CN105943031B - Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method - Google Patents
Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method Download PDFInfo
- Publication number
- CN105943031B CN105943031B CN201610326489.0A CN201610326489A CN105943031B CN 105943031 B CN105943031 B CN 105943031B CN 201610326489 A CN201610326489 A CN 201610326489A CN 105943031 B CN105943031 B CN 105943031B
- Authority
- CN
- China
- Prior art keywords
- signal
- wearable
- electrode
- digital
- nerve stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6864—Burr holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/0026—Stimulation of nerve tissue
Abstract
The present invention relates to a kind of wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method, association system includes: computer control and data processing unit, digital-to-analogue/AD conversion unit, power amplifier, wearable ultrasonic transducer, electrode assembly and signal amplification unit；Signal instruction is issued with data processing unit by computer control, digital-to-analogue/AD conversion unit generates respective waveforms after being connected to above-metioned instruction, it transfers to power amplifier that signal is enlarged into high voltage signal, and ultrasonic transducer is driven to emit ultrasonic wave, realize the purpose of nerve stimulation.The electricity physiological signal that electrode assembly is recorded is transmitted to digital-to-analogue/AD conversion unit and is converted to digital signal after signal amplifier amplifies, and receives digital signal with data processing unit by computer control, carries out data processing and show.The synchronous recording that set of system completes complicated ultrasound stimulation and electricity physiological signal is realized well, and technical support is provided to brain science research.
Description
[technical field]
The present invention relates to ultrasonic nerve stimulation studying technological domain, in particular to a kind of wearable TCD,transcranial Doppler nerve stimulation
With electrophysiological recording association system and method.
[background technique]
In recent years, as brain science research is gradually paid attention to by various countries, since ultrasonic nerve stimulation has safe nothing simultaneously
Wound, field stimulation is big and the advantages such as precision is high, ultrasonic nerve stimulation have become a hot topic of research content again.Although early in 1929
Year, just some researches show that ultrasounds can be used as a kind of nerve stimulation means, but up to the present, ultrasonic nerve stimulation is still within
The initial stage of development.Comparing, other have developed more mature nerve stimulation mode, match with ultrasonic nerve stimulation research
System is perfect not enough.The research of Neuscience be unable to do without the record of electricity physiological signal, and the record of brain electricity physiological signal is to comment
The important means of valence TCD,transcranial Doppler nerve stimulation success or not and effect of stimulation also has ultrasonic nerve stimulation mechanism study important
Effect.Therefore, TCD,transcranial Doppler nerve stimulation records brain electricity physiological signal in the research field with particularly important simultaneously
A technological difficulties in meaning, and area research experiment at present.
Currently, have been reported that related TCD,transcranial Doppler nerve stimulation when brain electricity physiological signal record research in, ultrasound mind
It is stimulated and what electricity physiological signal acquisition was generally used is two sets of independent legacy systems, this just makes experiment need two upstreams
Control terminal largely increases the complexity of experiment, and two systems can not also realize complicated ultrasound stimulation well
With the synchronous recording of electricity physiological signal.
Furthermore since ultrasonic transducer is directly placed at experimental subjects above-head, it is raw that this will result in traditional brain electricity
Reason signal record in measuring electrode conflict with the spatial position of ultrasonic transducer, this just need change wherein set of system to adapt to
The requirement of experiment, and this change will also tend to influence the effect and the scope of application of experiment.For example, for warp in existing document
The record of brain electricity physiological signal connects using reduction energy converter and the effective of experimental subjects head when cranium ultrasound nerve stimulation
Contacting surface product, and recording electrode is inserted into brain area in a manner of oblique incidence, or directly by electrode fabrication l-shaped, then be embedded to brain
It measures, to avoid interfering with the space of energy converter, wherein the length of L-type is to be embedded to the depth of brain.However, this two
All there is respective defect in kind of method, the first recording mode has just limited to the size and energy converter and reality of ultrasonic transducer first
The contact area of object is tested, the use of larger-diameter focused transducer, and this record are largely limited
The mode that electrode oblique cutting enters also increases the operation difficulty that recording electrode is accurately positioned deeper part brain area.Using second method
When, since neuronal cell diameter is only several to dozens of microns, and recording electrode is once made into, and embedding depth of electrode is just
It is determined via the length of L-type, it is other in the micron-scale that length is difficult control, (10 μm) tune of high-precision when being unfavorable for very much physical record
Whole embedding depth of electrode is to make eletrode tip be placed in the demand near target nerve member.Currently, the length of embedment considered is difficult to
Accurate control, this acquisition mode, which is only present in, records corticocerebral electricity physiological signal.
