CN113197564A - Portable neurovascular coupling detection device for conscious animals - Google Patents
Portable neurovascular coupling detection device for conscious animals Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
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Abstract
The application provides a portable neurovascular coupling detection device for a conscious animal, which comprises an image acquisition module, a laser emission module, a signal processing module, a power supply module, an electric signal acquisition module and an installation assembly, wherein the image acquisition module is used for acquiring images of the conscious animal; the mounting assembly is arranged at the head of the experimental object, and the laser emission module emits oblique laser to the head of the experimental object to form speckles on the head of the experimental object; the image acquisition module is arranged above the head of the experimental object and acquires a cerebral cortex blood flow image of the speckle part corresponding to the experimental object; the electric signal acquisition module is arranged at the head of the experimental object and is configured for acquiring an electroencephalogram signal of the experimental object; the signal processing module is configured to analyze the received cerebral cortex blood flow image and the electroencephalogram signal to obtain a coupling relation between the cerebral cortex blood flow image and the electroencephalogram signal. The beneficial effect of this application is: the installation component is portably installed on the head of an experimental object, and electroencephalogram signals and cerebral cortex blood flow images can be acquired under the clear-headed and movable conditions, so that the neurovascular coupling relation can be more truly obtained.
Description
Technical Field
The disclosure relates to the technical field of neurovascular coupling detection, in particular to a portable neurovascular coupling detection device for a conscious animal.
Background
Blood flow velocity is one of the very important functional metabolic parameters in the course of life activities. The dynamic monitoring of the time-space change of the blood flow velocity has great significance for researching the physiological change process of biological tissues, functional activities, drug effect evaluation and the like. The laser speckle blood flow imaging technology is a new rapid blood flow detection method in recent years, has the advantages of optical imaging, no ionizing radiation and non-contact measurement, and obtains relative blood flow velocity information by using backward speckles of biological tissues, and obtains full-field two-dimensional high-resolution blood flow distribution imaging in an imaging mode without combining mechanical scanning; the blood flow detection can be continuously carried out for a long time without injecting exogenous substances such as contrast agents and the like. The brain electrical activity is derived from the free discharge activity of the brain neuron population, and is the general reflection of the electrophysiological activity of the brain nerve cells on the surface of the cerebral cortex or scalp. The electroencephalogram signals contain a large amount of physiological and disease information, and research and analysis on the electroencephalogram signals can not only provide diagnosis basis for certain brain diseases, but also provide effective treatment means for certain brain diseases. People try to effectively extract and analyze electroencephalogram signals through a brain-computer interface (BCI), thereby achieving a certain control purpose. Because the electroencephalogram signal is a non-stationary random signal without ergodicity and the noise influence is great, the analysis and the processing of the electroencephalogram signal are important research contents.
Neurovascular coupling refers to the relationship between local neural activity and changes in Cerebral Blood Flow (CBF), with the magnitude and spatial distribution of changes in blood flow being related to changes in neural activity through a series of coupling factors, such as neurons, glia, and vascular cells. Many vessel-based brain function imaging techniques (e.g., fMRI) need to rely on this coupling relationship to infer changes in neural activity.
Disclosure of Invention
The purpose of this application is to above problem, provides one kind and can realize under ultrasonic stimulation that EEG signal gathers and blood flow formation of image device of working simultaneously to solve the poor problem of mobility.
In a first aspect, the present application provides a portable neurovascular coupling detection device for a conscious animal, comprising an image acquisition module, a laser emission module, a signal processing module, a power supply module, an electrical signal acquisition module and a mounting assembly; the power supply module is electrically connected with the signal processing module, and the signal processing module is respectively in signal connection with the image acquisition module and the electric signal acquisition module; the mounting assembly is mounted on the head of the experimental subject, the image acquisition module is arranged above the head of the experimental subject through the mounting assembly, and the image acquisition module is configured to acquire a cerebral cortex blood flow image of a speckle part corresponding to the experimental subject and send the cerebral cortex blood flow image to the signal processing module; the laser emitted by the laser emitting module obliquely irradiates the head of the experimental object and forms speckles on the head; the electric signal acquisition module is arranged at the head of the experimental object, and is configured for acquiring the electroencephalogram signals of the speckle parts corresponding to the experimental object and sending the electroencephalogram signals to the signal processing module; the signal processing module is configured to analyze the received cerebral cortex blood flow image and the electroencephalogram signal to obtain a coupling relation between the cerebral cortex blood flow image and the electroencephalogram signal.
