CN110368608B - Nerve regulation and control device - Google Patents
Nerve regulation and control device Download PDFInfo
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- CN110368608B CN110368608B CN201910665447.3A CN201910665447A CN110368608B CN 110368608 B CN110368608 B CN 110368608B CN 201910665447 A CN201910665447 A CN 201910665447A CN 110368608 B CN110368608 B CN 110368608B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
Abstract
A neuromodulation device and method for stimulating a target nerve nucleus. The device generates and transmits ultrasonic waves through an ultrasonic generation module, the ultrasonic waves are conducted through a first conduction module, and a directional guided wave module adjusts parameter information of the ultrasonic waves according to the position and the area of a target nerve nucleus group so as to change the conduction direction of the ultrasonic waves and conduct directional conduction; the directional guided wave module comprises a plurality of artificial structures which are used in a replacement mode, and one artificial structure corresponds to one group of target nerve nuclei. The second conduction module transmits the directionally-conducted ultrasonic waves so that the focused ultrasonic focal spots of the ultrasonic waves are projected on the target nerve nucleus. According to the nerve regulation and control device and the nerve regulation and control method, the artificial structure is correspondingly selected to work according to the position and the area of the group of target nerve nuclei to be stimulated, so that the ultrasonic focal spots are projected onto the group of target nerve nuclei after the ultrasonic waves adjust parameter information through the artificial structure, and intervention and treatment on brain functional diseases are realized.
Description
Technical Field
The invention belongs to the technical field of nerve regulation and control, and particularly relates to a nerve regulation and control device and method.
Background
Brain functional diseases such as Parkinson, epilepsy, depression and the like mainly result from dysfunction of deep brain nerve circuits, and multiple nerve nuclei in the nerve circuits cannot work together. The principle of the nerve regulation technology is to improve the function of a nerve loop by stimulating a plurality of nerve nuclei simultaneously, thereby achieving the treatment effect.
At present, the traditional nerve regulation and control technology stimulates a nerve nucleus by adopting an electronic phased array sound field modulation device, and the device adopts a plurality of multi-array element ultrasonic transducers to generate and emit a plurality of ultrasonic waves to stimulate a group of nerve nuclei. The multi-array element ultrasonic transducer has high cost, so the traditional electronic phased array sound field regulating and controlling device has high cost, complex circuit for controlling a plurality of multi-array element ultrasonic transducers, complex operation and low practicability.
Therefore, the traditional electronic phased array sound field modulation device has the problems that a plurality of multi-array element transducers are needed to work, the operation is complicated, the manufacturing cost is high, and the device cannot be popularized.
Disclosure of Invention
In view of this, the embodiment of the present invention provides a neural regulation device and method, and aims to solve the problems that a plurality of multi-array transducers are required to work, the operation is complicated, the manufacturing cost is high, and the neural regulation device and method cannot be popularized in the conventional technical scheme.
A first aspect of embodiments of the present invention provides a neuromodulation device for stimulating a target neural nucleus, the neuromodulation device comprising:
an ultrasonic generation module for generating and emitting ultrasonic waves;
the first conduction module is connected with the ultrasonic generation module and is used for conducting the ultrasonic waves;
the directional guided wave module is connected with the first conduction module and used for adjusting the parameter information of the ultrasonic waves according to the positions and the areas of a group of target nerve nuclei so as to change the conduction direction of the ultrasonic waves and conduct directional conduction; wherein the directional guided wave module comprises a plurality of artificial structures which are replaced and used, and one artificial structure corresponds to a group of target nerve nuclei; and
the second conduction module is connected with the directional guided wave module and is used for transmitting the directionally conducted ultrasonic waves so as to enable the focused ultrasonic focal spots of the ultrasonic waves to be projected on the target nerve nucleus.
A second aspect of embodiments of the present invention provides a neuromodulation method for stimulating a target nerve nuclei, the neuromodulation method comprising:
generating and emitting ultrasonic waves;
conducting the ultrasonic waves;
adjusting the parameter information of the ultrasonic wave according to the positions and areas of different target nerve nuclei so as to change the conduction direction of the ultrasonic wave and conduct directional conduction;
transmitting the ultrasound waves in a directed conduction such that focused ultrasound focal spots of the ultrasound waves are projected onto the target nerve nuclei.
According to the nerve regulation and control device and method, the parameter information of the ultrasonic waves is adjusted through the directional guided wave module according to the position and the area of the target nerve nucleus, so that the conduction direction of the ultrasonic waves is changed, and the directional conduction is carried out. Aiming at different cerebral nerve diseases, an applicable artificial structure is selected according to the position and the area of a corresponding group of target nerve nuclei for replacement and then is used, so that the ultrasonic focal spots of ultrasonic waves can be projected onto the group of nerve nuclei to stimulate the group of nerve nuclei, and the intervention and the treatment of the cerebral functional diseases are realized. The artificial structure is selected adaptively, so that the fixed-point stimulation is simple to operate, the maintenance cost is low, and the manufacturing cost is low.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.
Fig. 1 is a schematic block diagram of a neuromodulation apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of the composition of the neuromodulation device shown in FIG. 1;
FIG. 3 is a flowchart illustrating a method of neuromodulation according to another embodiment of the present invention;
fig. 4 is a flowchart illustrating a method for neuromodulation according to another embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Brain functional diseases such as Parkinson's disease, epilepsy, depression and the like are mainly caused by the fact that a nerve loop of a brain of a patient is obstructed and consists of at least one nerve nucleus group, and when the nerve nucleus groups in one nerve loop cannot work cooperatively, specific brain functional diseases can be caused. The invention aims to provide a nerve regulation and control device and a method, which are used for stimulating a target nerve nucleus, such as a group of target nerve nuclei corresponding to Parkinson's disease, so that the group of target nerve nuclei can work cooperatively, and intervention and treatment can be carried out on the cranial nerve diseases.
Fig. 1 is a schematic block diagram of a nerve modulation device according to an embodiment of the present invention, which only shows the relevant parts related to the embodiment for convenience of description, and the details are as follows:
a neuromodulation device for stimulating a target nerve nucleus. The nerve modulation device includes an ultrasound generation module 10, a first conduction module 20, a directional guided wave module 30, and a second conduction module 40.
The ultrasonic generation module 10 is connected to the first conduction module 20, the first conduction module 20 is connected to the directional guided wave module 30, the directional guided wave module 30 is connected to the second conduction module 40, and the second conduction module 40 is in contact with the skin of the living body.
Wherein the ultrasonic generating module 10 is used for generating and emitting ultrasonic waves. The first conducting module 20 is used for conducting ultrasonic waves.
The directional guided wave module 30 is used for adjusting the parameter information of the ultrasonic waves according to the positions and areas of a group of target nerve nuclei so as to change the conduction direction of the ultrasonic waves and conduct directional conduction; the guided wave module 30 includes a plurality of artificial structures 301, and one artificial structure 301 corresponds to one group of target nerve nuclei. According to the nerve regulation and control device provided by the embodiment, only one artificial structure 301 is selected for use according to actual needs in a single use.
Alternatively, the connection between the ultrasound generating module 10 and the artificial structure 301 in use includes, but is not limited to, a keyed connection, a pinned connection, or a threaded connection. Of course, the connection mode adopted between the ultrasound generating module 10 and the artificial structure 301 which is put into use does not affect the therapeutic effect of the nerve modulation device provided by the embodiment of the present invention on diseases.
The second conduction module 40 is configured to transmit the directionally-conducted ultrasound waves such that the focused ultrasound focal spots of the ultrasound waves are projected onto the target nerve nuclei.
Specifically, the first conducting module 20 and the second conducting module 40 conduct the received ultrasonic waves indiscriminately, and do not change the energy distribution pattern of the ultrasonic waves. The directional guided wave module 30 is realized by adopting a plurality of artificial structures 301, and aiming at a group of target nerve nuclei to be stimulated, a corresponding artificial structure 301 is selected and put into use so as to adjust the parameter information of the ultrasonic waves and change the energy distribution form of the ultrasonic waves; finally, an ultrasound focal spot is projected onto the set of nuclei, which are simultaneously stimulated to intervene and treat the corresponding brain functional disorder.
The artificial structure 301 is a composite material formed by artificially designing a spatial three-dimensional structure thereof, and is generally formed by arranging one or more elastic materials periodically or non-periodically to form a lattice arrangement structure having a size close to the wavelength of ultrasonic waves.
The lattice arrangement structure of the artificial structure 301 has an acoustic band gap, and ultrasonic waves propagating in such a lattice arrangement structure exhibit some special properties, so that the artificial structure 301 can realize functions of an acoustic filter, directional guided waves, fixed-point guided waves and the like. The ultrasonic waves are conducted after parameter information is adjusted through the artificial structure 301, single-point stimulation and multi-point stimulation can be achieved according to actual needs, and the stimulation position and area can be adjusted.
When the lattice size in the artificial structure 301 is much smaller than the ultrasonic length, acoustic properties that some natural materials cannot achieve can be achieved by introducing special microstructure elements. For example, by equivalent parameters including density anisotropy, negative mass density, negative elastic modulus, and the like.
In the embodiment of the present invention, different artificial structures 301 are designed for different brain functional diseases, and are used for stimulating a corresponding group of nerve nuclei; meanwhile, the artificial structure 301 dedicated to the patient can be designed according to the specific condition of the patient, so that the patient can be treated in a personalized manner, and the treatment effect is better. In practical applications, the specific composition of the artificial structure 301 and the scale of the lattice arrangement structure may be set according to actual needs, and the specific invention is not limited.
The lattice arrangement of each artificial structure 301 determines its effect on the energy distribution profile of the ultrasonic wave. The plurality of artificial structures 301 adjust the parameter information of the ultrasonic wave according to the respective lattice arrangement structures to determine the position and size of the ultrasonic focal spot.
For example, an artificial structure 301 may be implemented to transform the energy distribution profile of the ultrasound waves into: has an area of 1.01mm2And the ultrasound focal spot is projected on the target nerve nucleus bolus a; for another example, another artificial structure 301 can realize the energy distribution shape conversion of the ultrasonic wave: has three areas of 0.21mm2、1.00mm2And 1.11mm2And the three ultrasonic focal spots are projected on a target nerve nucleus B, a target nerve nucleus C and a target nerve nucleus D respectively.
In an alternative embodiment, the prosthetic structure 301 is formed from at least one resilient material and is formed from a predetermined material and a predetermined thickness.
In an alternative embodiment, the artificial structure 301 is made of at least one of epoxy resin and silicone rubber according to a predetermined material ratio and a predetermined thickness. Epoxy resin and silica gel both belong to elastic materials with good sound permeability, and a plurality of artificial structures 301 with different lattice arrangement structures can be prepared by changing the proportion of the epoxy resin and the silica gel and the thickness of the artificial structures 301.
According to the nerve regulation and control device provided by the embodiment of the invention, the directional guided wave module 30 consisting of the plurality of artificial structures 301 is adopted to adjust the parameter information of the ultrasonic waves according to the position and the area of the target nerve nucleus, so that the conduction direction of the ultrasonic waves is changed and the directional conduction is carried out, namely, the energy distribution form of the ultrasonic waves is changed. Therefore, the ultrasonic waves emitted by the ultrasonic generation module 10 are conducted to the skin of the living body through the artificial structure 301 according to the preset direction and position, so that the ultrasonic focal spots are projected onto a group of target nerve nuclei to be stimulated, and a plurality of target nerve nuclei with different depths and different areas are stimulated at the same time.
In an alternative embodiment, the ultrasound generating module 10 is implemented using a single-element ultrasound transducer 02, in particular a planar single-element ultrasound transducer.
Specifically, the single-element ultrasound transducer 02 generates only one beam of ultrasound, and after the beam passes through the artificial structure 301, the parameter information changes, is transmitted in a specific direction, and is finally focused on a group of target nerve nuclei corresponding to the artificial structure 301.
