CN103041306A - Traditional Chinese medicine composition for curing climacteric syndrome of women and preparation method thereof - Google Patents

Traditional Chinese medicine composition for curing climacteric syndrome of women and preparation method thereof Download PDF

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CN103041306A
CN103041306A CN2012105852634A CN201210585263A CN103041306A CN 103041306 A CN103041306 A CN 103041306A CN 2012105852634 A CN2012105852634 A CN 2012105852634A CN 201210585263 A CN201210585263 A CN 201210585263A CN 103041306 A CN103041306 A CN 103041306A
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weight portions
radix
semen
rhizoma
powder
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CN103041306B (en
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侯磊磊
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Sichuan life source Health Management Co., Ltd.
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Qingdao Hengbo Instrument Co Ltd
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Abstract

The invention provides a traditional Chinese medicine composition for curing climacteric syndrome of women. The bulk drugs of the traditional Chinese medicine composition include fennelflower seeds, rhizoma curculiginis, fructus rosae laevigatae, semen boitae, polygala tenuifolia, cistanche, selfheal, seeds of feather cockscomb, semen sesami nigrum, eclipta, golden cypress, tortoise shell glue, curcuma zedoary, pollen typhae, lignum dalbergiae odoriferae, Chinese yam, acanthopanax, panax japonicus, radix paeoniae alba, roots of red-rooted salvia, folium apocyni veneti, uncaria, semen phaseoli, caulis bambusae in taeniam, oyster, roots of bidentate achyranthes, Changium smyrnioides, pericarpium citri reticulatae, semen coicis and liquorice. The traditional Chinese medicine composition shortens the course of treatment, improves curative effect, reduces recurrence possibility, improves living quality, and avoids side effects and complications.

Description

Be used for the treatment of Chinese medicine composition of menopausal syndrome and preparation method thereof
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome and preparation method thereof.
Background technology
Menopausal syndrome refers to some women during climacteric because the series of symptoms due to the gonadal hormone minimizing generally occurs in 44~55 years old.Clinical manifestation is the hectic fever sweating, vertigo and tinnitus, and palpitation and insomnia, irritated irritability, or appearance, edema of lower limbs, indigestion and loss of appetite, loose stool, or menoxenia, feelings will does not rather wait disease.Because occur in before and after menopause, the traditional Chinese medical science is referred to as " menopausal syndrome ".These syndromes are light or heavy, and persistent period or length or weak point very then affect live and work, bring very large misery to patient, and therefore how effective and stable solution menopausal syndrome problem becomes the focus of medical circle common concern.
One group of endocrine disturbance that modern medicine is thought climacteric syndrome to be the women occurred in climacteric and ovarian function decline in menopause and autonomic nervous dysfunction's symptomes complice.Modern medicine treatment mainly take complementing estrogen, correct the autonomic nervous dysfunction and improve symptom as main, adopt: the Drug therapys such as estrogen, oryzanol, vitamin E more, though curative effect is got instant result, but poor stability, easily repeatedly, and the life-time service estrogen can cause endometrial hyperplasia, increases the danger of endometrial carcinoma.
Chinese medicine is with a long history, has accumulated rich experience in treatment aspect the menopausal syndrome, improving symptom, prevents and treats complication, and the aspect such as improve the quality of living obtains comparatively effectively and treatment in stable long term effect.It is take strengthening vital QI to eliminate pathogenic factors as the Therapeutic Principle, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, integrally-regulated, but Shorten the Treatment Process, improves curative effect, reduces recurrence, the quality of making the life better.
Motherland's medical research shows that the reason of menopausal syndrome is mainly to suffer from a deficiency of the kidney as main.The postmenopausal women liver blood is hindered repeatly, the kidney qi degradation, and the kidney failing to nourish the liver, heart-fire is short, and painstaking effort are not given birth to, and kidney water loses to be grown, and kidney essense is more lost.It is disorderly organism balance to occur, the heart, liver,spleen,kidney occur inharmonious or pathologic changes, so hectic fever sweating in various degree, irritated irritability, chest distress and palpitation symptoms, soreness of waist and knee joint, limb face edema occur, gloomyly easily cry, the clinical symptoms such as insomnia forgetfulness, vertigo and tinnitus.Primary disease cause of disease key mainly is the stagnation of liver-QI of suffering from a deficiency of the kidney, and it is that kidney qi is gradually lost because age increases day by day, and menses gradually exhausts, irregular menstrual cycle, bromhidrosis day declines, and all hopes is difficult to be satisfied, and long-pendingly thinks into worry, long-pendingly considers into melancholy, long-pending melancholy Cheng Yu forms, and by conditioning kidney yin kidney yang, improves stagnation of liver-QI, thereby reaches the purpose for the treatment of primary disease.
The present invention provides a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome on the basis of theory of Chinese medical science, it can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better, can not have side effects, and prevents the generation of complication.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome is provided, and it can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better, can not have side effects, and prevents the generation of complication.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome, the crude drug of this Chinese medicine composition comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Wherein, the weight portion of each crude drug is respectively Semen Nigellae 49 weight portions ~ 59 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 36 weight portions ~ 46 weight portions, Fructus Rosae Laevigatae 31 weight portions ~ 41 weight portions, Semen Platycladi 17 weight portions ~ 27 weight portions, Radix Polygalae 21 weight portions ~ 31 weight portions, Herba Cistanches 42 weight portions ~ 52 weight portions, Spica Prunellae 26 weight portions ~ 36 weight portions, Semen Celosiae 23 weight portions ~ 33 weight portions, Semen Sesami Nigrum 57 weight portions ~ 67 weight portions, Herba Ecliptae 73 weight portions ~ 83 weight portions, Cortex Phellodendri 43 weight portions ~ 53 weight portions, Colla Plastri Testudinis 51 weight portions ~ 61 weight portions, Rhizoma Curcumae 21 weight portions ~ 31 weight portions, Pollen Typhae 33 weight portions ~ 43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portions ~ 29 weight portions, Rhizoma Dioscoreae 82 weight portions ~ 92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portions ~ 70 weight portions, Rhizoma Panacis Japonici 43 weight portions ~ 53 weight portions, the Radix Paeoniae Alba 22 weight portions ~ 32 weight portions, Radix Salviae Miltiorrhizae 31 weight portions ~ 41 weight portions, Folium Apocyni Veneti 16 weight portions ~ 26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portions ~ 37 weight portions, Semen Phaseoli 16 weight portions ~ 26 weight portions, Caulis Bambusae In Taenia 13 weight portions ~ 23 weight portions, Concha Ostreae 9 weight portions ~ 19 weight portions, Radix Achyranthis Bidentatae 39 weight portions ~ 49 weight portions, Radix Changii 23 weight portions ~ 33 weight portions, Pericarpium Citri Reticulatae 51 weight portions ~ 61 weight portions, Semen Coicis 22 weight portions ~ 32 weight portions, Radix Glycyrrhizae 27 weight portions ~ 37 weight portions.
Wherein, the weight portion of each crude drug is respectively Semen Nigellae 51 weight portions ~ 57 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 38 weight portions ~ 44 weight portions, Fructus Rosae Laevigatae 33 weight portions ~ 39 weight portions, Semen Platycladi 19 weight portions ~ 25 weight portions, Radix Polygalae 23 weight portions ~ 29 weight portions, Herba Cistanches 44 weight portions ~ 50 weight portions, Spica Prunellae 28 weight portions ~ 34 weight portions, Semen Celosiae 25 weight portions ~ 31 weight portions, Semen Sesami Nigrum 59 weight portions ~ 65 weight portions, Herba Ecliptae 75 weight portions ~ 81 weight portions, Cortex Phellodendri 45 weight portions ~ 51 weight portions, Colla Plastri Testudinis 53 weight portions ~ 59 weight portions, Rhizoma Curcumae 23 weight portions ~ 29 weight portions, Pollen Typhae 35 weight portions ~ 41 weight portions, Lignum Dalbergiae Odoriferae 21 weight portions ~ 27 weight portions, Rhizoma Dioscoreae 84 weight portions ~ 90 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portions ~ 68 weight portions, Rhizoma Panacis Japonici 45 weight portions ~ 51 weight portions, the Radix Paeoniae Alba 24 weight portions ~ 30 weight portions, Radix Salviae Miltiorrhizae 33 weight portions ~ 39 weight portions, Folium Apocyni Veneti 18 weight portions ~ 24 weight portions, Ramulus Uncariae Cum Uncis 29 weight portions ~ 35 weight portions, Semen Phaseoli 18 weight portions ~ 24 weight portions, Caulis Bambusae In Taenia 15 weight portions ~ 21 weight portions, Concha Ostreae 11 weight portions ~ 17 weight portions, Radix Achyranthis Bidentatae 41 weight portions ~ 47 weight portions, Radix Changii 25 weight portions ~ 31 weight portions, Pericarpium Citri Reticulatae 53 weight portions ~ 59 weight portions, Semen Coicis 24 weight portions ~ 30 weight portions, Radix Glycyrrhizae 29 weight portions ~ 35 weight portions.