More importantly records electrophysiologicalsignals signals require at experimental subjects simultaneously for ultrasonic nerve stimulation existing at present
In anesthesia and stationary state, therefore, existing method is for requiring experimental subjects to be in awake and active state experimental study (such as
Learning and memory, metabolism etc.) it is all not applicable.
In conclusion the recording method of brain electricity physiological signal sets experiment when existing TCD,transcranial Doppler nerve stimulation
All there is apparent limitation in standby, target brain area, research object and research contents, lack the association system of complete set.Therefore,
It proposes complete set, is in awake and active state wearable TCD,transcranial Doppler nerve stimulation in particular for experimental subjects
It is just particularly important with electrophysiological recording association system.
[summary of the invention]
The purpose of the invention is to overcome above-mentioned the shortcomings of the prior art, a kind of wearable TCD,transcranial Doppler is proposed
Nerve stimulation and electrophysiological recording association system and method.The System and method for realizes complicated ultrasound stimulation and electro physiology well
The function of the synchronous recording of signal provides new technical support to brain science research.
In order to solve the above technical problems, the present invention adopts the following technical scheme:
A kind of wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system, comprising: computer control and data
Processing unit, digital-to-analogue/AD conversion unit, power amplifier, wearable ultrasonic transducer, electrode assembly and signal amplification are single
Member；Wherein,
The computer control and data processing display unit, ultrasonic wave emits when for TCD,transcranial Doppler nerve stimulation to be arranged
Parameter and electricity physiological signal data acquisition parameters issue control instruction, and realize the follow-up data processing of electricity physiological signal and show
Show；
Digital-to-analogue/the AD conversion unit generates nerve stimulation ultrasound hair according to control instruction for receiving control instruction
Ejected wave shape, and by nerve stimulation ultrasound emission waveform transfer to power amplification unit；Amplify list through signal for receiving and acquiring
The amplified electricity physiological signal of member, and it is converted into digital signal, it is input to computer control and data processing display unit；
The power amplifier, the ultrasound emission waveform for generating digital-to-analogue/AD conversion unit is after power amplification
It is input to wearable ultrasonic transducer, it is driven to emit ultrasonic wave；
The wearable ultrasonic transducer, for receiving the ultrasonic stimulation waveform of power amplifier sending and generating ultrasound
Wave realizes the stimulatory function to target neural tissue；
The electrode assembly is transmitted to signal amplifier for recording brain electricity physiological signal, and by electricity physiological signal；
The signal amplification unit amplifies electricity physiological signal for the electricity physiological signal that receiving electrode component record arrives
After be transmitted to digital-to-analogue/AD conversion unit.
As a further improvement of the present invention, the electrode assembly is by electrode contact, electrode fixed link and recording electrode structure
At recording electrode is fixed on electrode fixed link, and electrode contact is connected with recording electrode, for connecting and transmitting electricity physiological signal extremely
Signal amplifier；Through-hole is provided on the wearable ultrasonic transducer, electrode fixed link and recording electrode are arranged in described
In through-hole, electrode assembly and wearable ultrasonic transducer is made to become an overall structure.
As a further improvement of the present invention, the wearable ultrasonic transducer includes transducer enclosure, transducer enclosure
The contact surface of the upper energy converter connector being arranged for connecting power amplifier, transducer enclosure bottom and experimental subjects is energy converter
Array element face.
As a further improvement of the present invention, the recording electrode material is metal electrode or glass electrode, quantity one
Root or more.
