CN103052397B - 用于预防及治疗非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白 - Google Patents

用于预防及治疗非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白 Download PDF

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Publication number
CN103052397B
CN103052397B CN201180033866.7A CN201180033866A CN103052397B CN 103052397 B CN103052397 B CN 103052397B CN 201180033866 A CN201180033866 A CN 201180033866A CN 103052397 B CN103052397 B CN 103052397B
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China
Prior art keywords
e4orf1
albumen
adenovirus
seq
liver
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Expired - Fee Related
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CN201180033866.7A
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English (en)
Chinese (zh)
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CN103052397A (zh
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N·杜源德哈
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Louisiana State University
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Louisiana State University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10333—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201180033866.7A 2010-07-08 2011-07-08 用于预防及治疗非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白 Expired - Fee Related CN103052397B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36244310P 2010-07-08 2010-07-08
US61/362,443 2010-07-08
PCT/US2011/043338 WO2012006512A1 (en) 2010-07-08 2011-07-08 Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease

Publications (2)

Publication Number Publication Date
CN103052397A CN103052397A (zh) 2013-04-17
CN103052397B true CN103052397B (zh) 2017-09-19

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CN201180033866.7A Expired - Fee Related CN103052397B (zh) 2010-07-08 2011-07-08 用于预防及治疗非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白

Country Status (11)

Country Link
US (2) US8951980B2 (enExample)
EP (1) EP2590665B1 (enExample)
JP (1) JP5965397B2 (enExample)
KR (1) KR101831638B1 (enExample)
CN (1) CN103052397B (enExample)
AU (1) AU2011274537B9 (enExample)
CA (1) CA2803787C (enExample)
ES (1) ES2550962T3 (enExample)
NZ (1) NZ606236A (enExample)
TW (1) TWI531650B (enExample)
WO (1) WO2012006512A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014062794A1 (en) 2012-10-17 2014-04-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for improving glucose uptake
US9354963B2 (en) * 2014-02-26 2016-05-31 Microsoft Technology Licensing, Llc Service metric analysis from structured logging schema of usage data
US10047107B2 (en) 2014-04-23 2018-08-14 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Small molecule analogs of E4orf1
GB201910299D0 (en) * 2019-07-18 2019-09-04 Aouadi Myriam Medical uses, methods and uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064836A1 (en) * 2005-11-30 2007-06-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Adenovirus 36 e4 orf 1 gene and protein and their uses
US20070218081A1 (en) * 2005-12-27 2007-09-20 Atkinson Richard L Adipogenic adenoviruses as a biomarker for disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004004775T2 (de) * 2004-08-12 2007-11-22 Roche Diagnostics Gmbh Verfahren zur Diagnose von Leberfibrose.
US20060045919A1 (en) 2004-08-27 2006-03-02 Samueli Institute Homeopathic compositions and methods for the treatment of cancer
JP2008105945A (ja) * 2005-02-07 2008-05-08 Ajinomoto Co Inc アディポネクチンの分泌促進又は誘導作用を有するアシルアミド化合物
JP2008273938A (ja) * 2007-03-30 2008-11-13 Shiseido Co Ltd アディポネクチン産生促進剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064836A1 (en) * 2005-11-30 2007-06-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Adenovirus 36 e4 orf 1 gene and protein and their uses
US20070218081A1 (en) * 2005-12-27 2007-09-20 Atkinson Richard L Adipogenic adenoviruses as a biomarker for disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ad36 adipogenic adenovirus in human non-alcoholic fatty liver disease;Trovato Guglielmo M et al.;《Liver International》;20100228;第30卷(第2期);184-190 *
human adenovirus-36 and non-alcoholic fatty liver disease;Atkinson Richard L;《Liver International》;20100228;第30卷(第2期);164-165 *

Also Published As

Publication number Publication date
KR20130100262A (ko) 2013-09-10
JP5965397B2 (ja) 2016-08-03
JP2013531681A (ja) 2013-08-08
AU2011274537A1 (en) 2013-02-14
KR101831638B1 (ko) 2018-02-23
TWI531650B (zh) 2016-05-01
AU2011274537B9 (en) 2017-02-23
NZ606236A (en) 2014-09-26
WO2012006512A1 (en) 2012-01-12
EP2590665A1 (en) 2013-05-15
CA2803787A1 (en) 2012-01-12
US20170340699A1 (en) 2017-11-30
TW201217529A (en) 2012-05-01
CA2803787C (en) 2018-12-04
AU2011274537B2 (en) 2016-12-15
HK1185261A1 (en) 2014-02-14
US20120027845A1 (en) 2012-02-02
ES2550962T3 (es) 2015-11-13
EP2590665B1 (en) 2015-09-16
US8951980B2 (en) 2015-02-10
CN103052397A (zh) 2013-04-17

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