CN103071246A - Repairing device and method for stimulating nerves by near infrared light - Google Patents
Repairing device and method for stimulating nerves by near infrared light Download PDFInfo
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- CN103071246A CN103071246A CN2013100528003A CN201310052800A CN103071246A CN 103071246 A CN103071246 A CN 103071246A CN 2013100528003 A CN2013100528003 A CN 2013100528003A CN 201310052800 A CN201310052800 A CN 201310052800A CN 103071246 A CN103071246 A CN 103071246A
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- nervous tissue
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Abstract
The invention discloses a repairing device and a repairing method for stimulating nerves by near infrared light. An optical fiber is connected with a laser, and near infrared laser generated by the laser is transmitted onto nervous tissue to be repaired; a microelectrode array is inserted in the nervous tissue to be repaired, and is connected with a multichannel acquisition instrument through an electrode adapter and a leading wire; the multichannel acquisition instrument is connected with a computer through a transmission cable; the multichannel acquisition instrument carries out amplification; wave filtering and digitalized treatment on induced potential acquired by the microelectrode array, and the induced potential is treated, displayed and stored through the computer; the included angle between the optical fiber long axis of the optical fiber and the axis of recording a microelectrode is 0 to 45 degrees; and the wave length of the near infrared light generated by the laser is in the range of 780-2526nm. Through the device and the method disclosed by the invention, the nervous tissue can be efficiently activated so as to induce nerve impulse and realize the repairing of neurological function, and the device is relatively short in artifact time interval, relatively high in resolution factor and is not contacted with the nervous tissue directly.
Description
Technical field
The invention belongs to the device and method that function of nervous system repairs, be specifically related to the neuroactive prosthetic device of a kind of near infrared light and method.
Background technology
The impaired meeting of function of nervous system brings great pain to patient, and is difficult to utilize biological method to cure the nervous system injury of the overwhelming majority at present.From the angle of function of nervous system's Information Conduction path, function of nervous system repairs and can launch at levels such as sensor, nervus centripetalis, nerve centre, nervus centrifugalis and effectors.Cerebral cortex is five-star nerve centre, is the best nerve prosthesis method of neural repairing effect, and its stimulating method comprises electricity irritation, magnetic stimulation and photostimulation etc.
Raising along with science and technology and clinical level, the nerve electric stimulation reparation was once becoming study hotspot, it mainly is to utilize nerve microelectrode fully-integrated with the functional rehabilitation integrated circuit or mix System on Chip/SoC in integrated, the human implantable, to realize the reparation of function of nervous system.Yet, repair the carrying out of raising, nerve electric stimulation clinical practice of resolution along with electricity irritation, traditional electricity irritation exposes following limitation gradually:
(1) there is artefact in electrical stimulation method, need vibration just can disappear in tissue fluid, and the time is longer;
(2) because the microelectrode size is subjected to the restriction of processing technique, and microelectrode can be by the immersion corrosion, so the raising of electricity irritation resolution can be subject to the constraint of microelectrode array in tissue fluid;
(3) realization of electricity irritation is the flow of charge form, it is the ion flow form in the biological tissue, need the conversion of two kinds of form of energy, thus need to consider transmission and the conversion of electricity irritation energy in biological tissue, and also electricity irritation need to be considered the power supply supply problem of implantation circuit and implantation circuit.
Summary of the invention
The purpose of this invention is to provide the neuroactive prosthetic device of a kind of near infrared light and method, can effectively activate nervous tissue and make it to induce neural impulse, realizing the reparation of function of nervous system, and the artefact time-histories is short, resolution is higher, directly do not contact with nervous tissue.
The neuroactive prosthetic device of near infrared light of the present invention comprises laser instrument, optical fiber, microelectrode array, electrode converting interface, lead-in wire, multichannel collecting instrument, transmission cable and computer;
Described optical fiber is connected with laser instrument, and laser instrument produces near-infrared laser, is used for being sent to the nervous tissue of pre-reparation;
Described microelectrode array is used for being inserted into the nervous tissue of pre-reparation, and be connected with the multichannel collecting instrument by electrode converting interface, lead-in wire, this multichannel collecting instrument is connected with computer by transmission cable, the multichannel collecting instrument brings out current potential amplification, filtering and digitized processing with what microelectrode array collected, and by Computer Processing, demonstration and storage;
The optical fiber major axis of described optical fiber is 0～45 ° with the axis angle of record microelectrode;
The near infrared wave-length coverage that described laser instrument produces is 780～2526nm.
