to a group The target nerve nucleus.

Preferably, before replacing an artificial structure and adjusting the parameter information of the ultrasonic wave according to the position and area of a set of the target nerve nucleus to change the conduction direction of the ultrasonic wave and conduct directional conduction, the method further includes:

Deriving the material composition of the artificial structure according to the position and area of the target nerve nucleus, and calculating the ratio of the material composition and calculating the thickness of the artificial structure;

Prepare the corresponding artificial structure.

Preferably, replacing and using the artificial structure specifically includes:

The artificial structure is replaced manually or through a mechanical device.

Beneficial effect

The nerve control device and method provided in the present application adjust the parameter information of ultrasonic waves according to the position and area of the target nerve nucleus through a directed wave module, so as to change the conduction direction of the ultrasonic waves and conduct directional conduction. For different cranial neurological diseases, only need to select the applicable artificial structure according to the position and area of the corresponding set of target nerve nuclei, replace it and put it into use, and then project the ultrasound focal spot on the set of nerve nuclei. Above, this group of nerve nuclei is stimulated to intervene and treat brain functional diseases. The adaptive selection of artificial structure can realize fixed-point stimulation, simple operation, low maintenance cost, and low cost.

Description of the drawings

FIG. 1 is a schematic diagram of a module structure of a neuromodulation device provided by an embodiment of this application;

Fig. 2 is a schematic diagram of the composition of the nerve regulation device shown in Fig. 1;

FIG. 3 is a specific flowchart of a neuromodulation method provided by another embodiment of this application;

FIG. 4 is a specific flowchart of a neuromodulation method provided by another embodiment of this application.

The reference signs in this application refer to the following relationships:

10- Ultrasonic generation module, 20- First conduction module, 30- Oriented guided wave module, 40- Second conduction module, 301- Artificial structure; 01: Wire; 02: Single-element ultrasonic transducer; 04: Fixer ; 05: deionized water; 06: first holder; 07: second water bag; 08: deionized water; 09: second holder; 010: skull; 011: ultrasonic propagation path; 012: target nerve Nucleus; 013: target nerve nucleus; 014: target nerve nucleus; 015: target nerve nucleus.

Embodiments of the invention

In order to make the purpose, technical solutions, and advantages of this application clearer, the following further describes this application in detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the application, and are not used to limit the application.

Functional brain diseases such as Parkinson’s disease, epilepsy, depression, etc., are mainly caused by obstacles in the neural circuit of the patient’s brain. The neural circuit is composed of at least one nerve nucleus. When working together, it will lead to specific brain functional diseases. This application aims to provide a neuromodulation device and method for stimulating target nerve nuclei, such as stimulating a group of target nerve nuclei corresponding to Parkinson’s disease, so that the group of target nerve nuclei can work together, so that the brain Intervention and treatment of neurological diseases.

FIG. 1 is a schematic diagram of the module structure of a neuromodulation device provided by an embodiment of this application. For ease of description, only the parts related to this embodiment are shown, and the details are as follows:

A nerve regulation device used to stimulate target nerve nuclei. The nerve control device includes an ultrasound generation module 10, a first conduction module 20, a directional guide wave module 30 and a second conduction module 40.

The ultrasound generating module 10 is connected to the first conduction module 20, the first conduction module 20 is connected to the oriented wave module 30, the oriented wave module 30 is connected to the second conduction module 40, and the second conduction module 40 is in contact with the skin of the organism.

Among them, the ultrasonic generating module 10 is used to generate and emit ultrasonic waves. The first conduction module 20 is used to conduct ultrasonic waves.

The directed wave module 30 is used to adjust the parameter information of the ultrasonic wave according to the position and area of a set of target nerve nuclei, so as to change the conduction direction of the ultrasonic wave and conduct directional conduction; wherein, the directed wave module 30 includes multiple artificial structures for replacement 301. An artificial structure 301 corresponds to a group of target nerve nuclei. In the nerve regulation device provided in this embodiment, only one artificial structure 301 is selected for use in a single use according to actual needs.

Optionally, the connection mode between the ultrasonic generation module 10 and the artificial structure 301 put into use includes but is not limited to key connection, pin connection or thread connection. Of course, the connection method used between the ultrasound generating module 10 and the artificial structure 301 put into use does not affect the therapeutic effect of the neuromodulation device provided in the embodiment of the present application on the disease.

