JP2009529502A - タンパク質凝集の障害の処置のためのシクロヘキサン多価アルコール処方物 - Google Patents

タンパク質凝集の障害の処置のためのシクロヘキサン多価アルコール処方物 Download PDF

Info

Publication number
JP2009529502A
JP2009529502A JP2008557568A JP2008557568A JP2009529502A JP 2009529502 A JP2009529502 A JP 2009529502A JP 2008557568 A JP2008557568 A JP 2008557568A JP 2008557568 A JP2008557568 A JP 2008557568A JP 2009529502 A JP2009529502 A JP 2009529502A
Authority
JP
Japan
Prior art keywords
compound
dosage form
alkyl
cyclohexane polyalcohol
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008557568A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009529502A5 (https=
Inventor
ジョアン マクローリン，
アントニオ クルス，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2009529502A publication Critical patent/JP2009529502A/ja
Publication of JP2009529502A5 publication Critical patent/JP2009529502A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008557568A 2006-03-09 2007-03-09 タンパク質凝集の障害の処置のためのシクロヘキサン多価アルコール処方物 Pending JP2009529502A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78052606P 2006-03-09 2006-03-09
US81986406P 2006-07-11 2006-07-11
US89766707P 2007-01-26 2007-01-26
PCT/CA2007/000395 WO2007101353A1 (en) 2006-03-09 2007-03-09 A cyclohexane polyalcohol formulation for treatment of disorders of protein aggregation

Publications (2)

Publication Number Publication Date
JP2009529502A true JP2009529502A (ja) 2009-08-20
JP2009529502A5 JP2009529502A5 (https=) 2011-04-14

Family

ID=38474578

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008557568A Pending JP2009529502A (ja) 2006-03-09 2007-03-09 タンパク質凝集の障害の処置のためのシクロヘキサン多価アルコール処方物

Country Status (14)

Country Link
US (1) US20100113613A1 (https=)
EP (1) EP1996175A4 (https=)
JP (1) JP2009529502A (https=)
KR (1) KR20090026247A (https=)
CN (1) CN103054837A (https=)
AU (1) AU2007222864A1 (https=)
BR (1) BRPI0708725A2 (https=)
CA (1) CA2644804A1 (https=)
EA (1) EA200801967A1 (https=)
IL (1) IL193970A0 (https=)
MX (1) MX2008011553A (https=)
NZ (1) NZ571181A (https=)
WO (1) WO2007101353A1 (https=)
ZA (1) ZA200908303B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014515408A (ja) * 2011-06-03 2014-06-30 エラン ファーマシューティカルズ，リミティド ライアビリティー カンパニー 行動及び精神障害の治療のためのシロ−イノシトール
JP2016516016A (ja) * 2013-03-06 2016-06-02 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
US20100173960A1 (en) * 2006-09-21 2010-07-08 Antonio Cruz The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
US20100292157A1 (en) * 2006-11-24 2010-11-18 Antonio Cruz Combination Treatments for Alzheimer's Disease and Similar Diseases
DE102007030695A1 (de) * 2007-07-01 2009-01-08 Sciconcept Gmbh Co-Kristalle aus Harnstoff mit Amid- und/oder Harnstoffderivaten
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
CA2889446C (en) 2012-10-25 2021-05-11 The General Hospital Corporation Combination therapies for the treatment of alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
AU2014340182B2 (en) 2013-10-22 2019-05-23 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
CA3033079A1 (en) 2016-08-31 2018-03-08 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
JP7202376B2 (ja) 2017-07-20 2023-01-11 エーゼットセラピーズ， インコーポレイテッド クロモリンナトリウムおよびイブプロフェンの粉末製剤
KR20210071943A (ko) 2018-07-02 2021-06-16 더 제너럴 하스피탈 코포레이션 크로몰린 소듐 및 α-락토스의 분말화된 제형
AU2018445164B2 (en) 2018-10-11 2025-05-29 Vifor (International) Ltd. Inositol phosphates for the treatment of ectopic calcification
WO2020123449A1 (en) 2018-12-10 2020-06-18 The General Hospital Corporation Cromolyn esters and uses thereof
EP4132507A4 (en) 2020-04-06 2024-05-15 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075882A1 (en) * 2003-02-27 2004-09-10 Ellipsis Biotherapeutics Corporation Methods of preventing, treating and diagnosing disorders of protein aggregation

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4515722A (en) * 1982-03-30 1985-05-07 Merck & Co., Inc. Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents
US4474806A (en) * 1982-05-10 1984-10-02 Merck & Co., Inc. Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents
US4952396A (en) * 1986-11-19 1990-08-28 Linus Pauling Institute Of Science & Medicine Method of using phytic acid for inhibiting tumor growth
US4847082A (en) * 1987-01-21 1989-07-11 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
US4758430A (en) * 1987-01-21 1988-07-19 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
SE8904355D0 (sv) * 1989-12-21 1989-12-21 Perstorp Ab Medicament
US5217959A (en) * 1990-09-06 1993-06-08 Robert Sabin Method of treating multiple sclerosis with phytic acid
US5112814A (en) * 1990-10-24 1992-05-12 Robert Sabin Method of treatment of Parkinson's disease using phytic acid
KR0185215B1 (ko) * 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
SE9102068L (sv) * 1991-07-03 1993-01-04 Perstorp Ab Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav
SE469260B (sv) * 1992-02-25 1993-06-14 Perstorp Ab En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat
ATE292131T1 (de) * 1992-10-05 2005-04-15 Virginia Tech Intell Prop Zwischenprodukt zur herstellung von d-chiro- inosose und (+)-d-chiro-inositol
US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5840294A (en) * 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
US5972328A (en) * 1993-03-29 1999-10-26 Queen's University At Kingston Method for treating amyloidosis
DE69333071T2 (de) * 1993-04-05 2004-05-06 Aveve N.V. Phytate-Hydrolyse und enzymatische Zusammensetzung für die Hydrolyse von Phytat
CA2168953A1 (en) * 1993-08-11 1995-02-16 Kiyoshi Sato Process for producing d-chiro-inositol
SE502574C2 (sv) * 1994-01-25 1995-11-13 Perstorp Ab En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat
US5858326A (en) * 1995-06-06 1999-01-12 Neurochem, Inc. Methods of increasing amyloid deposition
US5756541A (en) * 1996-03-11 1998-05-26 Qlt Phototherapeutics Inc Vision through photodynamic therapy of the eye
US6232486B1 (en) * 1996-06-11 2001-05-15 Nutrimed Biotech Molecular probes and modulators for PI-PLC and PI 3-kinase
US5977078A (en) * 1996-09-20 1999-11-02 The Regents Of The Univesity Of California Inositol polyphosphate derivatives and methods of using same
US5880099A (en) * 1996-09-20 1999-03-09 The Regents Of The University Of California Inositol polyphosphates and methods of using same
US5998485A (en) * 1997-06-16 1999-12-07 Cedars-Sinai Medical Center Method for modulating immune response with inositol
US6153603A (en) * 1997-06-27 2000-11-28 Perstorp Ab Method of treating angiogenesis in tumor tissue
US6310073B1 (en) * 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
US6818430B1 (en) * 1999-06-07 2004-11-16 Hokko Chemical Industry Co., Ltd. Process for producing L-epi-2-inosose and novel process for producing epi-inositol
US6329256B1 (en) * 1999-09-24 2001-12-11 Advanced Micro Devices, Inc. Self-aligned damascene gate formation with low gate resistance
WO2001028356A2 (en) * 1999-10-18 2001-04-26 Muscletech Research And Development Inc. Food supplement for increasing lean mass and strength
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
DE10031955A1 (de) * 2000-06-30 2002-01-17 Deutsches Krebsforsch Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel
US8034803B2 (en) * 2001-02-06 2011-10-11 Qlt Inc. Photodynamic therapy of occult age-related macular degeneration
WO2002062385A2 (en) * 2001-02-06 2002-08-15 Qlt, Inc. Method to prevent vision loss
US20030181531A1 (en) * 2003-02-11 2003-09-25 David Sherris Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
US6599891B2 (en) * 2001-07-20 2003-07-29 Qlt Inc. Treatment of macular edema
US20040058313A1 (en) * 2002-04-24 2004-03-25 Abreu Marcio Marc Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
ATE458042T1 (de) * 2003-10-14 2010-03-15 Hokko Chem Ind Co Verfahren zur herstellung von scyllo-inositol
CN103301094A (zh) * 2004-11-17 2013-09-18 乔安妮·麦克劳林 用于治疗蛋白聚集疾病的含鲨肌醇衍生物的组合物和方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075882A1 (en) * 2003-02-27 2004-09-10 Ellipsis Biotherapeutics Corporation Methods of preventing, treating and diagnosing disorders of protein aggregation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014515408A (ja) * 2011-06-03 2014-06-30 エラン ファーマシューティカルズ，リミティド ライアビリティー カンパニー 行動及び精神障害の治療のためのシロ−イノシトール
JP2016516016A (ja) * 2013-03-06 2016-06-02 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法