Also comprise locating rack, this locating rack comprises bracing frame, the first hold-down bars, the second hold-down bars, angle adjusting mechanism and height adjustment mechanism, described the first hold-down bars is connected with bracing frame by angle adjusting mechanism, the outfan of optical fiber is fixed on the first hold-down bars, and regulate the locus of fiber-optic output by angle adjusting mechanism, described microelectrode array is fixed on the second hold-down bars, and regulates the locus of microelectrode array by height adjustment mechanism.
Described angle adjusting mechanism is comprised of the first screw, the second screw, connector and metal ball, metal ball is fixed on the bracing frame, one end of connector is connected with the first hold-down bars, and pass through the first screw lock between the first hold-down bars and the connector, the other end of connector is connected with metal ball, and passes through the second screw lock between connector and the metal ball; Described height adjustment mechanism is the 3rd screw.
Described laser instrument is pulsed laser, its pulsewidth＜10ms, and frequency＜100Hz, drive current amplitudes is＜4A that threshold current is＜999mA that step-length is 10mA.
Described microelectrode array can gather pre-local field potentials and the SPIKE signal that nervous tissue brings out of repairing under the near-infrared laser irradiation.
The neuroactive restorative procedure of near infrared light of the present invention, its step is as follows:
Step 3, the outfan of optical fiber is fixed on the locating rack, and the outfan of optical fiber aims at pre-nervous tissue zone of repairing, the near-infrared laser of laser instrument output can be radiated on the nervous tissue zone of pre-reparation;
The laser of step 4, the drive current of regulating laser instrument, pulsewidth, frequency parameter control laser instrument output different wave length, the pre-nervous tissue of repairing of microelectrode array collection brings out current potential under the near-infrared laser irradiation, and by electrode converting interface, lead-in wire input multichannel collecting instrument, the multichannel collecting instrument brings out current potential amplification, filtering and digitized processing with what microelectrode array collected, and processes, shows and store by transmission cable input computer.
In the described step 2, described microelectrode array is fixed on the second hold-down bars of locating rack, and regulates the locus of microelectrode array by the 3rd screw.
In the described step 3, the outfan of described optical fiber is fixed on the first hold-down bars of locating rack, and regulates the locus of fiber-optic output by the first screw, the second screw and metal ball.
Method of nervous tissue being repaired with the neuroactive prosthetic device of near infrared light described above,
(1) because the absorption of light energy is very fast, so the artefact time-histories is shorter;
(2) owing to the restriction that can not be subject to microelectrode processing technique, microelectrode Biocompatibility, so the resolution of photostimulation function of nervous system recovery technique is higher;
(3) because the penetration depth of near infrared light in tissue can reach more than the 5cm, the energy direct effect is to skin, hypodermic blood vessel, lymphatic vessel, teleneuron, so adopt the near-infrared laser stimulating method to need not to contact, need not in biological tissue's body, to settle circuit with organizing directly, need not to consider the power issue of implantation circuit.
In sum, the present invention utilizes near infrared light nervous tissue, can effectively activate nervous tissue and make it to induce neural impulse, thereby reach the purpose that function of nervous system repairs, have that the artefact time-histories is short, resolution is higher, direction of stimulation is better, and the advantage that does not directly contact with nervous tissue.
Description of drawings
Fig. 1 is structural representation of the present invention.
The specific embodiment
The invention will be further described below in conjunction with accompanying drawing:
The neuroactive prosthetic device of near infrared light as shown in Figure 1 comprises laser instrument 1, optical fiber 2, microelectrode array 10, electrode converting interface 8, lead-in wire 4, multichannel collecting instrument 5, transmission cable 6 and computer 7; Optical fiber 2 is connected with laser instrument 1, and laser instrument 1 produces near-infrared laser, is used for being sent to the nervous tissue 9 of pre-reparation; Microelectrode array 10 is used for being inserted into the nervous tissue 9 of pre-reparation, and be connected with multichannel collecting instrument 5 by electrode converting interface 8, lead-in wire 4, this multichannel collecting instrument 5 is connected with computer 7 by transmission cable 6, multichannel collecting instrument 5 brings out current potential amplification, filtering and digitized processing with what microelectrode array 10 collected, and processes, shows and storage by computer 7; The optical fiber major axis of optical fiber 2 is 0～45 ° with the axis angle of record microelectrode 10.
The electrode that the neuroactive prosthetic device of this near infrared light replaces in the electricity irritation by optical fiber 2, by the stimulus signal generating source in the laser replacement electricity irritation, optical fiber 2 is placed the neurocyte top of pre-reparation, conduction laser irradiation neurocyte activates or suppresses neural impulse, thereby repairs function of nervous system corresponding to cortex target region.
Also comprise locating rack 3, this locating rack 3 comprises bracing frame 3h, the first hold-down bars 3a, the second hold-down bars 3f, angle adjusting mechanism and height adjustment mechanism, described the first hold-down bars 3a is connected with bracing frame 3h by angle adjusting mechanism, the outfan of optical fiber 2 uses the medical adhesive tape looping on the first hold-down bars 3a, and carry out the fine adjustment distance of optical fiber 2 major axis and the pre-angle of repairing nervous tissue's 9 horizontal planes and optical fiber 2 outfans and pre-nervous tissue 9 of repairing (that is: regulate) by the locus that angle adjusting mechanism is regulated optical fiber 2 outfans, can be radiated at preferably on nervous tissue 9 zones of pre-reparation with the near-infrared laser of guaranteeing laser instrument 1 output, described microelectrode array 10 is by going between 4 usefulness medical adhesive tape loopings on the second hold-down bars 3f, and carry out fine adjustment by the locus that height adjustment mechanism is regulated microelectrode array 10, to guarantee that regulating microelectrode array 10 vertical insertions repairs nervous tissue 9 and the insertion depth of accurate position the record microelectrode in advance.
Further, angle adjusting mechanism is comprised of the first screw 3b, the second screw 3c, connector 3g and metal ball 3d, metal ball 3d is fixed on the bracing frame 3h, the end of connector 3g is connected with the first hold-down bars 3a, and lock by the first screw 3b between the first hold-down bars 3a and the connector 3g, the other end of connector 3g is connected with metal ball 3d, and locks by the second screw 3c between connector 3g and the metal ball 3d; Described height adjustment mechanism is the 3rd screw 3e.
Described laser instrument 1 is pulsed laser, comprises laser diode, power supply and drive circuit, light path system, optical fiber interface.Drive circuit is comprised of timing circuit, pulse generator, electrical switch and power supply.Send the low-energy laser (continuously or the pulse signal of distinct pulse widths, different frequency) of different wave length by regulating drive current, pulsewidth, frequency parameter control laser instrument 1, pulsewidth＜the 10ms of this laser instrument 1, frequency＜100Hz, drive current amplitudes is＜4A, threshold current is＜999mA that step-length is 10mA.The near infrared wave-length coverage that this laser instrument 1 produces is 780～2526nm.
Described microelectrode array 10 can gather pre-local field potentials and the SPIKE signal that nervous tissue 9 brings out of repairing under the near-infrared laser irradiation.
Pre-reparation of the present invention nervous tissue 9 comprises the nervous tissues such as visual cortex, motor cortex and cochlea.