As a further improvement of the present invention, the contact interface daubing coupling agent in the transducer array element face and experimental subjects
Or carry out other acoustic propagation coupling processings；The transducer enclosure is fixed by sealing adhesive plaster with experimental subjects, and sealing adhesive plaster is viscous
After being affixed on experimental subjects head, make ultrasonic transducer that there is wearable function, and prevent couplant from leaking outside.
As a further improvement of the present invention, the digital-to-analogue/AD conversion unit, power amplifier and signal amplification unit
It is encapsulated in inside wearable ultrasonic transducer in integrated circuit form, and forms an entirety, digital-to-analogue/modulus with electrode assembly
Converting unit is communicated by radio receiving transmitting module and computer control with data processing display unit wireless connection.
As a further improvement of the present invention, ultrasonic wave emission parameter includes ultrasonic baseband, pulse width, pulse repetition
Frequency, pulse number and stimulus intensity；When electricity physiological signal data acquisition parameters include the sample rate of electricity physiological signal, acquisition
Between, delay and filtering mode.
A kind of wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording Combined Trials method, comprising:
The emission parameter of nerve stimulation ultrasonic wave is used for data processing unit setting by computer control；
After digital-to-analogue/AD conversion unit is connected to above-metioned instruction, respective waveforms are generated, are enlarged into signal by power amplifier
High voltage signal, and wearable ultrasonic transducer transmitting ultrasonic wave is driven, realize the purpose of nerve stimulation；
The electricity physiological signal that electrode assembly is recorded is transmitted to digital-to-analogue/analog-to-digital conversion list after signal amplification unit amplifies
Member converts analog signals into digital signal；
Computer control receives digital signal with data processing unit and carries out the number of electricity physiological signal according to requirement of experiment
According to handling and show.
Compared with prior art, the beneficial effects of the present invention are:
The invention proposes a kind of TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system, in whole system, ultrasound
Nerve stimulation and two parts of electrophysiological recording are believed by same terminal (computer control and data processing unit) and second level completely
It number receives and to be controlled with transmitting unit (digital-to-analogue/AD conversion unit), experimental facilities and operating process are simplified, for complicated ultrasound thorn
Swash and provides guarantee with the synchronism of electricity physiological signal record.Set of system is realized well completes complicated ultrasound stimulation and electricity
The synchronous recording of physiological signal provides new technical support to brain science research.
Further, electrode assembly is made of electrode contact, electrode fixed link and recording electrode, electrode fixed link and record electricity
Pole is arranged in the through-hole on wearable ultrasonic transducer, and electrode assembly and ultrasonic transducer is made to become an overall structure.Solution
The problem of measuring electrode in traditional brain electricity physiological signal record of having determined conflicts with the spatial position of ultrasonic transducer.
Further, using the wearable function of communicating, and pass through sealing adhesive plaster realization ultrasonic transducer is wirelessly connected, simultaneously
TCD,transcranial Doppler nerve stimulation and electrophysiological recording system are realized, convenient for experiment of the experimental subjects under awake active state.To
It completes to test in a manner of wireless control, and is more conducive to for the experiment in the case of experimental subjects free movement.
Experimental method of the invention, easy to operate, precise control realize ultrasound stimulation note synchronous with electricity physiological signal
Record.The research in the awake active state of experimental subjects may be implemented, used when also having well solved TCD,transcranial Doppler nerve stimulation
Measuring electrode conflicts with the spatial position of ultrasonic transducer in traditional brain electricity physiological signal record.
[Detailed description of the invention]
Fig. 1 is a kind of wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system block diagram of the invention；
Fig. 2 is the ultrasonic nerve stimulation stimulation pulse signal schematic diagram of the embodiment of the present invention；
Fig. 3 is the ultrasonic transducer of the embodiment of the present invention and the structural schematic diagram of electrode assembly.
Wherein, 101, data processing unit；102, digital-to-analogue/AD conversion unit；103, power amplifier；104, wearable
Ultrasonic transducer；105, electrode assembly；106, signal amplification unit 104, wearable ultrasonic transducer；301, energy converter connector；
302, through-hole；303, transducer enclosure；304, transducer array element face；305, adhesive plaster is sealed；105, electrode assembly；306, electrode connects
Head；307, electrode fixed link；308, recording electrode.
