CN104548392B - TCD,transcranial Doppler stimulating apparatus and stimulating method - Google Patents
TCD,transcranial Doppler stimulating apparatus and stimulating method Download PDFInfo
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- CN104548392B CN104548392B CN201510021745.0A CN201510021745A CN104548392B CN 104548392 B CN104548392 B CN 104548392B CN 201510021745 A CN201510021745 A CN 201510021745A CN 104548392 B CN104548392 B CN 104548392B
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Abstract
The method for carrying out nerve fiber positioning and neuromodulation is stimulated the invention provides a kind of TCD,transcranial Doppler stimulating apparatus and a kind of TCD,transcranial Doppler,TCD,transcranial Doppler stimulating apparatus includes host computer unit,Ultrasound pulse transmission unit,Ultrasonic transduction unit and power circuit,Because TCD,transcranial Doppler stimulating apparatus provided by the invention uses ic-type,Also include echo amplifying circuit,The focal length of ultrasonic transduction unit is 30mm,The regulation of ultrasound pulse transmission voltage is realized by the regulation of power source supplying voltage simultaneously,So that TCD,transcranial Doppler stimulating apparatus small volume provided by the invention,Spatial positioning resolution is high,And feasible system self-test,Simultaneously because ultrasound intensity is adjustable,Low ultrasound intensity may be selected and carry out tissue positioning and neuromodulation,High ultrasound intensity is selected to carry out tissue damage,To verify the positional information at stimulation position.
Description
Technical field
The invention belongs to nerve stimulation technique field, and in particular to a kind of TCD,transcranial Doppler stimulating apparatus and one kind surpass through cranium
Sound stimulat is used for the method for neuromodulation.
Background technology
Traditional being stimulated through cranial nerve generally has three kinds of methods：External electrode method, through skin and bone tissue electrode by arteries and veins
Rush electric current input brain tissue；Microelectrode method, it is mainly used in the neuromodulation of deep-brain；Neural stem cell method, relative to first two
Method, the time of appearance is later, and this method refers to leading to high frequency electric in coil, produces alternating electromagnetic field, forms electromagnetic wave
Into nerve fiber to play Neuromodulation.The defects of certain all be present in three kinds of traditional methods.External electrode method can only
The nerve fiber of superficial is stimulated, microelectrode method needs to insert electrodes into brain, is that one kind has a damage method, and Neural stem cell method
Focus be Centimeter Level, it is difficult to accurate positioning.
Brain neuroblastoma is modulated using TCD,transcranial Doppler ripple, is important application of the ultrasound in non-invasive medical field, by body
The focusing ultrasonic wave of outer transmitting, makes focus act on nerve fiber, and the efficient modulation to brain neuroblastoma can be achieved.But prior art
In TCD,transcranial Doppler stimulate generating means mostly be to be spliced by more equipment, not only volume is big, inconvenient for use, and does not possess
Stimulate positioning and ultrasound intensity self-checking function.
The content of the invention
The present invention is carried out to solve the above problems, a kind of warp of the detectable ultrasonic echo by providing integrated form
Cranium ultrasound stimulation device, it is not only easy to use, and possess stimulation positioning and ultrasound intensity self-checking function.
Present invention employs following technical scheme：
TCD,transcranial Doppler stimulating apparatus provided by the invention, for producing the ultrasonic pulse stimulated encephalic nerve, tool
There is such feature, including：Host computer unit, for transmitting manipulation order parameter；Ultrasound pulse transmission unit, and host computer list
Member connection, including the programmable pulse generating assembly and ultrasound pulse transmission circuit being linked in sequence, programmable pulse generation group
Part is used for the manipulation order parameter for receiving host computer unit, and drives ultrasound pulse transmission circuit to send high electric field pulse；Ultrasound
Transducing unit, connected with ultrasound pulse transmission unit, for high electric field pulse signal to be converted into ultrasonic pulse, and power supply electricity
Road, for being powered to ultrasound pulse transmission unit, wherein, the pulse voltage of ultrasound pulse transmission circuit is adjustable.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that, in addition to：Echo reception amplifies
Circuit, for amplifying ultrasound echo signal.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that：Ultrasound pulse transmission unit is also
Including isolation circuit, the noise voltage by a small margin for blocking ultrasound pulse transmission unit enters ultrasonic echo and receives amplification electricity
Road.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that, in addition to：Oscillograph, it is used for
Show the ultrasound echo signal of echo reception amplifying circuit output.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that：Ultrasonic transduction unit is focusing
Ultrasonic transducer.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that：Host computer unit is desk-top meter
The various computers that can run Graphic Operating System such as calculation machine, notebook or tablet PC, its interface configurations
Manipulation order parameter includes ultrasonic centre frequency, pulse duration, pulse recurrence frequency and pulse duration.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that：Ultrasound pulse transmission voltage is
It is adjustable.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have the feature that：Echo reception amplifying circuit increases
Benefit is adjustable.
