WO2021026873A1 - Ultrasonic treatment device and method, and data processing device - Google Patents

Abstract

An ultrasonic treatment device (100) and method, and a data processing device. The method comprises: generating an electric pulse signal having a specific pulse waveform, a preset depth and a preset number of focusing points; generating ultrasonic waves in a preset focusing range and a preset frequency range according to the electric pulse signal, and transmitting the ultrasonic waves to a specific functional area of the brain to intervene and treat a nervous system disease; performing analysis on a brain wave signal by collecting the brain wave signal of the specific functional area of the brain, and adjusting a parameter of the specific pulse waveform when the brain wave signal is abnormal, so that the brain wave signal is recovered to be normal. The brain nerve regulation effect can be achieved by means of the ultrasonic waves; the ultrasonic treatment effect is monitored in real time according to changes of the brain wave signals; parameters of the ultrasonic waves are fed back and adjusted; craniotomy is not needed; noninvasive treatment of the nervous system disease can be achieved, and the operation process is simple.

Description

Ultrasonic treatment device, method and data processing device Technical field

This application belongs to the technical field of neuromodulation, and in particular relates to an ultrasound treatment device, a method and a data processing device.

Background technique

Neuromodulation technology is an important tool to promote the development of neuroscience. Among them, deep brain stimulation (Deep Brain Stimulation, DBS), transcranial direct current stimulation (transcranial direct Current stimulatioin (tDCS), transcranial magnetic stimulation (TMS) and vagus nerve stimulation and other neuromodulation technologies have been applied in the treatment of Parkinson's disease. Deep brain electrical stimulation is to implant electrodes into the subthalamic nucleus, the inner globus pallidus, and thalamus in the brain. Controllable high-frequency current stimulation can improve the abnormal nerve function of the target nucleus and achieve the purpose of effective intervention and treatment of diseases , This method has been approved for clinical Parkinson's treatment. Techniques such as transcranial direct current stimulation and transcranial magnetic stimulation are noninvasive techniques for detecting and treating neurological abnormalities. Transcranial direct current stimulation uses two electrode pads attached to the scalp to input a constant current into a specific area of the skull, and changes the cortical excitability of spontaneous nerve activity by changing the depolarization or hyperpolarization direction of the neuron membrane potential of the cerebral cortex. Transcranial magnetic stimulation uses a magnetic coil placed on the scalp to generate a magnetic field perpendicular to the plane of the coil, which passes through the scalp and skull almost without attenuation, reaches the nerve nucleus of the brain and generates an induced current, which depolarizes the nerve cells. Evoked potential. Through the single pulse, double pulse and repetitive transcranial magnetic stimulation modes, it can regulate the excitatory or inhibitory characteristics of nerve cells, thereby regulating the function of the cortex.

technical problem

Although the clinical or scientific experimental effects of the above neuromodulation technology have been confirmed, there are still many limitations and technical challenges. For example, deep brain electrical stimulation is an invasive technique. Clinically, one or two electrodes are implanted into deep brain tissue to stimulate the nucleus through craniotomy, which will cause permanent damage to the brain tissue and neural circuits. The target cannot be replaced. It is difficult to achieve more nuclei stimulation, and the setting of stimulation parameters depends on the experience of the operator, and the stimulation parameters cannot be adjusted in time according to changes in the patient's condition. Transcranial direct current stimulation and transcranial magnetic stimulation only act on the patient's motor cortex, and do not have the ability to penetrate the skull to deeply stimulate the nucleus.

Technical solutions

In view of this, the embodiments of the present application provide an ultrasound treatment device, method, and data processing device to solve the problem that deep brain electrical stimulation in the prior art will cause permanent damage to brain tissue and neural circuits, and the target cannot be replaced, It is difficult to stimulate more nuclei, and the setting of stimulation parameters depends on the experience of the operator, and the stimulation parameters cannot be adjusted in time according to the changes of the patient’s condition. Transcranial direct current stimulation and transcranial magnetic stimulation only act on the patient’s motor cortex. There is no problem of the ability to penetrate the skull to deeply stimulate the nucleus.

The first aspect of the embodiments of the present application provides an ultrasonic treatment device, including:

Ultrasonic phased array module, used to generate electric pulse signals with specific pulse waveform, preset depth and preset number of focus focal points;

The ultrasonic transducer module is electrically connected to the ultrasonic phased array module, and is used to convert the electrical pulse signal into an ultrasonic wave with a preset focus range and a preset frequency range, and transmit it to a specific functional area of the brain. Intervention and treatment of neurological diseases;

A brain wave signal acquisition module for collecting brain wave signals in a specific functional area of the brain;

The data processing module is electrically connected to the ultrasonic phased array module, the ultrasonic transducer module, and the brain wave signal acquisition module, and is used to analyze the brain wave signal and generate the brain wave signal. Send a waveform adjustment command to the ultrasonic phased array module when abnormal;

The ultrasonic phased array module is also used to adjust the parameters of the specific pulse waveform according to the waveform adjustment instruction to restore the brain wave signal to normal.

The second aspect of the embodiments of the present application provides an ultrasound treatment method, including:

Generate electric pulse signals with specific pulse waveform, preset depth and preset number of focus focal points;

Converting the electrical pulse signal into an ultrasonic wave with a preset focus range and a preset frequency range, and transmits it to a specific functional area of the brain to intervene and treat neurological diseases;

Collecting brain wave signals of specific functional areas of the brain;

Analyzing the brain wave signal, and adjusting the parameters of the specific pulse waveform when the brain wave signal is abnormal, so that the brain wave signal returns to normal.