According to the technical scheme provided by the embodiment of the application, the mounting assembly comprises a fixed shell and a body backpack; a first set range of the head of the experimental subject is set as an experimental region, and a second set range in the experimental region is set as a signal acquisition region; the fixed shell is fixed on a skull in an experimental area, laser emitted by the laser emitting module is obliquely shot on a cerebral cortex of a signal acquisition area and speckles are formed on the surface of the cerebral cortex, and the image acquisition module is fixed at the top end of the fixed shell to acquire a cerebral cortex blood flow image in an area corresponding to the speckles; the electric signal acquisition module is arranged in the signal acquisition area to acquire an electroencephalogram signal of a cerebral cortex in the area; the signal processing module and the power supply module are arranged in a body backpack, and the body backpack is fixed on the body of the experimental object.
According to the technical scheme provided by the embodiment of the application, the detection device further comprises an ultrasonic stimulation module electrically connected with the power module, the ultrasonic stimulation module is installed at the head of the experimental object to generate ultrasonic stimulation to the experimental object, and when the ultrasonic stimulation module is enabled, the image acquisition module and the electric signal acquisition module can respectively acquire the cerebral cortex blood flow image and the electroencephalogram signal of the experimental object under the ultrasonic stimulation and respectively transmit the cerebral cortex blood flow image and the electroencephalogram signal to the signal processing module.
According to the technical scheme provided by the embodiment of the application, the ultrasonic stimulation module comprises an ultrasonic transducer and a collimator, the ultrasonic transducer is fixedly connected with the collimator, and one end of the collimator, which is far away from the ultrasonic transducer, is in contact with the surface of the skull of the experimental region.
According to the technical scheme provided by the embodiment of the application, the image acquisition module is set to be a CMOS camera.
According to the technical scheme provided by the embodiment of the application, the laser emitting module is set as a laser diode.
According to the technical scheme provided by the embodiment of the application, the type of the laser diode is set to HL 6322G.
According to the technical scheme provided by the embodiment of the application, the signal processing module is set as an embedded ARM system.
According to the technical scheme provided by the embodiment of the application, the detection device further comprises a data storage module, the signal processing module is in signal connection with the data storage module, and the data storage module is configured to receive data sent by the signal processing module so as to perform offline analysis on the data.
The invention has the beneficial effects that: the application provides a portable neurovascular coupling detection device for conscious animals, establishes the region of predetermineeing of subject's head into the detection zone and fixes the installation component in the position that corresponds predetermined region, and the installation component adopts the mode that can portably install to install in the predetermined region of subject. The mounting assembly is fixed and then emits laser to the preset area through the laser emission module to form speckles in the preset area, and then the image acquisition module and the electric signal acquisition module are used for acquiring cerebral cortex blood flow images and electroencephalogram signals of the experimental object under the clear-headed and movable conditions, so that the neurovascular coupling relationship of the experimental object under the clear-headed and movable conditions can be truly analyzed, and the detection device is simple, convenient to mount and more real and accurate in detection data.
Drawings
FIG. 1 is a schematic structural diagram of a first embodiment of the present application;
the text labels in the figures are represented as: 1. an image acquisition module; 2. a laser emission module; 3. a signal processing module; 4. a power supply module; 5. an electric signal acquisition module; 6. (ii) an experimental subject; 7. a stationary housing; 8. a body backpack; 9. an ultrasonic transducer; 10. a collimator.
Detailed Description
In order that those skilled in the art will better understand the technical solutions of the present invention, the following detailed description of the present invention is provided in conjunction with the accompanying drawings, and the description of the present section is only exemplary and explanatory, and should not be construed as limiting the scope of the present invention in any way.
Fig. 1 is a schematic diagram of a first embodiment of the present application, including an image acquisition module 1, a laser emission module 2, a signal processing module 3, a power module 4, an electrical signal acquisition module 5, and a mounting assembly; the power supply module 4 is used for supplying power to the signal processing module 3, and the signal processing module 3 is respectively in signal connection with the image acquisition module 1 and the electric signal acquisition module 5; the mounting assembly is mounted on the head of the experimental object 6, and the laser emission module 2 obliquely irradiates the head of the experimental object 6 to form speckles on the head of the experimental object 6; the image acquisition module 1 is arranged above the head of the experimental object 6 through the mounting assembly and vertically acquires a cerebral cortex blood flow image of a speckle part corresponding to the experimental object and sends the cerebral cortex blood flow image to the signal processing module 3; the electric signal acquisition module 5 is arranged at the head of the experimental object 6 and is configured for acquiring the electroencephalogram signal of the experimental object 6 and sending the electroencephalogram signal to the signal processing module 3; the signal processing module 3 is configured to analyze the received cerebral cortex blood flow image and the electroencephalogram signal to obtain a coupling relationship between the two.