Further, the invention provides a kind of TCD,transcranial Doppler stimulating apparatus to carry out nerve fiber positioning and neuromodulation
Method, it is characterised in that comprise the following steps：
Step 1, " station-keeping mode " is selected in the control interface of host computer unit；
Step 2, determines the position for the nerve fiber that needs are stimulated on brain position indicator, and places needle point in this place
Reverberation, ultrasonic transduction unit is directed at needle point reverberation；
Step 3, impulse ejection circuit repeat the high pressure pulse electric signal sent, drive ultrasound to change after isolation circuit
Energy unit sends ultrasonic pulse；
Step 4, position and the angle of ultrasonic transduction unit are adjusted, when echo-signal is most strong, illustrates needle point reverberation
Position is exactly the focal position of ultrasonic transduction unit；
Step 5, keep ultrasonic transduction cell position constant, needle point reverberation is removed from brain position indicator, will need to stimulate
Body is fixed on brain position indicator by brain map requirement；
Step 6, " stimulus modality " is selected in the control interface of upper computer module；
Step 7, appropriate pulse parameter, pulse voltage and ultrasonic transduction unit are selected, produce ultrasound stimulation pulse thorn
Swash nerve fiber, nerve fiber is modulated.
Further, present invention also offers a kind of TCD,transcranial Doppler stimulating apparatus carry out nerve fiber damage method,
It is used for the positional information for verifying the site of action of ultrasound stimulation in zoopery, it is characterised in that comprise the following steps：
Step 1, " station-keeping mode " is selected in the control interface of host computer unit；
Step 2, determines the position for the nerve fiber that needs are stimulated on brain position indicator, and places needle point in this place
Reverberation, ultrasonic transduction unit is directed at needle point reverberation；
Step 3, impulse ejection circuit repeat the high pressure pulse electric signal sent, drive ultrasound to change after isolation circuit
Energy unit sends ultrasonic pulse；
Step 4, position and the angle of ultrasonic transduction unit are adjusted, when echo-signal is most strong, illustrates needle point reverberation
Position is exactly the focal position of ultrasonic transduction unit；
Step 5, keep ultrasonic transduction cell position constant, needle point reverberation is removed from brain position indicator, will need to stimulate
Body is fixed on brain position indicator by brain map requirement；
Step 6, " Wear mode " is selected in the control interface of host computer unit, under " Wear mode ", improve pulse
Voltage, while impulse ejection circuit sends continuous impulse, to damage the nerve fiber of focal point.
Invention effect and effect
Stimulated the invention provides a kind of TCD,transcranial Doppler stimulating apparatus and a kind of TCD,transcranial Doppler and carry out nerve fiber positioning
And the method for neuromodulation, TCD,transcranial Doppler stimulating apparatus include the host computer unit for command parameters；And host computer
The ultrasound pulse transmission unit of unit connection, including programmable pulse generating assembly, the ultrasound pulse transmission circuit being linked in sequence
And isolation circuit；Ultrasonic transduction unit, connected with ultrasound pulse transmission unit, for high electric field pulse to be converted into ultrasonic arteries and veins
Punching, and power circuit, for being powered to ultrasound pulse transmission unit, because TCD,transcranial Doppler stimulating apparatus provided by the invention is adopted
With ic-type, in addition to echo amplifying circuit, the focal length of ultrasonic transduction unit is 30mm, while passes through power source supplying voltage
Regulation realize the regulation of ultrasound pulse transmission voltage so that TCD,transcranial Doppler stimulating apparatus small volume provided by the invention, it is empty
Between positioning resolution it is high, and feasible system self-test judges whether status of equipment shifts, simultaneously because ultrasound intensity can
Adjust, low ultrasound intensity may be selected and carry out tissue positioning and neuromodulation, select high ultrasound intensity to carry out tissue damage, with checking
In the positional information of zoopery moderate stimulation site of action.