Wherein, the dosage form of described Chinese medicine composition is tablet, powder, soft capsule, oral liquid, syrup, pill.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was syrup, this preparation method was specially:
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with filtrate that second step obtains, adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and hold over night is filtered, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution;
The 4th step, other gets sucrose and decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, the volatile oil that adding antiseptic, second step obtain, the powder that the first step obtains, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 3g/ml~4g/ml, packing, sterilization namely gets described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portions~120 weight portions, and the addition of described antiseptic is 0.5 weight portion~1 weight portion.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was powder, this preparation method was specially:
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, add after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate, the filtrate concentrating under reduced pressure obtains and gets dry extract, and is ground into powder;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mixes with filtrate that second step obtains, the adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), hold over night, filter, filtrate decompression is concentrated, obtains to get dry extract, and is ground into powder;
The 4th step, use ethanol with the dilution proportion of volume ratio 1:1 ~ 1:2 the volatile oil that second step obtains, it is for subsequent use to get volatile oil ethanol dilution liquid, takes by weighing beta-schardinger dextrin-and places container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after the dilution slowly is added in the beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h get Benexate Hydrochloride, and be for subsequent use;
The 5th step, the powder of the first step to the three steps acquisition and the Benexate Hydrochloride of the 4th step acquisition are mixed, be ground into 100 orders ~ 150 purpose powder, vacuum drying obtains powder.
The present invention also provides a kind of Chinese medicine composition syrup that is used for the treatment of menopausal syndrome, and the crude drug of described syrup comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Wherein, the preparation method of described syrup is specially: the first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with filtrate that second step obtains, adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and hold over night is filtered, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution;
The 4th step, other gets sucrose and decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, the volatile oil that adding antiseptic, second step obtain, the powder that the first step obtains, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 3g/ml~4g/ml, packing, sterilization namely gets described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portions~120 weight portions, and the addition of described antiseptic is 0.5 weight portion~1 weight portion.
The present invention also provides a kind of Chinese medicine composition composition powders that is used for the treatment of menopausal syndrome, and the crude drug of described powder comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Wherein, the preparation method of described powder is specially: the first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, add after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate, the filtrate concentrating under reduced pressure obtains and gets dry extract, and is ground into powder;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mixes with filtrate that second step obtains, the adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), hold over night, filter, filtrate decompression is concentrated, obtains to get dry extract, and is ground into powder;
The 4th step, use ethanol with the dilution proportion of volume ratio 1:1 ~ 1:2 the volatile oil that second step obtains, it is for subsequent use to get volatile oil ethanol dilution liquid, takes by weighing beta-schardinger dextrin-and places container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after the dilution slowly is added in the beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h get Benexate Hydrochloride, and be for subsequent use;
The 5th step, the powder of the first step to the three steps acquisition and the Benexate Hydrochloride of the 4th step acquisition are mixed, be ground into 100 orders ~ 150 purpose powder, vacuum drying obtains powder.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention, it can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better, can not have side effects, and prevents the generation of complication.
The specific embodiment
" Plain Questions innocent opinion in ancient times " said: " seven years old kidney qi of woman contained, and dental transition is sent out long; 27 and the menarche, conception vessel is logical, and taichong channel is contained, and regular menstrual cycle is so there is son ... seventy-seven conception vessels are empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, and menopause is so senile appearance and loss of fecundity are also." namely be description living, long to the women, strong, old, own physiological change rule.Woman seventy-seven front and back were closed on through disconnected year, ' decline kidney qi day, menses will exhaust, and rush gradually void of wantonly two arteries and veins, decrease fertility so that disappear.Most women can tide over smoothly, and are a part of then because the difference of the aspects such as body constitution, delivery and feed infant, work and rest, society and Nervous and Mental Factors, body can not adapt to these physiological changies, the generation of imbalance between YIN and YANG initiation primary disease occurs.
For climacteric syndrome, there are no independently name of disease record, also can seek without traditional typing standard in ancient doctor's nationality.Its clinical manifestation sporadically appears in the discussion of the diseases such as " hysteria ", " senile metrorrhagia ", " Bulbus Lilii syndrome ", " melancholia ", " being insomnia ".The generation of woman's menstruation and kidney,spleen,liver three are dirty closely related, and wherein the kidney being the origin of congenital constitution, and store essential substances gas and main reproduction are to the important role of rising of menstruation; The spleen being the foundation of acquired constitution, main transporting, spleen and stomach function is sound, and then QI and blood biochemistry is active, sea of blood spill-over, menstruation can be risen on time; Blood stored in the liver, main catharsis has important regulating action in the cyclically-varying of menstruation.When it is close on 40, step into presenium from the middle age, the imbalance of kidney spleen hepatic insufficiency, menstruation is gradually from having to nothing, if produced climacteric syndrome just human body can not adapt to this process.
Climacteric the kidney qi degradation, menses will exhaust.Punching appoints a uterine function to go down, and menoxenia and arriving is broken off, and is the female reproduction physiological phenomenon originally.Because of some women's renal failure degree too early or overrun, or stronger because of the interference of the factor such as social, psychological, cause the yin and yang imbalance of kidney, conscience gas fire is contained partially, a punching QI and blood can not be let out down, superinverse is violated in the heart, liver, spleen, series of symptoms then occurs.Sick position is mainly at kidney, and the pathogenesis main points are the kidney qi degradation, and virtual loss is appointed in punching, and menses will exhaust, imbalance between YIN and YANG, and function is disorderly.Primary disease is the deficiency of both YIN and YANG of kidney, and how dirty can involve conscience spleen etc.; Be designated as the stagnation of QI, belonging to the card of deficiency in origin and excess in superficiality, in the treatment, in restoring normal coordination between the heart and kidney, Long Lu Zishuiqinggan, harmonizing the functional activities of vital QI, blood circulation promoting and blood stasis dispelling should be carried throughout.
The married woman is take blood as this, take gas as usefulness, QI and blood be through, pregnant, produce, the material base of breast, and internal organs are energy and blood of human body the source of vital function, and are wherein particularly crucial with the effect of liver spleen kidney.The kidney being the origin of congenital constitution, store essential substances, and main reproduction, the vital essence of being hidden in the kidney is the basic of human body growth promoter and reproduction, to the important role of rising of women's menstruation.Menses is that essence in kidney fills the product when arriving to a certain degree, has the human body reproductive organ of promotion maturation, and keeps the material of reproductive function.Essence is again for changing the source of blood, can be for the passing through of uterus, tire is pregnant provides material base, the generation of Woman climacteric disease with rush conception vessel void, exhaustion of kidney-essence with promoting reproductive function, asthenia of renal qi is relevant.
The spleen being the foundation of acquired constitution, main transporting is source of generating QI and blood.The women is take blood as this, menstruation, tire are pregnant, suckling is all take blood as usefulness, the generation of blood not only needs essence of water and grain as material base, the transporting that also must rely on spleen just can become Tianjin blood, and spleen and stomach function is sound, and then QI and blood biochemistry is active, sea of blood spill-over, menstruation can be risen on time, the treatment primary disease should be mended thanks to exhausting of congenital kidney essense with acquired essence, contains by ridging and educates the five internal organs, YIN and YANG balance regulating.
Liver is to the particularly important blood stored in the liver of women, and main catharsis has important regulating action in the cyclically-varying of menstruation, the blood of each oneization life of whole body, except the nutrition whole body, remainder, at woman's sea of blood of then making a bet, regularly hide and rush down and be menstruation, thus saying of " woman being take liver as congenital " arranged, although menstruation go out in kidney, whether normal, with kidney or logical or close relevantly, but on the function of regulating menstruation, be subject to the direct impact of liver.
The traditional Chinese medical science is also thought kidney qi degradation before and after menopause, and punching is appointed deficient, and menses gradually exhausts, yin and yang imbalance, and the internal organs qi and blood disorder, depressed emotion does not relax in addition, depression of liver-QI, the wet operation of water is obstructed, the poly-wet expectorant that is, stagnation of Qi and phelgm checks ascending or descending movement of vital Qi, and causes primary disease.Its sick this is being suffered from a deficiency of the kidney, and involves the internal organs such as the heart, liver, spleen.According to forefathers' " all kinds of diseases and ailments hold concurrently expectorant ", " none disease does not concern expectorant ", " sending out of expectorant and fire do not arranged, not owing to void also." understanding, weakened body resistance is this, expectorant is turbid to be mark, therefore treatment is upper should adopt activating QI to eliminate phlegm, the method for enriching yin and nourishing kidney is with coordinating YIN and YANG, is in harmonious proportion punching times.