The second conduction module 40 is used to transmit the directionally conducted ultrasonic waves, so that the ultrasonic focal spot focused by the ultrasonic waves is projected on the target nerve nucleus.

Specifically, both the first conduction module 20 and the second conduction module 40 only conduct the received ultrasonic waves without difference, and do not change the energy distribution form of the ultrasonic waves. The directed wave module 30 is implemented by using multiple artificial structures 301. For a group of target nerve nuclei to be stimulated, a corresponding artificial structure 301 is selected and put into use to adjust the parameter information of the ultrasound to make the energy distribution shape of the ultrasound. Changes occur; finally, the ultrasound focal spot is projected onto the group of nerve nuclei, and the group of nerve nuclei are stimulated at the same time to intervene and treat the corresponding brain functional diseases.

The artificial structure 301 is a composite material formed by artificially specially designing its spatial three-dimensional structure. It is usually composed of one or more elastic materials arranged periodically or non-periodically to form a lattice arrangement structure with a size close to the ultrasonic wavelength.

There is an acoustic band gap in the lattice arrangement structure of the artificial structure 301. The ultrasonic waves propagating in this kind of lattice arrangement structure will exhibit some special properties, so that the artificial structure 301 can realize acoustic filters, directed waves, and fixed-point guided waves. And other functions. The ultrasonic wave is conducted after adjusting the parameter information of the artificial structure 301, and can realize single-point stimulation and multi-point stimulation according to actual needs, and the position and area of the stimulation can be adjusted.

When the size of the crystal lattice in the artificial structure 301 is much smaller than the ultrasonic length, by introducing special microstructure units, some acoustic properties that cannot be achieved by natural materials can be achieved. For example, it can be described by equivalent parameters, including density anisotropy, negative mass density, negative elastic modulus, etc.

In the embodiments of the present application, different artificial structures 301 are designed for different functional brain diseases to stimulate the corresponding set of nerve nuclei; at the same time, according to the specific conditions of the patient, the artificial structure dedicated to the patient can also be designed. The structure 301 is used to provide personalized treatment to patients, and the treatment effect is better. In practical applications, the specific composition of the artificial structure 301 and the scale of the lattice arrangement structure can be set according to actual needs, which are not specifically limited in this application.

The lattice arrangement structure of each artificial structure 301 determines its effect on the ultrasonic energy distribution shape. The multiple artificial structures 301 adjust the parameter information of the ultrasonic wave according to the respective lattice arrangement structure to determine the position and size of the ultrasonic focal spot.

For example, an artificial structure 301 can convert the energy distribution form of ultrasound into: an ultrasound focal spot with an area of 1.01 mm ² and the ultrasound focal spot is projected on the target nerve nucleus A; another example is another artificial structure 301 can realize the transformation of the energy distribution form of ultrasound into: three ultrasound focal spots with areas of 0.21mm ² , 1.00mm ² and 1.11mm ² respectively, and the three ultrasound focal spots are respectively projected on the target nerve nucleus B and target nerve Nucleus C and the target nerve nucleus D.

In an alternative embodiment, the artificial structure 301 is made of at least one elastic material according to a preset material and a preset thickness.

In an optional embodiment, the artificial structure 301 is made of at least one of epoxy resin and silica gel, and is made according to a preset material ratio and a preset thickness. Both epoxy resin and silica gel are elastic materials with good sound permeability. By changing the ratio of epoxy resin and silica gel and the thickness of the artificial structure 301, multiple artificial structures 301 with different lattice arrangements can be prepared.

The nerve control device provided by the embodiment of the application adopts the directional guide wave module 30 composed of a plurality of artificial structures 301 to adjust the parameter information of the ultrasonic wave according to the position and area of the target nerve nucleus, so as to change the transmission direction of the ultrasonic wave and perform directional transmission. , That is, to change the energy distribution form of ultrasound. Therefore, the ultrasonic waves emitted by the ultrasonic generating module 10 will be transmitted to the skin of the organism according to the preset direction and position after passing through the artificial structure 301, so that the ultrasonic focal spot is projected on a group of target nerve nuclei to be stimulated, and the depth and area are different. Different multiple target nerve nuclei are stimulated.