Brief description of the drawings
Fig. 1 is the structural representation of the TCD,transcranial Doppler stimulating apparatus of the present invention；
Fig. 2 is the process flow diagram flow chart that neuromodulation is carried out using the TCD,transcranial Doppler stimulating apparatus of the present invention.
Embodiment
Illustrate the embodiment of the present invention below in conjunction with accompanying drawing.
Fig. 1 is the structural representation of the TCD,transcranial Doppler stimulating apparatus in the present embodiment.
Changed as shown in figure 1, including host computer unit 1, ultrasound pulse transmission unit 2, ultrasound through cranial nerve stimulating apparatus 100
Can unit 3, pressure limiting circuit 4, echo reception amplifying circuit 5, oscillograph 6, power circuit 7 and synchronizing indicator 8.Wherein, surpass
Ping transmitter unit 2, pressure limiting circuit 4, echo reception amplifying circuit 5 and power circuit 7 are located in cabinet, miscellaneous part position
In outside cabinet.Ultrasound pulse transmission unit 2 includes programmable pulse generating assembly 21, the ultrasound pulse transmission circuit being linked in sequence
22 and isolation circuit 23.
Host computer unit 1 passes down the parameter of control signal and ultrasonic pulse by serial ports to programmable pulse generating assembly
21, after programmable pulse generating assembly 21 receives parameter, control signal and the parameter of ultrasonic pulse are converted into special parameter
Under switching pulse EP+ and EP-, switching pulse driving ultrasound pulse transmission circuit 22 sends high electric field pulse, high electric field pulse
Ultrasonic transduction unit 3 is input to after isolation circuit 23.Then, high electric field pulse be converted to by ultrasonic transduction unit 3 be used for into
The ultrasonic pulse of row neuromodulation.
Pressure limiting circuit 4 and ultrasonic echo receive amplifying circuit 5 and connected, for avoiding ultrasound echo signal from returning to ultrasonic pulse
Transmitter unit, the adjustable gain of echo reception amplifying circuit 5, for amplifying the ultrasound echo signal of encephalic neural reflex, stimulating
Amplified ultrasound echo signal is exported by echo and shown in oscillograph 6 with certain forms during positioning, easy to operation
Person's observed echo directly perceived.
Power circuit 7 is used to be powered ultrasound pulse transmission unit 2, while the voltage of power circuit is adjustable, is used for
Adjust the pulse voltage of ultrasound pulse transmission circuit 22, and then adjust ultrasound intensity, the low sound intensity be used for nerve fiber positioning and
Nerve stimulation, the high sound intensity are damaged for tissue.
Synchronizing indicator 8 and programmable pulse generating assembly 21 connect, for monitoring programmable pulse generating assembly in real time
21 working condition.
In the present embodiment, host computer unit is that desktop computer, notebook or tablet PC etc. are various can be with
Run Graphic Operating System computer, the parameter information of its interface configurations and in the range of：Ultrasonic centre frequency (Ft) is
100KHZ-2MHZ, pulse duration (PD) are 0.1ms-10ms, and pulse recurrence frequency (PRF) is 10HZ-2KHZ, during pulse persistance
Between (SD) be 0.5min-60min.
In the present embodiment, programmable pulse emitting module is realized with FPGA, and FPGA launches special parameter after receiving data
Under switching pulse EP+, EP- to ultrasound pulse transmission circuit.