In sum, theoretical to the understanding of menopausal syndrome and treatment according to the traditional Chinese medical science, the present invention proposes with nourishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, calming heart and tranquilizing mind, blood circulation promoting and blood stasis dispelling, activating QI to eliminate phlegm is the Therapeutic Principle, proposed a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome, it comprises following crude drug: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition only is made of the above-mentioned raw materials medicine.
In the side, Semen Nigellae, the Rhizoma Curculiginis warming the kidney to invigorate YANG, promoting the flow of QI-blood by warming the meridian, has the oestrogen-like hormone effect, again without bad side effect, can regulate the function of hypothalmus-pituitary-adrenal axis, antioxidation is arranged, antidotal effect, thereby play the effect that prevents and treats climacteric syndrome, Fructus Rosae Laevigatae invigorating the liver and kidney replenishing QI and blood and take the photograph vigour, Semen Platycladi, the Radix Polygalae mind calming is decided gas and is calmed the nerves, the Herba Cistanches kidney-replenishing, benefiting essence-blood, Spica Prunellae, Semen Celosiae, Semen Phaseoli the kidney invigorating watery diarrhea liver-fire, Cortex Phellodendri is cold in nature and enter kidney channel, can reducing the minister-fire and hard kidney tonifying YIN, and Semen Sesami Nigrum, the Herba Ecliptae kidney tonifying is smart, nourishing YIN blood, the yin nourishing easing the affected liver, Colla Plastri Testudinis liver nourishing YANG hyperactivity suppressing, nourishing YIN and benefiting blood and reducing the asthenic fever, Rhizoma Curcumae, the Pollen Typhae blood circulation promoting and blood stasis dispelling, the Lignum Dalbergiae Odoriferae blood-activating and qi-promoting, it is cloudy that the Rhizoma Dioscoreae enriching spleen-QI is grown spleen, has training to mend the effect of first the foundation of acquired constitution, Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the Rhizoma Panacis Japonici promoting blood circulation to remove blood stasis, nourishing YIN lung moistening, the Radix Paeoniae Alba joint venture of nourishing blood, easing the affected liver to relieve pain, the Radix Salviae Miltiorrhizae vital energy regualting and blood circulation-promoting, to improve microcirculation, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis heat clearing away liver is flat, suppressing the hyperactive liver is calmed the nerves, the Caulis Bambusae In Taenia removing heat-phlegm, relieving restlessness is with all worries set aside, the Concha Ostreae suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, the Radix Achyranthis Bidentatae kidney tonifying, essence replenishing, get it and help the waist knee joint, benefit vigour, the effect of tonify deficiency labor is invigorated blood circulation in addition, in the descending effect side of priming, Xin Wen and bitter cold share, tonifying YANG and YIN nourishing develop simultaneously, not only mend but also not warm, kidney tonifying without scorching partially, make cloudy positive helping and fountainhead is inexhaustible, positive cloudy helping and biochemical infinite, reach the effect of YIN and YANG balancing, the Radix Changii moistening the lung and resolving phlegm, the yin nourishing stomach function regulating, the Pericarpium Citri Reticulatae activating QI to eliminate phlegm, the Semen Coicis invigorating spleen to remove dampness, wet and go expectorant to disappear, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, the kidney invigorating raw material components in the side can obviously improve estrogen level, have estrogen-like effects, and can build up resistance, defying age; The kidney tonifying, essence replenishing raw material components has the effect of short follicular development maturation, can obviously improve the blood confession in ovary and uterus, and all medicines share, and play altogether nourishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, the effect of calming heart and tranquilizing mind, blood circulation promoting and blood stasis dispelling, activating QI to eliminate phlegm.
Each crude drug pharmacology is as follows:
Semen Nigellae: latin name Nigellae Semen, sweet in the mouth, suffering, warm in nature, have kidney-tonifying and brain tonic, an effect of the lactogenesis that stimulates the menstrual flow, diuresis, cure mainly that tinnitus is forgetful, amenorrhea is newborn few, the cards such as pyretic stranguria, stranguria caused by urinary stone.
Rhizoma Curculiginis: acrid in the mouth, warm in nature, return kidney, Liver Channel, have the kidney warming sun, the effect of strengthening bone and muscle cures mainly the sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula, the cards such as yang deficiency cold diarrhea.
Fructus Rosae Laevigatae: latin name Rosae Laevigatae Fructus, sour in the mouth, sweet, property is puckery, flat, returns kidney, bladder, large intestine channel, has the controlling nocturnal emission with astringent drugs reducing urination, stopping metrorrhagia and leukorrhagia, the effect of relieving diarrhea with astringents cures mainly emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, the cards such as chronic diarrhea chronic dysentery.
Semen Platycladi: latin name Platycladi Semen, sweet in the mouth, property is flat, and GUIXIN, kidney, large intestine channel have tranquilizing by nourishing the heart, and the effect of loosening bowel to relieve constipation cures mainly restlessness of asrhenia type and insomnia, severe palpitation, the cards such as dryness of the intestine constipation.
Radix Polygalae: bitter in the mouth, suffering, slightly warm in nature, GUIXIN, kidney, lung meridian have the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminate the phlegm, and the effect of detumescence is used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, the cards such as breast swell and pain.
Herba Cistanches: sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation is used for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill.
Spica Prunellae: bitter in the mouth, suffering, cold in nature, enter liver, gallbladder meridian, have and relieve inflammation or internal heat, make eye bright, eliminating stagnation, the effect of detumescence cures mainly conjunctival congestion and swelling pain, order pearl nyctalgia, it is dizzy to have a headache, scrofula, goiter swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.
Semen Celosiae: bitter in the mouth, cold nature is returned Liver Channel, has purging liver-fire, and the effect of improving acuity of vision and removing nebula cures mainly liver-heat conjunctival congestion, the living nebula film of order, blurring of vision, the cards such as dizziness due to liver-fire.
Semen Sesami Nigrum: sweet in the mouth, property is flat, returns liver, kidney, large intestine channel, has invigorating the liver and kidney, benefiting essence-blood, the effect that intestine moistening is dry is used for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, the cards such as dryness of the intestine constipation.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis is used for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in the stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Cortex Phellodendri: latin name Phellodendri Chinensis Cortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, the hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus, Cortex Phellodendri has good antibacterial action to multiple gram-positive bacterium.
Colla Plastri Testudinis: latin name Testudinis Carapacis et Plastri Colla, salty in the mouth, sweet, cool in nature, return liver, kidney, heart channel, the effect of have YIN nourishing, nourish blood, stopping blooding cures mainly deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, soreness of the waist and knees, blood deficiency and yellow complexion, the cards such as bleeding not during menses.
Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature, enter liver, spleen channel, have the removing blood stasis circulation of qi promoting, the effect of removing food stagnancy pain relieving is for the lump in the abdomen mass in the abdomen of caused by energy stagnation and blood stasis, breast abdomen stasis of blood pain, amenorrhea, dysmenorrhea, abdominal distention, traumatic injury, the blood stasis card such as swell and ache, Rhizoma Curcumae can obviously increase femoral artery blood flow, and anticoagulant and antithrombotic form.
Pollen Typhae: sweet in the mouth, property is flat, enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.Be used for spitting blood epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature, return liver, spleen channel, have promoting flow of QI and blood, the effect of analgesic hemostatic.Be used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, the cards such as traumatic hemorrhage.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, little sweet, warm in nature, enter spleen, kidney, heart channel, has replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, be used for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity soft, be slow in action, the card such as the body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Rhizoma Panacis Japonici: latin name Panacis Japonici Rhizoma, sweet in the mouth, little hardship, warm in nature, return liver, spleen, lung meridian, have strengthening by means of tonics, eliminating stasis to stop pain, the effect that hemostasis is eliminated the phlegm cures mainly after being ill weakness, chronic cough spitting of blood, cough with copious phlegm, the cards such as injury from falling down.
The Radix Paeoniae Alba: latin name Paeoniae Radix Alba, bitter in the mouth, acid, cool in nature, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, inferior card is with in metrorrhagia.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, the removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, the effect of nourishing blood to tranquillize the mind cures mainly menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
Folium Apocyni Veneti: sweet in the mouth, hardship, cool in nature, enter Liver Channel, have suppressing the hyperactive liver and calm the nerves, the effect of clearing away heat and promoting diuresis is used for dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, the cards such as nephritis edema.