The third aspect of the embodiments of the present application provides a data processing device, including a memory, a processor, and a computer program stored in the memory and running on the processor, and the processor executes the computer program When realizing the steps of the ultrasonic treatment method described in the second aspect of the embodiments of the present application.

The fourth aspect of the embodiments of the present application provides a computer-readable storage medium, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the implementation is as described in the second aspect of the embodiments of the present application. Describe the steps of ultrasound therapy.

Beneficial effect

The embodiment of the application provides an ultrasonic treatment device including an ultrasonic phased array module, an ultrasonic transducer module, a brain wave signal acquisition module, and a data processing module. The ultrasonic phased array module generates a specific pulse waveform and a preset depth. And a preset number of electric pulse signals with focus focus; the ultrasound transducer module generates ultrasound with a preset focus range and a preset frequency range according to the electric pulse signal, and transmits it to specific functional areas of the brain to intervene in neurological diseases And treatment; collect brain wave signals in specific functional areas of the brain through the brain wave signal acquisition module; analyze brain wave signals through the data processing module, and send waveform adjustment instructions to the ultrasonic phased array module when the brain wave signal is abnormal; The ultrasonic phased array module adjusts the parameters of the specific pulse waveform according to the waveform adjustment instructions to restore the brain wave signal to normal. Ultrasound can be used to achieve brain nerve regulation. By collecting and analyzing the brain wave signal, it can be based on the change of the brain wave signal Real-time monitoring of the effect of ultrasound treatment, and feedback adjustment of ultrasound parameters according to changes in brain wave signals, without the need for craniotomy, can achieve non-invasive treatment of neurological diseases, and the operation process is simple.

Description of the drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only of the present application. For some embodiments, those of ordinary skill in the art can obtain other drawings based on these drawings without creative work.

FIG. 1 is a schematic diagram of a structure of an ultrasonic treatment device provided by an embodiment of the present application;

2 is a schematic diagram of another structure of the ultrasonic treatment device provided by the embodiment of the present application;

Fig. 3 is a schematic diagram of a specific pulse waveform provided by an embodiment of the present application;

FIG. 4 is a schematic flowchart of an ultrasound treatment method provided by an embodiment of the present application;

FIG. 5 is a schematic diagram of another flow chart of the ultrasound treatment method provided by the embodiment of the present application;

FIG. 6 is a schematic diagram of another flow chart of the ultrasound treatment method provided by the embodiment of the present application;

Fig. 7 is a schematic structural diagram of a data processing device provided by an embodiment of the present application.

Embodiments of the invention

In order to enable those skilled in the art to better understand the solution of the present application, the technical solutions in the embodiments of the present application will be clearly described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are of the present application. Part of the embodiment, but not all the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative work should fall within the protection scope of this application.

The term "comprising" in the specification and claims of the application and the above-mentioned drawings and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes unlisted steps or units, or optionally includes Other steps or units inherent in these processes, methods, products or equipment. In addition, the terms "first", "second", and "third" are used to distinguish different objects, rather than describing a specific order.

As shown in FIG. 1, an embodiment of the present application provides an ultrasound treatment device 100 that can emit ultrasound to perform non-invasive treatment of neurological diseases (for example, Parkinson's disease). The ultrasound treatment device 100 includes an ultrasound phased array module 10 and an ultrasound transducer. The energy generator module 20, the brain wave signal acquisition module 30 and the data processing module 40, the ultrasonic phased array module 10, the ultrasonic transducer module 20 and the brain wave signal acquisition module 30 are electrically connected to the data processing module 40, respectively, the ultrasonic phased array The module 10 is also electrically connected with the ultrasonic transducer module 20.

In this embodiment, the ultrasonic phased array module 10 is used to generate electrical pulse signals with a specific pulse waveform, a preset depth, and a preset number of focus focal points.

In application, the ultrasonic phased array module is based on ultrasonic phased array technology. For example, the ultrasonic phased array module may include, but is not limited to, a signal transmitting circuit, a power amplifier circuit, an electronic phase control circuit, and an impedance matching circuit.

As shown in FIG. 2, in one embodiment, the ultrasonic phased array module 10 includes:

The signal transmitting circuit 11 is used to generate an electric pulse signal with a specific pulse waveform;

The power amplifying circuit 12 is electrically connected to the signal transmitting circuit 11, and is used for power amplifying the electric pulse signal of a specific pulse waveform;

The electronic phase control circuit 13 is electrically connected to the data processing module 40, the signal transmitting circuit 11, and the power amplifier circuit 12, and is used to process the electric pulse signal after power amplification into an electric circuit with a preset depth and a preset number of focus points. The pulse signal is also used to control the signal transmitting circuit 11 to adjust the parameters of the specific pulse waveform according to the waveform adjustment command;

The impedance matching circuit 14 is electrically connected to the ultrasonic transducer module 20 and the electronic phase control circuit 13 for impedance matching with the ultrasonic transducer module 20, and triggers the ultrasonic transducer module 20 to convert the electrical pulse signal into a preset Focus range and preset frequency range of ultrasound, and launch to specific functional areas of the brain.

