CN101485920A - Laser therapy device - Google Patents
Laser therapy device Download PDFInfo
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- CN101485920A CN101485920A CN 200910105414 CN200910105414A CN101485920A CN 101485920 A CN101485920 A CN 101485920A CN 200910105414 CN200910105414 CN 200910105414 CN 200910105414 A CN200910105414 A CN 200910105414A CN 101485920 A CN101485920 A CN 101485920A
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Abstract
The invention relates to a laser therapy device, which comprises a power supply, a laser, an output power controller, a pulse controller, a light gathering device, an optical fiber processing device and a central control system, wherein the central control system is used for controlling the power supply, the laser, the output power controller and the pulse controller; the power supply is used for supplying power to the laser; the laser is used for generating laser light; the laser light enters the light gathering device through the output power controller and the pulse controller; the laser light is transmitted to the optical fiber processing device after being gathered by the light gathering device; and the optical fiber processing device is used for irradiating the laser light into cells inoculated with light perception genes. The laser therapy device has cell specificity, and can effectively activate or inhibit the neuron.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, relate in particular to a kind of device for laser therapy.
Background technology
Central nervous system disease is meant the disease that brain and spinal cord etc. cause owing to reasons such as infection, heredity, degeneration, as epilepsy, parkinson, cerebral palsy of children, major depressive disorder etc., often state of an illness complexity, serious symptom, cause the obvious disability of patient, the forfeiture self care ability brings heavy mental pressure and financial burden for family and society.Therefore the treatment of central nervous system disease has caused extensive concern, and is more and more urgent to the treatment demand of this type of nervous system disease.
Traditional Therapeutic Method comprises Drug therapy and damages operation.Drug therapy is the central nervous system disease Therapeutic Method of using always.The outbreak of epileptics can be controlled and alleviate to antuepileptic, but be easy to generate drug resistance, and anti-insane spectrum is narrow, and side effect is big.Patient about 20% uses antuepileptic to still have outbreak repeatedly, fails to reach the effect of Taking Control of Epilepsy disease.Parkinsonian Drug therapy adopts alternative medicine more, started new era of parkinson Drug therapy as levodopa class medicine, but side effect such as also produced dizzy, vomiting, feel sick, and motor complications such as symptom fluctuation, unusual fluctuation disease appear in 50% above patient.Drug therapy cerebral palsy of children curative effect is limited, the weak point of holding time, and prolonged and repeated application has side effect, still needs further research.Then onset is slow, remission is not thorough for antidepressant drugs, relapse rate is high, still lacks ideal medicament.Damaging operation is under the condition that disease is clear and definite in brain, excision focus or damage target spot.But surgical risk is big, and the difficulty height has certain traumaticly, and irreversible damage often has unpredictable pernicious consequence again, causes case fatality rate and disability rate height.
At the problems referred to above, (Deep brain stimulation DBS) and through cranium repeatability low frequency magnetic stimulates (Transcranial Magnetic Stimulation, TMS) two technology to have developed the electricity irritation of deep brain nuclear group in recent years again.The electricity irritation of deep brain nuclear group is to utilize brain stereotactic operation a certain specific position implant electrode in brain, produces pulse by stimulus generator, and brain deep nerve nucleus is carried out chronic stimulation, thus dyskinetic disorders such as treatment epilepsy and parkinson.This method is not destroyed cerebral tissue and nervous tissue, is reversible, can adjust stimulus intensity and frequency external, for extensive patients has been brought Gospel.Stimulating through cranium repeatability low frequency magnetic is a kind of AT electrophysiological technique that neurocyte is stimulated in the brain outside.The action principle that stimulates through cranium repeatability low frequency magnetic is to produce transient magnetic field with a fast current pulse, skull is passed in this magnetic field, cause that contiguous nervous tissue produces the secondary electric current, the neurocyte depolarization, thereby produce the electrical activity that stimulates or block cerebral tissue, be mainly used in treatment epilepsy, parkinson, major depressive disorder, apoplexy, chronic pain etc. clinically.Stimulating through cranium repeatability low frequency magnetic is a kind of noinvasive, painless, safe new technique, and multiple central nervous system disease is all had certain curative effect.The aspect still needs further research but its mechanism of action, stimulus parameter, curative effect are held time etc.
