TWI531650B - 用於預防及治療非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白 - Google Patents

用於預防及治療非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白 Download PDF

Info

Publication number
TWI531650B
TWI531650B TW100124173A TW100124173A TWI531650B TW I531650 B TWI531650 B TW I531650B TW 100124173 A TW100124173 A TW 100124173A TW 100124173 A TW100124173 A TW 100124173A TW I531650 B TWI531650 B TW I531650B
Authority
TW
Taiwan
Prior art keywords
protein
adenovirus
nucleic acid
liver
seq
Prior art date
Application number
TW100124173A
Other languages
English (en)
Chinese (zh)
Other versions
TW201217529A (en
Inventor
尼克西爾 度朗哈
Original Assignee
路易斯安那州立大學暨農業機械學院管委會
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 路易斯安那州立大學暨農業機械學院管委會 filed Critical 路易斯安那州立大學暨農業機械學院管委會
Publication of TW201217529A publication Critical patent/TW201217529A/zh
Application granted granted Critical
Publication of TWI531650B publication Critical patent/TWI531650B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10333—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW100124173A 2010-07-08 2011-07-08 用於預防及治療非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白 TWI531650B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36244310P 2010-07-08 2010-07-08

Publications (2)

Publication Number Publication Date
TW201217529A TW201217529A (en) 2012-05-01
TWI531650B true TWI531650B (zh) 2016-05-01

Family

ID=44629893

Family Applications (1)

Application Number Title Priority Date Filing Date
TW100124173A TWI531650B (zh) 2010-07-08 2011-07-08 用於預防及治療非酒精性脂肪肝疾病的腺病毒ad36 e4orf1蛋白

Country Status (11)

Country Link
US (2) US8951980B2 (enExample)
EP (1) EP2590665B1 (enExample)
JP (1) JP5965397B2 (enExample)
KR (1) KR101831638B1 (enExample)
CN (1) CN103052397B (enExample)
AU (1) AU2011274537B9 (enExample)
CA (1) CA2803787C (enExample)
ES (1) ES2550962T3 (enExample)
NZ (1) NZ606236A (enExample)
TW (1) TWI531650B (enExample)
WO (1) WO2012006512A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014062794A1 (en) 2012-10-17 2014-04-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for improving glucose uptake
US9354963B2 (en) * 2014-02-26 2016-05-31 Microsoft Technology Licensing, Llc Service metric analysis from structured logging schema of usage data
US10047107B2 (en) 2014-04-23 2018-08-14 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Small molecule analogs of E4orf1
GB201910299D0 (en) * 2019-07-18 2019-09-04 Aouadi Myriam Medical uses, methods and uses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004004775T2 (de) * 2004-08-12 2007-11-22 Roche Diagnostics Gmbh Verfahren zur Diagnose von Leberfibrose.
US20060045919A1 (en) 2004-08-27 2006-03-02 Samueli Institute Homeopathic compositions and methods for the treatment of cancer
JP2008105945A (ja) * 2005-02-07 2008-05-08 Ajinomoto Co Inc アディポネクチンの分泌促進又は誘導作用を有するアシルアミド化合物
ES2472325T3 (es) * 2005-11-30 2014-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Gen y proteína del adenovirus 36 E4 orf 1 y sus usos
WO2007120362A2 (en) * 2005-12-27 2007-10-25 Obetech, Llc Adipogenic adenoviruses as a biomarker for disease
JP2008273938A (ja) * 2007-03-30 2008-11-13 Shiseido Co Ltd アディポネクチン産生促進剤

Also Published As

Publication number Publication date
KR20130100262A (ko) 2013-09-10
JP5965397B2 (ja) 2016-08-03
JP2013531681A (ja) 2013-08-08
AU2011274537A1 (en) 2013-02-14
KR101831638B1 (ko) 2018-02-23
AU2011274537B9 (en) 2017-02-23
NZ606236A (en) 2014-09-26
CN103052397B (zh) 2017-09-19
WO2012006512A1 (en) 2012-01-12
EP2590665A1 (en) 2013-05-15
CA2803787A1 (en) 2012-01-12
US20170340699A1 (en) 2017-11-30
TW201217529A (en) 2012-05-01
CA2803787C (en) 2018-12-04
AU2011274537B2 (en) 2016-12-15
HK1185261A1 (en) 2014-02-14
US20120027845A1 (en) 2012-02-02
ES2550962T3 (es) 2015-11-13
EP2590665B1 (en) 2015-09-16
US8951980B2 (en) 2015-02-10
CN103052397A (zh) 2013-04-17

Similar Documents

Publication Publication Date Title
Krishnapuram et al. Template to improve glycemic control without reducing adiposity or dietary fat
Cariou The metabolic triad of non‐alcoholic fatty liver disease, visceral adiposity and type 2 diabetes: implications for treatment
Kim et al. The adiponectin receptor agonist AdipoRon ameliorates diabetic nephropathy in a model of type 2 diabetes
Yan et al. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart
Choe et al. Macrophage HIF-2α ameliorates adipose tissue inflammation and insulin resistance in obesity
De Minicis et al. From NAFLD to NASH and HCC: pathogenetic mechanisms and therapeutic insights
Dadson et al. Adiponectin action: a combination of endocrine and autocrine/paracrine effects
Harrison et al. Advances in the understanding and treatment of nonalcoholic fatty liver disease
Steinberg et al. The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity
Kumar et al. Adiponectin modulates focal adhesion disassembly in activated hepatic stellate cells: implication for reversing hepatic fibrosis
Piao et al. A novel plasminogen activator inhibitor‐1 inhibitor, TM5441, protects against high‐fat diet‐induced obesity and adipocyte injury in mice
Guo et al. A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis
Zilu et al. Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress
US20170340699A1 (en) Adenovirus AD36 E4ORF1 Protein For Prevention and Treatment of Non-Alcoholic Fatty Liver Disease
Li et al. Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway
WO2018028433A1 (zh) Creg蛋白用于预防或治疗体重超重、肥胖及其相关疾病的医药用途
US10729634B2 (en) Sex hormone-binding globulin for use as a medicament
Boutari et al. Metabolism updates: new directions, techniques, and exciting research that is broadening the horizons
HK1185261B (en) Adenovirus ad36 e4orf1 protein for prevention and treatment of non-alcoholic fatty liver disease
US20200377565A1 (en) Brown Fat-Selective Adipokines
US8546347B2 (en) Composition for treatment and improvement of diabetes comprising caveolin as active ingredient and a method for treatment of diabetes using it
US20250281572A1 (en) Compositions and methods for treating and preventing metabolic disorders
Cefalu et al. Template to improve glycemic control without
US20120269796A1 (en) Method for Enhancing Pancreatic Beta Cell Proliferation, Increasing Serum Insulin Concentration, Decreasing Blood Glucose Concentration And Treating And/Or Preventing Diabetes
CN119792581A (zh) TrkB基因在制备肝纤维化治疗产品中的用途

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees