CN205252316U - Deep brain stimulation and laser doppler velocity measurement integrated device - Google Patents
Deep brain stimulation and laser doppler velocity measurement integrated device Download PDFInfo
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- CN205252316U CN205252316U CN201520827400.XU CN201520827400U CN205252316U CN 205252316 U CN205252316 U CN 205252316U CN 201520827400 U CN201520827400 U CN 201520827400U CN 205252316 U CN205252316 U CN 205252316U
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Abstract
The utility model provides a deep brain stimulation and laser doppler velocity measurement integrated device, the device is including laser instrument, splitting system, focusing lens a, focusing lens b, reflector, photoelectric detector, preamplifier, computer, direct current electrical stimulator, stimulus isolator, stimulating electrode, wherein, the laser instrument passes through optic fibre to be connected with splitting system, and photoelectric detector passes through the data line and is connected with preamplifier, and preamplifier passes through data line and computer link, and the signal input part that direct current electrical stimulator's output passes through data line and stimulus isolator is connected, and stimulus isolator's output passes through the data line and is connected with stimulating electrode's input. The utility model has the advantages of simple structure, control the convenience, can carry out deep brain stimulation and brain blood flow rate in step and measure.
Description
Technical field
The invention belongs to harmless regulation and control and measuring technology, particularly a kind of DBS and laser-DopplerIntegrated apparatus tests the speed
Background technology
Electro photoluminescence all obtains more and more in the cerebral disorders therapeutic processes such as nervous system basic research and epilepsyApplication widely, deep brain stimulation therapy is mainly that stimulating electrode is implanted in toy brain tissue, fortuneStimulate some nerve nucleus of its cerebral deep with impulse generator, correct abnormal brain electricity loop, thereby subtractLight these neurological symptoms. Some treatments with permanent unadjustable and irreversible damage brainMethod difference, DBS does not destroy brain structure, can allow further treatment from now on. Laser-DopplerTachymeter is to utilize laser doppler to measure a kind of instrument of fluid motion speed, and it has space and dividesThe advantages such as the rate of distinguishing is high, dynamic response is fast, measurement category is wide, non-cpntact measurement.
Under the effect of research DBS, the blood flow of cerebral vessels is being coupled with important meaning for analyzing neural blood vesselJustice. Carrying out the zooscopy of DBS and brain blood flow measurement, can be the clinical practice of DBSGuidance is provided.
Find by the retrieval to existing document, the patent Chinese Patent Application No. in past is:CN201210118753.3, name is called: a kind of high focusing multichannel is through cranium galvanic current stimulation device and controlMethod, although this device has advantages such as covering full head, high focusing, multichannel, it stimulates accurate positioning,And the advantage of customizable complex stimulus, but this device can not be realized the measurement that stimulation location blood flow is changed;Chinese Patent Application No. is: CN201210042918.3, name is called: through cranium galvanic current stimulation instrument, although shouldDevice can, in the time stimulating certain brain district, produce the stimulation that focuses on central precise positioning, but this deviceCan not realize the measurement that stimulation location blood flow is changed;
For overcoming above-mentioned deficiency and the defect of prior art, the present invention proposes a kind of direct current DBS withLDV integrated apparatus, this device can carry out direct current DBS and can realize again real-timeCBFV is measured.
Summary of the invention
The object of the invention is to provide that a kind of manipulation is convenient, rational in infrastructure, DBS and blood flow measurement togetherDBS and the LDV integrated apparatus of step.
For achieving the above object, adopted following technical scheme: device of the present invention comprises laser instrument 5, dividesPhotosystem 6, condenser lens a8, condenser lens b4, reflective mirror 7, photodetector 3, preamplifier 2,Computer 1, direct current stimulator 11, stimulation isolator 12, stimulating electrode 9; Wherein, laser instrument passes throughOptical fiber is connected with beam splitting system, and photodetector is connected with preamplifier by data wire, preamplifierBe connected with computer by data wire, the output of direct current stimulator is by data wire and stimulation isolatorSignal input part connects, and the output of stimulation isolator is connected with the input of stimulating electrode by data wire.
The course of work is as follows:
DBS therapy is that stimulating electrode is implanted in toy brain tissue, uses galvanic current stimulationThe stimulus signal that device produces stimulates some nerve nucleus of its cerebral deep, and brain function is regulated and controled. Laser is manyThe general tachymeter of strangling is the Doppler signal of measuring by the trace particle of laser probe, then according to speed and how generalThe relation of strangling frequency obtains VPV. In carrying out DBS, to the brain blood flow of stimulation locationSpeed is used laser-Doppler method to measure, and reaches synchronizeing of brain stimulation and brain blood flow detection.
Compared with prior art, tool of the present invention has the following advantages:
This device can carry out the measurement of toy DBS and VPV in real time.