But the deep brain is examined group's electricity irritation and is also had some shortcomings through the stimulation of cranium repeatability low frequency magnetic, for example:
1. shortage cell-specific.The electricity irritation of deep brain nuclear group can not realize a certain specific cells hypotype is stimulated, and often causes side effect, and because neurogliocyte cicatrization and electrode can be insulated, therapeutical effect can only continue some months by several years.In several cm range around cranium repeatability low frequency magnetic stimulation can only the stimulation brain, can't stimulate the deep neuron at all.
2. both all can not realize suppressing neuronic purpose.
Summary of the invention
In view of this, be necessary to lack cell-specific and can not suppress neuronic problem, provide a kind of and have cell-specific and can effectively suppress neuronic device for laser therapy at the Therapeutic Method of central nervous system disease.
A kind of device for laser therapy comprises power supply, laser instrument, output controller, impulse controller, beam condensing unit, optical fiber treating device and central control system; Described central control system is used to control described power supply, described laser instrument, described output controller and described impulse controller; Described power supply is used for to described laser instrument power supply; Described laser instrument is used to produce laser; Described laser enters described beam condensing unit through described output controller and described impulse controller; Described laser transfers to described optical fiber treating device after described beam condensing unit is assembled; Described optical fiber treating device is used for described laser irradiation has been imported the cell of light sensation gene.
Preferably, described laser instrument comprises first laser instrument and second laser instrument, described output controller comprises the first output controller and the second output controller, described impulse controller comprises first impulse controller and second impulse controller, described laser comprises first laser and second laser, described first laser instrument is used to produce described first laser, described second laser instrument is used to produce described second laser, described central control system controls described first laser instrument and the second laser instrument timesharing produces described first laser and described second laser, described first laser enters described beam condensing unit through described first output controller and described first impulse controller, described second laser enters described beam condensing unit through described second output controller and described second impulse controller, and described central control system also is used to regulate the intensity of described first laser and described second laser, repetition rate, pulse number and relative time relation.
Preferably, described first laser instrument is to utilize the frequency multiplication of the 946nm spectral line that neodymium-doped yttrium-aluminum garnet sends to produce the blue light of wavelength for 473nm, and adopt three Lithium biborates to carry out intracavity frequency doubling, and transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～10kHz.
Preferably, described second laser instrument is that the 1064nm and the 1342nm spectral line that utilize the Nd-doped yttrium vanadate crystal to send produce the gold-tinted of wavelength for 593.5nm by KTP crystal and frequency, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～50kHz.
Preferably, described optical fiber treating device be used for described laser be decomposed at least two the bundle after the laser after the described decomposition is used to shine again the described cell that imports the light sensation gene, laser before the described decomposition is by first fiber-optic transfer, laser after the described decomposition is by second fiber-optic transfer, described optical fiber treating device comprises optical fiber emanator and optical fiber integrator, described optical fiber emanator is connected with described second optical fiber with described first optical fiber, and described optical fiber integrator is used for fixing the relative position between described second optical fiber.
Preferably, described optical fiber emanator is spherical, and its surface is provided with a macropore and at least two apertures, and described macropore connects described first optical fiber, and each aperture connects one second optical fiber.
Preferably, described optical fiber integrator is plate, which is provided with at least two apertures, and each aperture is by one second optical fiber.
Preferably, described power supply, laser instrument, output controller, impulse controller, central control system and beam condensing unit are formed pulse generator, the volume range of described pulse generator is 4 cubic centimetres to 72 cubic centimetres, and the volume range of described optical fiber treating device is 4 cubic millimeters to 50 cubic millimeters.
Preferably, also comprise outside program controller, described outside program controller is used for opening or closing pulse generator, regulates laser generation parameter.
Preferably, also comprise record microelectrode and computer, described record microelectrode is used to write down the potential change of cell and the potential change of cell is sent to described computer, described computer is used for the information that records analyzed with behavioristics to be tested, and the result that will analyze and test is sent to described central control system, described central control system corresponding modify laser generation parameter.
