CN205041400U - Novel it is portable through cranium ultrasound stimulation and EEG signal collection device - Google Patents
Novel it is portable through cranium ultrasound stimulation and EEG signal collection device Download PDFInfo
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- CN205041400U CN205041400U CN201520514405.7U CN201520514405U CN205041400U CN 205041400 U CN205041400 U CN 205041400U CN 201520514405 U CN201520514405 U CN 201520514405U CN 205041400 U CN205041400 U CN 205041400U
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Abstract
The utility model discloses a novel it is portable through cranium ultrasound stimulation and EEG signal collection device belongs to harmless measuring technology, and the device includes: host computer module, power module, USB interface module, FPGA host system, driving pulse production module, echo receiving module and EEG signal collection module, system chart is shown as in the figure, the utility model discloses characterized in that: 1, can set up ultrasound stimulation signal parameter in the host computer module, include: length, pulse repetition rate(PRR), pulse duration and focusing ultrasonic transducer's excitation pulse voltage when central frequency, pulse, 2, echo receiving module and EEG signal collection module's gain can be set up in the host computer module, 3, the host computer has amazing time count -down to show, 4, can save ultrasound stimulation signal parameter, echo wave form, EEG signal data and brain wave shape a file the inside, carry out data analysis after being convenient for, the utility model relates to a small in size, nimble, the convenient operation of control.
Description
Technical field
This utility model relates to a kind of novel portable TCD,transcranial Doppler to stimulate and eeg signal acquisition device, and being mainly used in TCD,transcranial Doppler stimulates the experimental research affected EEG signals, belongs to Non-destructive Testing Technique.
Background technology
At present, owing to having the advantages such as non-invasive, effectiveness, safety, ease for operation, transcranial magnetic stimulation (transcranialmagneticstimulation, TMS), through cranium stimulus of direct current (transcranialdirectcurrentstimulation, tDCS) and TCD,transcranial Doppler stimulate (transcranialultrasoundstimulation, TUS) etc. through cranium stimulating technology by extensive concern.TMS, tDCS and TUS, as effective brain function regulation technology, have the ability of reversible change neuroelectricity conductance, and do not cause damage to nervous tissue, namely have safe neuroregulation ability.Although can regulate brain function with upper type, relative to TUS, the spatial resolution of TMS and tDCS is lower, be in a centimetre level, stimulate the degree of depth more shallow simultaneously, generally at 1 cm, only can stimulate to cortex, although degree of depth TMS can reach 6 centimetres the most deeply stimulate the degree of depth, resolution is still be not as high as TUS.Ultrasound wave has good penetrance, and it can penetrate Bone and soft tissue even metal structure, and therefore ultrasound wave has a wide range of applications with industrial in medical treatment.As far back as eighties of last century sixties, ultrasound stimulation is just proved has reversible physiological effect to nervous tissue, comprises excitement and depression effect.But know 2008, scientist just demonstrates pulsating ultrasound by zoopery for the first time to be stimulated and can carry out neuroregulation.The supersonic frequency be used for the treatment of is generally less than 1MHz, if reach same effect of stimulation, the frequency of use is lower, and the sound intensity of needs is less, so it is a kind of brain function regulation technology of very promising and Research Significance that low intensity ultrasound stimulates.
Through finding the retrieval of existing document, Chinese Patent Application No. is: 201210576849.4, name is called: TCD,transcranial Doppler stimulates the device and method repairing cranial nerve function, although provide the device and method of a kind of CO2 laser weld treatment, the functional generator in device and power amplifier etc. make device not have portability; Chinese Patent Application No. is: 201310351623.9, name is called: a kind of method and apparatus of TCD,transcranial Doppler brain regulation and control, the change of electric signal detection system monitoring decimal EEG signals although can require mental skill, also because functional generator, the driving of power amplifier motor etc. make device not have portability; Chinese Patent Application No. is: 201510021745.0, and name is called: TCD,transcranial Doppler stimulating apparatus and stimulating method, although be all integrated in by ultrasonic action on one piece of circuit board, ultrasonic echo display, by oscillograph, does not also have convenience; Chinese Patent Application No. is: 200810231556.6, and name is called: a kind of vein cranium ultrasonic therapy instrument and control technology, and epigynous computer section is only responsible for index display can not show ultrasonic echo and EEG signals.
