CN103041306B - Traditional Chinese medicine composition for curing climacteric syndrome of women and preparation method thereof - Google Patents

Traditional Chinese medicine composition for curing climacteric syndrome of women and preparation method thereof Download PDF

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CN103041306B
CN103041306B CN201210585263.4A CN201210585263A CN103041306B CN 103041306 B CN103041306 B CN 103041306B CN 201210585263 A CN201210585263 A CN 201210585263A CN 103041306 B CN103041306 B CN 103041306B
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范茜
张爱进
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Sichuan life source Health Management Co., Ltd.
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Qingdao Hengbo Instrument Co Ltd
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Abstract

The invention provides a traditional Chinese medicine composition for curing climacteric syndrome of women. The bulk drugs of the traditional Chinese medicine composition include fennelflower seeds, rhizoma curculiginis, fructus rosae laevigatae, semen boitae, polygala tenuifolia, cistanche, selfheal, seeds of feather cockscomb, semen sesami nigrum, eclipta, golden cypress, tortoise shell glue, curcuma zedoary, pollen typhae, lignum dalbergiae odoriferae, Chinese yam, acanthopanax, panax japonicus, radix paeoniae alba, roots of red-rooted salvia, folium apocyni veneti, uncaria, semen phaseoli, caulis bambusae in taeniam, oyster, roots of bidentate achyranthes, Changium smyrnioides, pericarpium citri reticulatae, semen coicis and liquorice. The traditional Chinese medicine composition shortens the course of treatment, improves curative effect, reduces recurrence possibility, improves living quality, and avoids side effects and complications.

Description

Be used for the treatment of Chinese medicine composition of menopausal syndrome and preparation method thereof
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome and preparation method thereof.
Background technology
Menopausal syndrome refer to some women during climacteric due to the series of symptoms of gonadal hormone due to reducing, generally occur in 44～55 years old.Clinical manifestation is hectic fever sweating, vertigo and tinnitus, and palpitation and insomnia, irritated irritability, or appearance, edema of lower limbs, indigestion and loss of appetite, loose stool, or menoxenia, feelings will does not rather wait disease.Owing to occurring in front and back in menopause, the traditional Chinese medical science is referred to as " menopausal syndrome ".These syndromes are light or heavy, and persistent period or length or short very affect live and work, to patient, bring very large misery, and therefore how effective and stable solution menopausal syndrome problem becomes the focus of medical circle common concern.
One group of endocrine disturbance that modern medicine is thought climacteric syndrome to be women occurred in climacteric and ovarian function decline in menopause and autonomic nervous dysfunction's symptomes complice.Modern medicine treatment mainly take complementing estrogen, correct autonomic nervous dysfunction and improve symptom as main, adopt: the Drug therapys such as estrogen, oryzanol, vitamin E more, though curative effect is got instant result, but poor stability, easily repeatedly, and life-time service estrogen can cause endometrial hyperplasia, increase the danger that carcinoma of endometrium occurs.
Chinese medicine is with a long history, in treatment, has accumulated rich experience aspect menopausal syndrome, improving symptom, prevents and treats complication, and the aspect such as improve the quality of living obtains comparatively effectively and treatment in stable long term effect.It take strengthening vital QI to eliminate pathogenic factors as Therapeutic Principle, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, integrally-regulated, and can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better.
Motherland's medical research shows, the reason of menopausal syndrome mainly be take and suffered from a deficiency of the kidney as main.Postmenopausal women liver blood is hindered repeatly, kidney qi degradation, and the kidney failing to nourish the liver, heart-fire is short, and painstaking effort are not raw, and kidney water loses to be grown, and kidney essense is more lost.Occur that organism balance is disorderly, the heart, liver,spleen,kidney occur that inharmonious or pathologic changes, so there is hectic fever sweating in various degree, irritated irritability, chest distress and palpitation symptoms, soreness of waist and knee joint, limb face edema, gloomyly easily cry, the clinical symptoms such as insomnia forgetfulness, vertigo and tinnitus.Primary disease cause of disease key is mainly the stagnation of liver-QI of suffering from a deficiency of the kidney, and it is that kidney qi is gradually lost because age increases day by day, and menses gradually exhausts, irregular menstrual cycle, bromhidrosis day declines, and all hopes is then difficult, long-pendingly thinks into worry, long-pendingly considers into melancholy, long-pending melancholy Cheng Yu forms, and by conditioning kidney yin kidney yang, improves stagnation of liver-QI, thereby reaches the object for the treatment of primary disease.
The present invention provides a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome on the basis of theory of Chinese medical science, and it can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better, can not have side effects, and prevents the generation of complication.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome is provided, and it can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better, can not have side effects, and prevents the generation of complication.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome, the crude drug of this Chinese medicine composition comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Semen Nigellae 49 weight portion ~ 59 weight portions, Rhizoma Curculiginis 36 weight portion ~ 46 weight portions, Fructus Rosae Laevigatae 31 weight portion ~ 41 weight portions, Semen Platycladi 17 weight portion ~ 27 weight portions, Radix Polygalae 21 weight portion ~ 31 weight portions, Herba Cistanches 42 weight portion ~ 52 weight portions, Spica Prunellae 26 weight portion ~ 36 weight portions, Semen Celosiae 23 weight portion ~ 33 weight portions, Semen Sesami Nigrum 57 weight portion ~ 67 weight portions, Herba Ecliptae 73 weight portion ~ 83 weight portions, Cortex Phellodendri 43 weight portion ~ 53 weight portions, Colla Plastri Testudinis 51 weight portion ~ 61 weight portions, Rhizoma Curcumae 21 weight portion ~ 31 weight portions, Pollen Typhae 33 weight portion ~ 43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portion ~ 29 weight portions, Rhizoma Dioscoreae 82 weight portion ~ 92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portion ~ 70 weight portions, Rhizoma Panacis Japonici 43 weight portion ~ 53 weight portions, the Radix Paeoniae Alba 22 weight portion ~ 32 weight portions, Radix Salviae Miltiorrhizae 31 weight portion ~ 41 weight portions, Folium Apocyni Veneti 16 weight portion ~ 26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portion ~ 37 weight portions, Semen Phaseoli 16 weight portion ~ 26 weight portions, Caulis Bambusae In Taenia 13 weight portion ~ 23 weight portions, Concha Ostreae 9 weight portion ~ 19 weight portions, Radix Achyranthis Bidentatae 39 weight portion ~ 49 weight portions, Radix Changii 23 weight portion ~ 33 weight portions, Pericarpium Citri Reticulatae 51 weight portion ~ 61 weight portions, Semen Coicis 22 weight portion ~ 32 weight portions, Radix Glycyrrhizae 27 weight portion ~ 37 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Semen Nigellae 51 weight portion ~ 57 weight portions, Rhizoma Curculiginis 38 weight portion ~ 44 weight portions, Fructus Rosae Laevigatae 33 weight portion ~ 39 weight portions, Semen Platycladi 19 weight portion ~ 25 weight portions, Radix Polygalae 23 weight portion ~ 29 weight portions, Herba Cistanches 44 weight portion ~ 50 weight portions, Spica Prunellae 28 weight portion ~ 34 weight portions, Semen Celosiae 25 weight portion ~ 31 weight portions, Semen Sesami Nigrum 59 weight portion ~ 65 weight portions, Herba Ecliptae 75 weight portion ~ 81 weight portions, Cortex Phellodendri 45 weight portion ~ 51 weight portions, Colla Plastri Testudinis 53 weight portion ~ 59 weight portions, Rhizoma Curcumae 23 weight portion ~ 29 weight portions, Pollen Typhae 35 weight portion ~ 41 weight portions, Lignum Dalbergiae Odoriferae 21 weight portion ~ 27 weight portions, Rhizoma Dioscoreae 84 weight portion ~ 90 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portion ~ 68 weight portions, Rhizoma Panacis Japonici 45 weight portion ~ 51 weight portions, the Radix Paeoniae Alba 24 weight portion ~ 30 weight portions, Radix Salviae Miltiorrhizae 33 weight portion ~ 39 weight portions, Folium Apocyni Veneti 18 weight portion ~ 24 weight portions, Ramulus Uncariae Cum Uncis 29 weight portion ~ 35 weight portions, Semen Phaseoli 18 weight portion ~ 24 weight portions, Caulis Bambusae In Taenia 15 weight portion ~ 21 weight portions, Concha Ostreae 11 weight portion ~ 17 weight portions, Radix Achyranthis Bidentatae 41 weight portion ~ 47 weight portions, Radix Changii 25 weight portion ~ 31 weight portions, Pericarpium Citri Reticulatae 53 weight portion ~ 59 weight portions, Semen Coicis 24 weight portion ~ 30 weight portions, Radix Glycyrrhizae 29 weight portion ~ 35 weight portions.