In an optional embodiment, the ultrasonic generation module 10 is implemented by a single-element ultrasonic transducer 02, specifically a planar single-element ultrasonic transducer.

Specifically, the single-element ultrasonic transducer 02 generates only one beam of ultrasound. After the beam passes through the artificial structure 301, the parameter information changes, and it is transmitted in a specific direction, and finally focused on a group corresponding to the artificial structure 301 On the target nerve nucleus.

The manufacturing cost of the artificial structure 301 is low. Compared with the expensive multi-element ultrasonic transducer, the present application uses a single single-element ultrasonic transducer 02 to emit ultrasonic waves. By replacing the artificial structure 301 to achieve the target nerve nucleus Stimulation, the cost of the device is low, and the universality is high; and the artificial structure 301 changes the energy distribution form of the ultrasound, so that the ultrasound focal spot is accurately projected on the target nerve nucleus to be stimulated, which is more targeted and achieves personality Chemical treatment, the treatment effect is greatly improved.

In this embodiment, the shape of the artificial structure 301 includes but is not limited to a rectangular parallelepiped, a cube, a cylinder, a truncated cone, or a prism.

Compared with the traditional use of multiple multi-element ultrasonic transducers to emit ultrasonic waves to stimulate nerve nuclei, the nerve control device provided in this embodiment is highly accurate and highly targeted. In addition, the control circuits and procedures for controlling multiple multi-element ultrasonic transducers to work are very complicated, and the maintenance of the control circuit is difficult. The neuromodulation device provided in this embodiment only needs to be selected and put into use according to the patient's brain functional disease. With the artificial structure 301, the control circuit and program for controlling a single single-element ultrasonic transducer 02 to work is simple, and the maintenance difficulty is low. Therefore, the neuromodulation device provided in this embodiment greatly reduces the material cost, research and development cost, manufacturing cost, use cost, and maintenance cost of medical equipment while improving the therapeutic effect.

Fig. 2 is a schematic diagram of the composition of the neuromodulation device shown in Fig. 1. For ease of description, only the parts related to this embodiment are shown, which are detailed as follows:

The reference signs in Figure 2 respectively indicate:

01: Wire; 02: Single-element ultrasonic transducer; 301: Artificial structure; 04: Fixer; 05: Deionized water; 06: First holder; 07: Second water bag 07; 08: Deionization Water; 09: second holder; 010: skull; 011: ultrasonic propagation path; 012: target nerve nucleus; 013: target nerve nucleus; 014: target nerve nucleus; 015: target nerve nucleus.

In an optional embodiment, both the first conduction module 20 and the second conduction module 40 described above are implemented by using deionized water, the deionized water is installed in a water bladder, and the water bladder is bonded with the artificial structure 301.

Specifically, the first conduction module 20 is placed in the first water bag, the outer surface of the first water bag is attached to the single-element ultrasonic transducer 02, and the first water bag is attached to the single-element ultrasonic transducer 02 The area of the outer surface of is greater than or equal to the area of the ultrasonic emission port of the single-element ultrasonic transducer 02 to transmit ultrasonic waves indiscriminately. Optionally, the first water bladder is an ultrasonic water bladder, which can either install the first conduction module 20, that is, deionized water 05, in the internal space, or it can conduct ultrasonic waves indiscriminately.

In an optional embodiment, the first water bladder is made of tissue analog material, and the tissue analog material can be ultrasonically transmitted.

In yet another embodiment, the first water bladder can coat the coupling agent on the outer surface to enhance the ability to transmit ultrasound.

At the same time, the outer surface of the first water bladder is attached to the artificial structure 301 put into use to transmit ultrasonic waves to the artificial structure 301. The first water bladder and the single-element ultrasonic transducer 02 can be adhesively fixed by nylon stickers, and the first water bladder and the artificial structure 301 can also be adhesively fixed by nylon stickers.

The second conductive module 40 is placed on the outer surface of the second water bladder 07 to be attached to the artificial structure 301, and the area of the outer surface where the second water bladder 07 is attached to the artificial structure 301 is greater than or equal to that of the artificial structure 301 and the second water bladder 07 is the area of the surface to be attached so as to completely transmit the ultrasonic wave conducted by the second water bladder 07 to the artificial structure 301.

Optionally, the second water bladder 07 is an ultrasonic water bladder, which can install the second conduction module 40, that is, deionized water 08 in the internal space, and can conduct ultrasonic waves without difference.

In an alternative embodiment, the second water bladder 07 is made of tissue analog material, which can be ultrasonically transmitted.

In another embodiment, the second water bladder 07 can coat the couplant on the outer surface, thereby enhancing the ability to transmit ultrasonic waves.

Optionally, the first water bladder is bonded to the artificial structure 301 and the single-element ultrasonic transducer 02 through nylon stickers, and the second water bladder 07 is bonded to the artificial structure 301 through nylon stickers. The nylon patch can be disassembled and reused, which facilitates the replacement of the artificial structure 301, the single-element ultrasonic transducer 02, the first water bladder or the first conduction module 20. The nylon stickers are arranged on the outer surface of the first water bag, the outer surface of the single-element ultrasonic transducer 02, and the outer surface of the artificial structure 301, specifically on the contact surface of the first water bag and the single-element ultrasonic transducer 02 And the position outside the contact surface of the first water bladder and the artificial structure 301 to prevent the nylon sticker from affecting the ultrasonic transmission process.

Of course, the first water bag can also be attached and fixed to the single-element ultrasonic transducer 02 and the artificial structure 301 through other detachable fixing devices. How the first water bladder fits the single-element ultrasonic transducer 02 and the artificial structure 301 does not affect the performance of the nerve regulation device of this embodiment.

For example, in the embodiment shown in FIG. 2, the single-element ultrasonic transducer 02 and the artificial structure 301 are fixed by the holder 04, and the deionized water 05 is clamped on the single-element ultrasonic transducer 02 and the artificial structure. Between structure 301. Of course, deionized water 05 is provided in the first water capsule. The first water bag is clamped between the single-element ultrasonic transducer 02 and the artificial structure 301.

Optionally, when the fixer 04 fixedly connects the single-element ultrasonic transducer 02 and the put-in-use artificial structure 301, a key connection, a pin connection or a threaded connection can be used.

Optionally, the second water bladder 07 is bonded to the artificial structure 301 through nylon stickers. The nylon sticker can be disassembled and reused, which is convenient to replace the artificial structure 301, the second water bladder 07 or the deionized water 08. The nylon stickers are arranged on the outer surface of the second water bladder 07 and the outer surface of the artificial structure 301, specifically at positions other than the contact surface between the second water bladder 07 and the artificial structure 301, so as to prevent the nylon stickers from affecting the ultrasonic transmission process.

Of course, the second water bladder 07 can also be attached and fixed by other detachable fixing devices, the single-element ultrasonic transducer 02 and the artificial structure 301. How the first water bladder fits the single-element ultrasonic transducer 02 and the artificial structure 301 does not affect the performance of the nerve regulation device of this embodiment.

For example, in the embodiment shown in FIG. 2, the upper surface of the second water bladder 07 is provided with a concave surface, and an artificial structure 301 put into use is placed in the concave surface and closely adheres to the concave surface. Under the premise of not affecting the ultrasonic transmission, nylon stickers or adhesives can be used to bond the artificial structure 301 to the concave surface.

The deionized water 08 is set in the second water bladder 07 and can be replaced regularly. The second water bladder 07 is made of a flexible material, and the outer surface of the second water bladder 07 fits the skin of the organism. For example, Figure 2 shows the second water bladder 07 fits the human skull 010. The second water bladder 07 adjusts its shape according to the undulations of the skin it contacts, and finally fits the skin of the organism completely. on.

Of course, the nerve control device provided in this embodiment is not only placed on the human skull 010, but only stimulates the brain nerves of the human body; according to actual needs, the nerve control device can also be placed in other positions of the organism, The peripheral organs and peripheral nerves of the organism are stimulated to achieve the therapeutic effect. The aforementioned organisms are not limited to humans, but can also be other animals.

Optionally, the first conduction module 20 and the second conduction module 40 can be implemented by other materials with good sound permeability.