In the present embodiment, the scope that ultrasonic echo receives amplifying circuit adjustable gain is：- 10dB-20dB, power circuit can
The ultrasonic pulse voltage range of offer is in ± 20V- ± 80V.
Ultrasonic transduction unit in the present embodiment is focused transducer, and the focal length of the ultrasonic transducer is 30mm,
Can be according to being actually needed, from three kinds of centre frequency difference 500KHZ, 1MHZ and 1.25MHZ focused transducer.
Further, the present embodiment additionally provides a kind of TCD,transcranial Doppler stimulating apparatus using in the present embodiment and carries out nerve
The method of tissue positioning, neuromodulation and tissue damage.
Fig. 2 is the side that nerve fiber positioning and neuromodulation are carried out using the TCD,transcranial Doppler stimulating apparatus in the present embodiment
Method flow chart.
As shown in Fig. 2 TCD,transcranial Doppler stimulates the step of carrying out nerve fiber positioning and neuromodulation as follows：
Step 1, " station-keeping mode " is selected in the control interface of host computer unit；
Step 2, determines the position for the nerve fiber that needs are stimulated on brain position indicator, and places needle point in this place
Reverberation；
Step 3, impulse ejection circuit 22 repeat to send two-way pulse electric signal, and two-way pulse electric signal is through isolation
Focused transducer 3 is driven to send ultrasonic pulse after circuit 23；
Step 4, believe by the alignment probe needle point reverberation of focused transducer 3 and by the observed echo of oscillograph 6
Number；
Step 5, position and the angle of focused transducer 3 are adjusted, finds echo maximum, now needle point reverberation
The position at place is the focal position of focused transducer 3；
Step 6, keep the position of focused transducer 3 constant, needle point reverberation is removed from brain position indicator, will
Body need to be stimulated to be fixed on by brain map requirement on brain position indicator；
Step 7, " stimulus modality " is selected in the control interface of host computer PC；
Step 8, appropriate pulse parameter, pulse voltage are selected according to actual conditions, focused transducer 3 produces super
Sound stimulat signal stimulus nerve fiber, is modulated to nerve fiber.
In the case of zoopery is applied to, after experiment terminates, if necessary to verify the position letter at stimulation position
Breath, can use Wear mode.In this mode, impulse ejection circuit 22 sends continuous wave, while also needs to impulse ejection
The pulse voltage of circuit 22 is improved to high voltage, after long enough, can damage the nerve fiber of focal point.To difference
The nerve fiber of position is damaged, it is necessary to be determined by experiment pulse voltage, ultrasonic wavelength and duration.
After experiment terminates, put to death and dissect animal, observe the change of its brain tissue, it is determined that the precise location stimulated.
Meanwhile the TCD,transcranial Doppler stimulating apparatus in the present embodiment can also carry out System self-test, particular content is：Surpass through cranium
After Sound stimulat device 100 assembles, by pulse-echo method, under the pulse voltage and echo gain amplifier of setting, survey
Determine the echo strength of focal point flat target under the conditions of vertical incidence and recorded；, can be identical during follow-up use
Under the conditions of determine echo strength and and original record contrasted, you can judgement equipment state whether offset.
Embodiment acts on and effect
Present embodiments providing a kind of TCD,transcranial Doppler stimulating apparatus and a kind of TCD,transcranial Doppler stimulates progress nerve fiber to determine
Position and the method for neuromodulation, TCD,transcranial Doppler stimulating apparatus include the host computer unit for command parameters；With it is upper
The ultrasound pulse transmission unit of machine unit connection, including programmable pulse generating assembly, the ultrasound pulse transmission electricity being linked in sequence
Road and isolation circuit；Ultrasonic transduction unit, connected with ultrasound pulse transmission unit, for high electric field pulse to be converted into ultrasound
Pulse, and power circuit, for being powered to ultrasound pulse transmission unit, because the TCD,transcranial Doppler that the present embodiment provides stimulates dress
Put and use ic-type, in addition to echo amplifying circuit, the focal length of ultrasonic transduction unit is 30mm, while is powered by power supply
Voltage is adjusted to realize the regulation of ultrasound pulse transmission voltage so that the TCD,transcranial Doppler stimulating apparatus volume that the present embodiment provides
Small, spatial positioning resolution is high, and feasible system self-test, judges whether status of equipment shifts, simultaneously because ultrasonic
Intensity is adjustable, and low ultrasound intensity may be selected and carry out tissue positioning and neuromodulation, select high ultrasound intensity to carry out tissue damage,
To verify the positional information at stimulation position.