Wherein, the dosage form of described Chinese medicine composition is tablet, powder, soft capsule, oral liquid, syrup, pill.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is syrup, this preparation method is specially:
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds with respect to 8～10 times of amount distilled water of mixture quality after pulverizing, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, stop heating, be down to room temperature, water extraction liquid is emitted, standing 1～2h, filter, obtain filtrate;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and the filtrate obtaining with second step mixes, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and standing over night is filtered, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution;
The 4th step, separately getting sucrose decocts with water, after dissolving, filter, concentrate and make syrup, mix with above-mentioned concentrated solution, boil, let cool, the volatile oil that adds antiseptic, second step to obtain, the powder that the first step obtains, by add or concentrated moisture to adjust volume to crude drug concentration be 3g/ml～4g/ml, subpackage, sterilizing, obtains described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portion～120 weight portions, and the addition of described antiseptic is 0.5 weight portion～1 weight portion.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is powder, this preparation method is specially:
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, after pulverizing, add with respect to 8～10 times of amount distilled water of mixture quality, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 1～2h, filters, obtain filtrate, filtrate concentrating under reduced pressure, obtains and gets dry extract, and is ground into powder;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with the filtrate of second step acquisition, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50% ~ 70% (V/V), standing over night, filter, filtrate decompression is concentrated, obtains and gets dry extract, and is ground into powder;
The 4th step, the volatile oil that second step is obtained is the dilution proportion with volume ratio 1:1 ~ 1:2 with ethanol, obtains volatile oil ethanol dilution liquid standby, takes beta-schardinger dextrin-and is placed in container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after dilution is slowly added in beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h, obtain Benexate Hydrochloride, standby;
The 5th step, the Benexate Hydrochloride that the powder that the first step to the three steps are obtained and the 4th step obtain mixes, and is ground into 100 order ~ 150 object powder, and vacuum drying obtains powder.
The present invention also provides a kind of Chinese medicine composition syrup that is used for the treatment of menopausal syndrome, and the crude drug of described syrup comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Wherein, the preparation method of described syrup is specially: the first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds with respect to 8～10 times of amount distilled water of mixture quality after pulverizing, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, stop heating, be down to room temperature, water extraction liquid is emitted, standing 1～2h, filter, obtain filtrate;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and the filtrate obtaining with second step mixes, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and standing over night is filtered, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution;
The 4th step, separately getting sucrose decocts with water, after dissolving, filter, concentrate and make syrup, mix with above-mentioned concentrated solution, boil, let cool, the volatile oil that adds antiseptic, second step to obtain, the powder that the first step obtains, by add or concentrated moisture to adjust volume to crude drug concentration be 3g/ml～4g/ml, subpackage, sterilizing, obtains described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portion～120 weight portions, and the addition of described antiseptic is 0.5 weight portion～1 weight portion.
The present invention also provides a kind of Chinese medicine composition composition powders that is used for the treatment of menopausal syndrome, and the crude drug of described powder comprises: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Wherein, the preparation method of described powder is specially: the first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, after pulverizing, add with respect to 8～10 times of amount distilled water of mixture quality, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 1～2h, filters, obtain filtrate, filtrate concentrating under reduced pressure, obtains and gets dry extract, and is ground into powder;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with the filtrate of second step acquisition, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50% ~ 70% (V/V), standing over night, filter, filtrate decompression is concentrated, obtains and gets dry extract, and is ground into powder;
The 4th step, the volatile oil that second step is obtained is the dilution proportion with volume ratio 1:1 ~ 1:2 with ethanol, obtains volatile oil ethanol dilution liquid standby, takes beta-schardinger dextrin-and is placed in container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after dilution is slowly added in beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h, obtain Benexate Hydrochloride, standby;
The 5th step, the Benexate Hydrochloride that the powder that the first step to the three steps are obtained and the 4th step obtain mixes, and is ground into 100 order ~ 150 object powder, and vacuum drying obtains powder.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention, it can Shorten the Treatment Process, improve curative effect, reduce recurrence, the quality of making the life better, can not have side effects, and prevents the generation of complication.
The specific embodiment
< < Plain Questions innocent opinion in ancient times > > says: " seven years old kidney qi of woman contained, and dental transition is sent out long; 27 and the menarche, conception vessel is logical, and taichong channel is contained, and regular menstrual cycle, therefore there is son ... seventy-seven conception vessels are empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, and menopause, therefore senile appearance and loss of fecundity are also." be description raw, long to women, strong, old, own physiological change rule.Woman seventy-seven front and back, closed on through disconnected year, ' decline kidney qi day, menses will exhaust, and rush wantonly two arteries and veins gradually empty, decrease fertility so that disappear.Most women can tide over smoothly, a part of due to the difference of the aspects such as body constitution, delivery and feed infant, work and rest, society and Nervous and Mental Factors, body can not adapt to these physiological changies, occurs the generation of imbalance between YIN and YANG initiation primary disease.
For climacteric syndrome, in ancient doctor's nationality, there are no independently name of disease record, also without traditional typing standard, can seek.Its clinical manifestation sporadically appears in the discussion of the diseases such as " hysteria ", " senile metrorrhagia ", " Bulbus Lilii syndrome ", " melancholia ", " being insomnia ".The generation of woman's menstruation and kidney,spleen,liver three are dirty closely related, and wherein the kidney being the origin of congenital constitution, store essential substances gas and main reproduction, the important role of rising to menstruation; The spleen being the foundation of acquired constitution, main transporting, spleen and stomach function is sound, and QI and blood biochemistry is active, sea of blood spill-over, menstruation can be risen on time; Blood stored in the liver, main catharsis has important regulating action in the cyclically-varying of menstruation.When it is close on 40, step into presenium from the middle age, the imbalance of kidney spleen hepatic insufficiency, menstruation is gradually from having to nothing, if produced climacteric syndrome just human body can not adapt to this process.
Climacteric kidney qi degradation, menses will exhaust.Punching appoints a uterine function to go down, and menoxenia and arriving is broken off, and is female reproduction physiological phenomenon originally.Because of some women's renal failure degree too early or overrun, or stronger because of the interference of the factor such as social, psychological, cause the yin and yang imbalance of kidney, conscience gas fire is contained partially, a punching QI and blood can not be let out down, superinverse is violated in the heart, liver, spleen, then occurs series of symptoms.Sick position is mainly at kidney, and pathogenesis main points are kidney qi degradation, and virtual loss is appointed in punching, and menses will exhaust, imbalance between YIN and YANG, and function is disorderly.Primary disease is the deficiency of both YIN and YANG of kidney, how dirtyly can involve conscience spleen etc.; Be designated as the stagnation of QI, belonging to the card of deficiency in origin and excess in superficiality, in treatment, in restoring normal coordination between the heart and kidney, Long Lu Zishuiqinggan, harmonizing the functional activities of vital QI, blood circulation promoting and blood stasis dispelling should be carried throughout.