Compared with a multi-array-element ultrasonic transducer with high manufacturing cost, the artificial structure 301 has the advantages that the manufacturing cost is low, the single-array-element ultrasonic transducer 02 is adopted to emit ultrasonic waves, the artificial structure 301 is replaced to stimulate the target nerve nucleus, and the device is low in cost and high in universality; moreover, the artificial structure 301 changes the energy distribution form of the ultrasonic wave, so that the ultrasonic focal spot is accurately projected on the target nerve nucleus to be stimulated, the pertinence is stronger, the personalized treatment is realized, and the treatment effect is greatly improved.
In this embodiment, the shape of the artificial structure 301 includes, but is not limited to, a cuboid, a cube, a cylinder, a truncated cone, or a truncated pyramid.
Compare traditional adoption a plurality of multi-array element ultrasonic transducer transmission ultrasonic wave to stimulate the nerve nucleus group, the neural regulation and control device that this embodiment provided accuracy is high, with strong points. In addition, the control circuit and the program for controlling the multiple multi-array-element ultrasonic transducers to work are very complex, the maintenance difficulty of the control circuit is high, the nerve regulation and control device provided by the embodiment only needs to select the artificial structure 301 to be put into use according to the brain functional diseases of the patient, the control circuit and the program for controlling the single-array-element ultrasonic transducer 02 to work are simple, and the maintenance difficulty is low. Therefore, the nerve regulation and control device that this embodiment provided greatly reduced medical equipment's material cost, research and development cost, cost of manufacture, use cost and maintenance cost when having promoted treatment.
Fig. 2 is a schematic diagram of the neural modulation device shown in fig. 1, and for convenience of explanation, only the parts related to the present embodiment are shown, and detailed as follows:
the reference numerals of fig. 2 denote:
01: a wire; 02: a single-element ultrasonic transducer; 301: artificial structure; 04: a holder; 05: deionized water; 06: a first gripper; 07: a second water bladder 07; 08: deionized water; 09: a second gripper; 010: the skull; 011: an ultrasonic propagation path; 012: a target nerve nucleus; 013: a target nerve nucleus; 014: a target nerve nucleus; 015: the target nerve nuclei.
In an alternative embodiment, the first conductive module 20 and the second conductive module 40 are implemented by using deionized water, and the deionized water is loaded in a water bag, and the water bag is adhered to the artificial structure 301.
Specifically, the first conductive module 20 is disposed in the first water bag, the outer surface of the first water bag is attached to the single-element ultrasonic transducer 02, and the area of the outer surface of the first water bag attached to the single-element ultrasonic transducer 02 is greater than or equal to the area of the ultrasonic emission port of the single-element ultrasonic transducer 02, so as to transmit ultrasonic waves indiscriminately. Optionally, the first water bag is an ultrasonic water bag, which can mount the first conduction module 20, i.e. the deionized water 05, in the inner space, and can conduct the ultrasonic wave without difference.
In an alternative embodiment, the first water sac is made of a tissue phantom material that is capable of ultrasound transmission.
In yet another embodiment, the first water pocket may have a couplant coated on the outer surface to enhance the ability to transmit ultrasound.
Meanwhile, the outer surface of the first water bladder is attached to the artificial structure 301 put into use, and the ultrasonic waves are transmitted to the artificial structure 301. The first water bag and the single-element ultrasonic transducer 02 can be bonded and fixed through a nylon tape, and the first water bag and the artificial structure 301 can also be bonded and fixed through the nylon tape.
The second conduction module 40 is arranged on the outer surface of the second water bag 07 to be attached to the artificial structure 301, and the area of the outer surface of the second water bag 07 to be attached to the artificial structure 301 is larger than or equal to the area of the surface of the artificial structure 301 to be attached to the second water bag 07, so that the ultrasonic waves conducted by the second water bag 07 are completely transmitted to the artificial structure 301.
Optionally, the second water bag 07 is an ultrasonic water bag, which can contain the second conduction module 40, i.e., the deionized water 08, in the inner space and can conduct ultrasonic waves without difference.
In an alternative embodiment, the second water bag 07 is made of a tissue phantom material that is ultrasonically transmissive.