In applications, the parameters of a specific pulse waveform include pulse strength, pulse frequency, pulse repetition frequency, pulse amplitude, pulse width (or pulse length), pulse duration, and duty cycle (or pulse interval). The initial values of the parameters of the specific pulse waveform can be set according to the excitatory and inhibitory effects of the specific pulse waveforms of different parameters on the specific functional areas of the brain.

In the application, the preset depth can be set according to the depth of the specific functional area of the brain that needs intervention and treatment. The preset depth is equal to the depth of the specific functional area that requires intervention and treatment.

In one embodiment, the preset depth is less than or equal to 15 cm.

In application, the preset number can be set according to the number of specific functional areas in the brain that require intervention and treatment. The preset number is less than or equal to the number of specific functional areas that require intervention and treatment. When the preset number is equal to the number of specific functional areas that require intervention and treatment, the ultrasound obtained by the conversion of electrical pulse signals can be used in each specific function. A focal point is formed at the location of the zone to achieve simultaneous intervention and treatment of all specific functional areas; when the preset number is less than the number of specific functional areas that require intervention and treatment, ultrasound can be used in the preset number of specific functions. A focal point is formed at the position of each specific functional area in the area, so as to achieve simultaneous intervention and treatment of the preset number of specific functional areas. After the intervention and treatment of the preset number of specific functional areas are completed, the ultrasound can be focused Intervene and treat a preset number of other specific functional areas, so that batch intervention and treatment of all specific functional areas can be realized.

In this embodiment, the ultrasonic transducer module 20 is used to convert electrical impulse signals into ultrasonic waves with a preset focus range and a preset frequency range, and transmit them to specific functional areas of the brain to intervene in neurological diseases. treatment.

In application, the ultrasonic transducer module includes the ultrasonic transducer that is matched with the ultrasonic phased array module. For example, the ultrasonic transducer module may include dual-mode or multi-mode ultrasonic transducer, dual-mode or multi-mode ultrasonic transducer The device includes two or more multi-element phased array probes. The modulus of an ultrasonic transducer refers to the number of its phased array probes. The number of multi-element phased array probes is multiple. The multiple array elements of the phased array probe can be arranged regularly into one-dimensional linear array, two-dimensional rectangular array, one-dimensional circular array, two-dimensional circular array or two-dimensional fan-shaped array, etc., and can also be arranged into three-dimensional U-shaped array or Any free-form surface array.

As shown in FIG. 2, in one embodiment, the ultrasonic transducer module 20 includes an N-mode ultrasonic transducer 21, and the N-mode ultrasonic transducer 21 includes N multi-element phased array probes;

Wherein, N≥2 and is an integer.

In application, the preset focus range can be set according to the area of the specific functional area of the brain that needs intervention and treatment. The preset focus range is less than or equal to the area of the specific functional area that needs intervention and treatment. The preset frequency range can be set in a frequency range that can produce excitatory or inhibitory effects on specific functional areas that require intervention and treatment, but does not cause harm to specific functional areas.

In one embodiment, the preset focus range is (0mm, 5mm), and the preset frequency range is 30KHz~5MHz.

In this embodiment, the brain wave signal acquisition module 30 is used to collect brain wave signals in specific functional areas of the brain.

In application, the brain wave signal acquisition module includes several electrodes and brain wave signal acquisition cards. Several electrodes are set in the scalp area corresponding to specific functional areas of the brain. The brain wave signal acquisition card collects brain wave signals in specific functional areas through several electrodes. . The brain wave signal acquisition module can be set in a head-mounted stent, or several electrodes are set in a head-mounted stent, so that when the user wears the head-mounted stent, the user's brain wave signals can be collected through the electrodes.

As shown in FIG. 2, in one embodiment, the brain wave signal acquisition module 30 includes:

Several electrodes 31 are used to set up the scalp area corresponding to specific functional areas of the brain;

The brain wave signal acquisition card 32 is electrically connected to the electrodes and the data processing module, and is used to collect brain wave signals of specific functional areas of the brain through a number of electrodes 31 and send them to the data processing module 40.

In application, the specific number of several electrodes is greater than or equal to the number of specific functional areas that need to collect brain wave signals, and the brain wave signals of a specific functional area can be collected through one or more electrodes.

In this embodiment, the data processing module 40 is electrically connected to the ultrasonic phased array module 10, the ultrasonic transducer module 20, and the brain wave signal acquisition module 30, and is used to analyze brain wave signals, and when the brain wave signals are generated When abnormal, a waveform adjustment command is sent to the ultrasonic phased array module 10;

The ultrasonic phased array module 10 is also used to adjust the parameters of the specific pulse waveform according to the waveform adjustment instruction to restore the brain wave signal to normal.