[specific embodiment]
The present invention will be further described in the following with reference to the drawings and specific embodiments, and the present invention is not limited to following embodiments.
As shown in Figure 1, there are six a kind of wearable TCD,transcranial Doppler nerve stimulation of the present invention and electrophysiological recording association systems
Part forms, and is computer control and data processing unit 101, digital-to-analogue/AD conversion unit 102, power amplifier respectively
103, wearable ultrasonic transducer 104, electrode assembly 105 and signal amplification unit 106.
Digital-to-analogue/the AD conversion unit 102 has both sides function.First, for receiving computer control and data
The control instruction that processing unit 101 issues generates nerve stimulation ultrasound emission waveform according to control instruction, and extremely by waveform transfer
Power amplification unit.Second, for receiving and acquire through the amplified electricity physiological signal of signal amplification unit 106, and by its turn
It is changed to the digital signal that computer can identify, is input to computer control and data processing display unit 101.Digital-to-analogue/modulus
The input port quantity of converting unit 102 is determined that the quantity of output port is determined by ultrasonic transducer by electrode assembly quantity.Its
Data acquisition function receives the control of computer control and data processing display unit 101.
The power amplifier 103, the ultrasound emission waveform for generating digital-to-analogue/AD conversion unit 102 is through power
It is input to wearable ultrasonic transducer 104 after amplification, it is driven to emit ultrasonic wave.
The signal amplification unit 106, for the electricity physiological signal that receiving electrode component 105 is recorded, due to computer
It can only identify digital signal, and the electricity physiological signal being recorded is analog signal, it is therefore desirable to it is passed after amplifying electricity physiological signal
Digital-to-analogue/AD conversion unit 102 is transported to, the identifiable digital signal of computer is converted to.
The computer control is with data processing display unit 101, ultrasonic wave when for TCD,transcranial Doppler nerve stimulation to be arranged
Emission parameter and electricity physiological signal data acquisition parameters, and realize the follow-up data processing and display of electricity physiological signal.This implementation
In example by taking relatively conventional Sinusoidal Pulse Waves as an example.
As shown in Fig. 2, ultrasonic wave emission parameter mainly includes ultrasonic baseband, pulse width, pulse recurrence frequency, pulse
Number and stimulus intensity.Different according to the electricity physiological signal to be recorded and analyzed, the processing of electricity physiological signal data acquisition parameters is main
Include but are not limited to sample rate, acquisition time, the delay etc. of electricity physiological signal, electricity physiological signal data processing mainly include but
It is not limited only to the high pass, low pass and bandpass filtering etc. of signal.
The wearable ultrasonic transducer 104, for receiving the high-voltage ultrasound wave stimulus wave of the sending of power amplifier 103
Shape generates ultrasonic wave, and then realizes the stimulatory function to target neural tissue.
The electrode assembly 105 is transmitted to signal amplifier for recording brain electricity physiological signal, and by electricity physiological signal
106。
As shown in figure 3, for the wearable ultrasonic transducer 104 and 105 structural schematic diagram of electrode assembly.Wearable ultrasound
Energy converter 104 includes energy converter connector 301, through-hole 302, transducer enclosure 303, transducer array element face 304, sealing adhesive plaster 305.
Electrode assembly 105 is made of electrode contact 306, electrode fixed link 307 and recording electrode 308.