The neuroactive restorative procedure of near infrared light of the present invention, its step is as follows:
Step 3, the outfan of optical fiber 2 is fixed on the first hold-down bars 3a of locating rack 3, and regulate the locus of optical fiber 2 outfans by the first screw 3b, the second screw 3c and metal ball 3d, aim at pre-nervous tissue 9 zones of repairing with the outfan of guaranteeing optical fiber 2, can be radiated at preferably on nervous tissue 9 zones of pre-reparation with the near-infrared laser of guaranteeing laser instrument 1 output;
Step 4, regulate the drive current of laser instrument 1, pulsewidth, low-energy laser (the continuous or distinct pulse widths of frequency parameter control laser instrument 1 output different wave length, the pulse signal of different frequency), when the pre-nervous tissue 9 of repairing of near-infrared laser irradiation, near-infrared laser can make this regional nervous tissue 9 excitements, to reach the purpose of repairing different function of nervous system, microelectrode array 10 gathers pre-nervous tissue 9 of repairing and bring out current potential under the near-infrared laser irradiation, and by electrode converting interface 8, lead-in wire 4 input multichannel collecting instrument 5, multichannel collecting instrument 5 amplifies the current potential that brings out that microelectrode array 10 collects, filtering and digitized processing, and input computers 7 by transmission cable 6 and process, show and storage, observe the neural response that photostimulation induces by computer 7.
Below take the visual cortex nerve as example, restorative procedure of the present invention is described further:
Cut off the animal skin of head, expose skull, accurately the location visual cortex is regional, thereby orient the on position of microelectrode array 10, the bone window is left in this zone of tailing edge, after cerebral dura mater exposes fully, microelectrode array 10 is inserted into the visual cortex neurological region, and with the optical fiber major axis with the record microelectrode axis angle be adjusted into 20 °, and the vertical dimension of the outfan of optical fiber 2 and visual cortex nervous tissue is 1 ~ 2mm, regulate the drive current of laser instrument 1, pulsewidth, low-energy laser (the continuous or distinct pulse widths of frequency parameter control laser instrument 1 output specific wavelength, the pulse signal of different frequency), bring out current potential by what computer 7 observation post collected, and record and storage are for follow-up labor.
Claims (8)
1. the neuroactive prosthetic device of near infrared light is characterized in that: comprise laser instrument (1), optical fiber (2), microelectrode array (10), electrode converting interface (8), lead-in wire (4), multichannel collecting instrument (5), transmission cable (6) and computer (7);
Described optical fiber (2) is connected with laser instrument (1), and laser instrument (1) produces near-infrared laser, is used for being sent to the nervous tissue (9) of pre-reparation;
Described microelectrode array (10) is used for being inserted into the nervous tissue (9) of pre-reparation, and by electrode converting interface (8), the lead-in wire (4) be connected with multichannel collecting instrument (5), this multichannel collecting instrument (5) is connected with computer (7) by transmission cable (6), multichannel collecting instrument (5) brings out current potential amplification, filtering and digitized processing with what microelectrode array (10) collected, and processes, shows and storage by computer (7);
The optical fiber major axis of described optical fiber (2) is 0～45 ° with the axis angle of record microelectrode (10);
The near infrared wave-length coverage that described laser instrument (1) produces is 780～2526nm.
2. the neuroactive prosthetic device of near infrared light according to claim 1, it is characterized in that: also comprise locating rack (3), this locating rack (3) comprises bracing frame (3h), the first hold-down bars (3a), the second hold-down bars (3f), angle adjusting mechanism and height adjustment mechanism, described the first hold-down bars (3a) is connected with bracing frame (3h) by angle adjusting mechanism, the outfan of optical fiber (2) is fixed on the first hold-down bars (3a), and regulate the locus of optical fiber (2) outfan by angle adjusting mechanism, described microelectrode array (10) is fixed on the second hold-down bars (3f), and regulates the locus of microelectrode array (10) by height adjustment mechanism.
3. the neuroactive prosthetic device of near infrared light according to claim 2, it is characterized in that: described angle adjusting mechanism is by the first screw (3b), the second screw (3c), connector (3g) and metal ball (3d) form, metal ball (3d) is fixed on the bracing frame (3h), one end of connector (3g) is connected with the first hold-down bars (3a), and lock by the first screw (3b) between the first hold-down bars (3a) and the connector (3g), the other end of connector (3g) is connected with metal ball (3d), and locks by the second screw (3c) between connector (3g) and the metal ball (3d); Described height adjustment mechanism is the 3rd screw (3e).