Married woman be take blood as this, take gas as use, QI and blood be through, pregnant, produce, the material base of breast, and internal organs are energy and blood of human body the source of vital function, wherein particularly crucial with the effect of liver spleen kidney.The kidney being the origin of congenital constitution, store essential substances, and main reproduction, the vital essence of being hidden in kidney is the basic of human body growth promoter and reproduction, the important role of rising to women's menstruation.Menses is the full product to a certain extent time of essence in kidney, has the human body reproductive organ of promotion ripe, and maintains the material of reproductive function.Essence is again for changing the source of blood, can be for the passing through of uterus, tire is pregnant provides material base, the generation of Woman climacteric disease with rush conception vessel void, exhaustion of kidney-essence with promoting reproductive function, asthenia of renal qi is relevant.
The spleen being the foundation of acquired constitution, main transporting, is source of generating QI and blood.Women be take blood as this, menstruation, tire are pregnant, suckling all be take blood as use, the generation of blood not only needs essence of water and grain as material base, the transporting that also must rely on spleen just can become Tianjin blood, and spleen and stomach function is sound, and QI and blood biochemistry is active, sea of blood spill-over, menstruation can be risen on time, treatment primary disease should be mended thanks to exhausting of congenital kidney essense with acquired essence, is contained and is educated the five internal organs, YIN and YANG balance regulating by ridging.
Liver is to the particularly important blood stored in the liver of women, and main catharsis has important regulating action in the cyclically-varying of menstruation, the blood of each portionization life of whole body, except the nutrition whole body, remainder, at woman's sea of blood of making a bet, regularly hide and rush down and be menstruation, thus have saying of " woman being take liver as congenital ", although menstruation go out in kidney, whether normal, to kidney or logical or close relevantly, but regulating in the function of menstruation, be subject to the direct impact of liver.
The traditional Chinese medical science is also thought kidney qi degradation before and after menopause, and punching is appointed deficient, and menses gradually exhausts, yin and yang imbalance, and internal organs qi and blood disorder, depressed emotion does not relax in addition, depression of liver-QI, the wet operation of water is obstructed, poly-wetting as expectorant, stagnation of Qi and phelgm, checks ascending or descending movement of vital Qi, and causes primary disease.Its sick this is being suffered from a deficiency of the kidney, and involves the internal organs such as the heart, liver, spleen.According to forefathers' " all kinds of diseases and ailments hold concurrently expectorant ", " none disease does not concern expectorant ", " do not have expectorant and fire, not due to void also." understanding, weakened body resistance is this, expectorant is turbid is mark, therefore treatment is upper should adopt activating QI to eliminate phlegm, the method for enriching yin and nourishing kidney is with coordinating YIN and YANG, is in harmonious proportion punching times.
In sum, theoretical to the understanding of menopausal syndrome and treatment according to the traditional Chinese medical science, the present invention proposes with nourishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, calming heart and tranquilizing mind, blood circulation promoting and blood stasis dispelling, activating QI to eliminate phlegm is Therapeutic Principle, a kind of Chinese medicine composition that is used for the treatment of menopausal syndrome has been proposed, it comprises following crude drug: Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition only consists of above-mentioned raw materials medicine.
In side, Semen Nigellae, Rhizoma Curculiginis warming the kidney to invigorate YANG, promoting the flow of QI-blood by warming the meridian, has oestrogen-like hormone effect, again without adverse side effect, can regulate the function of hypothalmus-pituitary-adrenal axis, has antioxidation, antidotal effect, thus play the effect that prevents and treats climacteric syndrome, Fructus Rosae Laevigatae invigorating the liver and kidney replenishing QI and blood and take the photograph vigour, Semen Platycladi, Radix Polygalae mind calming is determined gas and is calmed the nerves, Herba Cistanches kidney-replenishing, benefiting essence-blood, Spica Prunellae, Semen Celosiae, Semen Phaseoli the kidney invigorating watery diarrhea liver-fire, Cortex Phellodendri is cold in nature and enter kidney channel, can reducing the minister-fire and hard kidney tonifying YIN, Semen Sesami Nigrum, Herba Ecliptae kidney tonifying essence, nourishing YIN blood, yin nourishing easing the affected liver, Colla Plastri Testudinis liver nourishing YANG hyperactivity suppressing, nourishing YIN and benefiting blood and reducing the asthenic fever, Rhizoma Curcumae, Pollen Typhae blood circulation promoting and blood stasis dispelling, Lignum Dalbergiae Odoriferae blood-activating and qi-promoting, it is cloudy that Rhizoma Dioscoreae enriching spleen-QI is grown spleen, has training to mend the effect of first the foundation of acquired constitution, Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, Rhizoma Panacis Japonici promoting blood circulation to remove blood stasis, nourishing YIN lung moistening, the Radix Paeoniae Alba joint venture of nourishing blood, easing the affected liver to relieve pain, Radix Salviae Miltiorrhizae vital energy regualting and blood circulation-promoting, to improve microcirculation, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis heat clearing away liver is flat, suppressing the hyperactive liver is calmed the nerves, Caulis Bambusae In Taenia removing heat-phlegm, relieving restlessness is with all worries set aside, Concha Ostreae suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, Radix Achyranthis Bidentatae kidney tonifying, essence replenishing, gets it and helps waist knee joint, benefit vigour, the effect of tonify deficiency labor, invigorates blood circulation in addition, in the descending effect side of priming, Xin Wen and bitter cold share, and tonifying YANG and YIN nourishing develop simultaneously, and not only mend but also not warm, and kidney tonifying ly makes cloudy positive helping and fountainhead is inexhaustible partially without scorching, and positive cloudy helping and biochemistry is infinite reaches the effect of YIN and YANG balancing, Radix Changii moistening the lung and resolving phlegm, yin nourishing stomach function regulating, Pericarpium Citri Reticulatae activating QI to eliminate phlegm, Semen Coicis invigorating spleen to remove dampness, wets and goes expectorant to disappear, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, the kidney invigorating raw material components in side can obviously improve estrogen level, has estrogen-like effects, and can build up resistance, defying age, kidney tonifying, essence replenishing raw material components has the effect of short follicular development maturation, can obviously improve the blood confession in ovary and uterus, and all medicines share, and play altogether nourishing kidney-YIN, suppressing the hyperactive liver and subsiding YANG, the effect of calming heart and tranquilizing mind, blood circulation promoting and blood stasis dispelling, activating QI to eliminate phlegm.
Each crude drug pharmacology is as follows:
Semen Nigellae: latin name Nigellae Semen, sweet in the mouth, pungent, warm in nature, there is kidney-tonifying and brain tonic, the effect of the lactogenesis that stimulates the menstrual flow, diuresis, cure mainly that tinnitus is forgetful, amenorrhea is newborn few, the cards such as pyretic stranguria, stranguria caused by urinary stone.
Rhizoma Curculiginis: acrid in the mouth, warm in nature, return kidney, Liver Channel, there is the kidney warming sun, the effect of strengthening bone and muscle, cures mainly sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula, the cards such as yang deficiency cold diarrhea.
Fructus Rosae Laevigatae: latin name Rosae Laevigatae Fructus, sour in the mouth, sweet, property is puckery, flat, returns kidney, bladder, large intestine channel, has controlling nocturnal emission with astringent drugs reducing urination, stopping metrorrhagia and leukorrhagia, the effect of relieving diarrhea with astringents, cures mainly emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, the cards such as chronic diarrhea chronic dysentery.