Summary of the invention
For overcoming above-mentioned deficiency and the defect of prior art, the utility model proposes a kind of novel portable TCD,transcranial Doppler stimulates and eeg signal acquisition device, provides a kind of device portable, easy to operate for TCD,transcranial Doppler stimulates to the research of EEG signals impact.
This utility model is achieved through the following technical solutions:
A kind of novel portable TCD,transcranial Doppler stimulates and eeg signal acquisition device, comprise upper computer module, supply module, usb interface module, FPGA main control module, driving pulse generation module, echo reception module and electroencephalogramsignal signal acquisition module, described upper computer module comprises: optimum configurations interface, echo display interface and brain wave patterns display interface; Described supply module comprises the submodule of powering for driving pulse generation module and the submodule for other energize portions of device; Described echo reception module comprises: clipping module, programming amplifying module, filtration module and analog-to-digital conversion module; Described electroencephalogramsignal signal acquisition module comprises: preposition instrument amplification module, filtration module, programming amplifying module, 50Hz trap module and analog-to-digital conversion module
The implementation that driving pulse controls is: at upper computer module optimum configurations interface pair: mid frequency, pulse duration, pulse recurrence frequency, pulse duration are arranged, these parameters pass to FPGA main control module through usb interface module, produce corresponding control signal and control driving pulse generation module generation driving pulse thus encourage focused ultrasonic transducer to launch ultrasound stimulation signal;
The voltage-controlled implementation of driving pulse is: host computer optimum configurations interface sets driving voltage, parameter passes to FPGA main control module, FPGA main control module sends corresponding digital signals to digital regulation resistance, change the corresponding resistance of submodule that access is powered for driving pulse generation module, thus change driving pulse voltage.
The implementation that ultrasonic echo receiver module and electroencephalogramsignal signal acquisition module gain control is: arrange gain respectively at the echo display interface of upper computer module and brain wave patterns display interface, parameter passes to FPGA main control module through usb interface module, FPGA main control module send corresponding digital signals makes it produce different voltage to D/A converter module, this Control of Voltage programming amplifying module thus realize gain control.
With VC++ language MFC programming realization stimulation time countdown display, waveform display and data store.
Below this utility model is further elaborated:
Described echo reception module comprises: clipping module, programming amplifying module, filtration module and analog-to-digital conversion module, wherein, focused ultrasonic transducer, clipping module, programming amplifying module, filtration module are connected successively with analog-to-digital conversion module, clipping module prevents the high-voltage pulse pumping signal of driving pulse generation module from entering echo reception module, ultrasonic echo amplifies through programmable amplifying circuit, and filtration module filtering enters analog-to-digital conversion module and analog echo signal changed into digital data transmission to FPGA main control module.
Described electroencephalogramsignal signal acquisition module comprises: preposition instrument amplification module, filtration module, programming amplifying module, 50Hz trap module and analog-to-digital conversion module, wherein, micro machine array, preposition instrument amplification module, filtration module, programming amplifying module, 50Hz trap module is connected successively with analog-to-digital conversion module, the EEG signals that micro machine array acquisition comes once is amplified through preposition instrument amplification module, the filtering of filtration module low-and high-frequency, programming amplifying module secondary amplifies, 50Hz trap module filtering power frequency 50Hz interference enters analog-to-digital conversion module, simulation EEG signals be changed into digital data transmission to FPGA main control module.
