CN103054837A - 用于治疗蛋白积聚病症的环己烷多元醇制剂 - Google Patents
用于治疗蛋白积聚病症的环己烷多元醇制剂 Download PDFInfo
- Publication number
- CN103054837A CN103054837A CN201210257027XA CN201210257027A CN103054837A CN 103054837 A CN103054837 A CN 103054837A CN 201210257027X A CN201210257027X A CN 201210257027XA CN 201210257027 A CN201210257027 A CN 201210257027A CN 103054837 A CN103054837 A CN 103054837A
- Authority
- CN
- China
- Prior art keywords
- dosage form
- compound
- alkyl
- chemical compound
- cyclohexane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC1[C@@](*)[C@](C*)[C@@](*)[C@@](C)[C@@]1* Chemical compound CC1[C@@](*)[C@](C*)[C@@](*)[C@@](C)[C@@]1* 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78052606P | 2006-03-09 | 2006-03-09 | |
| US60/780526 | 2006-03-09 | ||
| US81986406P | 2006-07-11 | 2006-07-11 | |
| US60/819864 | 2006-07-11 | ||
| US89766707P | 2007-01-26 | 2007-01-26 | |
| US60/897667 | 2007-01-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800169728A Division CN101505741A (zh) | 2006-03-09 | 2007-03-09 | 用于治疗蛋白积聚病症的环己烷多元醇制剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103054837A true CN103054837A (zh) | 2013-04-24 |
Family
ID=38474578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210257027XA Pending CN103054837A (zh) | 2006-03-09 | 2007-03-09 | 用于治疗蛋白积聚病症的环己烷多元醇制剂 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100113613A1 (https=) |
| EP (1) | EP1996175A4 (https=) |
| JP (1) | JP2009529502A (https=) |
| KR (1) | KR20090026247A (https=) |
| CN (1) | CN103054837A (https=) |
| AU (1) | AU2007222864A1 (https=) |
| BR (1) | BRPI0708725A2 (https=) |
| CA (1) | CA2644804A1 (https=) |
| EA (1) | EA200801967A1 (https=) |
| IL (1) | IL193970A0 (https=) |
| MX (1) | MX2008011553A (https=) |
| NZ (1) | NZ571181A (https=) |
| WO (1) | WO2007101353A1 (https=) |
| ZA (1) | ZA200908303B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US20100173960A1 (en) * | 2006-09-21 | 2010-07-08 | Antonio Cruz | The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases |
| US20100292157A1 (en) * | 2006-11-24 | 2010-11-18 | Antonio Cruz | Combination Treatments for Alzheimer's Disease and Similar Diseases |
| DE102007030695A1 (de) * | 2007-07-01 | 2009-01-08 | Sciconcept Gmbh | Co-Kristalle aus Harnstoff mit Amid- und/oder Harnstoffderivaten |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| JP2014515408A (ja) * | 2011-06-03 | 2014-06-30 | エラン ファーマシューティカルズ,リミティド ライアビリティー カンパニー | 行動及び精神障害の治療のためのシロ−イノシトール |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| CA2889446C (en) | 2012-10-25 | 2021-05-11 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
| EP2964249A1 (en) * | 2013-03-06 | 2016-01-13 | Acorda Therapeutics, Inc. | Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| AU2014340182B2 (en) | 2013-10-22 | 2019-05-23 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CA3033079A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| JP7202376B2 (ja) | 2017-07-20 | 2023-01-11 | エーゼットセラピーズ, インコーポレイテッド | クロモリンナトリウムおよびイブプロフェンの粉末製剤 |
| KR20210071943A (ko) | 2018-07-02 | 2021-06-16 | 더 제너럴 하스피탈 코포레이션 | 크로몰린 소듐 및 α-락토스의 분말화된 제형 |
| AU2018445164B2 (en) | 2018-10-11 | 2025-05-29 | Vifor (International) Ltd. | Inositol phosphates for the treatment of ectopic calcification |
| WO2020123449A1 (en) | 2018-12-10 | 2020-06-18 | The General Hospital Corporation | Cromolyn esters and uses thereof |
| EP4132507A4 (en) | 2020-04-06 | 2024-05-15 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4515722A (en) * | 1982-03-30 | 1985-05-07 | Merck & Co., Inc. | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents |
| US4474806A (en) * | 1982-05-10 | 1984-10-02 | Merck & Co., Inc. | Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents |
| US4952396A (en) * | 1986-11-19 | 1990-08-28 | Linus Pauling Institute Of Science & Medicine | Method of using phytic acid for inhibiting tumor growth |
| US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| US4758430A (en) * | 1987-01-21 | 1988-07-19 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| SE8904355D0 (sv) * | 1989-12-21 | 1989-12-21 | Perstorp Ab | Medicament |
| US5217959A (en) * | 1990-09-06 | 1993-06-08 | Robert Sabin | Method of treating multiple sclerosis with phytic acid |
| US5112814A (en) * | 1990-10-24 | 1992-05-12 | Robert Sabin | Method of treatment of Parkinson's disease using phytic acid |
| KR0185215B1 (ko) * | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| SE9102068L (sv) * | 1991-07-03 | 1993-01-04 | Perstorp Ab | Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav |
| SE469260B (sv) * | 1992-02-25 | 1993-06-14 | Perstorp Ab | En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat |
| ATE292131T1 (de) * | 1992-10-05 | 2005-04-15 | Virginia Tech Intell Prop | Zwischenprodukt zur herstellung von d-chiro- inosose und (+)-d-chiro-inositol |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| DE69333071T2 (de) * | 1993-04-05 | 2004-05-06 | Aveve N.V. | Phytate-Hydrolyse und enzymatische Zusammensetzung für die Hydrolyse von Phytat |
| CA2168953A1 (en) * | 1993-08-11 | 1995-02-16 | Kiyoshi Sato | Process for producing d-chiro-inositol |
| SE502574C2 (sv) * | 1994-01-25 | 1995-11-13 | Perstorp Ab | En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat |
| US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| US6232486B1 (en) * | 1996-06-11 | 2001-05-15 | Nutrimed Biotech | Molecular probes and modulators for PI-PLC and PI 3-kinase |
| US5977078A (en) * | 1996-09-20 | 1999-11-02 | The Regents Of The Univesity Of California | Inositol polyphosphate derivatives and methods of using same |
| US5880099A (en) * | 1996-09-20 | 1999-03-09 | The Regents Of The University Of California | Inositol polyphosphates and methods of using same |
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| US6153603A (en) * | 1997-06-27 | 2000-11-28 | Perstorp Ab | Method of treating angiogenesis in tumor tissue |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| US6818430B1 (en) * | 1999-06-07 | 2004-11-16 | Hokko Chemical Industry Co., Ltd. | Process for producing L-epi-2-inosose and novel process for producing epi-inositol |
| US6329256B1 (en) * | 1999-09-24 | 2001-12-11 | Advanced Micro Devices, Inc. | Self-aligned damascene gate formation with low gate resistance |
| WO2001028356A2 (en) * | 1999-10-18 | 2001-04-26 | Muscletech Research And Development Inc. | Food supplement for increasing lean mass and strength |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| DE10031955A1 (de) * | 2000-06-30 | 2002-01-17 | Deutsches Krebsforsch | Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel |
| US8034803B2 (en) * | 2001-02-06 | 2011-10-11 | Qlt Inc. | Photodynamic therapy of occult age-related macular degeneration |
| WO2002062385A2 (en) * | 2001-02-06 | 2002-08-15 | Qlt, Inc. | Method to prevent vision loss |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| US6599891B2 (en) * | 2001-07-20 | 2003-07-29 | Qlt Inc. | Treatment of macular edema |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| ATE458042T1 (de) * | 2003-10-14 | 2010-03-15 | Hokko Chem Ind Co | Verfahren zur herstellung von scyllo-inositol |
| CN103301094A (zh) * | 2004-11-17 | 2013-09-18 | 乔安妮·麦克劳林 | 用于治疗蛋白聚集疾病的含鲨肌醇衍生物的组合物和方法 |
-
2007
- 2007-03-09 EP EP07710726A patent/EP1996175A4/en not_active Withdrawn
- 2007-03-09 MX MX2008011553A patent/MX2008011553A/es not_active Application Discontinuation
- 2007-03-09 CN CN201210257027XA patent/CN103054837A/zh active Pending
- 2007-03-09 NZ NZ571181A patent/NZ571181A/en not_active IP Right Cessation
- 2007-03-09 BR BRPI0708725-0A patent/BRPI0708725A2/pt not_active IP Right Cessation
- 2007-03-09 JP JP2008557568A patent/JP2009529502A/ja active Pending
- 2007-03-09 EA EA200801967A patent/EA200801967A1/ru unknown
- 2007-03-09 US US12/282,030 patent/US20100113613A1/en not_active Abandoned
- 2007-03-09 KR KR1020087024122A patent/KR20090026247A/ko not_active Ceased
- 2007-03-09 AU AU2007222864A patent/AU2007222864A1/en not_active Abandoned
- 2007-03-09 CA CA002644804A patent/CA2644804A1/en not_active Abandoned
- 2007-03-09 WO PCT/CA2007/000395 patent/WO2007101353A1/en not_active Ceased
-
2008
- 2008-09-08 IL IL193970A patent/IL193970A0/en unknown
-
2009
- 2009-11-24 ZA ZA2009/08303A patent/ZA200908303B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL193970A0 (en) | 2009-08-03 |
| EP1996175A1 (en) | 2008-12-03 |
| MX2008011553A (es) | 2008-12-09 |
| US20100113613A1 (en) | 2010-05-06 |
| JP2009529502A (ja) | 2009-08-20 |
| AU2007222864A8 (en) | 2010-06-10 |
| KR20090026247A (ko) | 2009-03-12 |
| EA200801967A1 (ru) | 2009-04-28 |
| CA2644804A1 (en) | 2007-09-13 |
| AU2007222864A1 (en) | 2007-09-13 |
| EP1996175A4 (en) | 2009-06-10 |
| WO2007101353A1 (en) | 2007-09-13 |
| BRPI0708725A2 (pt) | 2011-06-07 |
| NZ571181A (en) | 2011-12-22 |
| ZA200908303B (en) | 2012-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130424 |