CN103071138A - Chinese medicinal composition for treating chronic gastritis as well as preparation method and application - Google Patents
Chinese medicinal composition for treating chronic gastritis as well as preparation method and application Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating chronic gastritis. The Chinese medicinal composition is characterized by comprising the following bulk pharmaceutical herbs in parts by weight: 10-14 parts of heterophylly falsestarwort root, 10-20 parts of white atractylodes rhizome, 10-20 parts of poria cocos, 8-12 parts of ginger processed pinellia, 1-5 parts of medicinal evodia fruit, 8-12 parts of Chinese thorowax root, 8-16 parts of akebia fruit, 2-6 parts of dried ginger, 10-20 parts of immature bitter orange, 6-10 parts of dried tangerine or orange peel, 6-10 parts of officinal magnolia bark, 8-12 parts of baical skullcap root, 2-6 parts of coptis root, 12-18 parts of cuttlefish bone, 9-15 parts of corydalis tuber, and 12-18 parts of common bletilla pseudobulb. A better effect can be achieved by adding notholirion bulbuliferum, bract machilus bark, angelica polymorpha Maxim and lovely hemsleya root. Meanwhile, a modern superfine grinding technology and a cell disruption technology are adopted to prepare Chinese medicinal superfine powder, and the Chinese medicinal composition can be orally taken directly or taken after being mixed with boiled water, can be used to rapidly alleviate symptoms of the chronic gastritis, has stronger effects of invigorating spleen, supplementing qi, warming and harmonizing stomach, and promoting qi circulation to relieve pain, treats both symptoms and root causes, has a rapid curative effect, and is convenient to produce and take and low in preparation cost at the same time, thereby having good popularization values.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method and application that treat chronic gastritis, belong to the field of Chinese medicines.
Background technology
Chronic gastritis refers to that the chronic inflammatory disease of the gastric mucosa that a variety of causes causes sexually revises, a kind of commonly encountered diseases, frequently-occurring disease, its generation and drinking and eating irregularly, psychentonia factors are relevant, quickening along with people's rhythm of life, being growing more intense of various competitions, the sickness rate of chronic gastritis has the trend of continuous rising.Although there is no at present the report of the sickness rate among a large amount of crowds, it is generally acknowledged that its morbidity increases with age growth.There is data to show among 20～40 years old the people that people's gastric mucosa of 47% still belongs to normally, and only has for 18% Genus Homo normal range among the crowd more than 60 years old.When the old people became celestial, concurrent chronic gastritis person was very common.There is this sick sickness rate of external report may account for entire population's 30%.Although China there is not yet report, to find according to Jiangsu 49226 routine fibergastroscopies, chronic gastritis accounts for 54.92%.80～90% inflammation that gastric mucosa arranged among the gastroscopic patient of report are also arranged, and the male is more than the women.
The touching delay of the normal state of an illness of chronic gastritis although modern medicine has the method for numerous treatment chronic gastritiss, there is no so far specific treatment, moreover the complication such as gastric ulcer, upper gastrointestinal hemorrhage, anemia, gastric cancer, polyp of stomach can appear in chronic gastritis.Therefore, take active and effective measure, it is very necessary that chronic gastritis is effectively treated.
Motherland's medical science has just had the record of chronic gastritis (claiming " gastric abscess " in " interior warp ") in " interior warp ".Chronic gastritis belongs to the categories such as Chinese medicine " gastric abscess ", " feeling of fullness ", wherein mainly discusses more with " gastric abscess "." gastric abscess " claims again " stomachache ", is to be that gastral cavilty section pain is main a kind of syndrome on the umbilicus under the heart.It is the closest that the generation of gastric abscess and cold-evil violate stomach, eating and drinking without temperance and the uncomfortable relation of feelings will." interior warp " at first proposed the viewpoint that the cold-evil is caused a disease, " cold limbs enters stomach; give birth to pained then ... heart stomach is given birth to cold; chest and diaphragm is unfavorable; pained feeling of fullness " [the Plain Questions the most pure virginity will be discussed greatly], " the cold visitor is between gastrointestinal ... little network draws urgency, therefore pain ", " the cold visitor is in the intestines and stomach ... thus pain and vomit also " [Plain Questions lift pain opinion], having set forth the cold-evil, to violate stomach be the main cause that causes gastric abscess." interior warp " also proposed injury due to diet simultaneously, it also is the major reason that causes gastric abscess that feelings will is lost freely, such as " eating twice as usual; the intestines and stomach is to hinder " [Plain Questions numbness opinion], " strongly fragrant the sending out of wood ..., therefore the sick epigastralgia right below the heart of the people; inappetence " [the hexa-atomic large opinion of just recording of Plain Questions], " the nether world sky of fainting, wind is excessive to be won ..., the sick epigastralgia right below the heart of the people ... inappetence " and [the Plain Questions the most pure virginity will be discussed greatly].The cold-evil that " interior warp " proposes is caused a disease, established the etiologic etiological basis of gastric abscess due to injury due to diet and the feelings will.The etiology viewpoint that later many doctors continue to use " interior warp " more instructs Coryza Treated by Syndrome Differentiation, and has many doctors further to bring into play on this basis, makes it more perfect.Such as gold dollar period, Liu Wansu is loaded with " or heat stagnation is in interior, and the hard knot of abdominal distention pain person can not say and tremble with fear also " in " cause of disease formula six gas are for sick "; Clear leaf sky scholar has clearly proposed the viewpoint of heat transformed from stagnated cold, " examine interior through all pains, all main cold visitor, but pain of a specified duration for years, cold Bi Shengre " [Linzheng Zhinan Yi], and it is take the blood stasis theory as foundation, has proposed the famous theory argument of " sick just at warp, pain enters network for a long time ".
Therefore, the etiology and pathogenesis of gastric abscess is mainly cold-evil visitor stomach, eating and drinking without temperance, and taste are injured, thereby cause weakness of the spleen and stomach, or the double stagnation of QI, or double food stagnation, or it is hot and suffocating to hold concurrently, or double blood stasis etc., affect the transporting of taste, retention of heat due to blockage of dampness, stimulate depression of liver-QI, horizontal criminal's taste as meeting again feelings will, therefore the vexed distension of gastral cavilty section painful abdominal mass, and whenever after feed, occur or aggravation, or noisy burn feeling is arranged, pain is without syndrome of stagnation of QI such as timing grade, but and the stagnation of QI hyperamization stasis of blood and then causes gastralgia.Based on this, chronic gastritis should be take invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, the promoting the circulation of QI to relieve pain basic rule for the treatment of of heat clearing away as its treatment of holding concurrently.
In the prior art, it is the one of the main reasons that causes gastric abscess that " a kind of Chinese medicine composition for the treatment of gastritis and preparation method thereof " CN1919331 has ignored " cold-evil violates stomach ", proposition take regulate the flow of vital energy, invigorating middle warmer, damp eliminating be as the rule for the treatment of, if exopathogen does not remove and the invigorating middle warmer of only regulating the flow of vital energy, clinical efficacy probably is difficult to be guaranteed; In the etiology and pathogenesis of gastric abscess, cold-evil, diet, emotion all are risk factors, its disease originally be weakness of the spleen and stomach, " a kind of Chinese medicine of formula for treating gastropathy " CN101332285A proposes dissipating depression and moistening for dryness, sending down the abnormal ascending QI removing dampness, soothing liver-QI stomach function regulating method for the treatment of, only emphasize that emotion, diet cause a disease, the disease of having ignored weakness of the spleen and stomach reaches the risk factor cold-evil at all; Because of the long deficient symptom that easily causes weakness of the spleen and stomach of most chronic gastritis course of disease, " a kind of Chinese medicine composition for the treatment of chronic gastritis " CN102397516A has taken into full account cold-evil, the impact of emotion in gastric abscess causes a disease in prescription, but has ignored invigorating the spleen and benefiting QI to entangle weakness of the spleen and stomach originally.
Before the prepared slices of Chinese crude drugs are prepared into various dosage forms, the pretreatment procedure such as generally need to separate through extracting, concentrated and dry, all be accompanied by the long-time heating process, easily causing wherein, chemical composition changes, especially be rich in the Chinese medicine that is subjected to thermally labile or volatile component, cause active constituent content to descend, and then drug absorption reduce, bioavailability reduces, and curative effect of medication weakens.Simultaneously, because complex procedures, the operating time is long, and production efficiency descends, and causes production cost significantly to improve, and affects economic benefit and the capability of sustainable development of enterprise.
Summary of the invention
Purpose of the present invention be exactly to provide a kind of have better curative effect, take into account Chinese medicine composition and preparation method and application that the treatment chronic gastritis of dialectical prescription is carried out in the aspects such as void, reality, cold, heat, gas, blood.
The present invention is achieved in that from aspects such as empty, real, cold, heat, gas, blood chronic gastritis (i.e. " gastric abscess ") is carried out dialectical prescription, obtains clinically better effects.We are comprised of 20 kinds of Chinese medicines such as Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Evodiae, Radix Bupleuri, Bullus Notholirionis Bulbuliferi, Fructus Akebiae, Rhizoma Zingiberis, Fructus Aurantii Immaturus, Radix seu Cortex Machili bracteatae, Pericarpium Citri Reticulatae, Zijin sand, Cortex Magnoliae Officinalis, Radix Scutellariae, Rhizoma Coptidis, Radix Hemsleyae Macrospermae, Endoconcha Sepiae, Rhizoma Corydalis, Pseudobulbus Bletillae (Rhizoma Bletillae).Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Poria in the side, invigorating the spleen and benefiting QI is monarch drug, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Fructus Evodiae, Rhizoma Zingiberis, Radix Bupleuri, Bullus Notholirionis Bulbuliferi, Fructus Akebiae, warming middle-JIAO to send down the adverse QI, depressed liver-energy dispersing and QI regulating stomach function regulating are ministerial drug, be equipped with Radix seu Cortex Machili bracteatae, Pericarpium Citri Reticulatae, Zijin sand, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, promoting the circulation of QI to relieve pain, removing food stagnancy are except full, and Radix Scutellariae, Rhizoma Coptidis, Radix Hemsleyae Macrospermae bitter cold are with hot and suffocating clearly, Endoconcha Sepiae antacid cuticula, Rhizoma Corydalis, Pseudobulbus Bletillae (Rhizoma Bletillae) are invigorated blood circulation, hemostasis, blood stasis dispelling.All medicines share, and play altogether the merit of invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, promoting the circulation of QI to relieve pain.Cure mainly weakness of the spleen and stomach, incoordination between the liver and stomach, cold and heat also see, chronic gastritis due to the simulataneous insufficiency and excessive.