In applications, the data processing module can be a central processing unit (Central Processing Unit, CPU), other general-purpose processors, digital signal processors (Digital Signal Processor, DSP), Application Specific Integrated Circuit (ASIC), Field-Programmable Gate Array (Field-Programmable Gate Array, FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. The general-purpose processor may be a microprocessor or the processor may also be any conventional processor or the like. The data processing module can also be computing devices such as desktop computers, notebooks, palmtop computers, and cloud servers. When the computing device does not have a display screen, the computing device can also be electrically connected to the display to display the analysis results of brain wave signals and The working state parameters of the ultrasonic phased array module, the ultrasonic transducer module and the brain wave signal acquisition module, for example, the parameters of the specific pulse waveform of the electrical pulse signal, the preset depth, the preset number, the preset focus range and preset Set the frequency range and so on. The computing device can also be electrically connected to the human-computer interaction device, so that the user can set the working state and working state parameters of the ultrasonic phased array module, the ultrasonic transducer module, and the brain wave signal acquisition module through the human-computer interaction device. The status includes power on/off status, standby status, working time, total time of single treatment, etc. During a single treatment of a specific functional area of the brain, the total duration of the electrical pulse signal generated by the ultrasonic phased array module and the total duration of the ultrasonic wave emitted by the ultrasonic transducer are equal to the total duration of a single treatment.

As shown in FIG. 3, a schematic diagram of a specific pulse waveform is exemplarily shown.

In application, the data processing module analyzes brain wave signals during the process of intervention and treatment of neurological diseases by transmitting ultrasound, and can learn the effect of intervention and treatment according to the brain wave signal, and realize real-time monitoring of the effect of intervention and treatment Therefore, when the brain wave signal is abnormal, the waveform adjustment instruction can be sent to the ultrasonic phased array module, and the parameters of the specific pulse waveform can be adjusted in time to restore the brain wave signal to normal. If the brain wave signal cannot be restored to normal after one adjustment, you can repeatedly adjust the parameters of the specific pulse waveform according to the real-time monitoring results until the brain wave signal returns to normal.

In one embodiment, the parameters of the specific pulse waveform include pulse repetition frequency or duty cycle.

In application, the parameters of the specific waveform that need to be adjusted in this embodiment only include pulse repetition frequency or duty cycle.

In one embodiment, the specific functional areas of the brain include neurons and brain areas, and the brain wave signal is β wave;

The brain wave signal acquisition module is used to collect the β waves of the neuron and the brain area;

The data processing module is used to detect the change in the amplitude of the β wave of the neuron and the brain area; obtain the number of neurons whose amplitude change of the β wave is greater than a preset amplitude threshold; when the number is greater than the amount before treatment When the number or the amplitude of the beta wave in the brain area is greater than the amplitude before the treatment, send a waveform adjustment instruction to the ultrasonic phased array module;

The ultrasonic phased array module is also used to adjust the parameters of the specific pulse waveform according to the waveform adjustment instruction, so that the number of neurons whose amplitude change of the beta wave is greater than a preset amplitude threshold is less than the number before treatment and The amplitude of the β wave in the brain area is smaller than the amplitude before the treatment.

In application, the specific functional area of the brain in this embodiment may be the area where the neuron and the brain area are located, and the neuron mainly refers to the neuron that is located in the brain area or has a neural reflex relationship with the brain area. The brain wave signal specifically refers to the beta wave. According to the different types of god-level system diseases, brain regions can be specific brain regions related to neurological diseases.

In one embodiment, the neurological disease is Parkinson's disease, and the brain regions include the subthalamic nucleus, the medial globus pallidus, and the thalamus.

In application, the preset amplitude threshold can be set according to actual needs. When the amplitude change of the neuron's beta wave is greater than the preset amplitude threshold, it indicates that the neuron has abnormal beta wave oscillation. Before intervention and treatment of specific functional areas in the patient’s brain, the brainwave signal acquisition module can collect the β waves of related neurons, and determine the neurons with abnormal β wave oscillations according to the changes in the amplitude of the neuron’s β waves Quantity. After intervention and treatment of specific functional areas in the patient’s brain, if the number of neurons with abnormal β-wave oscillations increases compared to before the treatment, the data processing module sends a waveform adjustment command to the ultrasonic phased array module to adjust the specific pulse The parameters of the waveform so that the number of neurons with abnormal β wave oscillations is smaller than the number before treatment. When the amplitude of the β wave in the brain area is greater than the amplitude before the treatment, it indicates that the β wave oscillation in the brain area is abnormal. Before intervention and treatment of specific functional areas in the patient's brain, the brain wave signal acquisition module can be used to collect β waves in related brain areas. After intervention and treatment of specific functional areas in the patient’s brain, if the beta wave in the brain area is enhanced compared to before the treatment, the data processing module sends a waveform adjustment command to the ultrasonic phased array module to adjust the parameters of the specific pulse waveform. So that the amplitude of the β wave in the brain area is smaller than the amplitude before the treatment.

In one embodiment, the data processing module is further configured to analyze the parameters of the specific pulse waveform according to the parameters of the specific pulse waveform when the brainwave signal is abnormal and when the brainwave signal returns to normal. The excitability and inhibitory effects of specific functional areas of the brain are described, and waveform adjustment instructions are sent to the ultrasonic phased array module according to the excitability and inhibitory effects to adjust the parameters of the specific pulse waveform.

In application, the data processing module can analyze the excitability and inhibitory effects of specific pulse waveform parameters on specific functional areas of the brain based on the parameters of the specific pulse waveform when the brain wave signal is abnormal and when the brain wave signal returns to normal in the history record. Therefore, in the subsequent intervention and treatment of neurological diseases, waveform adjustment instructions can be sent to the ultrasonic phased array module according to excitability and inhibitory effects to adjust the parameters of specific pulse waveforms.