Brief description of the drawings
Fig. 1 is structured flowchart of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention will be further described:
In structured flowchart of the present invention as shown in Figure 1, device of the present invention comprises laser instrument 5, point spectrumSystem 6, condenser lens a8, condenser lens b4, reflective mirror 7, photodetector 3, preamplifier 2, meterCalculation machine 1, direct current stimulator 11, stimulation isolator 12, stimulating electrode 9; Wherein, laser instrument 5 passes throughOptical fiber is connected with beam splitting system 6, and photodetector 3 is connected with preamplifier 2 by data wire, prepositionAmplifier 2 is connected with computer 1 by data wire, the output of direct current stimulator 11 by data wire withThe signal input part of stimulation isolator 12 connects, and the output of stimulation isolator 12 is by data wire and stimulationThe input of electrode 9 connects, and stimulating electrode 9 is imbedded in toy head 10.
Described laser instrument 5 is He-Ni laser instrument.
Described stimulation isolator 12 is JL-E stimulation isolator.
Described stimulating electrode 9 is nickel-cadmium single-channel electrodes.
Apply the method for this device, comprise following operating procedure:
(1) toy is placed on stereotaxic apparatus, the head 10 of fixing toy, by opening cranium handThe part skull that art is removed animal, removes dura mater, retains complete blood vessel, adjusts the three-dimensional coordinate of position indicatorStimulating electrode 9 is placed in toy brain tissue accurately;
(2) stereotaxic apparatus of fixing toy is placed on condenser lens a8 under, adjustThe position of stereotaxic instrument and condenser lens a8, so that the focus of condenser lens a8 can focus on headVessel position, the angle of adjustment stereotaxic instrument and condenser lens a8, so that condenser lens and head blood vesselForm inclination angle;
(3) configuring direct current egersimeter 11 produces the required signal parameter of DBS;
(4) signal that direct current stimulator 11 produces, through stimulation isolator 12, is delivered to stimulating electrode 9Input;
(5) stimulating electrode 9 receives after stimulus signal, and toy head 10 nerve fibers are stimulated;
(6) when direct current brain stimulation, open laser instrument 5 switches, configuration laser instrument 5 parameters, laser instrument5 laser that send are decomposed into aplanatic two bundle sources of parallel light, two bundle sources of parallel light through beam splitting system 6 by light sourceFocus at its intersection point place by condenser lens a8, its focus just in time the blood vessel of head tissue and with blood vessel shapeAngled;
(7) light source is radiated at after head blood vessel, and after the scattering process of blood flow, scattered light is again by reflectionMirror 7, focuses on photodetector 3 places by condenser lens b4 again by the scattered light of speculum 7;
(8) photodetector 3 receives after scattered light signal, and scattered light signal is converted to corresponding telecommunicationsNumber;
(9) photodetector 3 by electrical signal transfer to preamplifier 2, through the amplification of preamplifier 2After effect, pass to computer 1;
(10) after computer 1 receives the signal of telecommunication, the host computer in computer 1 to Electric signal processing fromAnd obtain the CBFV of stimulation location.
Above-described embodiment is described the preferred embodiment of the present invention, not to thisBright scope limits, and designs under the prerequisite of spirit those of ordinary skill in the art not departing from the present inventionVarious distortion that technical scheme of the present invention is made, improvement, modification, substitute, combination, simplify, all shouldFall in the definite protection domain of the claims in the present invention book.
Claims (2)
1. DBS and a LDV integrated apparatus, is characterized in that: described device comprises laser instrument, beam splitting system, condenser lens a, condenser lens b, reflective mirror, photodetector, preamplifier, computer, direct current stimulator, stimulation isolator, stimulating electrode; Wherein, laser instrument is connected with beam splitting system by optical fiber, photodetector is connected with preamplifier by data wire, preamplifier is connected with computer by data wire, the output of direct current stimulator is connected with the signal input part of stimulation isolator by data wire, and the output of stimulation isolator is connected with the input of stimulating electrode by data wire.
2. a kind of DBS according to claim 1 and LDV integrated apparatus, is characterized in that: described integrated apparatus can be realized DBS and brain blood flow measurement simultaneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520827400.XU CN205252316U (en) | 2015-10-23 | 2015-10-23 | Deep brain stimulation and laser doppler velocity measurement integrated device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520827400.XU CN205252316U (en) | 2015-10-23 | 2015-10-23 | Deep brain stimulation and laser doppler velocity measurement integrated device |
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| CN205252316U true CN205252316U (en) | 2016-05-25 |
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| CN201520827400.XU Expired - Fee Related CN205252316U (en) | 2015-10-23 | 2015-10-23 | Deep brain stimulation and laser doppler velocity measurement integrated device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758161A (en) * | 2019-01-30 | 2019-05-17 | 西安交通大学 | A kind of deep brain stimulation electrode of detectable brain deep nuclei blood oxygen level |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758161A (en) * | 2019-01-30 | 2019-05-17 | 西安交通大学 | A kind of deep brain stimulation electrode of detectable brain deep nuclei blood oxygen level |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160525 Termination date: 20161023 |
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| CF01 | Termination of patent right due to non-payment of annual fee |