In yet another embodiment, the second water bag 07 may have a coupling agent coated on the outer surface to enhance the ability to transmit ultrasonic waves.
Optionally, the first water bag is bonded to the artificial structure 301 and the single-element ultrasonic transducer 02 through a nylon tape, and the second water bag 07 is bonded to the artificial structure 301 through a nylon tape. The nylon sticker can be detached and reused, and the artificial structure 301, the single-element ultrasonic transducer 02, the first water bag or the first conductive module 20 are convenient to replace. The nylon pastes and sets up in the surface of first water pocket, single-array element ultrasonic transducer 02's surface and artificial structure 301's surface, specifically sets up in the position beyond the contact surface of first water pocket and single-array element ultrasonic transducer 02's contact surface and first water pocket and artificial structure 301's contact surface to avoid nylon to paste the conduction process that influences the ultrasonic wave.
Of course, the first water bag can also be attached and fixed with the single-element ultrasonic transducer 02 and the artificial structure 301 through other detachable fixing devices. How the first water sac is attached to the single-element ultrasonic transducer 02 and the artificial structure 301 does not affect the performance of the nerve regulation device of the present embodiment.
For example, in the embodiment shown in fig. 2, the single-element ultrasonic transducer 02 and the artificial structure 301 are fixed by the fixture 04, and the deionized water 05 is sandwiched between the single-element ultrasonic transducer 02 and the artificial structure 301. Of course, deionized water 05 was placed in the first water bladder. The first water pocket is sandwiched between the single-element ultrasonic transducer 02 and the artificial structure 301.
Optionally, when the fixture 04 is used to fixedly connect the single-element ultrasonic transducer 02 and the manual structure 301 in use, key connection, pin connection, or thread connection may be used.
Optionally, second water bladder 07 is bonded to artificial structure 301 with a nylon patch. The nylon sticker can be detached and reused, and the artificial structure 301, the second water bag 07 or the deionized water 08 can be replaced conveniently. The nylon sticker is arranged on the outer surface of the second water bag 07 and the outer surface of the artificial structure 301, and is specifically arranged at a position outside the contact surface of the second water bag 07 and the artificial structure 301, so that the nylon sticker is prevented from influencing the ultrasonic conduction process.
Of course, the second water bag 07 may also be attached and fixed by the single-element ultrasonic transducer 02 and the artificial structure 301 through other detachable fixing devices. How the first water sac is attached to the single-element ultrasonic transducer 02 and the artificial structure 301 does not affect the performance of the nerve regulation device of the present embodiment.
For example, in the embodiment shown in fig. 2, the upper surface of the second water bladder 07 is provided with a concave surface, and an artificial structure 301 put into use is placed in the concave surface to be closely fitted thereto. The artificial structure 301 may be bonded to the concave surface using a nylon patch or adhesive without affecting the transmission of the ultrasonic waves.
Deionized water 08 is provided in the second water bladder 07 and can be replaced periodically. The second water bag 07 is made of flexible material, and the outer surface of the second water bag 07 is attached to the skin of the living body. For example, fig. 2 shows that the second water sac 07 is attached to the skull 010 of the human body, and the second water sac 07 adjusts its shape according to the fluctuation of the skin in contact with the second water sac, and finally completely attaches to the skin of the living body.
Of course, the nerve control device provided in this embodiment is not only disposed on the skull 010 of the human body, but also only stimulates the brain nerves of the human body; according to the actual requirement, the nerve regulation and control device can also be arranged at other positions of an organism to stimulate peripheral organs and peripheral nerves of the organism so as to achieve the treatment effect. The above-mentioned organism is not limited to a human being, but may be other animals.
Alternatively, the first and second transmission modules 20 and 40 may be implemented using other materials having good acoustic transparency.