The energy converter connector 301 receives the high voltage stimulus waveform of its transmitting for connecting power amplifier 103.Institute
It states through-hole 302 and penetrates through energy converter longitudinal direction, for the electrode assembly by records electrophysiologicalsignals signals.Its number and experiment need to record electricity
The number of the target brain area of physiological signal is identical, and what distributing position and experimental subjects brain map determined needs records electrophysiologicalsignals signals
The position of target brain area is corresponding.The transducer enclosure 303 need to have electromagnetic shielding action, with anti-tampering electricity physiological signal.Institute
Transducer array element face 304 to be stated to contact with experimental subjects, contact interface needs daubing coupling agent or does other acoustic propagation coupling processings, with
Just ultrasonic wave enters experimental subjects brain.Transducer array element face 304 be plane or curved surface, view test whether need to form it is poly-
Depending on burnt ultrasound, generally Dan Zhenyuan ultrasonic transducer can also be if necessary more array element ultrasonic transducers, and the present embodiment is adopted
With single array element non-focused ultrasound energy converter.The sealing adhesive plaster 305 is pasted on for fixing ultrasonic transducer in animal head
It can also prevent couplant from leaking outside after experimental subjects skin of head, make wearable ultrasonic transducer.Ultrasonic transduction body
Product is depending on experimental subjects, element number of array, stimulation precision and target brain area.
The electrode contact 306 is connected with recording electrode 308, for connecting and transmitting electricity physiological signal to signal amplifier
106.The electrode fixed link 307, for forming support for electrode contact 306 and recording electrode 308, mobile note when convenient for experiment
Electrode is recorded, and after electrode to be recorded arrival target brain area, electrode assembly is fixed on ultrasonic transduction using electrode fixed link 307
On device, so that electrode assembly and ultrasonic transducer be made to form an entirety.The recording electrode 308, for recording electro physiology letter
Number, according to requirement of experiment, recording electrode material is metal electrode or glass electrode, and recording electrode quantity can be one or more
Root, the present embodiment use metallic nickel chromium electrode.
As a further improvement of the present invention, the digital-to-analogue/AD conversion unit 102, power amplifier 103 and signal are put
Big unit 106 can be encapsulated in integrated circuit form inside wearable ultrasonic transducer 104, and with 105 shape of electrode assembly
At an entirety, digital-to-analogue/AD conversion unit is wirelessly connected by radio receiving transmitting module and computer control with data processing unit
Capable communication is tapped into, to complete to test in a manner of wireless control, is more conducive in the case of experimental subjects free movement
Experiment.
The operation principle of the present invention is that: it is included but are not limited to by computer control and the setting of data processing unit 101
Nerve stimulation ultrasonic wave is used for including ultrasonic baseband, pulse width, pulse recurrence frequency, pulse number and stimulus intensity etc.
Emission parameter.After digital-to-analogue/AD conversion unit 102 is connected to above-metioned instruction, respective waveforms are generated, transfer to power amplifier that will believe
Number it is enlarged into high voltage signal, and ultrasonic transducer is driven to emit ultrasonic wave, realizes the purpose of nerve stimulation.Digital-to-analogue/modulus turns
The quantity for changing the output port of unit 102 is determined by ultrasonic transducer.At the same time, the electricity physiological signal that electrode assembly is recorded
After signal amplifier amplifies, it is transmitted to digital-to-analogue/AD conversion unit 102, since the electricity physiological signal being recorded is simulation letter
Number, so needing to be converted into the identifiable digital signal of computer, digital-to-analogue/modulus by digital-to-analogue/AD conversion unit 102
The quantity of the output port of converting unit 102 is determined by ultrasonic transducer 104.Finally, by computer control and data processing list
Member 101 receives the digital signal converted and carries out the data processing of electricity physiological signal and display according to requirement of experiment.The whole series system
In system, ultrasonic nerve stimulation and two parts of electrophysiological recording are completely by same data terminal (computer control and data processing
Unit 101) and second signal receive and controlled with transmitting unit (digital-to-analogue/AD conversion unit 102), for complicated ultrasound stimulation and electricity
The synchronism of physiological signal record provides guarantee.
The wearable ultrasonic transducer that is embodied in mentioned in the present invention is integrally designed with electrode assembly, and this design
The research in the awake active state of experimental subjects not only may be implemented, also well solved traditional brain electricity physiological signal record
Middle measuring electrode conflicts with the spatial position of ultrasonic transducer.
The experiment that TCD,transcranial Doppler nerve stimulation is carried out by this system and records the experiment of brain electricity physiological signal is described below
Process:
Firstly, connection system respectively forms unit as shown in Figure 1.
Anaesthesia experiment object sloughs its crown hair, is fixed on stereotaxic apparatus.