The nerve regulation device provided in this embodiment is connected to an external support device with a base placed on the ground, a wall, or other fixed objects through the first holder 06 and the second holder 09. Among them, the first clamp 06 is used to clamp the single-element ultrasonic transducer 02, the second clamp 09 is used to clamp the artificial structure 301; the first clamp 06 and the second clamp 09 are nested use. When the artificial structure 301 needs to be replaced, it is only necessary to separate the single-element ultrasonic transducer 02 from the first water bladder, and unfix the fixer 04 between the artificial structure 301 and the single-element ultrasonic transducer 02, and The artificial structure 301 to be put into use and the single-element ultrasonic transducer 02 are fixed by the fixer 04.

As shown in FIG. 2, the ultrasonic waves generated and emitted by the single-element ultrasonic transducer 02 are transmitted to the artificial structure 301 through the first water bag and deionized water 05, and the artificial structure 301 adjusts its parameter information. The ultrasonic wave whose parameter information has been adjusted reflects the change of the ultrasonic wave propagation path 011 and the change of the position and area of the ultrasonic focal spot in a macroscopic view. For example, after the adjustment of the artificial structure 301 shown in FIG. 2, the ultrasonic wave is conducted along the ultrasonic wave propagation path 011, and after passing through the second water bladder 07 and deionized water 08, it is transmitted to the human skull 010, forming three Ultrasound focal spots are projected on the target nerve nucleus 012, target nerve nucleus 013, target nerve nucleus 014, and target nerve nucleus 015. Specifically, the target nerve nucleus 13 shown in FIG. 2 is the subthalamic nucleus, and the target nerve nucleus 14 is the inner side of the globus pallidus.

With the nerve control device provided in this embodiment, only the artificial structure 301 is selected and put into use according to the position and area of the target nerve nucleus in the nerve loop to be stimulated, and the ultrasound can be projected on the nerve loop to be stimulated. On each target nerve nucleus, intervention and treatment of brain functional diseases are carried out to improve the patient's condition, convenient to use, and low cost. Different artificial structures 301 reform the energy distribution form of the ultrasound to modulate a specific ultrasound sound field, so that the ultrasound can generate multiple ultrasound focal spots with different depths and different stimulation ranges. Different artificial structures 301 are designed and put into work according to the patient's individual or the condition of the functional brain disease itself to modulate the personalized ultrasonic sound field distribution state, that is, the energy distribution form, so as to achieve the effect of precise treatment and personalized treatment.

The nerve control device provided in this embodiment uses a single plane single-element ultrasonic transducer 02 to generate and emit ultrasonic waves, and achieve precise treatment by replacing the artificial structure 301, which abandons the traditional use of multiple multi-element ultrasonic transducers for nerves. The method of nucleus stimulation is low cost, and the accuracy of the stimulation position is greatly improved, which has a better therapeutic effect.

In an optional embodiment, the above-mentioned neuromodulation device further includes a power supply module, which is connected to the single-element ultrasonic transducer 02 through a wire 01 for powering the single-element ultrasonic transducer 02. The power supply module provides electrical energy to the single-element ultrasonic transducer 02 through the wire 01, so as to excite the single-element ultrasonic transducer 02 to generate and emit ultrasonic waves. Specifically, the power supply module is implemented using an existing power supply circuit, and the electrical energy provided by the power supply circuit is transmitted to the single-array ultrasonic transducer 02 in the form of an alternating current signal whose frequency is within a preset frequency range.

In an optional embodiment, the aforementioned neuromodulation device further includes an adjustment module connected to the power supply module for adjusting the frequency, amplitude, and phase of the alternating current signal to increase or decrease the frequency of ultrasonic waves, thereby Increase or decrease the degree of stimulation of the target nerve nucleus.

FIG. 3 is a specific flowchart of a neuromodulation method provided by another embodiment of this application. For ease of description, only the parts related to this embodiment are shown, which are detailed as follows:

A nerve regulation method for stimulating a target nerve nucleus, including the following steps:

S01: Generate and emit ultrasonic waves;

S02: Conducting ultrasound;

S03: Adjust the parameter information of ultrasound according to the position and area of different target nerve nuclei to change the conduction direction of ultrasound and conduct directional conduction;

S04: Transmit the directionally conducted ultrasound so that the ultrasound focal spot focused by the ultrasound is projected on the target nerve nucleus.