In this embodiment, the installation component is conveniently worn on the subject 6 through the form such as bandage, and the subject 6 in this embodiment adopts the rat commonly used in laboratory to detect. Because the installation component is dressed on subject 6 through simple connection structure to install respectively on the installation component through with optical emission module, signal processing module 3, power module 4, signal of telecommunication collection module 5, consequently dress the installation component and be equivalent to connecting whole set of detection device on subject 6 behind subject 6. The installation component is worn behind the experimental object 6, the data acquisition process of testing process does not influence the activity of experimental object 6, because this detection device detects time measuring can go on under the clear-headed and mobilizable state of experimental object 6, and be different from fixing it on the white rat locater after can only anaesthetizing experimental object 6 among the prior art, consequently, the data under the true condition of experimental object 6 are reflected more really to the detection data that goes on through this detection device, consequently, it is more true accurate to use this device to detect the testing result who obtains, reflects the relation between 6 cerebral cortex blood flow image of experimental object and the EEG signal under the same moment more really. In this embodiment, in order to better acquire the image of the experimental object 6 at the speckle position, the image acquisition module 1 is disposed right above the speckle position corresponding to the experimental object 6, that is, the image acquisition module 1 vertically acquires the image of the experimental object 6 at the speckle position, so that the laser emission module 2 can only be disposed so that the laser emitted by the laser emission module is obliquely irradiated on the head of the experimental object due to the position occupation of the image acquisition module 1.
In a preferred embodiment, the mounting assembly comprises a stationary housing 7 and a body backpack 8; a first set range of the head of the experimental subject is set as an experimental region, and a second set range in the experimental region is set as a signal acquisition region; the fixed shell is fixed on a skull in an experimental area, laser emitted by the laser emitting module is obliquely shot on a cerebral cortex of a signal acquisition area and speckles are formed on the surface of the cerebral cortex, and the image acquisition module is fixed at the top end of the fixed shell to acquire a cerebral cortex blood flow image in an area corresponding to the speckles; the electric signal acquisition module is arranged in the signal acquisition area to acquire an electroencephalogram signal of a cerebral cortex in the area; the signal processing module and the power supply module are arranged in a body backpack, and the body backpack is fixed on the body of the experimental object.
In the preferred embodiment, a first setting range of the head of the subject is set as an experimental area, a second setting range in the experimental area is set as a signal acquisition area, for example, a circular area with a diameter of 6mm is selected as an experimental area on the head of a white rat, the scalp and dura mater of the experimental area are stripped to expose the skull of the experimental area, the fixed housing 7 is abutted against the surface of the skull of the experimental area, a circular area with a diameter of 3mm is selected as a signal acquisition area in the experimental area, and the skull of the signal acquisition area is stripped to expose the cortex, i.e., brain tissue, of the area, so that the laser generated by the laser emitting module 2 is obliquely applied to the cortex of the signal acquisition area to form speckles thereon. After speckles are formed, the image acquisition module 1 and the electric signal acquisition module 5 synchronously acquire data of the cerebral cortex of the signal acquisition area: the image acquisition module 1 acquires a cerebral cortex blood flow image on a cerebral cortex of a signal acquisition area; the electric signal acquisition module 5 is arranged on the cerebral cortex of the signal activity area to acquire the electroencephalogram signals of the area.
In the preferred embodiment, a body backpack 8 is worn on the back of the subject 6 so as not to interfere with its normal activities.
In a preferred embodiment, the detecting device further comprises an ultrasonic stimulation module electrically connected to the power module, the ultrasonic stimulation module is mounted on the head of the subject to generate ultrasonic stimulation to the subject, and when the ultrasonic stimulation module is enabled, the image acquisition module and the electrical signal acquisition module can respectively acquire the cerebral cortex blood flow image and the electroencephalogram signal of the subject under the ultrasonic stimulation and respectively transmit the cerebral cortex blood flow image and the electroencephalogram signal to the signal processing module.