Target brain area position is determined according to brain map, marks electrode entry site in skull surface according to map, and right
It answers site to bore and opens aperture so that electrode is inserted into brain.
Electrode assembly is passed through into ultrasonic transducer through-hole and is positioned at target brain area into experimental subjects brain.
In recording electrode and skull intersection, it is fixed on electrode assembly on experimental subjects skull.
Ultrasonic coupling agent is smeared on experimental subjects head and energy converter contact position, and sealing adhesive plaster is pasted on experimental subjects
Skin of head fixes energy converter and is tightly attached to experimental subjects head.Later by electrode fixed link and energy converter in electrode assembly
It is fixed, so that experimental subjects, energy converter and electrode assembly be made to form an entirety, wearable purpose is realized, convenient for experiment
Experiment of the object under awake active state.
The connection for disconnecting ultrasonic transducer and electrode assembly and upstream equipment is again coupled to each after animal restores normal
Equipment, by computer control and data processing display unit be arranged ultrasonic baseband, pulse width, pulse recurrence frequency,
The electro physiologies such as the ultrasound stimulations such as pulse number and stimulus intensity parameter and sample rate, acquisition time, delay and filtering mode are adopted
Collection and processing parameter.If experiment does not need experimental subjects and is in awake active state, connects without off device, be arranged immediately
Every ultrasound stimulation and electro physiology acquisition and processing parameter.
Confirmation parameters setting connected with instrument it is errorless after can start TCD,transcranial Doppler nerve stimulation and to record brain electric
Physiological signal experiment.
The above-mentioned only present invention preferably feasible embodiment, however, the present invention is not limited thereto is made various according to above-described embodiment
It deforms or applies within this technical solution protection scope.
Claims (7)
1. a kind of wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system characterized by comprising computer control
System is changed with data processing display unit (101), digital-to-analogue/AD conversion unit (102), power amplifier (103), wearable ultrasound
It can device (104), electrode assembly (105) and signal amplification unit (106)；Wherein,
The computer control and data processing display unit (101), ultrasonic wave is sent out when for TCD,transcranial Doppler nerve stimulation to be arranged
Penetrate parameter and electricity physiological signal data acquisition parameters, issue control instruction, and realize the follow-up data processing of electricity physiological signal with
Display；
Digital-to-analogue/the AD conversion unit (102) generates nerve thorn according to control instruction for receiving the control instruction
Swash ultrasound emission waveform, and by nerve stimulation ultrasound emission waveform transfer to power amplifier (103)；For receiving and acquiring warp
Signal amplification unit (106) amplified electricity physiological signal, and it is converted into digital signal, it is input to computer control and number
According to processing display unit (101)；
The power amplifier (103), the ultrasound emission waveform for generating digital-to-analogue/AD conversion unit (102) is through power
It is input to wearable ultrasonic transducer (104) after amplification, it is driven to emit ultrasonic wave；
The wearable ultrasonic transducer (104), for receiving the ultrasonic stimulation waveform of power amplifier (103) sending and producing
Raw ultrasonic wave, realizes the stimulatory function to target neural tissue；
The electrode assembly (105), is transmitted to signal amplification unit for recording brain electricity physiological signal, and by electricity physiological signal
(106)；
The signal amplification unit (106) believes electro physiology for the electricity physiological signal that receiving electrode component (105) are recorded
Number amplification after be transmitted to digital-to-analogue/AD conversion unit (102)；
The electrode assembly (105) is made of electrode contact (306), electrode fixed link (307) and recording electrode (308), record
Electrode (308) is fixed on electrode fixed link (307), and electrode contact (306) is connected with recording electrode (308), for connecting simultaneously
Electricity physiological signal is transmitted to signal amplification unit (106)；Through-hole (302) are provided on the wearable ultrasonic transducer (104),
Electrode fixed link (307) and recording electrode (308) are arranged in the through-hole (302), and electrode assembly (105) surpasses with wearable
Sonic transducer (104) becomes one structure.