The invention is not restricted to the scope of embodiment, for those skilled in the art, as long as respectively
Kind of change in the spirit and scope of the present invention that described claim limits and determines, these changes be it will be apparent that
All are using the innovation and creation of present inventive concept in the row of protection.
Claims (5)
- A kind of 1. TCD,transcranial Doppler stimulating apparatus, for producing the ultrasonic pulse stimulated encephalic nerve, it is characterised in that bag Include：Host computer unit, for transmission of control signals and ultrasonic pulse parameter；Ultrasound pulse transmission unit, connected with the host computer unit, including the programmable pulse generating assembly being linked in sequence with And ultrasound pulse transmission circuit, the programmable pulse generating assembly are used for the manipulation order ginseng for receiving the host computer unit Number, and drive the ultrasound pulse transmission circuit to send high electric field pulse,Ultrasonic transduction unit, connected with the ultrasound pulse transmission unit, for the high electric field pulse to be converted into ultrasonic arteries and veins Punching,Oscillograph, for showing the ultrasound echo signal of echo reception amplifying circuit output,Echo reception amplifying circuit, for amplifying the ultrasound echo signal through the encephalic neural reflex, amplified is described super Sound echo-signal is exported by echo and shown in the oscillograph, person's observed echo directly perceived easy to operation, andPower circuit, for being powered to the ultrasound pulse transmission unit,Wherein, the pulse voltage of the ultrasound pulse transmission circuit is adjustable,Needle point reverberation is arranged on to the position for the nerve fiber for needing to be stimulated on brain position indicator, and by the ultrasonic transduction Unit is directed at the needle point reverberation, adjusts position and the angle of the ultrasonic transduction unit, surpasses described in the oscillograph When sound echo-signal is most strong, the position of the needle point reverberation is the focal position of the ultrasonic transduction unit.
- 2. TCD,transcranial Doppler stimulating apparatus according to claim 1, it is characterised in that：Wherein, the ultrasound pulse transmission unit also includes isolation circuit, and the isolation circuit is used to block the ultrasonic pulse The noise voltage by a small margin of transmitter unit enters the ultrasonic echo and receives amplifying circuit.
- 3. TCD,transcranial Doppler stimulating apparatus according to claim 1, it is characterised in that：Wherein, the ultrasonic transduction unit is focused transducer.
- 4. TCD,transcranial Doppler stimulating apparatus according to claim 1, it is characterised in that：Wherein, the host computer unit is the computer that can run Graphic Operating System, and the interface of the computer is configured The ultrasonic pulse parameter include ultrasonic centre frequency, pulse duration, pulse recurrence frequency and pulse duration.
- 5. TCD,transcranial Doppler stimulating apparatus according to claim 2, it is characterised in that：Wherein, the echo reception amplifying circuit adjustable gain.
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| CN107684671B (en) * | 2016-08-05 | 2019-11-12 | 中国科学院深圳先进技术研究院 | A kind of supersonic therapeutic system |
| EP3634568A4 (en) * | 2017-06-07 | 2021-03-24 | HRL Laboratories, LLC | Targeted steerable transcranial intervention to accelerate memory consolidation |
| KR102124421B1 (en) | 2018-03-14 | 2020-06-18 | 한국과학기술연구원 | Method for deciding location of ultrasonic transducer |
| CN112043379B (en) * | 2020-08-06 | 2021-10-01 | 韶关东阳光自动化设备有限公司 | Accurate focusing method and system of phased array transducer |
| CN111938628B (en) * | 2020-09-01 | 2024-01-23 | 天津大学 | Brain power supply signal detection device based on transcranial focusing ultrasonic stimulation |
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