The nerve control device provided in this embodiment is connected to an external support device placed on the ground, wall or other fixed object through the first holder 06 and the second holder 09. The first clamp holder 06 is used for clamping the single-element ultrasonic transducer 02, and the second clamp holder 09 is used for clamping the artificial structure 301; the first holder 06 and the second holder 09 are nested for use. When the artificial structure 301 needs to be replaced, only the array element ultrasonic transducer 02 is separated from the first water sac, the fixer 04 between the artificial structure 301 and the array element ultrasonic transducer 02 is released from fixation, and the artificial structure 301 and the array element ultrasonic transducer 02 which need to be put into use are fixed through the fixer 04.
As shown in fig. 2, the ultrasonic waves generated and emitted by the single-element ultrasonic transducer 02 are conducted to the artificial structure 301 through the first water bag and the deionized water 05, and the parameter information of the artificial structure 301 is adjusted. The ultrasonic wave with the adjusted parameter information macroscopically shows the change of the ultrasonic wave propagation path 011 and the change of the position and the area of the ultrasonic focal spot. For example, after the artificial structure 301 shown in fig. 2 is adjusted, the ultrasonic wave is transmitted along the ultrasonic propagation path 011, passes through the second water sac 07 and the deionized water 08, and is transmitted to the skull 010 of the human body, and the three ultrasonic focal spots formed are projected on the target nerve nuclei 012, 013, 014, and 015. Specifically, the target nucleus pulposus 13 shown in fig. 2 is the subthalamic nucleus, and the target nucleus pulposus 14 is the inner side of the globus pallidus.
Through the neural regulation and control device that this embodiment provided, only need according to waiting in the nervous loop of stimulation, the position and the area of target nerve nucleus group, corresponding selection artificial structure 301 comes into operation, can throw the ultrasonic wave on waiting to stimulate each target nerve nucleus group of nervous loop, intervenes and treats brain functional disease, improves patient's the state of an illness, convenient to use to low in cost. The energy distribution form of the ultrasonic wave is reformed through different artificial structures 301, and a specific ultrasonic sound field is modulated, so that the ultrasonic wave can generate a plurality of ultrasonic focal spots with different depths and different stimulation ranges. According to the personal or brain functional disease condition of the patient, different artificial structures 301 are designed to work, and the personalized ultrasonic sound field distribution state, namely the energy distribution form, is modulated, so that the effects of precise treatment and personalized treatment are achieved.
The nerve regulation and control device that this embodiment provided adopts single plane single array element ultrasonic transducer 02 to produce and launch the ultrasonic wave, realizes accurate treatment through changing artifical structure 301, has abandoned traditional adoption a plurality of multi-array element ultrasonic transducer to carry out amazing method to the nerve nucleus, low in cost to the accuracy nature of amazing position improves greatly, has better treatment.
In an optional embodiment, the above-mentioned nerve regulation and control device further includes a power supply module, connected to the single-element ultrasound transducer 02 through a wire 01, for supplying power to the single-element ultrasound transducer 02. The power supply module supplies electric energy to the single-array element ultrasonic transducer 02 through a lead 01, so that the single-array element ultrasonic transducer 02 is excited to generate ultrasonic waves and emit the ultrasonic waves. Specifically, the power supply module is implemented by using an existing power supply circuit, the electric energy provided by the power supply circuit is transmitted to the single-element ultrasonic transducer 02 in the form of an alternating current signal, and the frequency of the alternating current signal is within a preset frequency range.
In an optional embodiment, the nerve modulation device further includes a regulating module, connected to the power supply ground module, for regulating the frequency, amplitude and phase of the alternating current signal to increase or decrease the frequency of the ultrasonic wave, so as to increase or decrease the stimulation degree on the target nerve nucleus.
Fig. 3 is a specific flowchart of a neural modulation method according to another embodiment of the present invention, which only shows the relevant parts related to this embodiment for convenience of description, and the details are as follows:
a neuromodulation method for stimulating a target nerve nuclei, comprising the steps of:
s01: generating and emitting ultrasonic waves;
s02: conducting ultrasonic waves;
s03: adjusting the parameter information of the ultrasonic wave according to the positions and areas of different target nerve nuclei so as to change the conduction direction of the ultrasonic wave and conduct directional conduction;
s04: the directionally-guided ultrasound waves are transmitted such that an ultrasound focused ultrasound focal spot is projected onto a targeted nucleus pulposus.