2. wearable TCD,transcranial Doppler nerve stimulation according to claim 1 and electrophysiological recording association system, feature exist
In the wearable ultrasonic transducer (104) includes transducer enclosure (303), is arranged on transducer enclosure (303) for connecting
The contact surface of the energy converter connector (301) of power amplifier (103), transducer enclosure (303) bottom and experimental subjects is transducing
Device array element face (304).
3. wearable TCD,transcranial Doppler nerve stimulation according to claim 1 and electrophysiological recording association system, feature exist
In recording electrode (308) material is metal electrode or glass electrode, and quantity is one or more.
4. wearable TCD,transcranial Doppler nerve stimulation according to claim 2 and electrophysiological recording association system, feature exist
In, the transducer array element face (304) and the contact interface daubing coupling agent of experimental subjects or carries out other acoustic propagations and couple place
Reason；The transducer enclosure (303) is fixed by sealing adhesive plaster (305) with experimental subjects, and sealing adhesive plaster (305) is pasted on experiment
Object header.
5. wearable TCD,transcranial Doppler nerve stimulation according to claim 1 and electrophysiological recording association system, feature exist
In the digital-to-analogue/AD conversion unit (102), power amplifier (103) and signal amplification unit (106) are with integrated circuit
It is internal that form is encapsulated in wearable ultrasonic transducer (104), and forms an entirety with electrode assembly (105), and digital-to-analogue/modulus turns
Unit (102) are changed to be wirelessly connected and led to data processing display unit (101) by radio receiving transmitting module and computer control
Letter.
6. wearable TCD,transcranial Doppler nerve stimulation according to claim 1 and electrophysiological recording association system, feature exist
In ultrasonic wave emission parameter includes ultrasonic baseband, pulse width, pulse recurrence frequency, pulse number and stimulus intensity；Electricity is raw
Reason signal data acquisition parameter includes sample rate, acquisition time, delay and the filtering mode of electricity physiological signal.
7. a kind of test based on wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system described in claim 1
Method, which comprises the following steps:
The emission parameter of nerve stimulation ultrasonic wave is used for data processing display unit (101) setting by computer control；
After digital-to-analogue/AD conversion unit (102) is connected to above-metioned instruction, respective waveforms are generated, by power amplifier (103) by signal
It is enlarged into high voltage signal, and wearable ultrasonic transducer (104) is driven to emit ultrasonic wave, realizes the purpose of nerve stimulation；
The electricity physiological signal that electrode assembly (105) is recorded is transmitted to digital-to-analogue/modulus after signal amplification unit (106) amplify
Converting unit (102), converts analog signals into digital signal；
Computer control receives digital signal with data processing display unit (101), according to requirement of experiment, carries out electricity physiological signal
Data processing and display.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610326489.0A CN105943031B (en) | 2016-05-17 | 2016-05-17 | Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610326489.0A CN105943031B (en) | 2016-05-17 | 2016-05-17 | Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105943031A CN105943031A (en) | 2016-09-21 |
| CN105943031B true CN105943031B (en) | 2018-12-07 |
Family
ID=56912859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610326489.0A Active CN105943031B (en) | 2016-05-17 | 2016-05-17 | Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105943031B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468235A (en) * | 2017-07-31 | 2017-12-15 | 中国科学院电子学研究所 | Neuromodulation detects integrated system and method |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362465A (en) * | 2017-07-06 | 2017-11-21 | 上海交通大学 | It is a kind of that the system synchronous with eeg recording is stimulated for human body TCD,transcranial Doppler |
| AU2019395260A1 (en) * | 2018-12-13 | 2021-07-15 | Liminal Sciences, Inc. | Systems and methods for a wearable device including stimulation and monitoring components |
| CN109864750A (en) * | 2019-01-31 | 2019-06-11 | 华南理工大学 | Based on the state of mind assessment and regulating system and its working method stimulated through cranium |