Compared with prior art, this uses novel advantage to be:
1, ultrasound stimulation signal parameter can be set in upper computer module, comprise: the driving pulse voltage of mid frequency, pulse duration, pulse recurrence frequency, pulse duration and focused ultrasonic transducer; Wherein, driving pulse voltage is larger, and the ultrasound wave sound intensity that focused ultrasonic transducer is launched is larger, so achieve the control of ultrasound stimulation signal intensity;
2, the design of echo reception module and host computer echo display interface makes operator can observe ultrasonic echo waveform intuitively and the moment guarantees the existence of ultrasound stimulation signal, guarantee to test accuracy, the design of electroencephalogramsignal signal acquisition module and brain wave patterns display interface makes operator observe TCD,transcranial Doppler intuitively to stimulate neuronic impact;
3, the gain of echo reception module and electroencephalogramsignal signal acquisition module can be set in upper computer module;
4, host computer has stimulation time countdown to show;
5, ultrasound stimulation signal parameter, echo waveform, EEG signals data and brain wave patterns can be stored in inside a file, after being convenient to, carry out data analysis;
6, TCD,transcranial Doppler stimulates and ultrasonic echo receives, eeg signal acquisition is integrated on one piece of circuit board by this device, compact, control flexible, easy to operate, for TCD,transcranial Doppler stimulates the application on clinical medicine to provide strong experimental basis.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of novel portable TCD,transcranial Doppler stimulation of the present utility model and eeg signal acquisition device;
Fig. 2 is the process flow diagram flow chart utilizing novel portable TCD,transcranial Doppler of the present utility model stimulation and eeg signal acquisition device to carry out neuroregulation;
Fig. 3 is that ultrasound stimulation signal parameter of the present utility model arranges interface;
Fig. 4 is echo display interface of the present utility model;
Fig. 5 is brain wave patterns display interface of the present utility model.
Detailed description of the invention
Below in conjunction with accompanying drawing, this utility model is described further: the present embodiment is implemented under premised on technical solutions of the utility model; give detailed embodiment and concrete operating process, but protection domain of the present utility model is not limited to following embodiment.
As shown in Figure 1, the novel portable TCD,transcranial Doppler that the present embodiment relates to stimulates and eeg signal acquisition device, comprise: upper computer module 1, usb interface module 2, FPGA main control module 3, driving pulse generation module 4, echo reception module 5, electroencephalogramsignal signal acquisition module 6, supply module 10, focused ultrasonic transducer 7 and subjects 8, described driving pulse generation module 4 comprises field effect transistor driven element module 13 and complementary type common drain SEPP single ended push-pull output module 14; Described echo reception module 5 comprises and connecting successively: clipping module 20, programming amplifying module 17 filtration module 16 and analog-to-digital conversion module 15; Described electroencephalogramsignal signal acquisition module comprises and connecting successively: preposition instrument amplification module 27, filtration module 26, programming amplifying module 23,50Hz trap module 22 and analog-to-digital conversion module 21.
As shown in Figure 2, the application of the stimulation of novel portable TCD,transcranial Doppler and eeg signal acquisition device, comprises the following steps:
1: start;
2: at the optimum configurations interface of upper computer module 1, ultrasound stimulation signal parameter is set, set gain respectively at echo display interface and brain wave patterns display interface;
3: focusing ultrasonic type transducer 7 is aimed at the specific neural tissue sites of subjects 8 head, and place microelectrode array acquisition EEG signals;
4: click and start to stimulate button, the parameter that upper computer module 1 sets is transferred to FPGA main control module 3 through usb interface module 2;
5:FPGA main control module 3 is according to the setting at host computer optimum configurations interface, produce corresponding two path control signal, control the amplification of echo reception module 5 and the amplification of electroencephalogramsignal signal acquisition module 6 according to echo display interface and arranging of brain wave patterns display interface amplification;
The two path control signal that 6:FPGA main control module 3 produces controls driving pulse generation module 4 and launches driving pulse;
7: driving pulse excitation focused ultrasonic transducer 7 produces ultrasound stimulation signal stimulus nervous tissue;
8: echo reception module 5 receives the echo-signal that ultrasound stimulation signal reflects through intracranial nervous tissue;
9: electroencephalogramsignal signal acquisition module 6 gathers by the post-stimulatory EEG signals of TCD,transcranial Doppler;
10: the digital data transmission of echo reception module 5 and electroencephalogramsignal signal acquisition module 6 is to FPGA main control module 3;
11: by usb interface module 2 by the digital data transmission of FPGA main control module 3 to host computer;
12: upper computer module 1 is carried out Filtering Processing to the digital signal received and drawn ultrasonic echo waveform and EEG signals waveform.
In the present embodiment, upper computer module is the various computers that can run Graphic Operating System such as desk computer, notebook or tablet PC.