In application, the other hardware structures of the ultrasound treatment device except for the N multi-array element phased array probes and several electrodes can be integrated in one body through fixed connection or detachable connection, and set in a housing or bracket In the main structure of an ultrasonic treatment device with a compact structure and a small volume, N multi-element phased array probes and several electrodes can be electrically connected to the main structure through a fixed connection or a detachable connection. The ultrasound treatment device can be configured as a wearable device to facilitate intervention and treatment on the user's brain, for example, a head-mounted device or a shoulder-back device.

In this embodiment, by providing an ultrasonic treatment device including an ultrasonic phased array module, an ultrasonic transducer module, a brain wave signal acquisition module, and a data processing module, the ultrasonic phased array module generates a specific pulse waveform, preset depth and A preset number of electric pulse signals with focus focus; the ultrasound transducer module generates ultrasound waves with a preset focus range and a preset frequency range according to the electric pulse signals, and transmits them to specific functional areas of the brain to intervene in neurological diseases. Treatment; collect brainwave signals in specific functional areas of the brain through the brainwave signal acquisition module; analyze the brainwave signals through the data processing module, and send waveform adjustment instructions to the ultrasonic phased array module when the brainwave signal is abnormal; The ultrasonic phased array module adjusts the parameters of the specific pulse waveform according to the waveform adjustment instructions to restore the brain wave signal to normal. Ultrasound can be used to achieve brain nerve regulation. By collecting and analyzing the brain wave signal, it can be based on the change of the brain wave signal in real time Monitor the effect of ultrasound treatment, and adjust the parameters of ultrasound according to changes in brain wave signals. No craniotomy is required, and non-invasive treatment of neurological diseases can be achieved, and the operation process is simple.

As shown in FIG. 4, an embodiment of the present application provides an ultrasound treatment method based on the ultrasound treatment device 100. The ultrasound treatment method may be a software program method executed by the data processing module 40, and the data processing module 40 is executing the software program. In the method, the ultrasonic phased array module 10, the ultrasonic transducer module 20 and the brain wave signal acquisition module 30 are automatically controlled to perform corresponding operations. The ultrasound treatment method includes:

Step S401: Generate an electrical pulse signal with a specific pulse waveform, a preset depth, and a preset number of focus focal points.

In application, step S401 may be executed by the data processing module 40 controlling the ultrasonic phased array module 10.

Step S402: Convert the electrical pulse signal into an ultrasonic wave with a preset focus range and a preset frequency range, and transmit it to a specific functional area of the brain to intervene and treat neurological diseases.

In application, step S402 can be executed by the data processing module 40 controlling the ultrasonic transducer module 20.

Step S403: Collect brain wave signals of specific functional areas of the brain.

In application, step S403 can be executed by the data processing module 40 controlling the brain wave signal acquisition module 30.

Step S404: Analyze the brain wave signal, and adjust the parameters of the specific pulse waveform when the brain wave signal is abnormal, so that the brain wave signal returns to normal.

In application, step S404 can be performed by the data processing module 40. When the brain wave signal is abnormal, the data processing module 40 sends a waveform adjustment command to the ultrasonic phased array module 10 to control the ultrasonic phased array module 10 to perform adjustment specific Operation of pulse waveform parameters.

In the application, the user can input the control command used to adjust the parameters of the specific pulse waveform through the human-computer interaction mode supported by the data processing module 40, and then input the control command used to control the data processing module 40 to issue the waveform adjustment command. The control data processing module 40 sends a waveform adjustment command to the ultrasonic phased array module 10.

As shown in FIG. 5, in one embodiment, the specific functional areas of the brain include neurons and brain areas, and the brain wave signal is β wave;

Step S404 includes:

Step S501: Detect changes in the amplitude of the β wave of the neuron and the brain area.

In application, the data processing module 40 is also used to control the brain wave signal acquisition module 10 to collect β waves of neurons and brain regions, and execute step S501.

In an embodiment, step S501 includes:

Obtaining the difference between the amplitude of the β wave of the neuron and the normal neuron of the same type as the amplitude change of the neuron;

Comparing the magnitude of the amplitude change of the neuron with a preset amplitude threshold;

The magnitude between the amplitude of the β wave in the brain area and the amplitude of the β wave in the brain area before the treatment is compared.

In application, the difference between the amplitude of the β wave of the neuron and the normal neuron of the same type can be obtained through the logic operation circuit in the data processing module 40. The comparison circuit or comparator in the data processing module 40 can be used to compare the magnitude of the change in the amplitude of the neuron and the preset amplitude threshold, as well as the amplitude of the β wave in the brain area and the β wave in the brain area before treatment. The size between.

Step S502: Obtain the number of neurons whose amplitude variation of the β wave is greater than a preset amplitude threshold.

In application, it is possible to obtain that the amplitude change of the β wave is greater than the preset amplitude by counting the number of comparison results indicating that the amplitude change of the neuron output by the comparison circuit or the comparator in the data processing module 40 is greater than the preset amplitude threshold. Threshold the number of neurons.

Step S503: When the number is greater than the number before the treatment, adjust the parameters of the specific pulse waveform so that the number is less than the number before the treatment;

Step S504: When the amplitude of the β wave in the brain area is greater than the amplitude before the treatment, adjust the parameters of the specific pulse waveform so that the amplitude of the β wave in the brain area is smaller than the amplitude before the treatment.