Ramulus Uncariae Cum Uncis: sweet in the mouth, slightly warm in nature enters Liver Channel, and the effect of heat clearing away, suppressing the hyperactive liver and subsiding YANG, relieving spasm by subduing liver-wind is arranged, and is mainly used in the anxious spasm of giving birth to due to wind or the liver-wind stirring up internally of heat, twitch, restlessness, excessive rising of liver-YANG or Liver Channel have the headache of heat dizzy, the cards such as conjunctival congestion and swelling pain.
Semen Phaseoli: latin name Vigae Semen, sweet in the mouth, acid, property is flat, has diuretic kinds that disappear, and the effect of removing toxic substances and promoting pus discharge is for cards such as edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Caulis Bambusae In Taenia: cold nature, sweet in the mouth attaches to the lung and stomach meridians, and has removing heat-phlegm, and the effect that relieves restlessness and prevents vomiting is held the cards such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.
Concha Ostreae: salty in the mouth, cold nature enters liver, gallbladder, kidney channel, has suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect, cure mainly vertigo and tinnitus, brothers' chatter, palpitation and insomnia, dysphoria, infantile convulsion is demented, the scrofula goiter, the breast caking, spontaneous sweating, seminal emission frequent micturition, bleeding not during menses, acid regurgitation stomachache, the cards such as eczema skin infection.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat, enters liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, the effect of inducing diuresis for treating stranguria syndrome, treatment soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, lump in the abdomen, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, the cards such as laryngopharynx swelling and pain.
Radix Changii: sweet in the mouth, little hardship, cold nature is returned lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, the yin nourishing stomach function regulating, the effect of suppressing the hyperactive liver detoxifcation is used for the cough due to lung-heat, vomiting regurgitation, the lack of appetite xerostomia, conjunctival congestion is dizzy, the cards such as furunculosis skin infection.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, hot loose logical temperature, fragrant odour is longer than and is regulated the flow of vital energy, and can enter the spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, be used for lung qi and gather around the cards such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen.
Semen Coicis: latin name Coicis Semen, sweet in the mouth, light, cold nature enters lung, spleen, large intestine channel, has invigorating the spleen to arrest diarrhea, the diuretic eliminating impediment, the effect of row's skin ulcer pus cures mainly wet the having loose bowels of lung stomach of being stranded; Damp is invaded the hydrosarca of stain skin, dysuria; The damp and hot resistance in the numbness of QI and blood passes to and the scorchingly hot cards such as lung abscess in the lung intestinal, acute appendicitis that pent up.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
On the treatment menopausal syndrome, the Chinese medicine composition of the present invention's preparation has the patient of adjusting internal organs equilibrium between yin and yang, regulates the internal organs physiological function, improve the blood supply of ovary etc., thereby delay the aging of ovary, keep ovarian function, play the effect that prevents and treats climacteric syndrome.
The weight portion of each crude drug is respectively Semen Nigellae 49 weight portions ~ 59 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 36 weight portions ~ 46 weight portions, Fructus Rosae Laevigatae 31 weight portions ~ 41 weight portions, Semen Platycladi 17 weight portions ~ 27 weight portions, Radix Polygalae 21 weight portions ~ 31 weight portions, Herba Cistanches 42 weight portions ~ 52 weight portions, Spica Prunellae 26 weight portions ~ 36 weight portions, Semen Celosiae 23 weight portions ~ 33 weight portions, Semen Sesami Nigrum 57 weight portions ~ 67 weight portions, Herba Ecliptae 73 weight portions ~ 83 weight portions, Cortex Phellodendri 43 weight portions ~ 53 weight portions, Colla Plastri Testudinis 51 weight portions ~ 61 weight portions, Rhizoma Curcumae 21 weight portions ~ 31 weight portions, Pollen Typhae 33 weight portions ~ 43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portions ~ 29 weight portions, Rhizoma Dioscoreae 82 weight portions ~ 92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portions ~ 70 weight portions, Rhizoma Panacis Japonici 43 weight portions ~ 53 weight portions, the Radix Paeoniae Alba 22 weight portions ~ 32 weight portions, Radix Salviae Miltiorrhizae 31 weight portions ~ 41 weight portions, Folium Apocyni Veneti 16 weight portions ~ 26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portions ~ 37 weight portions, Semen Phaseoli 16 weight portions ~ 26 weight portions, Caulis Bambusae In Taenia 13 weight portions ~ 23 weight portions, Concha Ostreae 9 weight portions ~ 19 weight portions, Radix Achyranthis Bidentatae 39 weight portions ~ 49 weight portions, Radix Changii 23 weight portions ~ 33 weight portions, Pericarpium Citri Reticulatae 51 weight portions ~ 61 weight portions, Semen Coicis 22 weight portions ~ 32 weight portions, Radix Glycyrrhizae 27 weight portions ~ 37 weight portions.
The weight portion of each crude drug further preferably is respectively Semen Nigellae 51 weight portions ~ 57 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 38 weight portions ~ 44 weight portions, Fructus Rosae Laevigatae 33 weight portions ~ 39 weight portions, Semen Platycladi 19 weight portions ~ 25 weight portions, Radix Polygalae 23 weight portions ~ 29 weight portions, Herba Cistanches 44 weight portions ~ 50 weight portions, Spica Prunellae 28 weight portions ~ 34 weight portions, Semen Celosiae 25 weight portions ~ 31 weight portions, Semen Sesami Nigrum 59 weight portions ~ 65 weight portions, Herba Ecliptae 75 weight portions ~ 81 weight portions, Cortex Phellodendri 45 weight portions ~ 51 weight portions, Colla Plastri Testudinis 53 weight portions ~ 59 weight portions, Rhizoma Curcumae 23 weight portions ~ 29 weight portions, Pollen Typhae 35 weight portions ~ 41 weight portions, Lignum Dalbergiae Odoriferae 21 weight portions ~ 27 weight portions, Rhizoma Dioscoreae 84 weight portions ~ 90 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portions ~ 68 weight portions, Rhizoma Panacis Japonici 45 weight portions ~ 51 weight portions, the Radix Paeoniae Alba 24 weight portions ~ 30 weight portions, Radix Salviae Miltiorrhizae 33 weight portions ~ 39 weight portions, Folium Apocyni Veneti 18 weight portions ~ 24 weight portions, Ramulus Uncariae Cum Uncis 29 weight portions ~ 35 weight portions, Semen Phaseoli 18 weight portions ~ 24 weight portions, Caulis Bambusae In Taenia 15 weight portions ~ 21 weight portions, Concha Ostreae 11 weight portions ~ 17 weight portions, Radix Achyranthis Bidentatae 41 weight portions ~ 47 weight portions, Radix Changii 25 weight portions ~ 31 weight portions, Pericarpium Citri Reticulatae 53 weight portions ~ 59 weight portions, Semen Coicis 24 weight portions ~ 30 weight portions, Radix Glycyrrhizae 29 weight portions ~ 35 weight portions.
The weight portion of each crude drug most preferably is respectively Semen Nigellae 54 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 41 weight portions, Fructus Rosae Laevigatae 36 weight portions, Semen Platycladi 22 weight portions, Radix Polygalae 26 weight portions, Herba Cistanches 47 weight portions, Spica Prunellae 31 weight portions, Semen Celosiae 28 weight portions, Semen Sesami Nigrum 62 weight portions, Herba Ecliptae 78 weight portions, Cortex Phellodendri 48 weight portions, Colla Plastri Testudinis 56 weight portions, Rhizoma Curcumae 26 weight portions, Pollen Typhae 38 weight portions, Lignum Dalbergiae Odoriferae 24 weight portions, Rhizoma Dioscoreae 87 weight portions, Radix Et Caulis Acanthopanacis Senticosi 65 weight portions, Rhizoma Panacis Japonici 48 weight portions, the Radix Paeoniae Alba 27 weight portions, Radix Salviae Miltiorrhizae 36 weight portions, Folium Apocyni Veneti 21 weight portions, Ramulus Uncariae Cum Uncis 32 weight portions, Semen Phaseoli 21 weight portions, Caulis Bambusae In Taenia 18 weight portions, Concha Ostreae 14 weight portions, Radix Achyranthis Bidentatae 44 weight portions, Radix Changii 28 weight portions, Pericarpium Citri Reticulatae 56 weight portions, Semen Coicis 27 weight portions, Radix Glycyrrhizae 32 weight portions.