In the present embodiment, optimum configurations interface parameter scope is, ultrasound stimulation signal center frequency: 100KHZ-2.5MHZ, pulse duration: 0.1ms-20ms, pulse recurrence frequency: 10HZ-2KHZ, pulse duration: 0.1min-60min, driving pulse voltage (peak-to-peak value): 40-200V; The gain ranging that echo display interface and brain wave patterns display interface can be arranged is 0dB-80dB.
In the present embodiment, the 5V of monoblock surface-mounted integrated circuit Jin Yong USB interface powers, and meets the convenience requirement of the stimulation of novel portable TCD,transcranial Doppler and eeg signal acquisition device.
In the present embodiment, analog-to-digital conversion module adopts 10 analog-digital converter AD9051, and this chip only needs+5V power supply and an encoded clock can realize 60MSPS sampling rate and 10 bit resolutions.
In the present embodiment, D/A converter module adopts 4 path 10 figure place weighted-voltage D/A converter AD7805.
In the present embodiment, microelectrode array described in microelectrode array is silver chloride powder electrode.
Present embodiments provide a kind of novel portable TCD,transcranial Doppler to stimulate and eeg signal acquisition device, this utility model achieves the real-time control of ultrasound stimulation signal and the Real-time Collection of EEG signals, operator can be made to observe the impact of TCD,transcranial Doppler stimulation on EEG signals intuitively, compact, control flexible, easy to operate, for TCD,transcranial Doppler stimulates application on clinical medicine to provide strong experimental basis.
This utility model is not limited to the scope of detailed description of the invention; to those skilled in the art; as long as various change to limit and in the spirit and scope of the present utility model determined in described claim; these changes are apparent, and the utility model that all utilize this utility model to conceive is created all at the row of protection.
Claims (5)
1. a novel portable TCD,transcranial Doppler stimulates and eeg signal acquisition device, this device comprises upper computer module, supply module, usb interface module, FPGA main control module, driving pulse generation module, echo reception module and electroencephalogramsignal signal acquisition module, wherein: described upper computer module comprises: optimum configurations interface, echo display interface and brain wave patterns display interface; Described supply module comprises the submodule of powering for driving pulse generation module and the submodule for other energize portions of device; Described echo reception module comprises: clipping module, programming amplifying module, filtration module and analog-to-digital conversion module; Described electroencephalogramsignal signal acquisition module comprises: preposition instrument amplification module, filtration module, programming amplifying module, 50Hz trap module and analog-to-digital conversion module, it is characterized in that: at upper computer module optimum configurations interface to the optimum configurations of ultrasound stimulation signal, these parameters pass to FPGA main control module through usb interface module, produce corresponding control signal and control driving pulse generation module generation driving pulse thus encourage focused ultrasonic transducer to launch ultrasound stimulation signal; At the echo display interface of upper computer module and brain wave patterns display interface, gain is set respectively, parameter passes to FPGA main control module through usb interface module, FPGA main control module sends corresponding digital signals makes it produce different voltage to D/A converter module, this Control of Voltage programming amplifying module thus realize gain control, described echo display interface is for observing the ultrasound echo signal through the reflection of intracranial nervous tissue, and described brain wave patterns display interface handled easily person observes the impact of TCD,transcranial Doppler stimulation on brain wave patterns.
2. a kind of novel portable TCD,transcranial Doppler according to claim 1 stimulates and eeg signal acquisition device, it is characterized in that: echo reception module receives the ultrasonic echo be reflected back through intracranial nervous tissue, electroencephalogramsignal signal acquisition module receives the EEG signals that micro machine array acquisition comes, be converted to digital data transmission respectively to FPGA main control module, be transferred to host computer by usb interface module, upper computer module is to data Filtering Processing and draw ultrasonic echo waveform and EEG signals waveform.
3. a kind of novel portable TCD,transcranial Doppler according to claim 1 stimulates and eeg signal acquisition device, it is characterized in that: the parameter that the optimum configurations interface of upper computer module is mainly arranged is: the driving pulse voltage of mid frequency, pulse duration, pulse recurrence frequency, pulse duration and ultrasonic transducer, wherein the driving pulse voltage of ultrasonic transducer is larger, and the ultrasonic energy that focused ultrasonic transducer produces is larger.
4. a kind of novel portable TCD,transcranial Doppler according to claim 1 stimulates and eeg signal acquisition device, it is characterized in that: focused ultrasonic transducer will be aimed at the specific neural tissue sites of subjects's head when applying this device, wherein, the focused ultrasonic transducer ultrasound wave launched need separate with the head of plastic sheeting by itself and human body through ultrasonic coupling medium.
5. a kind of novel portable TCD,transcranial Doppler according to claim 1 stimulates and eeg signal acquisition device, it is characterized in that: described driving pulse module produces driving pulse voltage and arranged by host computer, and scope is peak-to-peak value 40-200V.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943031A (en) * | 2016-05-17 | 2016-09-21 | 西安交通大学 | Wearable transcranial ultrasound nerve stimulation and electrophysiological recording combined system and method |
| CN105943126A (en) * | 2016-07-08 | 2016-09-21 | 山东威瑞外科医用制品有限公司 | Ultrasound knife exciting device and exciting method |
| CN107469232A (en) * | 2017-08-08 | 2017-12-15 | 江西脑调控技术发展有限公司 | A kind of electrodeless electro-therapeutic apparatus of intermediate frequency |
| CN108498948A (en) * | 2018-03-29 | 2018-09-07 | 南京宽诚科技有限公司 | A kind of biology gastroenteritic power instrument |
| CN108829238A (en) * | 2018-05-04 | 2018-11-16 | 天津大学 | A kind of brain-computer interface means of communication based on ultrasonic modulation |
| CN110584658A (en) * | 2019-08-22 | 2019-12-20 | 西安八水健康科技有限公司 | Electroencephalogram acquisition system for transcranial electrical stimulation and vagus nerve stimulation |
| WO2021026873A1 (en) * | 2019-08-15 | 2021-02-18 | 深圳先进技术研究院 | Ultrasonic treatment device and method, and data processing device |
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| CN114917495A (en) * | 2022-04-28 | 2022-08-19 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
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- 2015-07-16 CN CN201520514405.7U patent/CN205041400U/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943031A (en) * | 2016-05-17 | 2016-09-21 | 西安交通大学 | Wearable transcranial ultrasound nerve stimulation and electrophysiological recording combined system and method |
| CN105943126B (en) * | 2016-07-08 | 2018-06-29 | 山东威瑞外科医用制品有限公司 | Ultrasound knife exciting bank and motivational techniques |
| CN105943126A (en) * | 2016-07-08 | 2016-09-21 | 山东威瑞外科医用制品有限公司 | Ultrasound knife exciting device and exciting method |
| CN107469232B (en) * | 2017-08-08 | 2019-11-26 | 江西脑调控技术发展有限公司 | A kind of electrodeless electro-therapeutic apparatus of intermediate frequency |
| CN107469232A (en) * | 2017-08-08 | 2017-12-15 | 江西脑调控技术发展有限公司 | A kind of electrodeless electro-therapeutic apparatus of intermediate frequency |
| CN108498948A (en) * | 2018-03-29 | 2018-09-07 | 南京宽诚科技有限公司 | A kind of biology gastroenteritic power instrument |
| CN108829238A (en) * | 2018-05-04 | 2018-11-16 | 天津大学 | A kind of brain-computer interface means of communication based on ultrasonic modulation |
| WO2021026873A1 (en) * | 2019-08-15 | 2021-02-18 | 深圳先进技术研究院 | Ultrasonic treatment device and method, and data processing device |
| CN110584658A (en) * | 2019-08-22 | 2019-12-20 | 西安八水健康科技有限公司 | Electroencephalogram acquisition system for transcranial electrical stimulation and vagus nerve stimulation |
| CN112870562A (en) * | 2021-01-06 | 2021-06-01 | 上海交通大学 | Implanted piezoelectric MEMS ultrasonic transducer and preparation method thereof |
| CN113197564A (en) * | 2021-04-27 | 2021-08-03 | 燕山大学 | Portable neurovascular coupling detection device for conscious animals |
| CN114917495A (en) * | 2022-04-28 | 2022-08-19 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
| CN114917495B (en) * | 2022-04-28 | 2023-02-24 | 燕山大学 | Multi-parameter adjustable signal source device for transcranial ultrasonic stimulation |
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