One of technical solution of the present invention: a kind of Chinese medicine composition for the treatment of chronic gastritis, it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 10-20 parts in Poria, 8-12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 8-12 parts of Radix Bupleuri, 8-16 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 10-20 parts of Fructus Aurantii Immaturuss, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts of Cortex Magnoliae Officinalis, 8-12 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 12-18 parts of Endoconcha Sepiaes, 9-15 parts of Rhizoma Corydalis, 12-18 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Preferably: the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts in Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 12 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 15 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 15 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Further: a kind of Chinese medicine composition for the treatment of chronic gastritis, it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 6-12 parts in Poria, 3-9 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 6-12 parts of Radix Bupleuri, 3-9 parts of Bullus Notholirionis Bulbuliferi, 6-12 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 5-15 parts of Fructus Aurantii Immaturuss, 6-12 parts of Radix seu Cortex Machili bracteataes, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts in Zijin sand, 6-10 parts of Cortex Magnoliae Officinalis, 3-9 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 3-9 parts of Radix Hemsleyae Macrospermae, 12-18 parts of Endoconcha Sepiaes, 6-12 parts of Rhizoma Corydalis, 6-12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Further preferred: the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts in Poria, 6 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 9 parts of Radix seu Cortex Machili bracteataes, 8 parts of Pericarpium Citri Reticulataes, husky 8 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 6 parts of Radix Hemsleyae Macrospermae, 15 parts of Endoconcha Sepiaes, 9 parts of Rhizoma Corydalis, 9 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Above-mentioned Chinese medicine composition has following dosage form: powder, hard capsule, soft capsule, tablet, pill.
Two of technical solution of the present invention: a kind of preparation technology who treats the Chinese medicine composition of chronic gastritis comprises the steps:
With the prepared slices of Chinese crude drugs of each crude drug, in 60 ℃ of dryings 12 hours, mixed powder was broken into coarse powder, puts into super micron mill again, pulverized 1～75 μ m superfine powder, and get final product; Or get superfine powder and record capsule or soft capsule; Or get superfine powder and be pressed into tablet; Or get superfine powder and make pill.
Preparation technology uses " specification requirement of new Chinese medicine Study on Preparation " in principle, and the micron order medicine that uses superfine communication technique, Ultracytochemical wall breaking technology and modern preparation technique to be prepared from is used as medicine, and makes powder; Or add some accessory substances, such as water, sugar, starch etc., make hard capsule, soft capsule, tablet, pill.
Three of technical solution of the present invention: the above-mentioned a kind of application of Chinese medicine composition in treatment chronic gastritis Chinese medicine composition for the treatment of chronic gastritis.
The above-mentioned a kind of application of Chinese medicine composition in the Chinese medicine composition of preparation treatment chronic gastritis for the treatment of chronic gastritis.
When oral the or boiled water of this Chinese medicine composition was taken after mixing it with water, every part was adopted gram to be unit, every day potion, minute secondary is oral, be 2 months the course for the treatment of, can reach the clinical cure effect.
The present invention adopts the hold concurrently method of heat clearing away of invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, promoting the circulation of QI to relieve pain, the treatment chronic gastritis, and curative effect is better, and cure rate is high, and few side effects is 96.3% through the clinical observation total effective rate.
Beneficial effect of the present invention:
(1) the present invention link closely ancient Chinese medicine doctor about epigastric pain because of Pathogenesis Theory, i.e. " cold-evil visitor stomach, eating and drinking without temperance, feelings will are lost smooth; cause weakness of the spleen and stomach ", from aspect dialectical prescriptions such as empty, real, cold, heat, gas, blood, proposition is held concurrently heat clearing away as basic therapy take invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, regulating qi to disperse stagnation, both considered invigorating the spleen and benefiting QI with entangle weakness of the spleen and stomach this, take into account again cold-evil, diet and feelings will because of, realize treating both the principal and secondary aspects of a disease.Outstanding by clinical observation result proved compositions curative effect.