Semen Platycladi: latin name Platycladi Semen, sweet in the mouth, property is flat, and GUIXIN, kidney, large intestine channel, have tranquilizing by nourishing the heart, and the effect of loosening bowel to relieve constipation, cures mainly restlessness of asrhenia type and insomnia, severe palpitation, the cards such as dryness of the intestine constipation.
Radix Polygalae: bitter in the mouth, pungent, slightly warm in nature, GUIXIN, kidney, lung meridian, have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the effect of detumescence, the insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, the cards such as breast swell and pain.
Herba Cistanches: sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill.
Spica Prunellae: bitter in the mouth, pungent, cold in nature, enter liver, gallbladder meridian, have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, the effect of detumescence, cures mainly conjunctival congestion and swelling pain, and order pearl nyctalgia, has a headache dizzy, scrofula, goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.
Semen Celosiae: bitter in the mouth, cold nature, returns Liver Channel, has purging liver-fire, and the effect of improving acuity of vision and removing nebula cures mainly liver-heat conjunctival congestion, the raw nebula film of order, blurring of vision, the cards such as dizziness due to liver-fire.
Semen Sesami Nigrum: sweet in the mouth, property is flat, returns liver, kidney, large intestine channel, has invigorating the liver and kidney, benefiting essence-blood, the effect that intestine moistening is dry, for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, the cards such as dryness of the intestine constipation.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Cortex Phellodendri: latin name Phellodendri Chinensis Cortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus, Cortex Phellodendri has good antibacterial action to multiple gram-positive bacterium.
Colla Plastri Testudinis: latin name Testudinis Carapacis et Plastri Colla, salty in the mouth, sweet, cool in nature, return liver, kidney, heart channel, the effect of have YIN nourishing, nourish blood, stopping blooding, cures mainly deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, soreness of the waist and knees, blood deficiency and yellow complexion, the cards such as bleeding not during menses.
Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature, enter liver, spleen channel, have removing blood stasis circulation of qi promoting, the effect of removing food stagnancy pain relieving, for the lump in the abdomen mass in the abdomen of caused by energy stagnation and blood stasis, breast abdomen stasis of blood pain, amenorrhea, dysmenorrhea, abdominal distention, traumatic injury, the blood stasis card such as swell and ache, Rhizoma Curcumae can obviously increase femoral artery blood flow, and anticoagulant and antithrombotic form.
Pollen Typhae: sweet in the mouth, property is flat, enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature, return liver, spleen channel, there is promoting flow of QI and blood, the effect of analgesic hemostatic.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, the cards such as traumatic hemorrhage.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.
Rhizoma Panacis Japonici: latin name Panacis Japonici Rhizoma, sweet in the mouth, micro-hardship, warm in nature, return liver, spleen, lung meridian, there is strengthening by means of tonics, eliminating stasis to stop pain, the effect that hemostasis is eliminated the phlegm, cures mainly weakness after being ill, chronic cough spitting of blood, cough with copious phlegm, the cards such as injury from falling down.
The Radix Paeoniae Alba: latin name Paeoniae Radix Alba, bitter in the mouth, acid, cool in nature, enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior card.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, the effect of nourishing blood to tranquillize the mind, cures mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
Folium Apocyni Veneti: sweet in the mouth, hardship, cool in nature, enter Liver Channel, there is suppressing the hyperactive liver and calm the nerves, the effect of clearing away heat and promoting diuresis, for dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, the cards such as nephritis edema.
Ramulus Uncariae Cum Uncis: sweet in the mouth, slightly warm in nature, enters Liver Channel, has the effect of heat clearing away, suppressing the hyperactive liver and subsiding YANG, relieving spasm by subduing liver-wind, is mainly used in the spasm due to the anxious raw wind of heat or liver-wind stirring up internally, twitch, restlessness, excessive rising of liver-YANG or Liver Channel have the headache of heat dizzy, the cards such as conjunctival congestion and swelling pain.
Semen Phaseoli: latin name Vigae Semen, sweet in the mouth, acid, property is flat, has the diuretic kind that disappears, and the effect of removing toxic substances and promoting pus discharge, for cards such as edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Caulis Bambusae In Taenia: cold nature, sweet in the mouth, attaches to the lung and stomach meridians, and has removing heat-phlegm, and the effect relieving restlessness and preventing vomiting is held the cards such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.
Concha Ostreae: salty in the mouth, cold nature, enters liver, gallbladder, kidney channel, has suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating effect, cure mainly vertigo and tinnitus, brothers' chatter, palpitation and insomnia, dysphoria, infantile convulsion is demented, scrofula goiter, breast caking, spontaneous sweating, seminal emission frequent micturition, bleeding not during menses, acid regurgitation stomachache, the cards such as eczema skin infection.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat, enters liver, kidney channel, there is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, the effect of inducing diuresis for treating stranguria syndrome, treatment soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, lump in the abdomen, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, the cards such as laryngopharynx swelling and pain.
Radix Changii: sweet in the mouth, micro-hardship, cold nature, returns lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, yin nourishing stomach function regulating, the effect of suppressing the hyperactive liver removing toxic substances, for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, the card such as conjunctival congestion is dizzy, furunculosis skin infection.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, pungent loose logical temperature, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, for lung qi, gather around the cards such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen.
Semen Coicis: latin name Coicis Semen, sweet in the mouth, light, cold nature, enters lung, spleen, large intestine channel, has invigorating the spleen to arrest diarrhea, diuretic eliminating impediment, the effect of row's skin ulcer pus, cures mainly having loose bowels of wet tired lung stomach; Damp is invaded the hydrosarca of stain skin, dysuria; Damp and hot resistance in the numbness of QI and blood passes to and the scorchingly hot cards such as lung abscess in lung intestinal, acute appendicitis that pent up.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, by adding Radix Glycyrrhizae can play QI invigorating, neutralizes, and is in harmonious proportion the effect of each component.
On treatment menopausal syndrome, Chinese medicine composition prepared by the present invention has the patient of adjusting internal organs equilibrium between yin and yang, regulates internal organs physiological function, improve the blood supply of ovary etc., thereby delay the aging of ovary, maintain ovarian function, play the effect that prevents and treats climacteric syndrome.
In described Chinese medicine composition, the weight portion of each crude drug is respectively Semen Nigellae 49 weight portion ~ 59 weight portions, Rhizoma Curculiginis 36 weight portion ~ 46 weight portions, Fructus Rosae Laevigatae 31 weight portion ~ 41 weight portions, Semen Platycladi 17 weight portion ~ 27 weight portions, Radix Polygalae 21 weight portion ~ 31 weight portions, Herba Cistanches 42 weight portion ~ 52 weight portions, Spica Prunellae 26 weight portion ~ 36 weight portions, Semen Celosiae 23 weight portion ~ 33 weight portions, Semen Sesami Nigrum 57 weight portion ~ 67 weight portions, Herba Ecliptae 73 weight portion ~ 83 weight portions, Cortex Phellodendri 43 weight portion ~ 53 weight portions, Colla Plastri Testudinis 51 weight portion ~ 61 weight portions, Rhizoma Curcumae 21 weight portion ~ 31 weight portions, Pollen Typhae 33 weight portion ~ 43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portion ~ 29 weight portions, Rhizoma Dioscoreae 82 weight portion ~ 92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portion ~ 70 weight portions, Rhizoma Panacis Japonici 43 weight portion ~ 53 weight portions, the Radix Paeoniae Alba 22 weight portion ~ 32 weight portions, Radix Salviae Miltiorrhizae 31 weight portion ~ 41 weight portions, Folium Apocyni Veneti 16 weight portion ~ 26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portion ~ 37 weight portions, Semen Phaseoli 16 weight portion ~ 26 weight portions, Caulis Bambusae In Taenia 13 weight portion ~ 23 weight portions, Concha Ostreae 9 weight portion ~ 19 weight portions, Radix Achyranthis Bidentatae 39 weight portion ~ 49 weight portions, Radix Changii 23 weight portion ~ 33 weight portions, Pericarpium Citri Reticulatae 51 weight portion ~ 61 weight portions, Semen Coicis 22 weight portion ~ 32 weight portions, Radix Glycyrrhizae 27 weight portion ~ 37 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is further preferably respectively Semen Nigellae 51 weight portion ~ 57 weight portions, Rhizoma Curculiginis 38 weight portion ~ 44 weight portions, Fructus Rosae Laevigatae 33 weight portion ~ 39 weight portions, Semen Platycladi 19 weight portion ~ 25 weight portions, Radix Polygalae 23 weight portion ~ 29 weight portions, Herba Cistanches 44 weight portion ~ 50 weight portions, Spica Prunellae 28 weight portion ~ 34 weight portions, Semen Celosiae 25 weight portion ~ 31 weight portions, Semen Sesami Nigrum 59 weight portion ~ 65 weight portions, Herba Ecliptae 75 weight portion ~ 81 weight portions, Cortex Phellodendri 45 weight portion ~ 51 weight portions, Colla Plastri Testudinis 53 weight portion ~ 59 weight portions, Rhizoma Curcumae 23 weight portion ~ 29 weight portions, Pollen Typhae 35 weight portion ~ 41 weight portions, Lignum Dalbergiae Odoriferae 21 weight portion ~ 27 weight portions, Rhizoma Dioscoreae 84 weight portion ~ 90 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portion ~ 68 weight portions, Rhizoma Panacis Japonici 45 weight portion ~ 51 weight portions, the Radix Paeoniae Alba 24 weight portion ~ 30 weight portions, Radix Salviae Miltiorrhizae 33 weight portion ~ 39 weight portions, Folium Apocyni Veneti 18 weight portion ~ 24 weight portions, Ramulus Uncariae Cum Uncis 29 weight portion ~ 35 weight portions, Semen Phaseoli 18 weight portion ~ 24 weight portions, Caulis Bambusae In Taenia 15 weight portion ~ 21 weight portions, Concha Ostreae 11 weight portion ~ 17 weight portions, Radix Achyranthis Bidentatae 41 weight portion ~ 47 weight portions, Radix Changii 25 weight portion ~ 31 weight portions, Pericarpium Citri Reticulatae 53 weight portion ~ 59 weight portions, Semen Coicis 24 weight portion ~ 30 weight portions, Radix Glycyrrhizae 29 weight portion ~ 35 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is most preferably respectively Semen Nigellae 54 weight portions, Rhizoma Curculiginis 41 weight portions, Fructus Rosae Laevigatae 36 weight portions, Semen Platycladi 22 weight portions, Radix Polygalae 26 weight portions, Herba Cistanches 47 weight portions, Spica Prunellae 31 weight portions, Semen Celosiae 28 weight portions, Semen Sesami Nigrum 62 weight portions, Herba Ecliptae 78 weight portions, Cortex Phellodendri 48 weight portions, Colla Plastri Testudinis 56 weight portions, Rhizoma Curcumae 26 weight portions, Pollen Typhae 38 weight portions, Lignum Dalbergiae Odoriferae 24 weight portions, Rhizoma Dioscoreae 87 weight portions, Radix Et Caulis Acanthopanacis Senticosi 65 weight portions, Rhizoma Panacis Japonici 48 weight portions, the Radix Paeoniae Alba 27 weight portions, Radix Salviae Miltiorrhizae 36 weight portions, Folium Apocyni Veneti 21 weight portions, Ramulus Uncariae Cum Uncis 32 weight portions, Semen Phaseoli 21 weight portions, Caulis Bambusae In Taenia 18 weight portions, Concha Ostreae 14 weight portions, Radix Achyranthis Bidentatae 44 weight portions, Radix Changii 28 weight portions, Pericarpium Citri Reticulatae 56 weight portions, Semen Coicis 27 weight portions, Radix Glycyrrhizae 32 weight portions.
Above-mentioned Chinese medicine composition provided by the invention is oral drugs, can be prepared into any peroral dosage form, as tablet, powder, soft capsule, oral liquid, syrup, pill, is preferably syrup and powder.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is syrup, is specially:
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds with respect to 8～10 times of amount distilled water of mixture quality after pulverizing, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, stop heating, be down to room temperature, water extraction liquid is emitted, standing 1～2h, filter, obtain filtrate;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and the filtrate obtaining with second step mixes, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50% ~ 70% (V/V), and standing over night is filtered, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution;
The 4th step, separately getting sucrose decocts with water, after dissolving, filter, concentrate and make syrup, mix with above-mentioned concentrated solution, boil, let cool, the volatile oil that adds antiseptic, second step to obtain, the powder that the first step obtains, by add or concentrated moisture to adjust volume to crude drug concentration be 3g/ml～4g/ml, subpackage, sterilizing, obtains described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portion～120 weight portions, and the addition of described antiseptic is 0.5 weight portion～1 weight portion.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, is specially:
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, after pulverizing, add with respect to 8～10 times of amount distilled water of mixture quality, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 1～2h, filters, obtain filtrate, filtrate concentrating under reduced pressure, obtains and gets dry extract, and is ground into powder;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4 ~ 6 times of mixture qualities, boil 3 ~ 5h, filter, again add the distilled water with respect to 2 ~ 3 times of mixture qualities, boil 1 ~ 3h, filter, filtrate is merged, and mix with the filtrate of second step acquisition, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50% ~ 70% (V/V), standing over night, filter, filtrate decompression is concentrated, obtains and gets dry extract, and is ground into powder;
The 4th step, the volatile oil that second step is obtained is the dilution proportion with volume ratio 1:1 ~ 1:2 with ethanol, obtains volatile oil ethanol dilution liquid standby, takes beta-schardinger dextrin-and is placed in container, adding distil water is with the ratio heating for dissolving of 1:4 ~ 1:6, under 60 ℃ of constant temperature, stir, the volatile oil after dilution is slowly added in beta-schardinger dextrin-solution, stir 1 ~ 3h, put into 4 ℃ of cold preservation 12 ~ 24h of refrigerator, sucking filtration, dry 6 ~ 8h, obtain Benexate Hydrochloride, standby;
The 5th step, the Benexate Hydrochloride that the powder that the first step to the three steps are obtained and the 4th step obtain mixes, and is ground into 100 order ~ 150 object powder, and vacuum drying obtains powder.