Specifically, step S01 uses the ultrasonic generation module 10 to generate and emit ultrasonic waves, and the ultrasonic generation module 10 is implemented by using the single-element ultrasonic transducer 02. Step S02 conducts ultrasonic waves using the first conduction module 20. The first conducting module 20 is implemented by using deionized water, the deionized water is arranged in a first water bag, and the first water bag is attached to the single-array-element ultrasonic transducer 02 and the artificial structure 301.
Step S03 is to adjust the parameter information of the ultrasonic wave according to the position and area of the target nerve nuclei using the guided wave module 30, so as to change the conduction direction of the ultrasonic wave and perform the directional conduction. The directional guided wave module 30 includes a plurality of artificial structures 301 for replacement, one artificial structure 301 corresponds to a group of target nerve nuclei, and the group of target nerve nuclei corresponds to a brain functional disease or a disease of peripheral organs and peripheral nerves.
Step S04 transmits the directionally-conducted ultrasonic waves using the second conduction module 40. The second conduction module 40 is implemented using deionized water provided in the second water bladder 07. The second water pocket 07 is attached to the artificial structure 301 and to the skin of the living body.
It is noted that the deionized water in steps S02 and S04 may be replaced.
Fig. 4 is a specific flowchart of a neural modulation method according to another embodiment of the present invention, which only shows the relevant parts related to this embodiment for convenience of description, and the details are as follows:
in an alternative embodiment, the step S03 is specifically the step S031: the artificial structure 301 is replaced, and the parameter information of the ultrasonic waves is adjusted according to the positions and areas of a group of target nerve nuclei so as to change the conduction direction of the ultrasonic waves and conduct directional conduction; wherein one artificial structure 301 corresponds to a set of target nerve nuclei.
Specifically, when the artificial structure 301 is replaced, the replacement may be performed manually or by a mechanical device. The replacement process specifically comprises the following steps:
the fixation of the single-element ultrasonic transducer 02 and the artificial structure 301 by the fixator is released, the artificial structure 301 is replaced, and the poor social function transducer and the artificial structure 301 are fixed again by the fixator.
In an alternative embodiment, before performing step S031, the following steps are further included:
deducing the material components of the artificial structure 301 according to the position and the area of the target nerve nucleus, calculating the proportion of the material components and calculating the thickness of the artificial structure 301; a corresponding artificial structure 301 is prepared.
The ultrasonic waves are conducted after parameter information is adjusted through the artificial structure 301, single-point stimulation and multi-point stimulation can be achieved according to actual needs, and the stimulation position and area can be adjusted. Aiming at different brain functional diseases, different artificial structures 301 are designed for stimulating a corresponding group of nerve nuclei; meanwhile, the artificial structure 301 dedicated to the patient can be designed according to the specific condition of the patient, so that the patient can be treated in a personalized manner, and the treatment effect is better. In practical applications, the specific composition of the artificial structure 301 and the scale of the lattice arrangement structure may be set according to actual needs, and the specific invention is not limited.
In an alternative embodiment, before performing step S01, the method further includes the following steps:
and outputting an alternating current signal.
Specifically, the power supply module is adopted to provide electric energy in the form of alternating current signals to the single-element ultrasonic transducer 02, and the single-element ultrasonic transducer 02 converts the electric energy into ultrasonic waves and then transmits the ultrasonic waves.
In summary, the embodiments of the present invention provide a nerve modulation apparatus and method, in which the artificial structure 301 is selected to work according to the position and area of a group of target nerve nuclei to be stimulated, so that after the ultrasonic wave adjusts parameter information through the artificial structure 301, the ultrasonic focal spot is projected onto the group of target nerve nuclei, thereby implementing intervention and treatment on brain functional diseases. Only need select artifical structure 301 of coming into operation according to patient's brain functional disease, control single array element ultrasonic transducer 02 carries out the control circuit and the procedure of work simple, and the maintenance degree of difficulty is low, when having promoted treatment, greatly reduced medical equipment's material cost, research and development cost, cost of manufacture, use cost and maintenance cost.