(2) the present invention selects some to imitate the special characteristic medicine of power, such as Bullus Notholirionis Bulbuliferi, and the effect of tool the chest stuffiness relieving regulating QI to relieve pain, be usually used in heart peratodynia disease, and through experiment confirm [Zhao Yinping, Li Ying. the progress of Chinese medicine Bullus Notholirionis Bulbuliferi [J]. Xi'an Joint Univ.'s journal, 2002,5 (1): 104-106; Geng Zengyan, Huang Yue, Chen Jinming. the Bullus Notholirionis Bulbuliferi n-butyl alcohol extract is to the experimentation [J] of rat chronic gastritis effect. the Jilin Chinese medicine, 2009,29 (6): 527-528], Bullus Notholirionis Bulbuliferi can obviously suppress the acute attack of gastric antrum section mucosal inflammation, alleviates the gastric antrum section inflammatory damage that ammonia causes, can improve and delay the damaging action of gastric mucosa, the treatment of chronic gastritis, atrophic gastritis is had good therapeutic effect; Radix Hemsleyae Macrospermae, have heat-clearing and toxic substances removing, the effect of benefiting stomach and stopping pain is usually used in the treatment stomachache, and through experiment confirm [as if flower bud, Qin Renan. Radix Hemsleyae Macrospermae is to the research [J] of Experimental Gastric Ucler effect. Chinese pharmacology communication, 2003,20 (1): 64], Radix Hemsleyae Macrospermae can make the ulcer area and the ulcer index that reduce Experimental Gastric Ulcer in Rats reduce, reduce the rat gastric secretion, reduce gastric acidity and pepsin activity, and helicobacter pylori etc. is had better antibacterial and bactericidal action, and anti-inflammatory and analgesic effect is outstanding; Zijin is husky, the tool cold expelling, regulate the flow of vital energy, the merit of pain relieving, be exclusively used in treatment stomachache, stomachache, chest and hypochondrium, alone namely effectively [Xie Zongwan. national Chinese herbal medicine compilation. volume two [M]. Beijing: People's Health Publisher, 1996:615]; Radix seu Cortex Machili bracteatae has the effect of warming middle-JIAO to promote flow of QI pain relieving, be exclusively used in stomach abdominal distention and pain, acute gastroenteritis treatment [Xie Zongwan. national Chinese herbal medicine compilation. volume two [M]. Beijing: People's Health Publisher, 1996:399]; Etc..
(3) the present invention is in conjunction with Study on Supermicro-pulverization of Traditional Chinese Drugs technology, Ultracytochemical wall breaking technology and modern preparation technique, the novel micron order Chinese medicine that this Chinese medicine composition phase is developed, directly oral or increase mixing in water for oral taking, or be prepared into powder, hard capsule, soft capsule, tablet, pill etc.In preparation technology, chemical change does not occur in raw material of Chinese medicine substantially, just changes physical behavior, has kept the original characteristic of Chinese medicine, produces, takes very convenient, and can overcome the shortcoming that it decoct to extract trouble, takes inconvenience.By cell wall breaking, medicament effective component is fully discharged simultaneously, further improved clinical efficacy.
The specific embodiment
The present invention can conduct further description the present invention by the following examples by the technology contents implementation that illustrates in the summary of the invention, yet scope of the present invention is not limited to following embodiment.
Embodiment 1:
The crude drug of getting each composition weight portion is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts in Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 12 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 15 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 15 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 2:
The crude drug of getting each composition weight portion is: 10 parts of Radix Pseudostellariaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 4 parts of Fructus Evodiaes, 12 parts of Radix Bupleuri, 15 parts of Fructus Akebiaes, 2 parts of Rhizoma Zingiberiss, 18 parts of Fructus Aurantii Immaturuss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Cortex Magnoliae Officinalis, 9 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 12 parts of Endoconcha Sepiaes, 15 parts of Rhizoma Corydalis, 16 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 3:
The crude drug of getting each composition weight portion is: 14 parts of Radix Pseudostellariaes, 14 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts in Poria, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 2 parts of Fructus Evodiaes, 8 parts of Radix Bupleuri, 10 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 12 parts of Fructus Aurantii Immaturuss, 9 parts of Pericarpium Citri Reticulataes, 9 parts of Cortex Magnoliae Officinalis, 12 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 18 parts of Endoconcha Sepiaes, 18 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 4:
The crude drug of getting each composition weight portion is: 14 parts of Radix Pseudostellariaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 14 parts in Poria, 12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 8 parts of Fructus Akebiaes, 5 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 6 parts of Pericarpium Citri Reticulataes, 6 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 3 parts of Rhizoma Coptidis, 16 parts of Endoconcha Sepiaes, 15 parts of Rhizoma Corydalis, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 5:
The crude drug of getting each composition weight portion is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts in Poria, 6 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 9 parts of Radix seu Cortex Machili bracteataes, 8 parts of Pericarpium Citri Reticulataes, husky 8 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 6 parts of Radix Hemsleyae Macrospermae, 15 parts of Endoconcha Sepiaes, 9 parts of Rhizoma Corydalis, 9 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 6:
The crude drug of getting each composition weight portion is: 10 parts of Radix Pseudostellariaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts in Poria, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 5 parts of Fructus Evodiaes, 12 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 12 parts of Fructus Akebiaes, 5 parts of Rhizoma Zingiberiss, 12 parts of Fructus Aurantii Immaturuss, 10 parts of Radix seu Cortex Machili bracteataes, 6 parts of Pericarpium Citri Reticulataes, husky 6 parts of Zijin, 9 parts of Cortex Magnoliae Officinalis, 8 parts of Radix Scutellariaes, 3 parts of Rhizoma Coptidis, 5 parts of Radix Hemsleyae Macrospermae, 12 parts of Endoconcha Sepiaes, 8 parts of Rhizoma Corydalis, 8 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 7:
The crude drug of getting each composition weight portion is: 14 parts of Radix Pseudostellariaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Poria, 9 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 5 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 3 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 12 parts of Radix seu Cortex Machili bracteataes, 9 parts of Pericarpium Citri Reticulataes, husky 9 parts of Zijin, 9 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 8 parts of Radix Hemsleyae Macrospermae, 14 parts of Endoconcha Sepiaes, 10 parts of Rhizoma Corydalis, 10 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Embodiment 8:
The crude drug of getting each composition weight portion is: 12 parts of Radix Pseudostellariaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts in Poria, 8 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 4 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 9 parts of Bullus Notholirionis Bulbuliferi, 12 parts of Fructus Akebiaes, 3 parts of Rhizoma Zingiberiss, 14 parts of Fructus Aurantii Immaturuss, 12 parts of Radix seu Cortex Machili bracteataes, 6 parts of Pericarpium Citri Reticulataes, husky 9 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 4 parts of Radix Hemsleyae Macrospermae, 12 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
The present invention is described further by pharmacological testing, clinical observation test.
Test example 1, the test of pesticide effectiveness
One, purpose: observe we to the therapeutical effect of experimental chronic gastritis rat.
Two, method: use fresh pig bile glycerol adding gavage and copy rat chronic gastritis model.Rat model is divided into positive control SANJIU WEITAI group, this compositions group and this prescription prepared slices of Chinese crude drugs group, prior art matched group one (patent CN101332285A), prior art matched group two (patent CN102397516A) at random, gavage is respectively organized test liquid respectively, blank group and model group gavage equivalent distilled water, each organizes all continuously gavage 1 month; Observe rat body weight and gastric mucosa pathological histology and change, and detect rat stomach liquid measure, gastric acidity, pepsin activity and barrier mucus.Adopt mice caused by dimethylbenzene xylene ear swelling and acetic acid to cause the mouse writhing reaction model, observe our antiinflammatory, analgesic activity.
Three, material
1, laboratory animal: SD rat, male and female half and half, body weight 18O～200g; Kunming kind female mice, body weight 18～22g.
2, medicine: press the present embodiment 5 this compositions of preparation superfine powder, preparation test liquid 16g/kg(is equivalent to 5 times of people's consumption); Take by weighing the prepared slices of Chinese crude drugs by embodiment 5 prescription, make prepared slices of Chinese crude drugs group test liquid 16g/kg(and be equivalent to 5 times of people's consumption); Prepare matched group one test liquid 10.5g/kg(by " a kind of Chinese medicine of formula for treating gastropathy " CN101332285A and be equivalent to 5 times of people's consumption); Prepare matched group two test liquid 0.36g/kg(by " a kind of Chinese medicine composition for the treatment of chronic gastritis " CN102397516A embodiment 1 method and be equivalent to 5 times of people's consumption); SANJIU WEITAI KELI (Sanjiu Pharmaceutical Co., Ltd) 4g/kg(is equivalent to 5 times of people's consumption).
3, main pharmacological evaluation and result thereof
(1) impact that rat body weight is changed
The model group rat is few than blank group body weight gain, and the outward appearance fur lacks gloss, and movable the minimizing becomes thin.Each administration group rat body weight rate of increase increases than model group.Wherein this compositions group, prepared slices of Chinese crude drugs group, the increase of SANJIU WEITAI group extremely significantly (P＜0.01), matched group one increases significantly (P＜0.05), and matched group two increases there was no significant differences.
(2) gastric mucosa pathological histology is observed
1. perusal
Normal rat gastric mucosa pinkiness, surfacing is smooth, and the coat of the stomach muscular tension is stronger.Model group gastric mucosa color is more shallow, and the surface lacks gloss, and blood vessel is easily seen under the gastric mucosa, and the coat of the stomach muscular tension is relatively poor.Each administration group gastric mucosa color and coat of the stomach muscular tension are between between the two, and wherein this compositions group, prepared slices of Chinese crude drugs group, SANJIU WEITAI group are more near normal group.