The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine for the preparation for the treatment of menopausal syndrome.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 syrup 1
56g Colla Plastri Testudinis is ground into powder after lyophilization at the temperature of-14 ℃ of degree, by Semen Nigellae 54g, Rhizoma Curculiginis 41g, Fructus Rosae Laevigatae 36g, Herba Cistanches 47g, Herba Ecliptae 78g, Rhizoma Dioscoreae 87g, Radix Et Caulis Acanthopanacis Senticosi 65g, Rhizoma Panacis Japonici 48g, Radix Achyranthis Bidentatae 44g, Semen Sesami Nigrum 62g mixes, and adds 5kg distilled water after pulverizing, after jolting mixes, soak 40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃ of micro-8h of boiling, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 2h, filters, obtain filtrate, by Semen Platycladi 22g, Radix Polygalae 26g, Spica Prunellae 31g, Semen Celosiae 28g, Cortex Phellodendri 48g, Rhizoma Curcumae 26g, Pollen Typhae 38g, Lignum Dalbergiae Odoriferae 24g, Radix Paeoniae Alba 27g, Radix Salviae Miltiorrhizae 36g, Folium Apocyni Veneti 21g, Ramulus Uncariae Cum Uncis 32g, Semen Phaseoli 21g, Caulis Bambusae In Taenia 18g, Concha Ostreae 14g, Radix Changii 28g, Pericarpium Citri Reticulatae 56g, Semen Coicis 27g, Radix Glycyrrhizae 32g mixes, and adds the distilled water of 2.8kg, boils 5h, filter, again add the distilled water of 1.5kg, boil 3h, filter, filtrate is merged, and mix with the filtrate obtaining above, adding determining alcohol is that 80% ethanol to alcohol volume content is 60% (V/V), standing over night, filter, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution, the sucrose of separately getting 1.2kg decocts with water, after dissolving, filter the concentrated syrup of making, mix with above-mentioned concentrated solution, boil, let cool, add preservative sodium benzoate 65g, the volatile oil that obtained above, powder, by add or concentrated moisture to adjust volume to crude drug concentration be 4g/ml, subpackage, sterilizing, obtains described syrup.
Embodiment 2 syrups 2
53g Colla Plastri Testudinis is ground into powder after lyophilization at the temperature of-14 ℃ of degree, by Semen Nigellae 51g, Rhizoma Curculiginis 38g, Fructus Rosae Laevigatae 33g, Herba Cistanches 44g, Herba Ecliptae 75g, Rhizoma Dioscoreae 84g, Radix Et Caulis Acanthopanacis Senticosi 62g, Rhizoma Panacis Japonici 45g, Radix Achyranthis Bidentatae 41g, Semen Sesami Nigrum 59g mixes, and adds 4.6kg distilled water after pulverizing, after jolting mixes, soak 40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃ of micro-8h of boiling, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 2h, filters, obtain filtrate, by Semen Platycladi 19g, Radix Polygalae 23g, Spica Prunellae 28g, Semen Celosiae 25g, Cortex Phellodendri 45g, Rhizoma Curcumae 23g, Pollen Typhae 35g, Lignum Dalbergiae Odoriferae 21g, Radix Paeoniae Alba 24g, Radix Salviae Miltiorrhizae 33g, Folium Apocyni Veneti 18g, Ramulus Uncariae Cum Uncis 29g, Semen Phaseoli 18g, Caulis Bambusae In Taenia 15g, Concha Ostreae 11g, Radix Changii 25g, Pericarpium Citri Reticulatae 53g, Semen Coicis 24g, Radix Glycyrrhizae 29g mixes, and adds the distilled water of 2.5kg, boils 5h, filter, again add the distilled water of 1.2kg, boil 3h, filter, filtrate is merged, and mix with the filtrate obtaining above, adding determining alcohol is that 80% ethanol to alcohol volume content is 60% (V/V), standing over night, filter, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution, the sucrose of separately getting 1.1kg decocts with water, after dissolving, filter the concentrated syrup of making, mix with above-mentioned concentrated solution, boil, let cool, add preservative sodium benzoate 65g, the volatile oil that obtained above, powder, by add or concentrated moisture to adjust volume to crude drug concentration be 4g/ml, subpackage, sterilizing, obtains described syrup.
Embodiment 3 syrups 3
59g Colla Plastri Testudinis is ground into powder after lyophilization at the temperature of-14 ℃ of degree, by Semen Nigellae 57g, Rhizoma Curculiginis 44g, Fructus Rosae Laevigatae 39g, Herba Cistanches 50g, Herba Ecliptae 81g, Rhizoma Dioscoreae 90g, Radix Et Caulis Acanthopanacis Senticosi 68g, Rhizoma Panacis Japonici 51g, Radix Achyranthis Bidentatae 47g, Semen Sesami Nigrum 65g mixes, and adds 5.3kg distilled water after pulverizing, after jolting mixes, soak 40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃ of micro-8h of boiling, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 2h, filters, obtain filtrate, by Semen Platycladi 25g, Radix Polygalae 29g, Spica Prunellae 34g, Semen Celosiae 31g, Cortex Phellodendri 51g, Rhizoma Curcumae 29g, Pollen Typhae 41g, Lignum Dalbergiae Odoriferae 27g, Radix Paeoniae Alba 30g, Radix Salviae Miltiorrhizae 39g, Folium Apocyni Veneti 24g, Ramulus Uncariae Cum Uncis 35g, Semen Phaseoli 24g, Caulis Bambusae In Taenia 21g, Concha Ostreae 17g, Radix Changii 31g, Pericarpium Citri Reticulatae 59g, Semen Coicis 30g, Radix Glycyrrhizae 35g mixes, and adds the distilled water of 3.2kg, boils 5h, filter, again add the distilled water of 1.8kg, boil 3h, filter, filtrate is merged, and mix with the filtrate obtaining above, adding determining alcohol is that 75% ethanol to alcohol volume content is 60% (V/V), standing over night, filter, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution, the sucrose of separately getting 1.2kg decocts with water, after dissolving, filter the concentrated syrup of making, mix with above-mentioned concentrated solution, boil, let cool, add preservative sodium benzoate 65g, the volatile oil that obtained above, powder, by add or concentrated moisture to adjust volume to crude drug concentration be 4g/ml, subpackage, sterilizing, obtains described syrup.
Embodiment 4 powders 1
56g Colla Plastri Testudinis is ground into powder after lyophilization at the temperature of-14 ℃ of degree, by Semen Nigellae 54g, Rhizoma Curculiginis 41g, Fructus Rosae Laevigatae 36g, Herba Cistanches 47g, Herba Ecliptae 78g, Rhizoma Dioscoreae 87g, Radix Et Caulis Acanthopanacis Senticosi 65g, Rhizoma Panacis Japonici 48g, Radix Achyranthis Bidentatae 44g, Semen Sesami Nigrum 62g mixes, and adds 5kg distilled water after pulverizing, after jolting mixes, soak 40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃ of micro-8h of boiling, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 2h, filters, obtain filtrate, by Semen Platycladi 22g, Radix Polygalae 26g, Spica Prunellae 31g, Semen Celosiae 28g, Cortex Phellodendri 48g, Rhizoma Curcumae 26g, Pollen Typhae 38g, Lignum Dalbergiae Odoriferae 24g, Radix Paeoniae Alba 27g, Radix Salviae Miltiorrhizae 36g, Folium Apocyni Veneti 21g, Ramulus Uncariae Cum Uncis 32g, Semen Phaseoli 21g, Caulis Bambusae In Taenia 18g, Concha Ostreae 14g, Radix Changii 28g, Pericarpium Citri Reticulatae 56g, Semen Coicis 27g, Radix Glycyrrhizae 32g mixes, the distilled water that adds 2.8kg, boil 5h, filter, the distilled water that again adds 1.5kg, boil 3h, filter, filtrate is merged, and mix with the filtrate obtaining above, adding determining alcohol is that 80% ethanol to alcohol volume content is 60% (V/V), standing over night, filter, filtrate decompression is concentrated, obtain and get dry extract, be ground into powder, use ethanol with the dilution proportion of volume ratio 1:1 the volatile oil obtaining above, obtain volatile oil ethanol dilution liquid standby, take beta-schardinger dextrin-and be placed in container, adding distil water is with the ratio heating for dissolving of 1:5, under 60 ℃ of constant temperature, stir, volatile oil after dilution is slowly added in beta-schardinger dextrin-solution, stir 3h, put into 4 ℃ of cold preservation 24h of refrigerator, sucking filtration, dry 8h, obtains Benexate Hydrochloride, and the powder obtaining above and Benexate Hydrochloride are mixed, and is ground into 100 object powder, and vacuum drying, obtains powder.