In application, the data processing module 40 sends a waveform adjustment instruction to the ultrasonic phased array module 10 to control the ultrasonic phased array module 10 to perform an operation of adjusting parameters of a specific pulse waveform.

As shown in FIG. 6, in one embodiment, the ultrasound treatment method further includes the following operations performed by the data processing module 40:

Step S601: According to the parameters of the specific pulse waveform when the brainwave signal is abnormal and when the brainwave signal returns to normal, analyze the excitability and excitability of the parameters of the specific pulse waveform to the specific functional area of the brain Inhibitory effect

Step S602: Adjust the parameters of the specific pulse waveform according to the excitability and inhibitory effects.

In this embodiment, by providing an ultrasound treatment method, a data processing module is used to control an ultrasonic phased array module to generate electrical pulse signals with a specific pulse waveform, a preset depth, and a preset number of focused focal points; the data processing module controls the ultrasonic transducer The device module generates ultrasound with a preset focus range and a preset frequency range according to the electrical pulse signal, and transmits it to specific functional areas of the brain to intervene and treat neurological diseases; the data processing module controls the brain wave signal acquisition module to collect the brain’s Brainwave signals in specific functional areas; analyze the brainwave signals through the data processing module, and send waveform adjustment instructions to the ultrasonic phased array module when the brainwave signal is abnormal; control the ultrasonic phased array module through the data processing module according to the waveform The adjustment command adjusts the parameters of the specific pulse waveform to restore the brain wave signal to normal. Ultrasound can be used to achieve brain nerve regulation. By collecting brain wave signals and analyzing them, the effect of ultrasound treatment can be monitored in real time according to the changes in brain wave signals. The parameters of the ultrasound can be adjusted according to the feedback of changes in brain wave signals, without craniotomy, and non-invasive treatment of neurological diseases can be realized, and the operation process is simple.

It should be understood that the size of the sequence number of each step in the foregoing embodiment does not mean the order of execution. The execution sequence of each process should be determined by its function and internal logic, and should not constitute any limitation to the implementation process of the embodiment of the present application.

As shown in FIG. 7, a data processing device 7 provided by another embodiment of the present application includes: a processor (processor) 70, a communications interface (Communications Interface) 71, a bus 72, a memory (memory) 73, and A computer program 74 in the memory 71 that can be run on the processor 70, such as an ultrasound treatment program. The processor 70, the communication interface 71, and the memory 73 communicate with each other through the bus 72. When the processor 70 executes the computer program 74, the steps in the embodiment of the ultrasonic treatment method described above are implemented, for example, steps S401 to S404 shown in FIG. 4. The data processing device 7 may be a data processing module 40. The communication interface 71 is used to communicate with external devices, for example, an ultrasonic phased array module, an ultrasonic transducer module, a brain wave signal acquisition module, a human-computer interaction device, a personal computer, a smart phone, a cloud server, etc.

Exemplarily, the computer program 74 may be divided into one or more computer program units, and the one or more computer program units are stored in the memory 71 and executed by the processor 70 to complete This application. The one or more computer program units may be a series of computer program instruction segments capable of completing specific functions, and the instruction segments are used to describe the execution process of the computer program 74 in the data processing device 7. For example, the computer program 74 can be divided into a signal generation unit, a signal conversion unit, a signal acquisition unit, and a signal analysis unit. The functions of each computer program unit are as follows:

The signal generating unit is used to generate an electric pulse signal with a specific pulse waveform, a preset depth and a preset number of focus focal points;

The signal conversion unit is used to convert the electric pulse signal into an ultrasonic wave with a preset focus range and a preset frequency range, and transmit it to a specific functional area of the brain to intervene and treat neurological diseases;

A signal acquisition unit for acquiring brain wave signals of specific functional areas of the brain;

The signal analysis unit is configured to analyze the brain wave signal and adjust the parameters of the specific pulse waveform when the brain wave signal is abnormal, so that the brain wave signal returns to normal.

In an embodiment, the function of the signal analysis unit further includes:

Detecting changes in the amplitude of the β wave of the neuron and the brain region;

Obtain the number of neurons whose amplitude variation of the β wave is greater than the preset amplitude threshold;

When the number is greater than the number before treatment, adjusting the parameters of the specific pulse waveform to make the number less than the number before treatment;

When the amplitude of the β wave in the brain area is greater than the amplitude before the treatment, the parameters of the specific pulse waveform are adjusted so that the amplitude of the β wave in the brain area is smaller than the amplitude before the treatment.

In an embodiment, the function of the signal analysis unit further includes:

According to the parameters of the specific pulse waveform when the brain wave signal is abnormal and when the brain wave signal returns to normal, analyze the excitatory and inhibitory effects of the parameters of the specific pulse waveform on the specific functional areas of the brain ；

The parameters of the specific pulse waveform are adjusted according to the excitability and inhibitory effects.

The data processing device 7 may be a computing device such as a desktop computer, a notebook, a palmtop computer, and a cloud server. The data processing device 7 may include, but is not limited to, a processor 70, a communication interface 71, a bus 72, and a memory 73. Those skilled in the art can understand that FIG. 7 is only an example of the data processing device 7 and does not constitute a limitation on the data processing device 7. It may include more or less components than shown in the figure, or combine some components, or different For example, the data processing apparatus may also include input and output devices, network access devices, buses, etc.