2. om observation
The normal rats gastric epithelial is complete, without hyperemia, edema and erosion, the body of gland of dense arrangement is arranged in the lamina propria, and body of stomach is without obvious cell infiltration, and muscularis mucosae is thinner.The model group gastric mucosa is imperfect, mucosa attenuation or erosion, and body of stomach lamina propria endolymph cell and neutrophilic infiltration, muscularis mucosae thickens, and became uneven.Visible a small amount of lymphocyte, plasmocyte infiltrating in this combination object height group lamina propria, muscularis mucosae is thicker, has clear improvement than model group, is better than the SANJIU WEITAI group; Prepared slices of Chinese crude drugs group, SANJIU WEITAI group mucosa thicken, visible a small amount of granulation tissue hyperplasia in the lamina propria, and chronic inflammatory cell infiltrates less, is improved than model group; Two groups of mucosa gland structures of matched group destroy obviously, and chronic inflammatory cell infiltrates more obvious, and muscularis mucosae obviously thickens; One group of matched group is between two groups of SANJIU WEITAI group and matched groups.Experimental result shows, this compositions group can obviously be improved the pathology damage of rat model gastric mucosa, and the gastric mucosa of atrophy is had good repair, and matched group two repairs are not obvious.Wherein prepared slices of Chinese crude drugs group effect is suitable with the SANJIU WEITAI group, but is better than matched group one, matched group two.
(3) gastric analysis
Compare with model group, this compositions group, prepared slices of Chinese crude drugs group, matched group one all obviously reduce with SANJIU WEITAI group gastric juice amount (P＜0.05), matched group two affects without significance the gastric juice amount, points out this compositions to be conducive to promote model mice gastric juice to measure the recovery normal level.Each administration group and model group rat stomach acidity there was no significant difference.The model group pepsin activity obviously reduces (P＜0.001) than the blank group; Compare with model group, this compositions group, prepared slices of Chinese crude drugs group, matched group one and SANJIU WEITAI group pepsin activity significantly improve, compositions group difference extremely significantly (P＜0.01) wherein, matched group one, prepared slices of Chinese crude drugs group, the safe group of nine stomaches significant difference (P＜0.05), matched group two affects without significance.The model group barrier mucus obviously reduces (P＜0.001) than the blank group, this compositions group, prepared slices of Chinese crude drugs group and matched group one barrier mucus increase obviously, wherein the compositions group is than model group and SANJIU WEITAI group difference tool significance (P＜0.01) extremely, prepared slices of Chinese crude drugs group, matched group one are than model group and SANJIU WEITAI group difference tool significance (P＜0.05), matched group two there was no significant differences.The results are shown in Table 1.
Table 1 pair rat gastric juice analysis result (
)
Annotate: compare warp with the blank group
tCheck, * * p＜0.01, * * * p＜0.001; With model group △ P＜0.05, △ △ P＜0.01; With SANJIU WEITAI group #P＜0.05, ##P＜0.01
(4) anti-inflammatory and analgesic effect
1.The impact of xylol induced mice ear swelling
Adopt the gastric infusion mode, this compositions dosage is 16g/kg, prepared slices of Chinese crude drugs group 16g/kg, matched group one 10.5g/kg, matched group two 0.36g/kg, positive controls gives SANJIU WEITAI 4g/kg, continuous use 3 days, the blank group gives isopyknic normal saline.30min only drips in the mouse right ear front-back with dimethylbenzene 0.05ml/ after the last administration.Dislocation is put to death and to be cut ears behind the lh, with the 8mm belt puncher mouse ear is laid round auricle with the position, accurately weighs, take the difference of same mice left and right sides auricle as swelling.The results are shown in Table 2.
Table 2 xylol induced mice ear swelling affect result of the test (
, n=10)
| Group | Sample number (only) | Dosage (g/kg) | Swelling |
| The blank group | 10 | / | 19.4±5.8 |
| This compositions group | 10 | 16 | 13.5±4.3** |
| Prepared slices of Chinese crude drugs group | 10 | 16 | 15.0±4.3* |
| Matched group one | 10 | 10.5 | 16.9±3.6* |
| Matched group two | 10 | 0.36 | 17.2±5.4 |
| The SANJIU WEITAI group | 10 | 4 | 14.6±4.7* |
Annotate: compare warp with the blank group
tCheck, *
P＜0.05, * *
P＜0.01.
As shown in Table 2, each administration group swelling is all less than the blank group, wherein this compositions group and blank group have utmost point significant difference (
P＜0.01), prepared slices of Chinese crude drugs group, one group of matched group, SANJIU WEITAI group and blank group have significant difference (
P＜0.05), matched group two there was no significant differences.This compositions of experiment prompting has preferably antiinflammatory action, and prepared slices of Chinese crude drugs group is suitable with the SANJIU WEITAI group, and matched group two does not present obvious antiinflammatory action.