In this preferred embodiment, the ultrasonic stimulation module is provided to enable the detection device of this embodiment to have a function of acquiring data of the subject 6 under normal activity, and to perform ultrasonic stimulation on the subject 6 to detect the cerebral cortex blood flow image and the electroencephalogram signal of the subject 6 under the ultrasonic stimulation, so as to perform detection and analysis more comprehensively, i.e., to compare the contrast of the cerebral cortex blood flow image and the contrast of the electroencephalogram signal of the subject 6 under normal activity and under the ultrasonic stimulation.
In a preferred implementation manner of the above preferred embodiment, the ultrasonic stimulation module includes an ultrasonic transducer 9 and a collimator 10, the ultrasonic transducer 9 is fixedly connected to the collimator 10, and one end of the collimator 10 away from the ultrasonic transducer 9 is in contact with the surface of the skull of the experimental region.
In the preferred embodiment, the ultrasound transducer 9 is enabled to emit ultrasound waves and accurately stimulate the cortical brain region of the subject 6 via the collimator 10. A particular brain region of the subject 6 can be accurately stimulated by guidance of the collimator 10. The collimator 10 is a device that limits the sound wave output to a certain range, and can make the ultrasonic waves stimulate the target brain area of the experimental subject 6 in a targeted manner, thereby eliminating unnecessary interference. The collimator 10 is filled with an ultrasonic coupling agent, and can well conduct the ultrasonic waves to the skull of the experimental object 6.
Preferably, the image acquisition module 1 is a CMOS camera; the laser emitting module 2 is set as a laser diode, and the model of the laser diode is HL 6322G; the signal processing module 3 adopts an embedded ARM system.
In a preferred embodiment, the detection apparatus further includes a data storage module, the signal processing module 3 is in signal connection with the data storage module, and the data storage module is configured to receive data sent by the signal processing module 3, so as to perform offline analysis on the data.
The principles and embodiments of the present application are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present application. The foregoing is only a preferred embodiment of the present application, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present application, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments, or may be learned by practice of the invention.
Claims (9)
1. A portable neurovascular coupling detection device for a conscious animal is characterized by comprising an image acquisition module (1), a laser emission module (2), a signal processing module (3), a power supply module (4), an electric signal acquisition module (5) and an installation assembly; the power supply module is electrically connected with the signal processing module, and the signal processing module is respectively in signal connection with the image acquisition module and the electric signal acquisition module;
the mounting assembly is mounted on the head of an experimental object (6), the image acquisition module is arranged above the head of the experimental object through the mounting assembly, and is configured to acquire a cerebral cortex blood flow image of a speckle part corresponding to the experimental object and send the cerebral cortex blood flow image to the signal processing module;
the laser emitted by the laser emitting module obliquely irradiates the head of the experimental object and forms speckles on the head;
the electric signal acquisition module is arranged at the head of the experimental object, and is configured for acquiring the electroencephalogram signals of the speckle parts corresponding to the experimental object and sending the electroencephalogram signals to the signal processing module;
the signal processing module is configured to analyze the received cerebral cortex blood flow image and the electroencephalogram signal to obtain a coupling relation between the cerebral cortex blood flow image and the electroencephalogram signal.
2. The portable neurovascular coupling detection device for awake animals according to claim 1, wherein the mounting assembly includes a stationary housing (7) and a body backpack (8);
a first set range of the head of the experimental subject is set as an experimental region, and a second set range in the experimental region is set as a signal acquisition region; the fixed shell is fixed on a skull in an experimental area, laser emitted by the laser emitting module is obliquely shot on a cerebral cortex of a signal acquisition area and speckles are formed on the surface of the cerebral cortex, and the image acquisition module is fixed at the top end of the fixed shell to acquire a cerebral cortex blood flow image in an area corresponding to the speckles; the electric signal acquisition module is arranged in the signal acquisition area to acquire an electroencephalogram signal of a cerebral cortex in the area;
the signal processing module and the power supply module are arranged in a body backpack, and the body backpack is fixed on the body of the experimental object.
3. The device according to claim 2, further comprising an ultrasound stimulation module electrically connected to the power module, wherein the ultrasound stimulation module is mounted on the head of the subject to generate ultrasound stimulation thereon, and when the ultrasound stimulation module is enabled, the image acquisition module and the electrical signal acquisition module can respectively acquire the cerebral cortex blood flow image and the brain electrical signal of the subject under the ultrasound stimulation and respectively transmit the cerebral cortex blood flow image and the brain electrical signal to the signal processing module.