Above-mentioned device for laser therapy shines lesions position by producing laser, and this laser only works to the cell that has imported the light sensation gene, and therefore, this device for laser therapy has cell-specific.In addition, the laser that this device for laser therapy produces is directly to be deep in the skull to shine, thereby can effectively activate or suppress neuronal cell.
Description of drawings
Fig. 1 is the sketch map of device for laser therapy first embodiment.
Fig. 2 is the sketch map of blue laser.
Fig. 3 is the sketch map of Yellow light laser.
Fig. 4 is the sketch map of beam condensing unit.
Fig. 5 is the sketch map that optical fiber treating device uses on human body.
Fig. 6 is the amplification inclinating view of optical fiber emanator.
Fig. 7 is the amplification inclinating view of optical fiber integrator.
Fig. 8 is the sketch map of laser irradiation cell.
Fig. 9 is the neuronic sketch map that laser irradiation has imported the light sensation gene.
Figure 10 is the graph of a relation that brings out current potential and laser pulse.
Figure 11 is the sketch map of device for laser therapy second embodiment.
The specific embodiment
Device for laser therapy comprises power supply, laser instrument, output controller, impulse controller, beam condensing unit, optical fiber treating device and central control system; Described central control system is used to control described power supply, described laser instrument, described output controller and described impulse controller; Described power supply is used for to described laser instrument power supply; Described laser instrument is used to produce laser; Described laser enters described beam condensing unit through described output controller and described impulse controller; Described laser transfers to described optical fiber treating device after described beam condensing unit is assembled; Described optical fiber treating device is used for described laser is decomposed at least two bundles, and the laser after the described decomposition is used to shine the cell that has imported the light sensation gene.This device for laser therapy has cell-specific and can effectively suppress neuron.
The number of the laser instrument of this device for laser therapy, output controller and impulse controller can be 1,2,3 or more.Below be to be that example describes with 2 situation.
Fig. 1 is the sketch map of device for laser therapy first embodiment.The device for laser therapy 100 of first embodiment comprises power supply 10, first laser instrument 11, the first output controller 12, first impulse controller 13, second laser instrument 18, the second output controller 23, second impulse controller 19, beam condensing unit 14, optical fiber treating device 15, outside program controller 20 and central control system 17.Power supply 10 is a rechargable power supplies, and for example chargeable lithium cell once charges and can use at least 5 years.First laser instrument 11 is used to produce first laser, and second laser instrument 18 is used to produce second laser.First laser enters beam condensing unit 14, the second laser through the first output controller 12 and first impulse controller 13 and enters beam condensing unit 14 through the second output controller 23 and second impulse controller 19.Central control system 17 is used to control power supply 10, first laser instrument 11, second laser instrument 18, the first output controller 12, the second output controller 23, first impulse controller 13 and second impulse controller 19, thereby realizes any adjusting of intensity, repetition rate, pulse number and the relative time relation of first laser and second laser.Under the control of central control system 17, first laser and second laser are that timesharing produces, and promptly any time has only a kind of laser to enter beam condensing unit 14.First laser or second laser transfer to optical fiber treating device 15 by first optical fiber (figure does not show) after beam condensing unit 14 is assembled.Optical fiber treating device 15 is decomposed at least two bundle the 3rd laser or the 4th laser with first laser or second laser, and every bundle the 3rd laser or the 4th laser are by one second optical fiber (figure does not show) transmission.This at least two bundle the 3rd laser or the 4th laser are used for lesions position is shone.
The effect of the various instructions (referring to Fig. 1) that central control system 17 is sent is as follows:
1.P11 and P13 is used to control the output of first laser instrument 11, makes the output of first laser instrument 11 adjustable in the 10-50mW scope.
2.P21 and P23 is used to control the output of second laser instrument 18, makes the output of second laser instrument 18 adjustable in the 10-50mW scope.
3.P12 be used to control the repetition rate of the acousto-optic Q-switching of first laser instrument 11.
4.P22 be used to control the repetition rate of the acousto-optic Q-switching of second laser instrument 18.
5.T1 be used to control the luminous persistent period of first laser.
6.T2 be used to control the luminous persistent period of second laser.