Embodiment 5 acute toxicity testings
Choose 20 of kunming mices, male and female half and half, are provided by Qingdao City's laboratory animal and zoopery center, body weight is 22.17 ± 1.35g, by dosage gastric infusion every day of 60ml/kg, administration at twice, wherein, the direct gavage of syrup of embodiment 1 to embodiment 3 is in mice, and the powder of embodiment 4 is dissolved in distilled water, be mixed with the solution that crude drug concentration is 4g/ml, gavage mice, twice on the one, observe seven, without abnormal phenomena, without dead, body weight increases to 28.61 ± 1.72g.
The syrup of Chinese medicine composition of the present invention and powder clinical medicine dose are 10mL * 2=20ml every day, crude drug concentration is 4g/ml, become body weight for humans by 60kg, adult's oral dose is 20ml/60kg=0.33ml/kg, mice dosage every day is 60ml/kg, and quite the 60/0.33=182 of people's consumption doubly.
Result: Chinese medicine composition of the present invention is nontoxic.
Embodiment 6 Experiments of Zoology
Laboratory animal
Female SPF SD rat, 190～210g, by Qingdao City's laboratory animal and zoopery center, provided, by body weight, be divided at random blank group, model group and traditional Chinese medicine composition for treating group of the present invention, every group 10, raise in 22～26 ℃ of room temperatures, relative humidity 40%～70% barrier environment, throws light on by circadian rhythm.
Experiment reagent and instrument
High performance liquid chromatograph (Agilent1100); Phenomenex Luna C 18reversed phase chromatographic column, G1321A fluorescence detector (Agilent1100); Estradiol (E 2), follicle stimulating hormone (FSH), lutropin (LH) radioimmunoassay determination box, by Qingdao Better Biotechnology Co., Ltd., provide.5-hydroxy tryptamine (5-HT), norepinephrine (NE), dopamine (DA) standard substance: U.S. Sigma company product.
Animal model administration
Except blank group, other rats pentobarbital sodium 50mgkg -1intraperitoneal injection of anesthesia, except Normal group, pentobarbital sodium 40mg/kg intraperitoneal injection of anesthesia for other 2 groups of rats, abdomen position is fixed, from rat back most end rib, and midaxillary line and apart from about 2cm infall cropping outside spinal column, cut skin and the about 1.5-2cm of dorsal muscles, the shinny liparitosis of a visible milky in the otch visual field, fractionation of fatty group, just can see a thin-line-shaped irregular ovary that is yellowish red color.During clip, first fallopian tube under ovary (comprising fat) is used to fine rule ligation, then extract ovary, postoperative cornua uteri is sent back in abdominal cavity, suture muscles and skin, extract opposite side ovary with method, blank group rats underwent surgical exposure but non-spay.Postoperative continuous 3d intramuscular injection penicillin is in case infect.Within postoperative the 5th day, carry out vaginal smear, once-a-day, continuous 5d, to determine that ovary excises completely.Within postoperative the 9th day, start gastric infusion, the syrup 1 of the treatment group gavage embodiment of the present invention 1 preparation, directly gavage is in rat, and gavage amount is 6.5g/kg (is equivalent to clinical dosage 5 times), once-a-day, 14d continuously; Blank group and model control group gavage equal-volume pure water (10mLkg -1).
Index detects and statistics
24h after last administration, each organizes the anesthesia of rat pentobarbital sodium, abdominal aortic blood, centrifugalize serum, measures E by medicine box description with putting the method for exempting from 2, FSH, LH; The animal of getting after blood is breaked end and takes off thalamus rapidly, with chemiluminescence, measure Hypothalamic Neurotransmitter 5-HT, NE, DA content.
After sacrifice of animal, dissect, get uterus and adrenal gland weighs, calculate organ coefficient.
Statistical method
Measurement data adopts represent, between group, relatively adopt χ 2check, all data all adopt SPSS12.0 statistical software to process.
Result
Each organizes rat blood serum E 2, FSH, LH change relatively, the results are shown in Table 1.
Table 1 climacteric model is respectively organized rat blood serum E 2, FSH, LH change relatively
Grouping E 2(pg·mL -1) FSH(mIU·mL -1) LH(mIU·mL -1)
Matched group 6.39±0.81 1.51±0.46 3.71±0.80
Model group 3.17±0.62 3.02±0.80 6.01±1.02
Treatment group 5.22±0.72 2.29±0.61 4.77±0.61
As can be seen from Table 1, compare the serum E of model group with blank group 2level obviously reduces, and FSH, LH level obviously raise, and adopts the treatment of Chinese medicine composition of the present invention, can significantly improve E 2level, reduces FSH, LH level.
Each organizes rat 5-HT, NE, DA changes relatively, the results are shown in Table 2.
Table 2 climacteric model is respectively organized rat 5-HT, NE, DA changes relatively (ng/mg)
Grouping 5-HT NE DA
Matched group 0.68±0.17 1.53±0.29 0.46±0.13
Model group 1.07±0.23 1.03±0.42 0.31±0.05
Treatment group 0.81±0.12 1.38±0.35 0.41±0.07
As can be seen from Table 2, with the comparison of blank group, Ovariectomy model rat hypothalamus 5-HT content obviously raises, and NE, DA content obviously reduce, and take Chinese medicine composition prepared by the present invention, ovariectomized female rats hypothalamus 5-HT content be can obviously reduce, NE, DA content increased.
Impact on hot flushes in rats organ coefficient, the results are shown in Table 3.
Table 3 climacteric model is respectively organized the impact of Rats Organs and Tissues coefficient
Group Uterus coefficient Adrenal gland's coefficient
Matched group 0.194±0.052 0.033±0.006
Model group 0.129±0.038 0.026±0.003
Treatment group 0.172±0.043 0.030±0.005
As can be seen from Table 3, with the comparison of blank group, Ovariectomy model rat uterus coefficient and adrenal gland's coefficient obviously reduce, and can obviously increase ovariectomized female rats uterus coefficient by taking Chinese medicine composition prepared by the present invention; Each administration group of adrenal gland's coefficient is all increased without obvious compared with model group.
Embodiment 8 model cases
Example 1: Wu so-and-so, female, 47 years old.First visit on March 23 in 2009, readme started menstruation irregularis before half a year, and paroxysmal is warmed flushing, hectic fever sweating, a moment, Western medicine diagnose was climacteric syndrome from slow, the medicine therapeutic effect such as oral brain-refreshing essence tablet are not good.Nearly half a year irregular menses, above-mentioned symptom increases the weight of and accompanies feverish sensation in the palms and soles, irritated insomnia, cardiopalmus, soreness of waist and knee joint, xerostomia constipation, body of the tongue is partially red, white and thin fur, thready and stringy pulse.Electrocardioscopy is shown roughly normal, and chemoluminescence method inspectability hormonal readiness shows: E 2<20Pg/ml, FSH95mlu/ml, LH48mlu/ml, takes the syrup of the embodiment of the present invention 1 preparation, sooner or later each 1 time, each 10ml, 7 days 1 courses for the treatment of, after 2 courses for the treatment of, spirit takes a turn for the better, primary symptom obviously alleviates, continual cure is treated 2 courses for the treatment of, and remaining disease knowing removed, and follows up a case by regular visits to without recurrence after half a year.
Example 2: patient Liu, female, 41 years old, main cause " dizzy a week ", on January 22nd, 2009 is medical.Patient nearly February, Hypomenorrhea, cycle delay, occurred dizzyly before one week, ignore thing rotation, headache, companion is nervous, weak, lumbago, costa sternales feeling of distension and oppression, bitter taste, feels depressed, and worries too much, the poor dreaminess of sleeping, poor appetite, two just can, slightly sweating, red tongue, thin fur, stringy and thready pulse.Blood pressure 130/80mmHg, is diagnosed as climacteric syndrome, takes the syrup of the embodiment of the present invention 1 preparation, each 1 time sooner or later, each 10ml, 7 days 1 courses for the treatment of, after 10 days, primary symptom obviously alleviates, continual cure 10 days, without obvious disease, by drug withdrawal, after half a year, follow up a case by regular visits to without recurrence.