Above-mentioned Chinese medicine composition provided by the invention is oral drugs, can be prepared into any peroral dosage form, such as tablet, powder, soft capsule, oral liquid, syrup, pill, is preferably syrup and powder.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is syrup, is specially:
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with filtrate that second step obtains, adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and hold over night is filtered, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution;
The 4th step, other gets sucrose and decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, the volatile oil that adding antiseptic, second step obtain, the powder that the first step obtains, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 3g/ml~4g/ml, packing, sterilization namely gets described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portions~120 weight portions, and the addition of described antiseptic is 0.5 weight portion~1 weight portion.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, is specially:
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, add after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate, the filtrate concentrating under reduced pressure obtains and gets dry extract, and is ground into powder;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mixes with filtrate that second step obtains, the adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), hold over night, filter, filtrate decompression is concentrated, obtains to get dry extract, and is ground into powder;
The 4th step, use ethanol with the dilution proportion of volume ratio 1:1 ~ 1:2 the volatile oil that second step obtains, it is for subsequent use to get volatile oil ethanol dilution liquid, takes by weighing beta-schardinger dextrin-and places container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after the dilution slowly is added in the beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h get Benexate Hydrochloride, and be for subsequent use;
The 5th step, the powder of the first step to the three steps acquisition and the Benexate Hydrochloride of the 4th step acquisition are mixed, be ground into 100 orders ~ 150 purpose powder, vacuum drying obtains powder.
The present invention also provide above-mentioned Chinese medicine composition for the preparation of the treatment menopausal syndrome medicine in application.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
Embodiment 1 syrup 1
The 56g Colla Plastri Testudinis is being ground into powder after the lyophilization under the temperature of-14 ℃ of degree, with Semen Nigellae 54g, Rhizoma Curculiginis 41g, Fructus Rosae Laevigatae 36g, Herba Cistanches 47g, Herba Ecliptae 78g, Rhizoma Dioscoreae 87g, Radix Et Caulis Acanthopanacis Senticosi 65g, Rhizoma Panacis Japonici 48g, Radix Achyranthis Bidentatae 44g, Semen Sesami Nigrum 62g mixes, add the 5kg distilled water after the pulverizing, after jolting mixes, soak 40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃ of little 8h of boiling, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 2h, filter, obtain filtrate, with Semen Platycladi 22g, Radix Polygalae 26g, Spica Prunellae 31g, Semen Celosiae 28g, Cortex Phellodendri 48g, Rhizoma Curcumae 26g, Pollen Typhae 38g, Lignum Dalbergiae Odoriferae 24g, Radix Paeoniae Alba 27g, Radix Salviae Miltiorrhizae 36g, Folium Apocyni Veneti 21g, Ramulus Uncariae Cum Uncis 32g, Semen Phaseoli 21g, Caulis Bambusae In Taenia 18g, Concha Ostreae 14g, Radix Changii 28g, Pericarpium Citri Reticulatae 56g, Semen Coicis 27g, Radix Glycyrrhizae 32g mixes, the distilled water that adds 2.8kg, boil 5h, filter, again add the distilled water of 1.5kg, boil 3h, filter, filtrate is merged, and mix with the filtrate that obtains previously, adding determining alcohol is that 80% ethanol to alcohol volume content is 60% (V/V), hold over night, filter, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution, and the sucrose that other gets 1.2kg decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, add preservative sodium benzoate 65g, the volatile oil that the front obtains, powder, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 4g/ml, packing, sterilization namely gets described syrup.
Embodiment 2 syrups 2
The 53g Colla Plastri Testudinis is being ground into powder after the lyophilization under the temperature of-14 ℃ of degree, with Semen Nigellae 51g, Rhizoma Curculiginis 38g, Fructus Rosae Laevigatae 33g, Herba Cistanches 44g, Herba Ecliptae 75g, Rhizoma Dioscoreae 84g, Radix Et Caulis Acanthopanacis Senticosi 62g, Rhizoma Panacis Japonici 45g, Radix Achyranthis Bidentatae 41g, Semen Sesami Nigrum 59g mixes, add the 4.6kg distilled water after the pulverizing, after jolting mixes, soak 40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃ of little 8h of boiling, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 2h, filter, obtain filtrate, with Semen Platycladi 19g, Radix Polygalae 23g, Spica Prunellae 28g, Semen Celosiae 25g, Cortex Phellodendri 45g, Rhizoma Curcumae 23g, Pollen Typhae 35g, Lignum Dalbergiae Odoriferae 21g, Radix Paeoniae Alba 24g, Radix Salviae Miltiorrhizae 33g, Folium Apocyni Veneti 18g, Ramulus Uncariae Cum Uncis 29g, Semen Phaseoli 18g, Caulis Bambusae In Taenia 15g, Concha Ostreae 11g, Radix Changii 25g, Pericarpium Citri Reticulatae 53g, Semen Coicis 24g, Radix Glycyrrhizae 29g mixes, the distilled water that adds 2.5kg, boil 5h, filter, again add the distilled water of 1.2kg, boil 3h, filter, filtrate is merged, and mix with the filtrate that obtains previously, adding determining alcohol is that 80% ethanol to alcohol volume content is 60% (V/V), hold over night, filter, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution, and the sucrose that other gets 1.1kg decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, add preservative sodium benzoate 65g, the volatile oil that the front obtains, powder, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 4g/ml, packing, sterilization namely gets described syrup.
Embodiment 3 syrups 3
The 59g Colla Plastri Testudinis is being ground into powder after the lyophilization under the temperature of-14 ℃ of degree, with Semen Nigellae 57g, Rhizoma Curculiginis 44g, Fructus Rosae Laevigatae 39g, Herba Cistanches 50g, Herba Ecliptae 81g, Rhizoma Dioscoreae 90g, Radix Et Caulis Acanthopanacis Senticosi 68g, Rhizoma Panacis Japonici 51g, Radix Achyranthis Bidentatae 47g, Semen Sesami Nigrum 65g mixes, add the 5.3kg distilled water after the pulverizing, after jolting mixes, soak 40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃ of little 8h of boiling, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 2h, filter, obtain filtrate, with Semen Platycladi 25g, Radix Polygalae 29g, Spica Prunellae 34g, Semen Celosiae 31g, Cortex Phellodendri 51g, Rhizoma Curcumae 29g, Pollen Typhae 41g, Lignum Dalbergiae Odoriferae 27g, Radix Paeoniae Alba 30g, Radix Salviae Miltiorrhizae 39g, Folium Apocyni Veneti 24g, Ramulus Uncariae Cum Uncis 35g, Semen Phaseoli 24g, Caulis Bambusae In Taenia 21g, Concha Ostreae 17g, Radix Changii 31g, Pericarpium Citri Reticulatae 59g, Semen Coicis 30g, Radix Glycyrrhizae 35g mixes, the distilled water that adds 3.2kg, boil 5h, filter, again add the distilled water of 1.8kg, boil 3h, filter, filtrate is merged, and mix with the filtrate that obtains previously, adding determining alcohol is that 75% ethanol to alcohol volume content is 60% (V/V), hold over night, filter, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution, and the sucrose that other gets 1.2kg decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, add preservative sodium benzoate 65g, the volatile oil that the front obtains, powder, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 4g/ml, packing, sterilization namely gets described syrup.
Embodiment 4 powders 1
The 56g Colla Plastri Testudinis is being ground into powder after the lyophilization under the temperature of-14 ℃ of degree, with Semen Nigellae 54g, Rhizoma Curculiginis 41g, Fructus Rosae Laevigatae 36g, Herba Cistanches 47g, Herba Ecliptae 78g, Rhizoma Dioscoreae 87g, Radix Et Caulis Acanthopanacis Senticosi 65g, Rhizoma Panacis Japonici 48g, Radix Achyranthis Bidentatae 44g, Semen Sesami Nigrum 62g mixes, add the 5kg distilled water after the pulverizing, after jolting mixes, soak 40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃ of little 8h of boiling, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 2h, filter, obtain filtrate, with Semen Platycladi 22g, Radix Polygalae 26g, Spica Prunellae 31g, Semen Celosiae 28g, Cortex Phellodendri 48g, Rhizoma Curcumae 26g, Pollen Typhae 38g, Lignum Dalbergiae Odoriferae 24g, Radix Paeoniae Alba 27g, Radix Salviae Miltiorrhizae 36g, Folium Apocyni Veneti 21g, Ramulus Uncariae Cum Uncis 32g, Semen Phaseoli 21g, Caulis Bambusae In Taenia 18g, Concha Ostreae 14g, Radix Changii 28g, Pericarpium Citri Reticulatae 56g, Semen Coicis 27g, Radix Glycyrrhizae 32g mixes, the distilled water that adds 2.8kg, boil 5h, filter, the distilled water that again adds 1.5kg, boil 3h, filter, filtrate is merged, and mix with the filtrate that obtains previously, adding determining alcohol is that 80% ethanol to alcohol volume content is 60% (V/V), hold over night, filter, filtrate decompression is concentrated, obtain and get dry extract, be ground into powder, use ethanol with the dilution proportion of volume ratio 1:1 the volatile oil that obtains previously, it is for subsequent use to get volatile oil ethanol dilution liquid, take by weighing beta-schardinger dextrin-and place container, adding distil water stirs under 60 ℃ of constant temperature with the ratio heating for dissolving of 1:5, and the volatile oil after the dilution slowly is added in the beta-schardinger dextrin-solution, stir 3h, put into 4 ℃ of cold preservation 24h of refrigerator, sucking filtration, dry 8h gets Benexate Hydrochloride, the powder and the Benexate Hydrochloride that obtain are previously mixed, be ground into 100 purpose powder, vacuum drying obtains powder.
Embodiment 5 acute toxicity testings
Choose 20 of kunming mices, male and female half and half are provided by Qingdao City's laboratory animal and zoopery center, body weight is 22.17 ± 1.35g, presses dosage gastric infusion every day of 60ml/kg, at twice administration, wherein, the direct gavage of syrup of embodiment 1 to embodiment 3 is in mice, and the powder of embodiment 4 is dissolved in the distilled water, be mixed with the solution that crude drug concentration is 4g/ml, gavage mice, twice on the one, observed seven, without unusual phenomenon, without dead, body weight increases to 28.61 ± 1.72g.
The syrup of Chinese medicine composition of the present invention and powder clinical medicine dose are 10mL * 2=20ml every day, crude drug concentration is 4g/ml, become body weight for humans by 60kg, then adult's oral dose is 20ml/60kg=0.33ml/kg, mice dosage every day is 60ml/kg, and quite the 60/0.33=182 of people's consumption doubly.
The result: Chinese medicine composition of the present invention is nontoxic.
Embodiment 6 Experiments of Zoology
Laboratory animal
Female SPF SD rat, 190~210g, provided by Qingdao City's laboratory animal and zoopery center, be divided at random blank group, model group and traditional Chinese medicine composition for treating group of the present invention by body weight, every group 10, raise in 22~26 ℃ of room temperatures, relative humidity 40%~70% barrier environment is pressed the circadian rhythm illumination.
Experiment reagent and instrument
High performance liquid chromatograph (Agilent1100); Phenomenex Luna C 18Reversed phase chromatographic column, G1321A fluorescence detector (Agilent1100); Estradiol (E 2), follicle stimulating hormone (FSH), lutropin (LH) radioimmunoassay determination box, provide by Qingdao Better Biotechnology Co., Ltd..5-hydroxy tryptamine (5-HT), norepinephrine (NE), dopamine (DA) standard substance: U.S. Sigma company product.
The animal model administration
Except the blank group, other rats pentobarbital sodium 50mgkg -1Intraperitoneal injection of anesthesia, except Normal group, other 2 groups of rats pentobarbital sodium 40mg/kg intraperitoneal injection of anesthesia, the abdomen position is fixed, under rat back most end rib, and midaxillary line and apart from the about 2cm infall cropping of the spinal column outside, cut skin and the about 1.5-2cm of dorsal muscles, the shinny liparitosis of a visible milky in the otch visual field, fractionation of fatty group just can see a thin-line-shaped irregular ovary that is yellowish red color.First fallopian tube under the ovary (comprising fat) is used the fine rule ligation during clip, extract ovary again, postoperative is sent cornua uteri in the abdominal cavity back to, and suture muscles and skin are extractd the opposite side ovary with method, blank group rats underwent surgical exposure but non-spay.Postoperative continuous 3d intramuscular injection penicillin is in case infect.Postoperative carried out vaginal smear on the 5th day, and once-a-day, 5d excises fully with definite ovary continuously.Postoperative the 9th day beginning gastric infusion, the syrup 1 of the treatment group gavage embodiment of the invention 1 preparation, directly gavage is in rat, and the gavage amount is 6.5g/kg (is equivalent to clinical dosage 5 times), once-a-day, continuous 14d; Blank group and model control group gavage equal-volume pure water (10mLkg -1).
Index detects and statistics
24h after the last administration, each organizes the anesthesia of rat pentobarbital sodium, abdominal aortic blood, centrifugalize serum is measured E by the medicine box description with putting the method for exempting from 2, FSH, LH; With get behind the blood animal rapidly broken end take off thalamus, measure Hypothalamic Neurotransmitter 5-HT, NE, DA content with chemiluminescence.
Dissect behind the sacrifice of animal, get the uterus and the adrenal gland weighs, calculate organ coefficient.
Statistical method
Measurement data adopts χ is relatively adopted in expression between group 2Check, all data all adopt the SPSS12.0 statistical software to process.
The result
Each organizes rat blood serum E 2, FSH, LH change relatively, the results are shown in Table 1.
Table 1 climacteric model is respectively organized rat blood serum E 2, FSH, LH change relatively
Grouping E 2(pg·mL -1) FSH(mIU·mL -1) LH(mIU·mL -1)
Matched group 6.39±0.81 1.51±0.46 3.71±0.80
Model group 3.17±0.62 3.02±0.80 6.01±1.02
Treatment group 5.22±0.72 2.29±0.61 4.77±0.61
As can be seen from Table 1, compare the serum E of model group with the blank group 2Level obviously reduces, and FSH, LH level obviously raise, and adopts the treatment of Chinese medicine composition of the present invention, can significantly improve E 2Level reduces FSH, LH level.
Each organizes rat 5-HT, NE, DA changes relatively, the results are shown in Table 2.
Table 2 climacteric model is respectively organized rat 5-HT, NE, DA changes relatively (ng/mg)
Grouping 5-HT NE DA
Matched group 0.68±0.17 1.53±0.29 0.46±0.13
Model group 1.07±0.23 1.03±0.42 0.31±0.05
Treatment group 0.81±0.12 1.38±0.35 0.41±0.07
As can be seen from Table 2, compare with the blank group, Ovariectomy model rat hypothalamus 5-HT content obviously raises, and NE, DA content obviously reduce, and the Chinese medicine composition of taking the present invention's preparation can obviously reduce ovariectomized female rats hypothalamus 5-HT content, increases NE, DA content.
Impact on the hot flushes in rats organ coefficient the results are shown in Table 3.
Table 3 climacteric model is respectively organized the impact of Rats Organs and Tissues coefficient
Group The uterus coefficient Adrenal gland's coefficient
Matched group 0.194±0.052 0.033±0.006
Model group 0.129±0.038 0.026±0.003
Treatment group 0.172±0.043 0.030±0.005
As can be seen from Table 3, compare with the blank group, Ovariectomy model rat uterus coefficient and adrenal gland's coefficient obviously reduce, and can obviously increase ovariectomized female rats uterus coefficient by the Chinese medicine composition of taking the present invention's preparation; Each administration group of adrenal gland's coefficient is all increased without obvious than model group.
Embodiment 8 model cases
Example 1: Wu so-and-so, woman, 47 years old.First visit on March 23 in 2009, readme began menstruation irregularis before half a year, and paroxysmal is warmed flushing, the hectic fever sweating, a moment, Western medicine diagnose was climacteric syndrome from slow, the medicine therapeutic effect such as oral brain-refreshing essence tablet are not good.Nearly half a year irregular menses, above-mentioned symptom increases the weight of and accompanies feverish sensation in the palms and soles, irritated insomnia, cardiopalmus, soreness of waist and knee joint, xerostomia constipation, body of the tongue is partially red, white and thin fur, thready and stringy pulse.Electrocardioscopy is shown roughly normal, and chemoluminescence method inspectability hormonal readiness shows: E 2<20Pg/ml, FSH95mlu/ml, LH48mlu/ml takes the syrup of the embodiment of the invention 1 preparation, sooner or later each 1 time, each 10ml, 7 days 1 courses for the treatment of, spirit takes a turn for the better after 2 courses for the treatment of, primary symptom obviously alleviates, and continual cure is treated 2 courses for the treatment of, and remaining disease knowing removed, and follows up a case by regular visits to after half a year without recurrence.
Example 2: patient Liu, the woman, 41 years old, main cause " a dizzy week ", on January 22nd, 2009 is medical.Patient nearly February, Hypomenorrhea, cycle delay occurred dizzyly before one week, ignore thing rotation, headache, the companion is nervous, and is weak, lumbago, the costa sternales feeling of distension and oppression, bitter taste feels depressed, and worries too much, the poor dreaminess of sleeping, poor appetite, two just can, slightly sweating, red tongue, thin fur, stringy and thready pulse.Blood pressure 130/80mmHg is diagnosed as climacteric syndrome, takes the syrup of the embodiment of the invention 1 preparation, each 1 time sooner or later, each 10ml, 7 days 1 courses for the treatment of, primary symptom obviously alleviates after 10 days, continual cure 10 days, without obvious disease, by drug withdrawal, follow up a case by regular visits to after half a year without recurrence.
Example 3: Lee, the first visit in 12, of 45,2008 on Decembers, the main suit: menoxenia appears closely over the past half year, normal sense headache, bitter taste in the mouth and dry throat, vexed suspicious, whole body is warmed and is perspired, constipation with dry stool, the symptoms such as vexed insomnia.Disease is seen: spirit is relatively poor, tongue tip side of red, thin white fur of tongue, stringy and thready pulse is diagnosed as climacteric syndrome, takes the syrup of the embodiment of the invention 1 preparation, sooner or later each 1 time, each 10ml, 7 days 1 courses for the treatment of, the self-induction symptom takes a turn for the better after 7 days, perspire and insomnia but still have, continual cure drug withdrawal after 2 courses for the treatment of, with examining half a year, above-mentioned symptom is without repeatedly.
Embodiment 9 clinical datas
Diagnostic criteria
The diagnosis of climacteric syndrome Chinese medical discrimination is according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine, published in 1994) and " Gynecology of Chinese Medicine " (Shanghai science tech publishing house, published in 1997) judge pattern of syndrome, this studies the dialectical spleen kidney both deficiency type that is of selected case.Primary symptom: hectic fever antiperspirant goes out; Inferior disease: the confusion of the menstrual cycle, dizziness and tinnitus, spiritlessness and weakness, sensation of oppression over the chest with shortness of breath, appetite and hyposexuality, waist soreness, the few tongue of light red tongue, deep and weak pulse.Primary symptom is indispensable, and inferior disease is namely diagnosable more than 3.
Climacteric syndrome Western medicine diagnose standard is determined according to " diagnosis of common disease and curative effect determinate standard ".1. 45~60 years old age, amenorrhea is more than 1 year, hectic fever, cardiopalmus, depression, insomnia, emotional, fluctuation of blood pressure occur, systolic pressure raises and the performance such as paresthesia of skin.2. blood, urinary fsh (FSH) and interstitialcellstimulating hormone (ICSH) (LH) obviously rise, estradiol (E 2) (being lower than the early stage level of follicle) descends.3. secondary sex characteristics can have degeneration in various degree.4. the genitals can have atrophy in various degree, sometimes concurrent vaginitis.
Inclusive criteria
1. without mammary gland fibroma, cyclomastopathy, breast carcinoma, cervical cancer and other malignant tumor histories; 2. non-diabetic and other endocrinopathys; 3. do not take steroid or contraceptive, do not take lipid lowerers and anticoagulation; 4. without serious hypertension and venous thrombosis; 5. electrocardiogram is got rid of patients with coronary heart disease; Suspected Coronary Heart Disease is done angiography by Vasculocardiology Deparment to be got rid of; 6. hepatic and renal function is normal.
Physical data
Object of study is in August, 2008~2010 medical climacteric syndrome patient in year June, all meets diagnostic criteria and inclusive criteria.Divide at random treatment by Chinese herbs group 127 examples and western medicine group 113 examples by the table of random number method.46~60 years old treatment by Chinese herbs group age, average (50.4 ± 2.5) year; The course of disease 6 months~4.6 years, average (23.7 ± 9.8) individual month.45~59 years old western medicine group age, average (48.9 ± 2.3) year; The course of disease 8 months~4.2 years, average (21.5 ± 6.8) individual month.Two groups of patients' age, the course of disease, symptom degree no difference of science of statistics (P〉0.05), have comparability.
Grouping and administration
Western medicine group: use premarin and add medroxyprogestetone acetate.Adopt continuous therapy: premarin 0.625mg every day 1 time, oral; Medroxyprogestetone acetate 2mg, oral every day 1 time, totally 30 days.Take continuously according to clinical symptoms later on or took medicine again 3 months every other month.
The treatment by Chinese herbs group: take the syrup 1 of the embodiment of the invention 1 preparation, every day 2 times, each 10ml, each 1 time sooner or later, 1 month is 1 course for the treatment of, takes continuously 4 courses for the treatment of.
Observation index and method
The variation of symptom before and after the medication
The hectic fever sweating is divided into 4 minutes substantially, dizziness, tinnitus, tiredly is 2 minutes, and lumbago and skelalgia, uncomfortable in chest, appetite and hyposexuality etc. respectively are 1 minute.Every symptom according to the nothing of degree, light, in, heavy be that 0 minute, 1 minute, 2 minutes, 3 minutes degree is divided.Symptom score is the basic product that divides with degree that divides.Total points is each symptom score summation.Before relatively treating and the symptom score after treating.
Sex hormone measurement
E 2, FSH, L H, progesterone (P) detect the immunochemiluminescence method that all adopts, test kit provides by the rich bio tech ltd in sea, Qingdao.
Lipid determination
Adopt immunoturbidimetry to detect T-CHOL (TC), triglyceride (T G), HDL-C (HDL-C), low-density lipoprotein cholesterol (LDL-C), test kit provides by Qingdao Better Biotechnology Co., Ltd..
Treat 1 blood of 3 months check These parameters and monitorings, urine, the just inspections such as routine and hepatic and renal function, electrocardiogram.
Curative effect determinate standard
Draft with reference to " diagnosis of common disease and curative effect determinate standard ".Produce effects: hectic fever, sweating disappear, other transference cures or obviously alleviate; Effectively: hectic fever, sweating alleviate, other transference cures or obviously alleviate; Invalid: hectic fever, sweating and other symptoms are all without improving.
Statistical method
Measurement data adopts χ is relatively adopted in expression between group 2Check, all data all adopt the SPSS12.0 statistical software to process.
The result
The symptom overall score relatively the results are shown in Table 4 before and after two groups of patient treatments.
The symptom overall score relatively before and after the table 4 liang group patient treatment
Group The example number Before the treatment After the treatment
Treatment group 127 29.27±3.61 19.81±2.72
Matched group 113 27.92±2.56 23.73±2.95
As can be seen from Table 4, adopt after the traditional Chinese medicine composition for treating of the present invention treatment before, with respect to western medicine group, better efficacy.
Two groups of patient clinical curative effects relatively the results are shown in Table 5.
Table 5 liang group patient clinical curative effect relatively
Group The example number Produce effects Effectively Invalid Total effective rate (%)
Treatment group 127 75 37 15 88.2
Matched group 113 39 42 32 71.7
As can be seen from Table 5, adopt the clinical efficacy of Chinese medicine composition of the present invention to be better than western medicine group.
Serum sex hormone level relatively the results are shown in Table 6 before and after two groups of patient treatments.
Serum sex hormone level relatively before and after the table 6 liang group patient treatment
Group Time The example number E 2(pmol·L -1) FSH(IU·L -1) LH(IU·L -1)
Treatment group Before the treatment 127 43.51±9.22 86.13±7.91 79.62±6.35
? After the treatment 127 92.90±8.29 42.98±6.32 52.31±5.29
Matched group Before the treatment 113 45.26±7.33 84.72±7.43 80.06±6.40
? After the treatment 113 71.34±6.73 61.67±6.81 61.86±5.22
As can be seen from Table 6, adopt the Chinese medicine composition of the present invention E that can obviously raise 2Level, reduce FSH and L H level.
Blood lipid level relatively the results are shown in Table 8 before and after two groups of patient treatments.