4. The portable neurovascular coupling detection device for awake animals according to claim 3, wherein the ultrasonic stimulation module comprises an ultrasonic transducer and a collimator, the ultrasonic transducer (9) is fixedly connected with the collimator (10), and one end of the collimator far away from the ultrasonic transducer is in contact with the surface of the skull of the experimental region.
5. The device according to claim 2 or 4, wherein the image acquisition module is configured as a CMOS camera.
6. The portable neurovascular coupling detection device for awake animals according to claim 5, wherein the laser emission module is provided as a laser diode.
7. A portable neurovascular coupling detection device for awake animals according to claim 6, wherein the laser diode model is set to HL 6322G.
8. The portable neurovascular coupling detection device for awake animals according to claim 1, wherein the signal processing module is provided as an embedded ARM system.
9. The portable neurovascular coupling detection device for conscious animals according to claim 1, further comprising a data storage module, wherein the signal processing module is in signal connection with the data storage module, and the data storage module is configured to receive the data transmitted by the signal processing module for offline analysis thereof.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300815A (en) * | 2022-07-29 | 2022-11-08 | 燕山大学 | Closed-loop ultrasonic visual stimulation device and experimental method |
| CN115344122A (en) * | 2022-08-15 | 2022-11-15 | 中国科学院深圳先进技术研究院 | Sound wave non-invasive brain-computer interface and control method |
Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1792323A (en) * | 2005-12-30 | 2006-06-28 | 华中科技大学 | Method and equipment for transcranial cerebral blood flow high-resolution imaging |
| CN101919686A (en) * | 2010-09-21 | 2010-12-22 | 华中科技大学 | Multi-mode imaging system for observing cerebral cortex functions of moving animals |
| CN104873192A (en) * | 2015-06-10 | 2015-09-02 | 上海大学 | Miniature brain function monitoring and imaging apparatus and method |
| CN205041400U (en) * | 2015-07-16 | 2016-02-24 | 燕山大学 | Novel it is portable through cranium ultrasound stimulation and EEG signal collection device |
| CN105662389A (en) * | 2016-01-12 | 2016-06-15 | 崔天利 | System for detecting and evaluating human-brain activity |
| CN105832305A (en) * | 2016-06-20 | 2016-08-10 | 上海交通大学 | Head-wearing OCT (optical coherence tomography) imaging system for free moving animal |
| CN107692974A (en) * | 2017-10-25 | 2018-02-16 | 上海交通大学 | A kind of multi-parameter animal cortex blood flow monitoring device and method |
| CN107693962A (en) * | 2017-08-31 | 2018-02-16 | 深圳先进技术研究院 | A kind of wear-type ultrasonic conducting device |
| CN108403082A (en) * | 2018-01-24 | 2018-08-17 | 苏州中科先进技术研究院有限公司 | A kind of imaging in biological tissues system and imaging method |
| CN108478207A (en) * | 2018-01-09 | 2018-09-04 | 南京航空航天大学 | A kind of multi-modal physiological brain monitoring system |
| CN109924976A (en) * | 2019-04-29 | 2019-06-25 | 燕山大学 | The stimulation of mouse TCD,transcranial Doppler and brain electromyography signal synchronous |
| CN110882004A (en) * | 2019-11-06 | 2020-03-17 | 中国科学院深圳先进技术研究院 | Ultrasonic control and imaging device, method, server and storage medium |
| US20210068662A1 (en) * | 2018-04-02 | 2021-03-11 | University Of Alaska Fairbanks | Methods and systems for near infrared spectroscopy |
| CN112603268A (en) * | 2020-12-24 | 2021-04-06 | 华中光电技术研究所（中国船舶重工集团公司第七一七研究所） | Multi-mode optical microscopic imaging device and microscopic imaging method |
-
2021
- 2021-04-27 CN CN202110457713.0A patent/CN113197564A/en not_active Withdrawn
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1792323A (en) * | 2005-12-30 | 2006-06-28 | 华中科技大学 | Method and equipment for transcranial cerebral blood flow high-resolution imaging |
| CN101919686A (en) * | 2010-09-21 | 2010-12-22 | 华中科技大学 | Multi-mode imaging system for observing cerebral cortex functions of moving animals |
| CN104873192A (en) * | 2015-06-10 | 2015-09-02 | 上海大学 | Miniature brain function monitoring and imaging apparatus and method |
| CN205041400U (en) * | 2015-07-16 | 2016-02-24 | 燕山大学 | Novel it is portable through cranium ultrasound stimulation and EEG signal collection device |
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