2. on the impact of thermostimulation induced pain due to the hot plate method
Adopt the gastric infusion mode, this compositions dosage is 16g/kg, prepared slices of Chinese crude drugs group 16g/kg, matched group one 10.5g/kg, matched group two 0.36g/kg, positive controls gives SANJIU WEITAI 4g/kg, continuous use 3 days, the blank group gives isopyknic normal saline.Surveyed respectively the mice pain threshold in 15,30,60 minutes after the last administration, for preventing scalding, setting deadline is 60 s.Calculate the threshold of pain and improve percentage rate.The results are shown in Table 3.
Table 3 on thermostimulation induced pain due to the hot plate method affect result of the test (
, n=10)
Annotate: compare warp with the blank group
tCheck, *
P＜0.05, * *
P＜0.01, * * *
P＜0.001.
As shown in Table 3, with the blank group relatively, this compositions group, prepared slices of Chinese crude drugs group and SANJIU WEITAI group all can significantly improve pain threshold, have extremely significant difference (
P＜0.001).Matched group one when 60min than blank group difference tool extremely significance (
P＜0.001), matched group two there was no significant differences.This compositions of experiment prompting is good, rapid-action to the inhibitory action of thermostimulation induced pain, and effect is strong, and matched group one onset is slow, and matched group more than two is without effect.This compositions group, prepared slices of Chinese crude drugs group drug effect strengthen in time gradually simultaneously, and the SANJIU WEITAI group is the strongest when administration 30min, weakens to some extent during 60min.
4, test of pesticide effectiveness brief summary
Wherein this compositions group can significantly increase rat body weight, obviously improve rat model gastric mucosa color and coat of the stomach muscular tension, alleviate cell infiltration and mucosa pathology damage, the gastric mucosa of atrophy is had good repair, significantly improve pepsin activity, drug effect is suitable with the SANJIU WEITAI group.This compositions can obviously increase barrier mucus simultaneously, is better than the SANJIU WEITAI group.Prepared slices of Chinese crude drugs group drug effect is weaker than this compositions group, but obviously than matched group one and matched group the last two.Matched group two every test indexes may be little relevant with dosage all without obviously improving.
Test example 2, clinical observation on the therapeutic effect data
The treatment clinical method of chronic gastritis is a lot of, there is no definite curative effect.We adopted the present invention to treat one group of case in nearly 3 years, obtained preferably curative effect, now reported as follows:
1, clinical data
(1) physical data: this is tested 164 routine Patients with Chronic Gastritis and is my Out-patient Department patient, all patients all meet the diagnostic criteria of " gastric abscess " in State Administration of Traditional Chinese Medicine's revision " traditional Chinese medical science disease Standardization of diagnosis and curative effect ", and the patient is divided into two groups at random according to the odd or even number for the treatment of.
Treatment group 82 examples, male 48 examples wherein, women 34 examples, patient age is between 23～74 years old; The course of disease was in 1～27 year.Matched group 82 examples, male 43 examples wherein, women 39 examples, patient age is between 25～71 years old; The course of disease was in 1～22 year.
The no significant differences such as two groups of patients' sex, age, gastritis type and the course of disease, P＞0.05 has comparability.
(2) Therapeutic Method: matched group gives western medicine, comprises 2 times/d of omeprazole, each 20mg; 2 times/the d in amoxicillin, each 500mg; 3 times/d of metronidazole, each 0.2g; Treatment group is held concurrently heat clearing away as method for the treatment of take invigorating the spleen and benefiting QI, warming middle-JIAO for easing the stomach, promoting the circulation of QI to relieve pain, and directly oral or boiled water is taken after mixing it with water, and 1 dose of every day, divides sooner or later and takes for 2 times.Prescription adjusts accordingly in following scope endogenous cause of ill symptom:
10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 10-20 parts in Poria, 8-12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 8-12 parts of Radix Bupleuri, 8-16 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 10-20 parts of Fructus Aurantii Immaturuss, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts of Cortex Magnoliae Officinalis, 8-12 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 12-18 parts of Endoconcha Sepiaes, 9-15 parts of Rhizoma Corydalis, 12-18 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
Continuous use 2 months.
Two groups of patients all avoid during treating and use raw and cold food, do not eat pungent irritable food, and regular diet is had more meals a day but less food at each, and chews carefully and swallow slowly, and give up tobacco and wine, fasting coffee, strong tea and overheated food.
(3) curative effect determinate standard: according to curative effect determinate standard evaluation in " diagnosis basis of gastric abscess, card marquis classification, efficacy evaluation " in State Administration of Traditional Chinese Medicine's revision " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".
1. cure: gastric abscess and other transference cure, x-ray canel barium meal contrast examination or gastroscopy are normal;
2. take a turn for the better: stomachache is alleviated, and attack times reduces, other sx↓s, and x-ray canel barium meal contrast examination or gastroscopy take a favorable turn;
3. do not heal: symptom is without improvement, and x-ray canel barium meal contrast examination or gastroscopy are unchanged.