Specifically, in step S01, the ultrasonic generation module 10 is used to generate and emit ultrasonic waves, and the ultrasonic generation module 10 is implemented by a single-element ultrasonic transducer 02. Step S02 uses the first conduction module 20 to conduct ultrasonic waves. The first conduction module 20 is realized by using deionized water. The deionized water is arranged in a first water bladder, which is attached to the single-element ultrasonic transducer 02 and the artificial structure 301.

In step S03, the directional guide wave module 30 is used to adjust the parameter information of the ultrasonic waves according to the positions and areas of different target nerve nuclei, so as to change the conduction direction of the ultrasonic waves and conduct directional conduction. The guided wave module 30 includes a plurality of artificial structures 301 for replacement. One artificial structure 301 corresponds to a set of target nerve nuclei, and a set of target nerve nuclei corresponds to a functional brain disease or a disease of peripheral organs and peripheral nerves.

Step S04 uses the second conduction module 40 to transmit the directional conduction ultrasonic waves. The second conduction module 40 is realized by using deionized water provided in the second water capsule 07. The second water bladder 07 is attached to the artificial structure 301 and attached to the skin of the living body.

It is worth noting that the deionized water in step S02 and step S04 can be replaced.

FIG. 4 is a specific flowchart of a neuromodulation method provided by another embodiment of this application. For ease of description, only the parts related to this embodiment are shown, which are detailed as follows:

In an optional embodiment, the above-mentioned step S03 is specifically step S031: replacing the artificial structure 301, and adjusting the parameter information of the ultrasound according to the position and area of a set of target nerve nuclei, so as to change the conduction direction and orientation of the ultrasound Conduction; Among them, an artificial structure 301 corresponds to a group of target nerve nuclei.

Specifically, when replacing the artificial structure 301, it can be replaced manually or by a mechanical device. The specific replacement process is:

The fixation of the single-element ultrasonic transducer 02 and the artificial structure 301 by the fixer is released, the artificial structure 301 is replaced, and the poor social function transducer and the artificial structure 301 are fixed again by the fixer.

In an optional embodiment, before step S031 is executed, the following steps are further included:

The material composition of the artificial structure 301 is deduced according to the position and area of the target nerve nucleus, and the ratio of the material composition and the thickness of the artificial structure 301 are calculated; the corresponding artificial structure 301 is prepared.

The ultrasonic wave is conducted after adjusting the parameter information of the artificial structure 301, and can realize single-point stimulation and multi-point stimulation according to actual needs, and the position and area of the stimulation are adjustable. For different brain functional diseases, different artificial structures 301 are designed to stimulate the corresponding set of nerve nuclei; at the same time, according to the specific conditions of the patient, the artificial structure 301 dedicated to the patient can be designed to perform Personalized treatment, better treatment effect. In actual applications, the specific composition of the artificial structure 301 and the scale of the lattice arrangement structure can be set according to actual needs, and the specific application is not limited.

In an optional embodiment, before step S01 is executed, the following steps are further included:

Output AC signal.

Specifically, a power supply module is used to provide electrical energy in the form of an alternating current signal to the single-element ultrasonic transducer 02, and the single-element ultrasonic transducer 02 converts the electrical energy into ultrasonic waves for transmission.

In summary, the embodiments of the present application provide a neuromodulation device and method, according to the position and area of a group of target nerve nuclei to be stimulated, the artificial structure 301 is selected to work accordingly, so that the ultrasonic wave adjusts the parameter information through the artificial structure 301 Later, the ultrasound focal spot is projected on the target nerve nucleus to achieve intervention and treatment of functional brain diseases. It is only necessary to select the artificial structure 301 put into use according to the patient’s brain functional disease. The control circuit and procedure for controlling the single single-element ultrasonic transducer 02 to work is simple, and the maintenance difficulty is low. The treatment effect is improved and the treatment effect is greatly reduced. Material cost, R&D cost, production cost, usage cost and maintenance cost of medical equipment.

Various embodiments are described herein for various devices and methods. Many specific details are set forth to provide a thorough understanding of the overall structure, function, manufacture, and use of the embodiments as described in the specification and shown in the drawings. However, those skilled in the art will understand that the embodiments may be implemented without such specific details. In other examples, well-known operations, components and elements are described in detail so as not to make the implementation in the specification difficult to understand. Those skilled in the art will understand that the embodiments described herein and shown are non-limiting examples, and therefore can recognize that the specific structural and functional details disclosed herein may be representative and do not necessarily limit the embodiments Range.