4. according to claim 1 to the neuroactive prosthetic device of 3 arbitrary described near infrared lights, it is characterized in that: described laser instrument (1) is pulsed laser, its pulsewidth＜10ms, frequency＜100Hz, drive current amplitudes is＜4A that threshold current is＜999mA that step-length is 10mA.
5. according to claim 1 to the neuroactive prosthetic device of 3 arbitrary described near infrared lights, it is characterized in that: described microelectrode array (10) can gather pre-local field potentials and the SPIKE signal that nervous tissue (9) brings out of repairing under the near-infrared laser irradiation.
6. one kind with the method for nervous tissue being repaired such as the neuroactive prosthetic device of the arbitrary described near infrared light of claim 1 to 5, and its step is as follows:
Step 1, optical fiber (2) is connected with laser instrument (1), multichannel collecting instrument (5) is connected with microelectrode array (10) by electrode converting interface (8), lead-in wire (4), and multichannel collecting instrument (5) is connected with computer (7) by transmission cable (6);
Step 2, microelectrode array (10) is fixed on the locating rack (3), and microelectrode array (10) is inserted in nervous tissue (9) zone of pre-reparation;
Step 3, the outfan of optical fiber (2) is fixed on the locating rack (3), and the outfan of optical fiber (2) is aimed at pre-nervous tissue (9) zone of repairing, and the near-infrared laser of laser instrument (1) output can be radiated on nervous tissue (9) zone of pre-reparation;
The laser of step 4, the drive current of regulating laser instrument (1), pulsewidth, frequency parameter control laser instrument (1) output different wave length, microelectrode array (10) gathers pre-nervous tissue (9) of repairing and bring out current potential under the near-infrared laser irradiation, and by electrode converting interface (8), lead-in wire (4) input multichannel collecting instrument (5), multichannel collecting instrument (5) brings out current potential amplification, filtering and digitized processing with what microelectrode array (10) collected, and processes, shows and store by transmission cable (6) input computer (7).
7. method of nervous tissue being repaired with the neuroactive prosthetic device of near infrared light according to claim 6 is characterized in that:
In the described step 2, described microelectrode array (10) is fixed on second hold-down bars (3f) of locating rack (3), and regulates the locus of microelectrode array (10) by the 3rd screw (3e).
8. method of nervous tissue being repaired with the neuroactive prosthetic device of near infrared light according to claim 6 is characterized in that:
In the described step 3, the outfan of described optical fiber (2) is fixed on first hold-down bars (3a) of locating rack (3), and regulates the locus of optical fiber (2) outfan by the first screw (3b), the second screw (3c) and metal ball (3d).
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| CN103405291A (en) * | 2013-08-23 | 2013-11-27 | 重庆大学 | Transmission type multi-channel near-infrared light pulse cochlear nerve stimulation device |
| CN110058004A (en) * | 2019-04-11 | 2019-07-26 | 高权 | A kind of experimental provision of laser co-focusing detection electro photoluminescence safety |
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| US20110127405A1 (en) * | 2008-05-16 | 2011-06-02 | Nir Grossman | Optical stimulation of photosensitized cells |
| CN102283742A (en) * | 2011-08-15 | 2011-12-21 | 重庆大学 | Light stimulation based retinal prosthesis repairing device and repairing method |
| CN102793973A (en) * | 2012-08-03 | 2012-11-28 | 中国科学院深圳先进技术研究院 | Device for treating Parkinson's disease |
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| US20110127405A1 (en) * | 2008-05-16 | 2011-06-02 | Nir Grossman | Optical stimulation of photosensitized cells |
| CN101705184A (en) * | 2009-11-26 | 2010-05-12 | 浙江大学 | Full-automatic cell physiological parameter analyzer based on multi-parameter detection integrated chip |
| CN102283742A (en) * | 2011-08-15 | 2011-12-21 | 重庆大学 | Light stimulation based retinal prosthesis repairing device and repairing method |
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| CN103405291A (en) * | 2013-08-23 | 2013-11-27 | 重庆大学 | Transmission type multi-channel near-infrared light pulse cochlear nerve stimulation device |
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