(4) statistical method: adopt
tThe check and
ⅹ 2Check.
2, result
Two groups of patient clinical curative effects are relatively cured 15 examples in treatment group 82 examples, 64 examples that take a turn for the better, and 3 examples that do not heal, total effective rate is 96.3%; Cure 7 examples in matched group 82 examples, 63 examples that take a turn for the better, 12 examples that do not heal, total effective rate 85.4 %.Epidemiological Analysis by statistics, treatment group and matched group clinical efficacy exist extremely significant difference (
P＜0.01).
Claims (8)
1. a Chinese medicine composition for the treatment of chronic gastritis is characterized in that it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 10-20 parts in Poria, 8-12 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 8-12 parts of Radix Bupleuri, 8-16 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 10-20 parts of Fructus Aurantii Immaturuss, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts of Cortex Magnoliae Officinalis, 8-12 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 12-18 parts of Endoconcha Sepiaes, 9-15 parts of Rhizoma Corydalis, 12-18 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
2. a kind of Chinese medicine composition for the treatment of chronic gastritis according to claim 1 is characterized in that the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts in Poria, 10 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 10 parts of Radix Bupleuri, 12 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 15 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 15 parts of Endoconcha Sepiaes, 12 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
3. a Chinese medicine composition for the treatment of chronic gastritis is characterized in that it is comprised of the crude drug of following weight portion: 10-14 parts of Radix Pseudostellariaes, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 6-12 parts in Poria, 3-9 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 1-5 parts of Fructus Evodiaes, 6-12 parts of Radix Bupleuri, 3-9 parts of Bullus Notholirionis Bulbuliferi, 6-12 parts of Fructus Akebiaes, 2-6 parts of Rhizoma Zingiberiss, 5-15 parts of Fructus Aurantii Immaturuss, 6-12 parts of Radix seu Cortex Machili bracteataes, 6-10 parts of Pericarpium Citri Reticulataes, 6-10 parts in Zijin sand, 6-10 parts of Cortex Magnoliae Officinalis, 3-9 parts of Radix Scutellariaes, 2-6 parts of Rhizoma Coptidis, 3-9 parts of Radix Hemsleyae Macrospermae, 12-18 parts of Endoconcha Sepiaes, 6-12 parts of Rhizoma Corydalis, 6-12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
4. a kind of Chinese medicine composition for the treatment of chronic gastritis according to claim 3 is characterized in that the consumption of each crude drug is: 12 parts of Radix Pseudostellariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 9 parts in Poria, 6 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 3 parts of Fructus Evodiaes, 9 parts of Radix Bupleuri, 6 parts of Bullus Notholirionis Bulbuliferi, 9 parts of Fructus Akebiaes, 4 parts of Rhizoma Zingiberiss, 10 parts of Fructus Aurantii Immaturuss, 9 parts of Radix seu Cortex Machili bracteataes, 8 parts of Pericarpium Citri Reticulataes, husky 8 parts of Zijin, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Radix Scutellariaes, 4 parts of Rhizoma Coptidis, 6 parts of Radix Hemsleyae Macrospermae, 15 parts of Endoconcha Sepiaes, 9 parts of Rhizoma Corydalis, 9 parts of Pseudobulbus Bletillae (Rhizoma Bletillae).
5. arbitrary described a kind of Chinese medicine composition for the treatment of chronic gastritis is characterized in that this Chinese medicine composition has following dosage form: powder, hard capsule, soft capsule, tablet, pill according to claim 1-4.
6. arbitrary described a kind of preparation technology who treats the Chinese medicine composition of chronic gastritis is characterized in that this preparation technology comprises the steps: according to claim 1-4
With the prepared slices of Chinese crude drugs of each crude drug, in 60 ℃ of dryings 12 hours, mixed powder was broken into coarse powder, puts into super micron mill again, pulverized 1～75 μ m superfine powder, and get final product; Or get superfine powder and record capsule or soft capsule; Or get superfine powder and be pressed into tablet; Or get superfine powder and make pill.
7. according to claim 1-4 arbitrary described a kind of application of Chinese medicine composition in treatment chronic gastritis Chinese medicine composition for the treatment of chronic gastritis.
8. according to claim 1-4 arbitrary described a kind of application of Chinese medicine composition in the Chinese medicine composition of preparation treatment chronic gastritis for the treatment of chronic gastritis.
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| CN110604780A (en) * | 2019-11-04 | 2019-12-24 | 石河子大学医学院第一附属医院 | Stomach invigorating pill for treating chronic gastritis and preparation method thereof |
| CN116672423A (en) * | 2022-04-29 | 2023-09-01 | 裴正学 | Traditional Chinese medicine composition for treating chronic gastritis |
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| CN110604780A (en) * | 2019-11-04 | 2019-12-24 | 石河子大学医学院第一附属医院 | Stomach invigorating pill for treating chronic gastritis and preparation method thereof |
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