In addition, utilize the clock in the central control system 17 can also control the relative time of the luminous and pulse of first, second laser, thereby finally can realize any adjusting of intensity, repetition rate, pulse number and the relative time relation of first, second laser.
Fig. 4 is the sketch map of beam condensing unit 14.Beam condensing unit 14 comprises first plane mirror 301, second plane mirror 302 and convex lens 303.First laser enters convex lens 303, the second laser through first plane mirror 301 and enter convex lens 303 after second plane mirror 302 and 301 reflection of first plane mirror.First laser or the second laser planoconvex lens 303 assemble the back by first fiber-optic transfer to optical fiber treating device 15.
In use, power supply 10, first laser instrument 11, the first output controller 12, first impulse controller 13, second laser instrument 18, the second output controller 23, second impulse controller 19, central control system 17 and beam condensing unit 14 are formed pulse generator.The volume range of pulse generator is 4 cubic centimetres to 72 cubic centimetres.Pulse generator is imbedded near the position the clavicle of human body by operation.
In use, outside program controller 20 is equivalent to a remote controller, is used for opening or closing pulse generator, regulates laser generation parameter.
Fig. 5 is the sketch map that optical fiber treating device uses on human body.Optical fiber treating device 15 comprises optical fiber emanator 405 and optical fiber integrator 406.Optical fiber emanator 405 is connected with at least two second optical fiber 407 with first optical fiber 402.As shown in Figure 6, optical fiber emanator 405 is spherical, and its surface is provided with a macropore 52 and at least two apertures 51, and macropore 52 and at least two apertures 51 are oppositely arranged.Macropore 52 connects first optical fiber 402, and each aperture 51 connects one second optical fiber 407.As shown in Figure 7, optical fiber integrator 406 is used for fixing at least two second relative positions between the optical fiber 407.Optical fiber integrator 406 is plate, which is provided with at least two apertures 61.Each aperture 61 can pass through one second optical fiber 407.Like this, many second optical fiber 407 can cover target spot widely.The volume range of optical fiber treating device 15 is 4 cubic millimeters to 50 cubic millimeters, and therefore, optical fiber treating device 15 can be deep in the cortex 408 in the skull 401.
First optical fiber 402 is encased by the sleeve pipe 403 of the about 300-500 μ of diameter m, sleeve pipe 403 whole heeling-ins are in human epidermal, one end of sleeve pipe 403 connects pulse generator, the other end is fixed on the skull 401 by holder 404 in scalp 400, and passes skull 401 (in advance positional punch) and be deep into cortex 408.The length of second optical fiber 407 is adjustable, thereby can control the degree of depth that second optical fiber 407 is deep into cortex 408.
Fig. 8 is the sketch map of laser irradiation cell.The scope of 701 expression laser irradiations, 702 expressions have imported the cell of light sensation gene, 703 represent lead-in light sensillary base not because of cell.The light sensation gene can be photaesthesia channel gene or chlG gene, can import in a certain specific cell, tissue or the individuality light sensation gene and great expression by viral vector in the practice.Have only the importing that is mapped to by illumination the cell 702 of light sensation gene just can produce electricity and change and comprise excitement or inhibitory action, and all not lead-in light sensillary bases because of cell 703 and do not receive illumination importing the cell 702 of light sensation gene all unaffected.And, dissimilar light sensation genes a photaesthesia to specific wavelength, for example, the gene pairs sensitive to blue light of photoactivation type ionophorous protein, the gene pairs gold-tinted sensitivity of light inhibition type ionophorous protein.Because the range of exposures of dispersive each the 3rd laser beam or the 4th laser beam is littler, can shine non-specific site on every side, thereby guarantee the accuracy in treatment site.
Fig. 9 is the neuronic sketch map that laser irradiation has imported the light sensation gene, and Figure 10 is the graph of a relation that brings out current potential and laser pulse.When laser pulse arrived neuron 801, the dendron 802 of neuron 801 was accepted this photostimulation, and current potential is brought out in neuron 801 one of corresponding generation, brought out current potential and propagated by aixs cylinder 803.As seen from Figure 10, laser pulse 806 one of a correspondence are brought out current potential 805.
Above-mentioned device for laser therapy 100 resolves into the little laser beam of at least two bundles by optical fiber treating device 15 with a branch of big laser beam, and therefore, the area of the lesions position that this device for laser therapy 100 can shine is bigger.And the range of exposures of the little laser beam of every bundle is littler, can not shine non-specific site on every side, thereby has guaranteed the accuracy of this device for laser therapy 100.In addition, because this device for laser therapy 100 is to be placed in the human body, can carry, therefore, this device for laser therapy 100 is well suited for patient's daily use.
Figure 11 is the sketch map of device for laser therapy second embodiment.The structure of the device for laser therapy 900 of second embodiment and the device for laser therapy 100 of first embodiment is basic identical, and its difference is: the device for laser therapy 900 of second embodiment also comprises record microelectrode 16 and computer 21.Record microelectrode 16 is used to be imbedded in patient's lesions position, be sent to computer 21 with the potential change of record cell and with the potential change of cell, computer 21 is analyzed with behavioristics the information that records by specific software and is tested, and feedback information is sent to central control system 17 by wireless transmission method, central control system 17 corresponding modify laser generation parameters.The diameter of record microelectrode 16 is about 100 microns, and therefore, record microelectrode 16 can be deep in the cortex 408 in the skull 401.
Because the information that record microelectrode 16 is write down is to handle on computer 21, computer 21 can carry out more high-grade analyzing and processing to information, and therefore, 900 pairs of research worker of the device for laser therapy of second embodiment are studied very helpful.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art without departing from the inventive concept of the premise, can also make at least two distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1, a kind of device for laser therapy is characterized in that: comprise power supply, laser instrument, output controller, impulse controller, beam condensing unit, optical fiber treating device and central control system; Described central control system is used to control described power supply, described laser instrument, described output controller and described impulse controller; Described power supply is used for to described laser instrument power supply; Described laser instrument is used to produce laser; Described laser enters described beam condensing unit through described output controller and described impulse controller; Described laser transfers to described optical fiber treating device after described beam condensing unit is assembled; Described optical fiber treating device is used for described laser irradiation has been imported the cell of light sensation gene.
2, device for laser therapy according to claim 1, it is characterized in that: described laser instrument comprises first laser instrument and second laser instrument, described output controller comprises the first output controller and the second output controller, described impulse controller comprises first impulse controller and second impulse controller, described laser comprises first laser and second laser, described first laser instrument is used to produce described first laser, described second laser instrument is used to produce described second laser, described central control system controls described first laser instrument and the second laser instrument timesharing produces described first laser and described second laser, described first laser enters described beam condensing unit through described first output controller and described first impulse controller, described second laser enters described beam condensing unit through described second output controller and described second impulse controller, and described central control system also is used to regulate the intensity of described first laser and described second laser, repetition rate, pulse number and relative time relation.
3, device for laser therapy according to claim 2, it is characterized in that: described first laser instrument is to utilize the frequency multiplication of the 946nm spectral line that neodymium-doped yttrium-aluminum garnet sends to produce the blue light of wavelength for 473nm, and adopt three Lithium biborates to carry out intracavity frequency doubling, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～10kHz.
4, device for laser therapy according to claim 2, it is characterized in that: described second laser instrument is that the 1064nm and the 1342nm spectral line that utilize the Nd-doped yttrium vanadate crystal to send produce the gold-tinted of wavelength for 593.5nm by KTP crystal and frequency, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～50kHz.
5, device for laser therapy according to claim 1, it is characterized in that: described optical fiber treating device be used for described laser be decomposed at least two the bundle after the laser after the described decomposition is used to shine again the described cell that imports the light sensation gene, laser before the described decomposition is by first fiber-optic transfer, laser after the described decomposition is by second fiber-optic transfer, described optical fiber treating device comprises optical fiber emanator and optical fiber integrator, described optical fiber emanator is connected with described second optical fiber with described first optical fiber, and described optical fiber integrator is used for fixing the relative position between described second optical fiber.
6, device for laser therapy according to claim 5 is characterized in that: described optical fiber emanator is for spherical, and its surface is provided with a macropore and at least two apertures, and described macropore connects described first optical fiber, and each aperture connects one second optical fiber.