Also Published As

Publication number Publication date
IL193970A0 (en) 2009-08-03
EP1996175A1 (en) 2008-12-03
MX2008011553A (es) 2008-12-09
US20100113613A1 (en) 2010-05-06
AU2007222864A8 (en) 2010-06-10
CN103054837A (zh) 2013-04-24
KR20090026247A (ko) 2009-03-12
EA200801967A1 (ru) 2009-04-28
CA2644804A1 (en) 2007-09-13
AU2007222864A1 (en) 2007-09-13
EP1996175A4 (en) 2009-06-10
WO2007101353A1 (en) 2007-09-13
BRPI0708725A2 (pt) 2011-06-07
NZ571181A (en) 2011-12-22
ZA200908303B (en) 2012-08-29

Similar Documents

Publication Publication Date Title
JP2009529502A (ja) タンパク質凝集の障害の処置のためのシクロヘキサン多価アルコール処方物
KR101918669B1 (ko) 신경 장애 치료용 신규 조성물
CN106102737B (zh) 色甘酸衍生物以及成像和治疗的相关方法
US20100292157A1 (en) Combination Treatments for Alzheimer's Disease and Similar Diseases
USRE49873E1 (en) APP specific bace inhibitors (ASBIs) and uses thereof
US20200338040A1 (en) Methods for treating alzheimer's disease and related disorders
HUE035542T2 (hu) Brexpiprazolt vagy annak sóját és egy második hatóanyagot tartalmazó kombinációk központi idegrendszeri rendellenességek kezelésében történõ alkalmazásra
CN101426517B (zh) 用于预防和消除组织中纤维样和其他病理性沉积的、含ghrp-6的药物组合物
JP2012214516A (ja) シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法
US20100173960A1 (en) The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
US20070111970A1 (en) Inositol compounds and uses of same in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence
AU2017321782A1 (en) Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
JP7509865B2 (ja) アネキシンａ５の用途
CA2986431C (en) Galantamine clearance of amyloid.beta.
TW200843785A (en) Methods for preventing and treating neurodegenerative disorders
CA2949395A1 (en) Clearance of amyloid.beta.
CN101505741A (zh) 用于治疗蛋白积聚病症的环己烷多元醇制剂
CN112438970B (zh) 米那普仑或/和米那普仑的药用盐的新用途
CN104258371B (zh) Www三肽在制备治疗阿尔茨海默症药物中的用途
CN104258372B (zh) Rgd三肽在制备治疗阿尔茨海默症药物中的用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100302

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100302

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120912

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121129

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121206

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130515