Various embodiments are described herein for various apparatuses and methods. Numerous specific details are set forth in order to provide a thorough understanding of the overall structure, function, manufacture, and use of the embodiments as described in the specification and illustrated in the accompanying drawings. However, it will be understood by those skilled in the art that the embodiments may be practiced without such specific details. In other instances, well-known operations, components and elements have been described in detail so as not to obscure the embodiments in the description. It will be appreciated by those of ordinary skill in the art that the embodiments herein and shown are non-limiting examples, and thus, it can be appreciated that the specific structural and functional details disclosed herein may be representative and do not necessarily limit the scope of the embodiments.
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and reference may be made to the related descriptions of other embodiments for parts that are not described or illustrated in a certain embodiment.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.
In addition, functional units in the embodiments of the present invention may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
Claims (6)
1. A neuromodulation device for stimulating a target nucleus pulposus, the neuromodulation device comprising:
an ultrasonic generation module for generating and emitting ultrasonic waves;
the first conduction module is connected with the ultrasonic generation module and is used for conducting the ultrasonic waves;
the directional guided wave module is connected with the first conduction module and used for adjusting the parameter information of the ultrasonic waves according to the positions and the areas of a group of target nerve nuclei so as to change the conduction direction of the ultrasonic waves and conduct directional conduction; wherein the directional guided wave module comprises a plurality of artificial structures which are replaced and used, and one artificial structure corresponds to a group of target nerve nuclei; and
the second conduction module is connected with the directional guided wave module and is used for transmitting the directionally conducted ultrasonic waves so that focused ultrasonic focal spots of the ultrasonic waves are projected on the target nerve nucleus;
the artificial structure is a composite material, and is a lattice arrangement structure with the size close to the wavelength of ultrasonic waves formed by one or more elastic materials according to periodic arrangement or aperiodic arrangement; an acoustic band gap exists in the lattice arrangement structure of the artificial structure;
the artificial structure is used for converting the energy distribution form of the ultrasonic wave into an ultrasonic focal spot with a specific area, and the ultrasonic focal spot is directionally projected to a target nerve nucleus.
2. The neuromodulation device as in claim 1, wherein each of the artificial structures is made of at least one of epoxy and silicone in a predetermined material ratio and a predetermined thickness.
3. The neuromodulation device as in claim 1, wherein the ultrasound generation module is implemented using a single-element ultrasound transducer.
4. The neuromodulation device as in claim 1, wherein the first and second conduction modules are implemented using deionized water; the deionized water is arranged in the water bag, and the water bag is attached to the artificial structure.
5. The neuromodulation device as in claim 1, wherein the connection between the ultrasound generating module and the artificial structure comprises a keyed connection, a pinned connection, or a threaded connection.
6. The neuromodulation device as in claim 1, wherein the plurality of artificial structures adjust the parameter information of the ultrasound wave based on the respective lattice arrangement structure to determine the position and size of the ultrasound focal spot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910665447.3A CN110368608B (en) | 2019-07-23 | 2019-07-23 | Nerve regulation and control device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910665447.3A CN110368608B (en) | 2019-07-23 | 2019-07-23 | Nerve regulation and control device |
Publications (2)
| Publication Number | Publication Date |
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| KR102637479B1 (en) * | 2020-11-18 | 2024-02-16 | 주식회사 뉴로소나 | low intensity focused ultrasound treatment apparatus |
| CN114146890B (en) * | 2021-12-03 | 2022-09-13 | 深圳先进技术研究院 | Ultrasonic sound control method and sound tweezers device |
| CN114209355B (en) * | 2022-02-24 | 2022-06-10 | 深圳高性能医疗器械国家研究院有限公司 | Deep neural ultrasonic automatic positioning and mapping method, device, equipment and medium |
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| CN105944245A (en) * | 2016-05-31 | 2016-09-21 | 深圳先进技术研究院 | Head-mounted ultrasonic transducer |
| KR101850801B1 (en) * | 2016-09-05 | 2018-04-23 | 한국과학기술연구원 | Ultrasonic stimulation device used in MRI Device |
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