7, according to claim 5 or 6 described device for laser therapy, it is characterized in that: described optical fiber integrator is plate, which is provided with at least two apertures, and each aperture is by one second optical fiber.
8, device for laser therapy according to claim 1 and 2, it is characterized in that: described power supply, laser instrument, output controller, impulse controller, central control system and beam condensing unit are formed pulse generator, the volume range of described pulse generator is 4 cubic centimetres to 72 cubic centimetres, and the volume range of described optical fiber treating device is 4 cubic millimeters to 50 cubic millimeters.
9, device for laser therapy according to claim 8 is characterized in that: also comprise outside program controller, described outside program controller is used for opening or closing pulse generator, regulates laser generation parameter.
10, device for laser therapy according to claim 1 and 2, it is characterized in that: also comprise record microelectrode and computer, described record microelectrode is used to write down the potential change of cell and the potential change of cell is sent to described computer, described computer is used for the information that records analyzed with behavioristics to be tested, and the result that will analyze and test is sent to described central control system, described central control system corresponding modify laser generation parameter.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102517195A (en) * | 2011-12-27 | 2012-06-27 | 中国科学院深圳先进技术研究院 | Cell secreta production system based on photosensitive gene and cell secreta production method |
| CN101693138B (en) * | 2009-09-28 | 2014-10-29 | 深圳先进技术研究院 | Light stimulus system and control method thereof |
| CN106730396A (en) * | 2017-02-26 | 2017-05-31 | 常州亚当生物技术有限公司 | The therapeutic system of senile dementia and Parkinson's, therapeutic room and treatment glasses |
| WO2018214892A1 (en) * | 2017-05-23 | 2018-11-29 | 西安雅泽泰克医疗科技有限公司 | Laser therapy instrument and spinal cord repair method |
| CN109009428A (en) * | 2018-08-02 | 2018-12-18 | 南京生命源医药实业有限公司 | Infrared laser therapeutic device and system |
| CN112688155A (en) * | 2020-12-25 | 2021-04-20 | 武汉奇致激光技术股份有限公司 | Control method and control system for laser light intensity |
| WO2023108485A1 (en) * | 2021-12-15 | 2023-06-22 | 中国科学院深圳先进技术研究院 | Method for regulating heterogeneity of vascular endothelial cells by means of locus coeruleus and peripheral region thereof |
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| DE19721489A1 (en) * | 1997-05-23 | 1998-11-26 | Tibor Dr Nagypal | System for the photodynamic treatment of living beings, their organs and / or tissues |
| US7282060B2 (en) * | 2003-12-23 | 2007-10-16 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling laser-induced tissue treatment |
| CN1788645A (en) * | 2005-12-12 | 2006-06-21 | 林哲文 | Light conducting hair comb |
| CN101308991A (en) * | 2008-06-30 | 2008-11-19 | 山东大学 | Coupling cavity Raman frequency doubling completely solid yellow laser |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101693138B (en) * | 2009-09-28 | 2014-10-29 | 深圳先进技术研究院 | Light stimulus system and control method thereof |
| CN102517195A (en) * | 2011-12-27 | 2012-06-27 | 中国科学院深圳先进技术研究院 | Cell secreta production system based on photosensitive gene and cell secreta production method |
| CN106730396A (en) * | 2017-02-26 | 2017-05-31 | 常州亚当生物技术有限公司 | The therapeutic system of senile dementia and Parkinson's, therapeutic room and treatment glasses |
| WO2018214892A1 (en) * | 2017-05-23 | 2018-11-29 | 西安雅泽泰克医疗科技有限公司 | Laser therapy instrument and spinal cord repair method |
| CN109009428A (en) * | 2018-08-02 | 2018-12-18 | 南京生命源医药实业有限公司 | Infrared laser therapeutic device and system |
| CN112688155A (en) * | 2020-12-25 | 2021-04-20 | 武汉奇致激光技术股份有限公司 | Control method and control system for laser light intensity |
| WO2023108485A1 (en) * | 2021-12-15 | 2023-06-22 | 中国科学院深圳先进技术研究院 | Method for regulating heterogeneity of vascular endothelial cells by means of locus coeruleus and peripheral region thereof |
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