In the above-mentioned embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail or recorded in an embodiment, reference may be made to related descriptions of other embodiments.

The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the objectives of the solutions of the embodiments.

In addition, the functional units in each embodiment of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit. The above-mentioned integrated unit can be implemented in the form of hardware or software functional unit.

Claims

A nerve control device for stimulating a target nerve nucleus, characterized in that the nerve control device includes:

Ultrasonic generation module, used to generate and emit ultrasonic waves;

A first conduction module connected to the ultrasound generation module, and the first conduction module is used to conduct the ultrasound;

The orienting wave module is connected to the first conduction module, and the orienting wave module is used to adjust the parameter information of the ultrasonic wave according to the position and area of the target nerve nucleus group to change the conduction of the ultrasonic wave Direction and conduct directional conduction; wherein, the directional guide wave module includes a plurality of artificial structures for replacement, and one artificial structure corresponds to a group of the target nerve nuclei; and

The second conduction module is connected to the directed wave module, and the second conduction module is used to transmit the directionally conducted ultrasonic waves, so that the ultrasonic focal spot focused by the ultrasonic waves is projected on the target nerve nucleus on.
The nerve control device according to claim 1, wherein each of the artificial structures is made of at least one of epoxy resin and silica gel, and is made according to a preset material ratio and a preset thickness.
8. The neuromodulation device according to claim 1, wherein the ultrasound generation module is realized by a single element transducer.
The nerve control device according to claim 1, wherein the first conduction module and the second conduction module are both realized by using deionized water; the deionized water is installed in a water bag, and the water The capsule fits the artificial structure.
The nerve regulation device according to claim 1, wherein the connection mode between the ultrasound generating module and the artificial structure includes key connection, pin connection or thread connection.
The nerve control device according to claim 1, wherein the nerve control device is connected to an external support device through a first holder and a second holder;

Wherein, the first clamp is used to clamp the ultrasonic generating module, the second clamp is used to clamp the artificial structure, and the first clamp and the second clamp are nested use.
The nerve control device according to claim 1, wherein a plurality of the artificial structures adjust the parameter information of the ultrasound according to the respective lattice arrangement structure to determine the position and size of the ultrasound focal spot .
The neuromodulation device of claim 1, further comprising:

It is connected to the ultrasonic generation module through a wire, and is used to output an alternating current signal of a preset frequency range to the ultrasonic generation module to excite the ultrasonic generation module to generate the ultrasonic power supply module.
The neuromodulation device of claim 8, further comprising:

An adjustment module connected to the power supply module and used to adjust the frequency, amplitude, and phase of the alternating current signal to increase or decrease the frequency of the ultrasonic wave.
A nerve control method for stimulating a target nerve nucleus, characterized in that the nerve control method includes:

Generate and emit ultrasonic waves;

Conduct the ultrasound;

Adjusting the parameter information of the ultrasonic wave according to different positions and areas of the target nerve nucleus to change the conduction direction of the ultrasonic wave and conduct directional conduction;

The directionally conducted ultrasonic waves are transmitted, so that an ultrasonic focal spot focused by the ultrasonic waves is projected on the target nerve nucleus.
10. The nerve control method according to claim 10, wherein the parameter information of the ultrasound is adjusted according to the positions and areas of different target nerve nuclei to change the conduction direction of the ultrasound and conduct directional conduction, specifically:

Replace the artificial structure, and adjust the parameter information of the ultrasonic wave according to the position and area of a group of the target nerve nucleus to change the transmission direction of the ultrasonic wave and conduct directional conduction; wherein, one artificial structure corresponds to a group The target nerve nucleus.
The nerve control method according to claim 11, wherein the artificial structure is replaced, and the parameter information of the ultrasonic wave is adjusted according to the position and area of a set of the target nerve nucleus to change the transmission direction of the ultrasonic wave And before directional conduction, it also includes:

Deriving the material composition of the artificial structure according to the position and area of the target nerve nucleus, and calculating the ratio of the material composition and calculating the thickness of the artificial structure;

Prepare the corresponding artificial structure.
The nerve regulation method according to claim 11, wherein the replacement of the artificial structure is specifically:

The artificial structure is replaced manually or through a mechanical device.