Blood lipid level relatively before and after the table 8 liang group patient treatment
Group Time The example number TC TG HDL-C LDL-C
Treatment group Before the treatment 127 6.91±0.36 1.90±0.33 1.46±0.36 3.95±0.62
? After the treatment 127 5.31±0.27 1.13±0.41 1.21±0.22 2.31±0.49
Matched group Before the treatment 113 6.77±0.39 1.87±0.26 1.50±0.29 3.83±0.51
? After the treatment 113 5.93±0.42 1.42±0.51 1.32±0.40 2.81±0.23
As can be seen from Table 8, adopt Chinese medicine composition of the present invention can reduce TC, T G, LDL-C, HDL-C level.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims (10)

1. Chinese medicine composition that is used for the treatment of menopausal syndrome, it is characterized in that: the crude drug of this Chinese medicine composition comprises Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is respectively Semen Nigellae 49 weight portions ~ 59 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 36 weight portions ~ 46 weight portions, Fructus Rosae Laevigatae 31 weight portions ~ 41 weight portions, Semen Platycladi 17 weight portions ~ 27 weight portions, Radix Polygalae 21 weight portions ~ 31 weight portions, Herba Cistanches 42 weight portions ~ 52 weight portions, Spica Prunellae 26 weight portions ~ 36 weight portions, Semen Celosiae 23 weight portions ~ 33 weight portions, Semen Sesami Nigrum 57 weight portions ~ 67 weight portions, Herba Ecliptae 73 weight portions ~ 83 weight portions, Cortex Phellodendri 43 weight portions ~ 53 weight portions, Colla Plastri Testudinis 51 weight portions ~ 61 weight portions, Rhizoma Curcumae 21 weight portions ~ 31 weight portions, Pollen Typhae 33 weight portions ~ 43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portions ~ 29 weight portions, Rhizoma Dioscoreae 82 weight portions ~ 92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portions ~ 70 weight portions, Rhizoma Panacis Japonici 43 weight portions ~ 53 weight portions, the Radix Paeoniae Alba 22 weight portions ~ 32 weight portions, Radix Salviae Miltiorrhizae 31 weight portions ~ 41 weight portions, Folium Apocyni Veneti 16 weight portions ~ 26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portions ~ 37 weight portions, Semen Phaseoli 16 weight portions ~ 26 weight portions, Caulis Bambusae In Taenia 13 weight portions ~ 23 weight portions, Concha Ostreae 9 weight portions ~ 19 weight portions, Radix Achyranthis Bidentatae 39 weight portions ~ 49 weight portions, Radix Changii 23 weight portions ~ 33 weight portions, Pericarpium Citri Reticulatae 51 weight portions ~ 61 weight portions, Semen Coicis 22 weight portions ~ 32 weight portions, Radix Glycyrrhizae 27 weight portions ~ 37 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Semen Nigellae 51 weight portions ~ 57 weight portions in the described Chinese medicine composition, Rhizoma Curculiginis 38 weight portions ~ 44 weight portions, Fructus Rosae Laevigatae 33 weight portions ~ 39 weight portions, Semen Platycladi 19 weight portions ~ 25 weight portions, Radix Polygalae 23 weight portions ~ 29 weight portions, Herba Cistanches 44 weight portions ~ 50 weight portions, Spica Prunellae 28 weight portions ~ 34 weight portions, Semen Celosiae 25 weight portions ~ 31 weight portions, Semen Sesami Nigrum 59 weight portions ~ 65 weight portions, Herba Ecliptae 75 weight portions ~ 81 weight portions, Cortex Phellodendri 45 weight portions ~ 51 weight portions, Colla Plastri Testudinis 53 weight portions ~ 59 weight portions, Rhizoma Curcumae 23 weight portions ~ 29 weight portions, Pollen Typhae 35 weight portions ~ 41 weight portions, Lignum Dalbergiae Odoriferae 21 weight portions ~ 27 weight portions, Rhizoma Dioscoreae 84 weight portions ~ 90 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portions ~ 68 weight portions, Rhizoma Panacis Japonici 45 weight portions ~ 51 weight portions, the Radix Paeoniae Alba 24 weight portions ~ 30 weight portions, Radix Salviae Miltiorrhizae 33 weight portions ~ 39 weight portions, Folium Apocyni Veneti 18 weight portions ~ 24 weight portions, Ramulus Uncariae Cum Uncis 29 weight portions ~ 35 weight portions, Semen Phaseoli 18 weight portions ~ 24 weight portions, Caulis Bambusae In Taenia 15 weight portions ~ 21 weight portions, Concha Ostreae 11 weight portions ~ 17 weight portions, Radix Achyranthis Bidentatae 41 weight portions ~ 47 weight portions, Radix Changii 25 weight portions ~ 31 weight portions, Pericarpium Citri Reticulatae 53 weight portions ~ 59 weight portions, Semen Coicis 24 weight portions ~ 30 weight portions, Radix Glycyrrhizae 29 weight portions ~ 35 weight portions.
4. such as the described Chinese medicine composition of claims 1 to 3, it is characterized in that: the dosage form of described Chinese medicine composition is tablet, powder, soft capsule, oral liquid, syrup, pill.
5. the preparation method of the described Chinese medicine composition of claim 1 to 4, it is characterized in that: when the dosage form of described Chinese medicine composition was syrup, this preparation method was specially,
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with filtrate that second step obtains, adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and hold over night is filtered, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution;
The 4th step, other gets sucrose and decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, the volatile oil that adding antiseptic, second step obtain, the powder that the first step obtains, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 3g/ml~4g/ml, packing, sterilization namely gets described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portions~120 weight portions, and the addition of described antiseptic is 0.5 weight portion~1 weight portion.
6. the preparation method of the described Chinese medicine composition of claim 1 to 4, it is characterized in that: when the dosage form of described Chinese medicine composition was powder, this preparation method was specially,
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, add after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate, the filtrate concentrating under reduced pressure obtains and gets dry extract, and is ground into powder;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mixes with filtrate that second step obtains, the adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), hold over night, filter, filtrate decompression is concentrated, obtains to get dry extract, and is ground into powder;
The 4th step, use ethanol with the dilution proportion of volume ratio 1:1 ~ 1:2 the volatile oil that second step obtains, it is for subsequent use to get volatile oil ethanol dilution liquid, takes by weighing beta-schardinger dextrin-and places container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after the dilution slowly is added in the beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h get Benexate Hydrochloride, and be for subsequent use;
The 5th step, the powder of the first step to the three steps acquisition and the Benexate Hydrochloride of the 4th step acquisition are mixed, be ground into 100 orders ~ 150 purpose powder, vacuum drying obtains powder.
7. Chinese medicine composition syrup that is used for the treatment of menopausal syndrome, it is characterized in that: the crude drug of described syrup comprises Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
8. syrup as claimed in claim 7, it is characterized in that: the preparation method of described syrup is specially,
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing, stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with filtrate that second step obtains, adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and hold over night is filtered, filtrate decompression is concentrated into without the alcohol flavor, obtains concentrated solution;
The 4th step, other gets sucrose and decocts with water, after the dissolving, filter, concentrate and make syrup, with above-mentioned concentrated solution mixing, boil, let cool, the volatile oil that adding antiseptic, second step obtain, the powder that the first step obtains, adjusting volume to crude drug concentration by interpolation or concentrated moisture is 3g/ml~4g/ml, packing, sterilization namely gets described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portions~120 weight portions, and the addition of described antiseptic is 0.5 weight portion~1 weight portion.
9. Chinese medicine composition composition powders that is used for the treatment of menopausal syndrome, it is characterized in that: the crude drug of described powder comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
10. powder as claimed in claim 9, it is characterized in that: the preparation method of described powder is specially,
The first step is being ground into powder after the lyophilization with Colla Plastri Testudinis under the temperature of-10 ℃~-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, add after the pulverizing with respect to 8~10 times of amount distilled water of mixture quality, after jolting mixes, soak 30~40min, place volatile oil extractor, be heated to boiling, and keep 100 ℃~110 ℃ little 6~8h that boil, collecting volatile oil is not increasing stopped heating, be down to room temperature, water extraction liquid is emitted, leave standstill 1~2h, filter, obtain filtrate, the filtrate concentrating under reduced pressure obtains and gets dry extract, and is ground into powder;
The 3rd step was mixed in proportion remaining component, added the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mixes with filtrate that second step obtains, the adding determining alcohol is that 70%~80% ethanol to alcohol volume content is 50% ~ 70% (V/V), hold over night, filter, filtrate decompression is concentrated, obtains to get dry extract, and is ground into powder;
The 4th step, use ethanol with the dilution proportion of volume ratio 1:1 ~ 1:2 the volatile oil that second step obtains, it is for subsequent use to get volatile oil ethanol dilution liquid, takes by weighing beta-schardinger dextrin-and places container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after the dilution slowly is added in the beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h get Benexate Hydrochloride, and be for subsequent use;
The 5th step, the powder of the first step to the three steps acquisition and the Benexate Hydrochloride of the 4th step acquisition are mixed, be ground into 100 orders ~ 150 purpose powder, vacuum drying obtains powder.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103721223A (en) * 2013-12-14 2014-04-16 郑明立 Medicine for treating functional uterine bleeding and preparation method thereof
CN106362068A (en) * 2016-11-30 2017-02-01 盛春正 Medicine for treating weakness and chilling caused by yang deficiency
CN106578397A (en) * 2017-02-09 2017-04-26 安徽菲扬农业科技有限公司 Feed additive for preventing sow edema

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1072855A (en) * 1992-12-02 1993-06-09 杨晶珠 Prevent and treat climacteric syndrome medicaments preparation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1072855A (en) * 1992-12-02 1993-06-09 杨晶珠 Prevent and treat climacteric syndrome medicaments preparation method

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103721223A (en) * 2013-12-14 2014-04-16 郑明立 Medicine for treating functional uterine bleeding and preparation method thereof
CN106362068A (en) * 2016-11-30 2017-02-01 盛春正 Medicine for treating weakness and chilling caused by yang deficiency
CN106578397A (en) * 2017-02-09 2017-04-26 安徽菲扬农业科技有限公司 Feed additive for preventing sow edema

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