The so-called processor 70 may be a central processing unit (Central Processing Unit, CPU), it can also be other general-purpose processors, digital signal processors (Digital Signal Processor, DSP), application specific integrated circuits (Application Specific Integrated Circuit, ASIC), Field-Programmable Gate Array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components, etc. The general-purpose processor may be a microprocessor or the processor may also be any conventional processor or the like.

The memory 71 may be an internal storage unit of the data processing device 7, for example, a hard disk or a memory of the data processing device 7. The memory 71 may also be an external storage device of the data processing device 7, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), or a secure digital (Secure Digital, SD) card, flash card (Flash Card), etc. Further, the memory 71 may also include both an internal storage unit of the data processing apparatus 7 and an external storage device. The memory 71 is used to store the computer program and other programs and data required by the data processing device. The memory 71 can also be used to temporarily store data that has been output or will be output.

Those skilled in the art can clearly understand that for the convenience and conciseness of description, only the division of the above-mentioned functional units and modules is used as an example. In practical applications, the above-mentioned functions can be allocated to different functional units and modules as required. Module completion, that is, divide the internal structure of the device into different functional units or modules to complete all or part of the functions described above. The functional units and modules in the embodiments can be integrated into one processing unit, or each unit can exist alone physically, or two or more units can be integrated into one unit. The above-mentioned integrated units can be hardware-based Formal realization can also be realized in the form of software functional units. In addition, the specific names of the functional units and modules are only used to facilitate distinguishing each other, and are not used to limit the protection scope of the present application. For the specific working process of the units and modules in the foregoing system, reference may be made to the corresponding process in the foregoing method embodiment, which is not repeated here.

In the foregoing embodiments, the description of each embodiment has its own focus. For parts that are not detailed or recorded in a certain embodiment, reference may be made to related descriptions of other embodiments.

A person of ordinary skill in the art may be aware that the units and algorithm steps of the examples described in combination with the embodiments disclosed herein can be implemented by electronic hardware or a combination of computer software and electronic hardware. Whether these functions are executed by hardware or software depends on the specific application and design constraint conditions of the technical solution. Professionals and technicians can use different methods for each specific application to implement the described functions, but such implementation should not be considered beyond the scope of this application.

In the embodiments provided in this application, it should be understood that the disclosed device/data processing device and method may be implemented in other ways. For example, the device/data processing device embodiments described above are only illustrative. For example, the division of the modules or units is only a logical function division, and there may be other division methods in actual implementation, such as multiple Units or components can be combined or integrated into another system, or some features can be omitted or not implemented. In addition, the displayed or discussed mutual coupling or direct coupling or communication connection may be indirect coupling or communication connection through some interfaces, devices or units, and may be in electrical, mechanical or other forms.

The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the objectives of the solutions of the embodiments.

In addition, the functional units in each embodiment of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit. The above-mentioned integrated unit can be implemented in the form of hardware or software functional unit.

If the integrated computer program unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer readable storage medium. Based on this understanding, this application implements all or part of the processes in the above-mentioned embodiments and methods, and can also be completed by instructing relevant hardware through a computer program. The computer program can be stored in a computer-readable storage medium. When the program is executed by the processor, the steps of the foregoing method embodiments can be implemented. Wherein, the computer program includes computer program code, and the computer program code may be in the form of source code, object code, executable file, or some intermediate forms. The computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, U disk, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), electrical carrier signals, telecommunications signals, and software distribution media. It should be noted that the content contained in the computer-readable medium can be appropriately added or deleted in accordance with the requirements of the legislation and patent practice in the jurisdiction. For example, in some jurisdictions, according to the legislation and patent practice, the computer-readable medium Does not include electrical carrier signals and telecommunication signals.

The above-mentioned embodiments are only used to illustrate the technical solutions of the present application, not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that it can still implement the foregoing The technical solutions recorded in the examples are modified, or some of the technical features are equivalently replaced; these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the application, and should be included in Within the scope of protection of this application.

Claims (15)

1. An ultrasonic treatment device, characterized in that it comprises:

   Ultrasonic phased array module, used to generate electric pulse signals with specific pulse waveform, preset depth and preset number of focus focal points;

   The ultrasonic transducer module is electrically connected to the ultrasonic phased array module, and is used to convert the electrical pulse signal into an ultrasonic wave with a preset focus range and a preset frequency range, and transmit it to a specific functional area of the brain. Intervention and treatment of neurological diseases;

   A brain wave signal acquisition module for collecting brain wave signals in a specific functional area of the brain;

   The data processing module is electrically connected to the ultrasonic phased array module, the ultrasonic transducer module, and the brain wave signal acquisition module, and is used to analyze the brain wave signal and generate the brain wave signal. Send a waveform adjustment command to the ultrasonic phased array module when abnormal;

   The ultrasonic phased array module is also used to adjust the parameters of the specific pulse waveform according to the waveform adjustment instruction to restore the brain wave signal to normal.
2. The ultrasound treatment device according to claim 1, wherein the specific functional areas of the brain include neurons and brain regions, and the brain wave signal is a β wave;

   The brain wave signal acquisition module is used to collect the β waves of the neuron and the brain area;

   The data processing module is used to detect the change in the amplitude of the β wave of the neuron and the brain area; obtain the number of neurons whose amplitude change of the β wave is greater than a preset amplitude threshold; when the number is greater than the amount before treatment When the number or the amplitude of the beta wave in the brain area is greater than the amplitude before the treatment, send a waveform adjustment instruction to the ultrasonic phased array module;