| CN109924976A (en) * | 2019-04-29 | 2019-06-25 | 燕山大学 | The stimulation of mouse TCD,transcranial Doppler and brain electromyography signal synchronous |
| CN110478631A (en) * | 2019-08-15 | 2019-11-22 | 深圳先进技术研究院 | A kind of apparatus for ultrasonic therapeutic treatment, method and data processing equipment |
| CN111685733A (en) * | 2020-06-02 | 2020-09-22 | 脑谷人工智能研究院(南京)有限公司 | Radio physiological signal acquisition and processing system based on brain science research |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080319355A1 (en) * | 2007-06-20 | 2008-12-25 | Henry Nita | Ischemic stroke therapy |
| FR2955260A1 (en) * | 2010-01-15 | 2011-07-22 | Commissariat Energie Atomique | Medical probe e.g. deep electric neurostimulation probe, for acquiring or delivering signals inside patient's body, has planar substrate placed inside of probe body and provided with orientation perpendicular to longitudinal axis of probe |
| CN104857641A (en) * | 2015-04-24 | 2015-08-26 | 燕山大学 | Portable transcranial ultrasonic brain regulation and control instrument |
| CN205041400U (en) * | 2015-07-16 | 2016-02-24 | 燕山大学 | Novel it is portable through cranium ultrasound stimulation and EEG signal collection device |
| CN105536156A (en) * | 2015-12-25 | 2016-05-04 | 中国科学院深圳先进技术研究院 | Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof |
-
2016
- 2016-05-17 CN CN201610326489.0A patent/CN105943031B/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468235A (en) * | 2017-07-31 | 2017-12-15 | 中国科学院电子学研究所 | Neuromodulation detects integrated system and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105943031A (en) | 2016-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105943031B (en) | Wearable TCD,transcranial Doppler nerve stimulation and electrophysiological recording association system and method | |
| Tufail et al. | Ultrasonic neuromodulation by brain stimulation with transcranial ultrasound | |
| Pashaei et al. | Flexible body-conformal ultrasound patches for image-guided neuromodulation | |
| CN205041400U (en) | Novel it is portable through cranium ultrasound stimulation and EEG signal collection device | |
| CN101732054B (en) | Portable all-purpose otoacoustic emission detecting system | |
| US11707635B2 (en) | Conscious animal ultrasonic neural regulation device | |
| CN102308207A (en) | Elastography device and method | |
| WO2019119519A1 (en) | Ultrasonic excitation apparatus, method and system | |
| CN107362465A (en) | It is a kind of that the system synchronous with eeg recording is stimulated for human body TCD,transcranial Doppler | |
| US20160236012A1 (en) | Ultrasound stimulation of pancreatic beta cells | |
| KR101515809B1 (en) | Method of Performing Low Power Mode in Portable Ultrasonic Diagnostic Apparatus For Medical Machinery and Apparatus for enabling the method | |
| CN104548392B (en) | TCD,transcranial Doppler stimulating apparatus and stimulating method | |
| CN103006273A (en) | Portable ultrasonic three-dimensional measuring device for soft tissues | |
| Suarez-Castellanos et al. | Spatio-temporal characterization of causal electrophysiological activity stimulated by single pulse focused ultrasound: an ex vivo study on hippocampal brain slices | |
| CN114367065A (en) | Meninges lymphatic vessel stimulation device | |
| CN113197564A (en) | Portable neurovascular coupling detection device for conscious animals | |
| CN111407257B (en) | Device for synchronously acquiring animal intracranial nerve electrical signals under transcranial ultrasonic action | |
| CN106039600A (en) | Wirelessly-controlled wearable ultrasonic nerve stimulation apparatus | |
| Kim et al. | Investigation of displacement of intracranial electrode induced by focused ultrasound stimulation | |
| CN114366126A (en) | Closed-loop electroencephalogram regulation and control method and system | |
| CN210774334U (en) | On-site detection device for medical focusing transducer | |
| Pastras et al. | Vestibular compound action potentials and macular velocity evoked by sound and vibration in the guinea pig | |
| CN111643110A (en) | Electroencephalogram detection device based on focused ultrasound spatial coding | |
| Mulsow et al. | Click reception in the harbor porpoise (Phocoena phocoena): Effects of electrode and contact transducer location on the auditory brainstem response | |
| Cann et al. | Polarity of acoustic click stimuli for eliciting brainstem auditory evoked responses: a proposed standard |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |