CN103054993A - Traditional Chinese veterinary drug preparation for treating porcine diarrhea, and preparation method thereof - Google Patents
Traditional Chinese veterinary drug preparation for treating porcine diarrhea, and preparation method thereof Download PDFInfo
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- CN103054993A CN103054993A CN 201110322021 CN201110322021A CN103054993A CN 103054993 A CN103054993 A CN 103054993A CN 201110322021 CN201110322021 CN 201110322021 CN 201110322021 A CN201110322021 A CN 201110322021A CN 103054993 A CN103054993 A CN 103054993A
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Abstract
The invention relates to a traditional Chinese veterinary drug preparation for treating porcine diarrhea, and a preparation method thereof. The granules are prepared from 10-50g of the root of Chinese pulsatilla, 10-50g of berberis poiretii schneid, 5-30g of the bark of ash, 5-30g of cortex phellodendri, 10-30g of radix paeoniae alba, 10-30g of aplotaxis auriculata, 10-30g of pericarpium citri reticulatae, 10-30g of schisandra chinensis, 10-50g of purslane and 5-20g of liquorice. The traditional Chinese veterinary drug preparation has a good treatment effect for porcine diarrhea; and compared with the prior art, the prescription is rich in medicine source, reasonable in preparation technology and low in toxic and side effects; and compared with western drug therapy, the traditional Chinese veterinary drug preparation can be used for reducing the expenses for medicine, thus being beneficial to popularization.
Description
Technical field:
The present invention is a kind of herbal medicine preparation for the treatment of diarrhea of pigs and preparation method thereof, belongs to the technical field of veterinary drug.
Technical background:
Diarrhea of pigs is a kind of commonly encountered diseases and the frequently-occurring disease of pig, and this disease all has generation throughout the year, especially winter, early spring, late fall to fall ill more.Such as untimely treatment, or malpractice, pathogen is gradually contained, and healthy energy is not enough to refuse heresy and is day by day serious.The clinical symptoms of Adult Pig: acute diarrhea, draining sample feces, feces are canescence, taupe and with the feedstuff that there is not digestion, sick pig becomes thin, dehydration and thirsty, tired, the inappetence of spirit, the general course of disease approximately 5～7 days, after diarrhoea stops, but most ill domestic animal spontaneous recovery.10 ages in days are with the clinical symptoms of interior suckling pig: vomiting at first occurs, then begin rapid watery diarrhea, feces is yellow, yellow green, sometimes contain and do not digest ziega, stench, because serious dehydration, show 121 thirsty, body weight descends rapidly, and mortality rate is higher, and the Piglet Development of recovering is bad.Serious symptom suffers from pig because dehydration is rapid, and body weight obviously descends, and has a strong impact on the growth promoter of pig, after particularly piglet suffers from diarrhoea, has a strong impact on the survival rate of piglet.
The west veterinary thinks reason (1) bacterial diarrhea that causes diarrhea of pigs: escherichia coli, clostridieum welchii enteritis, swine dysentery bacillus, interior Lawson Salmonella.(2) viral diarrhea: transmissible gastroenteritis, epidemic diarrhea, rotavirus, PRV (Pseudorabies virus).(3) parasitic diarrhea: ascarid, coccidiosis, whipworm, balantidium Coli.(4) non-infective agent: temperature, hypoglycemia, daily ration antigen allergic diarrhea, avirulence Hakuri.As using western medicine, not only expense is high, and DeGrain for diarrhea of pigs.If this disease takes the treatment measure untimely, often easily cause piglet dead, become pig to lose flesh, weightening finish reduces, and Time To Market is postponed, and the domestic animal premunition descends, and causes huge economic loss to pig farmer.
For this situation, develop a kind of safe and effective, the thing that the little herbal medicine preparation of side effect has just become people to be badly in need of solving.
Summary of the invention:
The object of the invention is to: a kind of herbal medicine preparation for the treatment of diarrhea of pigs and preparation method thereof is provided; The present invention is Radix Pulsatillae 10-50g, Radix Berberidis 10-50g, Cortex Fraxini 5-30g, Cortex Phellodendri 5-30g, Radix Paeoniae Alba 10-30g, Saussurea lappa Clarke 10-30g, Pericarpium Citri Reticulatae 10-30g, Fructus Schisandrae Chinensis 10-30g, Herba Portulacae 10-50g, Radix Glycyrrhizae 5-20g makes oral liquid, compatibility is reasonable, and bioavailability is high, and preparation technology is advanced, certain preventive and therapeutic action is arranged, have a extensive future.China is the unique complete country that keeps unique traditional medicine theoretical system in the present world, and herbal medicine is the veterinary important component part of China's tradition, the applicating history in existing more than 2,000 year.Chinese medicine has the characteristics of Yin Yang balancing, eliminating pathogenic factor for supporting vital QI, treating both the principal and secondary aspects of a disease.Current pestilence characteristics present the situation of atypia virosis, bacterial disease, mixed infection, secondary infection more, can give full play to the advantage of herbal medicine at the weak area of Western medicine.Particularly for viral, the bacterial disease that account for major part in the livestock and poultry, Chinese medicine has multi-faceted adjusting and therapeutical effect, can improve immunity and the anti-stress ability of animal body.
The present invention consists of like this:
Said preparation is made by the Chinese medicine of following weight: Radix Pulsatillae 10-50g, Radix Berberidis 10-50g, Cortex Fraxini 5-30g, Cortex Phellodendri 5-30g, Radix Paeoniae Alba 10-30g, Saussurea lappa Clarke 10-30g, Pericarpium Citri Reticulatae 10-30g, Fructus Schisandrae Chinensis 10-30g, Herba Portulacae 10-50g, Radix Glycyrrhizae 5-20g.Further preferred: said preparation is made by the Chinese medicine of following weight: Radix Pulsatillae 30g, Radix Berberidis 30g, Cortex Fraxini 15g, Cortex Phellodendri 15g, Radix Paeoniae Alba 20g, Saussurea lappa Clarke 15g, Pericarpium Citri Reticulatae 15g, Fructus Schisandrae Chinensis 20g, Herba Portulacae 30g, Radix Glycyrrhizae 10g.
The preparation method of the herbal medicine preparation of described treatment diarrhea of pigs: get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water and extract 1-3 time, each 6-12 times of water gaging, decoct 0.5-2h, filter, filtrate is concentrated, remove impurity, clear liquor fill, sterilization namely gets oral liquid.Further preferred technique: get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water extraction, add 10 times of water gagings of medical material the 1st time, decoct 1.5h, filter; 8 times of water gagings that add medical material for the 2nd time decoct 1h, filter, merging filtrate, concentrated, it is 1: 1 that filtrate volume is concentrated into the medical material weight ratio, adopt flocculate with chitosan clarification remove impurity, impurity removal process is that pH value is 6.0, the addition of chitosan is 25%, the temperature of water-bath is 60 ℃, stirs 10min, leaves standstill 24h, filter, fill, sterilization namely gets oral liquid.
Primary disease mainly is because feeding and management is bad, climate variability, and being invaded by exogenous pathogen, injury due to diet, internal organs void declines and the factor such as visceral dysfunction causes.The diarrhea of pigs exopathogenic factor is the most obvious with wet relation of containing; Endogenous cause of ill is relevant with taste.Since spleen preferring dryness to dampness, main fresh food and water liquid transporting, and temper should rise; Stomach tide hundred arteries and veins, preferring moisture to dryness, main becoming thoroughly decomposed, gastric qi should be fallen, and both finish the function of " transporting and transforming nutrients from foodstuff, ascending the clear and descending the turbid " jointly.Any exopathogen or internal injury factor affecting spleen and stomach function can both cause the transporting imbalance, become thoroughly decomposed unable, and the food of receiving is not good, clear QI being mixed up with turbid QI, and the conduction dereliction of duty forms diarrhoea.Empty or for a long time sick because of body, the damage kidney yang, fatal fire is not enough and be difficult the yang-energy of spleen soil, then can increase the weight of the state of an illness.Dialectical " spouting diarrhea with tenesmus, all belong to heat ", this disease be accumulate in the damp and hot malicious heresy due to.Damp and hot upper steaming, spirit is depressed; Stomach-QI being unable to descend normally is therefore vomit; Damp and hot criminal's spleen, then loss of appetite: damp and hot tenesmus, intestinal conduction dereliction of duty, water is wet can not to divide profit, therefore rush down as annotating, feces is stench, short urination is few; Interior intenseness of heat, happiness is drunk water.Therefore with heat-clearing and toxic substances removing, stomach invigorating is amusing, eliminating turbid pathogen with aromatics, dehumidifying antidiarrheal is the rule for the treatment of.
The Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri are the product of bitter cold among the we, heat-clearing and toxic substances removing; The Radix Aucklandiae, Pericarpium Citri Reticulatae dispelling the damp pathogen with bitter and warm drugs, alleviating distention in middle-JIAO is regulated the flow of vital energy; Herba Portulacae purge heat poison and dysentery relieving; The Radix Paeoniae Alba, the sweet acidify of Radix Glycyrrhizae take relieving spasm to stop pain; Fructus Schisandrae Chinensis has the merit of expelling wind and cold, regulating QI to relieve pain, spasmolytic, warming middle-JIAO for easing the stomach.
Tradition impurity removal process ethanol precipitation commonly used, but loss of effective components is larger.The present invention adopts chitosan can make extracting solution obtain good clarifying effect, and the main component loss is less.Chitosan has another name called chitosan, it is a kind of chemical compound of aminopolysaccharide class, when in being scattered in acidic aqueous solution, forming macromolecular solution, in medicinal liquid, utilize electric charge and macromolecular bridging action, can remove the impurity such as insoluble granule in the solution and tannin, protein, resin, the solution that obtains clarifying.The characteristics such as chitosan has that preparation is simple, cost is low, safety non-toxic, with short production cycle, bio-soluble and biological degradability are good.Adopt flocculate with chitosan technique that this product extracting solution is processed, can play good removal impurity, improve the clarity effect, high to the retention rate of effective ingredient.
This product has good curative effect to diarrhea of pigs. and compared with prior art, the party's medicine medicine source is abundant, and processing technology is reasonable, and toxic and side effects is little, compares with the western medicine such as LIJUNJING, reduces expenses for medicine, is beneficial to popularization.
Concrete embodiment:
Embodiments of the invention 1:
Radix Pulsatillae 30g, Radix Berberidis 30g, Cortex Fraxini 15g, Cortex Phellodendri 15g, Radix Paeoniae Alba 20g, Saussurea lappa Clarke 15g, Pericarpium Citri Reticulatae 15g, Fructus Schisandrae Chinensis 20g, Herba Portulacae 30g, Radix Glycyrrhizae 10g
Get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water extraction, add 10 times of water gagings of medical material the 1st time, decoct 1.5h, filter; 8 times of water gagings that add medical material for the 2nd time decoct 1h, filter, merging filtrate, concentrated, it is 1: 1 that filtrate volume is concentrated into the medical material weight ratio, adopt flocculate with chitosan clarification remove impurity, impurity removal process is that pH value is 6.0, the addition of chitosan is 25%, the temperature of water-bath is 60 ℃, stirs 10min, leaves standstill 24h, filter, fill, sterilization namely gets oral liquid.Per kilogram of body weight 0.3-0.5ml during treatment, every day oral administration once, be used in conjunction 3-5 day.
Embodiments of the invention 2:
Radix Pulsatillae 10g, Radix Berberidis 10g, Cortex Fraxini 5g, Cortex Phellodendri 5g, Radix Paeoniae Alba 10g, Saussurea lappa Clarke 10g, Pericarpium Citri Reticulatae 10g, Fructus Schisandrae Chinensis 10g, Herba Portulacae 10g, Radix Glycyrrhizae 5g
Get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water and extract 1 time, 6 times of water gagings decoct 0.5h, filter, and filtrate is concentrated, remove impurity, and the clear liquor fill, sterilization namely gets oral liquid.
Embodiments of the invention 3:
Radix Pulsatillae 50g, Radix Berberidis 50g, Cortex Fraxini 30g, Cortex Phellodendri 30g, Radix Paeoniae Alba 30g, Saussurea lappa Clarke 30g, Pericarpium Citri Reticulatae 30g, Fructus Schisandrae Chinensis 30g, Herba Portulacae 50g, Radix Glycyrrhizae 20g
Get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water and extract 3 times, each 12 times of water gagings decoct 2h, filter, and filtrate is concentrated, remove impurity, and the clear liquor fill, sterilization namely gets oral liquid.
Claims (4)
1. herbal medicine preparation for the treatment of diarrhea of pigs, it is characterized in that: said preparation is made by the Chinese medicine of following weight: Radix Pulsatillae 10-50g, Radix Berberidis 10-50g, Cortex Fraxini 5-30g, Cortex Phellodendri 5-30g, Radix Paeoniae Alba 10-30g, Saussurea lappa Clarke 10-30g, Pericarpium Citri Reticulatae 10-30g, Fructus Schisandrae Chinensis 10-30g, Herba Portulacae 10-50g, Radix Glycyrrhizae 5-20g.
2. according to the herbal medicine preparation for the treatment of diarrhea of pigs claimed in claim 1, it is characterized in that: said preparation is made by the Chinese medicine of following weight: Radix Pulsatillae 30g, Radix Berberidis 30g, Cortex Fraxini 15g, Cortex Phellodendri 15g, Radix Paeoniae Alba 20g, Saussurea lappa Clarke 15g, Pericarpium Citri Reticulatae 15g, Fructus Schisandrae Chinensis 20g, Herba Portulacae 30g, Radix Glycyrrhizae 10g.
3. according to the preparation method of the herbal medicine preparation of claim 1 or 2 described treatment diarrhea of pigs, it is characterized in that: get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water and extract 1-3 time, each 6-12 times of water gaging, decoct 0.5-2h, filter, filtrate is concentrated, remove impurity, the clear liquor fill, sterilization namely gets oral liquid.
4. according to the preparation method of the herbal medicine preparation for the treatment of diarrhea of pigs claimed in claim 3, it is characterized in that: get the Radix Pulsatillae, Radix Berberidis, Cortex Fraxini, Cortex Phellodendri, the Radix Paeoniae Alba, Saussurea lappa Clarke, Pericarpium Citri Reticulatae, Fructus Schisandrae Chinensis, Herba Portulacae, Radix Glycyrrhizae and decoct with water extraction, 10 times of water gagings that add medical material for the 1st time, decoct 1.5h, filter; 8 times of water gagings that add medical material for the 2nd time decoct 1h, filter, merging filtrate, concentrated, it is 1: 1 that filtrate volume is concentrated into the medical material weight ratio, adopt flocculate with chitosan clarification remove impurity, impurity removal process is that pH value is 6.0, the addition of chitosan is 25%, the temperature of water-bath is 60 ℃, stirs 10min, leaves standstill 24h, filter, fill, sterilization namely gets oral liquid.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494007A (en) * | 2013-08-27 | 2014-01-08 | 安徽省瑞森生物科技有限责任公司 | Diarrhea-resistant forage for piglets and preparation method thereof |
| CN104171326A (en) * | 2014-07-29 | 2014-12-03 | 成都巨星农牧科技有限公司 | Anti-diarrhea premix additive for pig feed |
| CN104483440A (en) * | 2014-12-26 | 2015-04-01 | 成都乾坤动物药业有限公司 | Quality detection method of berberis poiretii schneid and purslane prepared granules |
| CN106727896A (en) * | 2016-12-21 | 2017-05-31 | 中国热带农业科学院热带生物技术研究所 | Application of the Chinese medicine composition containing timothy grass in preventing and treating pig virus diarrhoea medicine is prepared |
| CN106937970A (en) * | 2016-01-05 | 2017-07-11 | 天津中敖生物科技有限公司 | Treat traditional Chinese medicine oral liquid of newborn piglet diarrhoea and preparation method thereof |
| CN107397886A (en) * | 2017-08-09 | 2017-11-28 | 中国农业科学院兰州畜牧与兽药研究所 | Chinese medicine composition for preventing and treating piglet red dysentery and its preparation method and application |
| CN110755572A (en) * | 2019-11-29 | 2020-02-07 | 广东容大生物股份有限公司 | Traditional Chinese medicine compound preparation for preventing and treating porcine diarrhea and preparation method thereof |
| CN111602742A (en) * | 2020-05-08 | 2020-09-01 | 连云港市畜牧兽医站 | Feed additive for replacing antibiotics to prevent piglet diarrhea |
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2011
- 2011-10-21 CN CN 201110322021 patent/CN103054993A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494007A (en) * | 2013-08-27 | 2014-01-08 | 安徽省瑞森生物科技有限责任公司 | Diarrhea-resistant forage for piglets and preparation method thereof |
| CN104171326A (en) * | 2014-07-29 | 2014-12-03 | 成都巨星农牧科技有限公司 | Anti-diarrhea premix additive for pig feed |
| CN104483440A (en) * | 2014-12-26 | 2015-04-01 | 成都乾坤动物药业有限公司 | Quality detection method of berberis poiretii schneid and purslane prepared granules |
| CN104483440B (en) * | 2014-12-26 | 2016-03-02 | 成都乾坤动物药业有限公司 | A kind of quality determining method of three horse particles |
| CN106937970A (en) * | 2016-01-05 | 2017-07-11 | 天津中敖生物科技有限公司 | Treat traditional Chinese medicine oral liquid of newborn piglet diarrhoea and preparation method thereof |
| CN106727896A (en) * | 2016-12-21 | 2017-05-31 | 中国热带农业科学院热带生物技术研究所 | Application of the Chinese medicine composition containing timothy grass in preventing and treating pig virus diarrhoea medicine is prepared |
| CN107397886A (en) * | 2017-08-09 | 2017-11-28 | 中国农业科学院兰州畜牧与兽药研究所 | Chinese medicine composition for preventing and treating piglet red dysentery and its preparation method and application |
| CN110755572A (en) * | 2019-11-29 | 2020-02-07 | 广东容大生物股份有限公司 | Traditional Chinese medicine compound preparation for preventing and treating porcine diarrhea and preparation method thereof |
| CN111602742A (en) * | 2020-05-08 | 2020-09-01 | 连云港市畜牧兽医站 | Feed additive for replacing antibiotics to prevent piglet diarrhea |
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Application publication date: 20130424 |