   The ultrasonic phased array module is also used to adjust the parameters of the specific pulse waveform according to the waveform adjustment instruction, so that the number is less than the number before treatment and the amplitude of the beta wave of the brain area is less than the amplitude before treatment .
3. The ultrasonic treatment device of claim 2, wherein the neurological disease is Parkinson's disease, and the brain regions include the subthalamic nucleus, the medial globus pallidus, and the thalamus.
4. The ultrasonic treatment device of claim 1, wherein the data processing module is further configured to analyze the parameters of the specific pulse waveform when the brain wave signal is abnormal and when the brain wave signal returns to normal. The excitability and inhibitory effects of the parameters of the specific pulse waveform on the specific functional areas of the brain, and according to the excitability and inhibitory effects, a waveform adjustment command is sent to the ultrasonic phased array module to adjust the Parameters of specific pulse waveform.
5. The ultrasonic treatment device according to any one of claims 1 to 4, wherein the ultrasonic transducer module includes an N-mode ultrasonic transducer, and the N-mode ultrasonic transducer includes N multi-array element phases. Array probe

   Wherein, N≥2 and is an integer.
6. 5. The ultrasonic treatment device according to any one of claims 1 to 4, wherein the ultrasonic phased array module comprises:

   Signal transmitting circuit, used to generate electric pulse signal with specific pulse waveform;

   A power amplifying circuit, electrically connected to the signal transmitting circuit, for power amplifying the electrical pulse signal of the specific pulse waveform;

   The electronic phase control circuit is electrically connected to the data processing module, the signal transmission circuit, and the power amplifier circuit, and is used to process the electric pulse signal after power amplification into a preset depth and a preset number The electric pulse signal of the focus focus is also used to control the signal transmitting circuit to adjust the parameters of the specific pulse waveform according to the waveform adjustment instruction;

   The impedance matching circuit is electrically connected to the ultrasonic transducer module and the electronic phase control circuit, and is used to perform impedance matching with the ultrasonic transducer module, and trigger the ultrasonic transducer module to transmit the electrical pulse signal It is converted into ultrasound with a preset focus range and preset frequency range, and is transmitted to specific functional areas of the brain.
7. 5. The ultrasound treatment device according to any one of claims 1 to 4, wherein the brain wave signal acquisition module comprises:

   Several electrodes, which are used to set up the scalp area corresponding to the specific functional area of the brain;

   The brain wave signal acquisition card is electrically connected to the electrodes and the data processing module, and is used to collect brain wave signals of specific functional areas of the brain through the several electrodes and send them to the data processing module.
8. The ultrasound treatment device according to any one of claims 1 to 4, wherein the preset depth is less than or equal to 15 cm, the preset focus range is (0 mm, 5 mm), and the preset frequency range is 30kHz~5MHz.
9. 5. The ultrasonic treatment device according to any one of claims 1 to 4, wherein the parameter of the specific pulse waveform includes pulse repetition frequency or duty cycle.
10. An ultrasound treatment method, characterized in that it comprises:

    Generate electric pulse signals with specific pulse waveform, preset depth and preset number of focus focal points;

    Converting the electrical pulse signal into an ultrasonic wave with a preset focus range and a preset frequency range, and transmits it to a specific functional area of the brain to intervene and treat neurological diseases;

    Collecting brain wave signals of specific functional areas of the brain;

    Analyzing the brain wave signal, and adjusting the parameters of the specific pulse waveform when the brain wave signal is abnormal, so that the brain wave signal returns to normal.
11. 10. The ultrasound treatment method of claim 10, wherein the specific functional areas of the brain include neurons and brain regions, and the brain wave signal is a β wave;

    Analyzing the brain wave signal, and adjusting the parameters of the specific pulse waveform when the brain wave signal is abnormal, so that the brain wave signal returns to normal, including:

    Detecting changes in the amplitude of the β wave of the neuron and the brain region;

    Obtain the number of neurons whose amplitude variation of the β wave is greater than the preset amplitude threshold;

    When the number is greater than the number before treatment, adjusting the parameters of the specific pulse waveform to make the number less than the number before treatment;

    When the amplitude of the β wave in the brain area is greater than the amplitude before the treatment, the parameters of the specific pulse waveform are adjusted so that the amplitude of the β wave in the brain area is smaller than the amplitude before the treatment.
12. The ultrasound treatment method of claim 11, wherein the neurological disease is Parkinson's disease, and the brain regions include the subthalamic nucleus, the medial globus pallidus, and the thalamus.
13. The ultrasound treatment method according to any one of claims 10 to 12, further comprising:

    According to the parameters of the specific pulse waveform when the brain wave signal is abnormal and when the brain wave signal returns to normal, analyze the excitatory and inhibitory effects of the parameters of the specific pulse waveform on the specific functional areas of the brain ；

    The parameters of the specific pulse waveform are adjusted according to the excitability and inhibitory effects.
14. The ultrasound treatment method according to any one of claims 10 to 12, wherein the parameters of the specific pulse waveform include pulse repetition frequency or duty cycle.
15. A data processing device, comprising a memory, a processor, and a computer program stored in the memory and capable of running on the processor, wherein the processor executes the computer program as claimed in claim 10 To the steps of any one of the ultrasound treatment methods.