Example 3: Lee, the first visit in 12, of 45,2008 on Decembers, main suit: there is closely over the past half year menoxenia, normal sense headache, bitter taste in the mouth and dry throat, vexed suspicious, whole body is warmed and is perspired, constipation with dry stool, the symptoms such as vexed insomnia.Disease is seen: spirit is poor, tongue tip side of red, thin white fur of tongue, stringy and thready pulse, is diagnosed as climacteric syndrome, takes the syrup of the embodiment of the present invention 1 preparation, sooner or later each 1 time, each 10ml, 7 days 1 courses for the treatment of, after 7 days, self-induction symptom takes a turn for the better, but still have, perspire and insomnia, continual cure drug withdrawal after 2 courses for the treatment of, with examining half a year, above-mentioned symptom is without repeatedly.
Embodiment 9 clinical datas
Diagnostic criteria
The diagnosis of climacteric syndrome Chinese medical discrimination is according to < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > (State Administration of Traditional Chinese Medicine, within 1994, publish) and < < Gynecology of Chinese Medicine > > (Shanghai science tech publishing house, within 1997, publish) judge pattern of syndrome, this studies the dialectical spleen kidney both deficiency type that is of selected case.Primary symptom: hectic fever antiperspirant goes out; Inferior disease: the confusion of the menstrual cycle, dizziness and tinnitus, spiritlessness and weakness, sensation of oppression over the chest with shortness of breath, appetite and hyposexuality, waist soreness, the few tongue of light red tongue, deep and weak pulse.Primary symptom is indispensable, and 3 of inferior diseases are diagnosable above.
Climacteric syndrome Western medicine diagnose standard is determined according to the diagnosis of < < common disease and curative effect determinate standard > >.1. 45～60 years old age, amenorrhea is more than 1 year, occurs hectic fever, cardiopalmus, depression, insomnia, emotional, fluctuation of blood pressure, systolic pressure raises and the performance such as paresthesia of skin.2. blood, urinary fsh (FSH) and interstitialcellstimulating hormone (ICSH) (LH) obviously rise, estradiol (E 2) (lower than the early stage level of follicle) declines.3. secondary sex characteristics can have degeneration in various degree.4. genitals can have atrophy in various degree, sometimes concurrent vaginitis.
Inclusive criteria
1. without mammary gland fibroma, cyclomastopathy, breast carcinoma, cervical cancer and other malignant tumor histories; 2. non-diabetic and other endocrinopathys; 3. do not take steroid or contraceptive, do not take lipid lowerers and anticoagulation; 4. without serious hypertension and venous thrombosis; 5. electrocardiogram is got rid of patients with coronary heart disease; Suspected Coronary Heart Disease is done to angiography by Vasculocardiology Deparment to be got rid of; 6. hepatic and renal function is normal.
Physical data
Object of study is in August, 2008～2010 medical climacteric syndrome patient in year June, all meets diagnostic criteria and inclusive criteria.By table of random number method, divide at random treatment by Chinese herbs group 127 examples and western medicine group 113 examples.46～60 years old treatment by Chinese herbs group age, average (50.4 ± 2.5) year; The course of disease 6 months～4.6 years, average (23.7 ± 9.8) individual month.45～59 years old western medicine group age, average (48.9 ± 2.3) year; The course of disease 8 months～4.2 years, average (21.5 ± 6.8) individual month.Two groups of patients' age, the course of disease, symptom degree no difference of science of statistics (P>0.05), have comparability.
Grouping and administration
Western medicine group: application premarin adds medroxyprogestetone acetate.Adopt continuous therapy: premarin 0.625mg every day 1 time, oral; Medroxyprogestetone acetate 2mg, every day 1 time, oral, totally 30 days.According to clinical symptoms, take continuously later or take medicine again 3 months every other month.
Treatment by Chinese herbs group: take the syrup 1 of the embodiment of the present invention 1 preparation, every day 2 times, each 10ml, each 1 time sooner or later 1 month is 1 course for the treatment of, takes continuously 4 courses for the treatment of.
Observation index and method
The variation of symptom before and after medication
Hectic fever sweating is divided into 4 minutes substantially, dizziness, tinnitus, is tiredly 2 minutes, and lumbago and skelalgia, uncomfortable in chest, appetite and hyposexuality etc. are respectively 1 minute.Every symptom according to degree without, light, in, heavy be that the degree of 0 minute, 1 minute, 2 minutes, 3 minutes is divided.Symptom score is the basic product dividing with degree that divides.Total points is each symptom score summation.Symptom score before relatively treating and after treating.
Sex hormone measurement
E 2, FSH, L H, progesterone (P) detect and all adopt immunochemiluminescence method, test kit provides by Hai Bo bio tech ltd, Qingdao.
Lipid determination
Adopt immunoturbidimetry to detect T-CHOL (TC), triglyceride (T G), HDL-C (HDL-C), low-density lipoprotein cholesterol (LDL-C), test kit provides by Qingdao Better Biotechnology Co., Ltd..
Treat 1 blood of 3 months check These parameters and monitorings, urine, the just inspection such as routine and hepatic and renal function, electrocardiogram.
Curative effect determinate standard
Diagnosis and curative effect determinate standard > > with reference to < < common disease draft.Effective: hectic fever, sweating disappear, other transference cures or obviously alleviate; Effective: hectic fever, sweating alleviate, other transference cures or obviously alleviate; Invalid: hectic fever, sweating and other symptoms are all without improving.
Statistical method
Measurement data adopts represent, between group, relatively adopt χ 2check, all data all adopt SPSS12.0 statistical software to process.
Result
Before and after two groups of patient treatments, the comparison of symptom overall score, the results are shown in Table 4.
Symptom overall score comparison before and after table 4 liang group patient treatment
Group Number of cases Before treatment After treatment
Treatment group 127 29.27±3.61 19.81±2.72
Matched group 113 27.92±2.56 23.73±2.95
As can be seen from Table 4, adopt after traditional Chinese medicine composition for treating of the present invention before treatment, with respect to western medicine group, better efficacy.
The comparison of two groups of patient clinical curative effects, the results are shown in Table 5.
Table 5 liang group patient clinical curative effect comparison
Group Number of cases Effective Effectively Invalid Total effective rate (%)
Treatment group 127 75 37 15 88.2
Matched group 113 39 42 32 71.7
As can be seen from Table 5, adopt the clinical efficacy of Chinese medicine composition of the present invention to be better than western medicine group.
Before and after two groups of patient treatments, serum sex hormone level comparison, the results are shown in Table 6.
Serum sex hormone level comparison before and after table 6 liang group patient treatment
Group Time Number of cases E 2(pmol·L -1) FSH(IU·L -1) LH(IU·L -1)
Treatment group Before treatment 127 43.51±9.22 86.13±7.91 79.62±6.35
? After treatment 127 92.90±8.29 42.98±6.32 52.31±5.29
Matched group Before treatment 113 45.26±7.33 84.72±7.43 80.06±6.40
? After treatment 113 71.34±6.73 61.67±6.81 61.86±5.22
As can be seen from Table 6, adopt the Chinese medicine composition of the present invention E that can obviously raise 2level, reduce FSH and L H level.
Before and after two groups of patient treatments, blood lipid level comparison, the results are shown in Table 8.
Blood lipid level comparison before and after table 8 liang group patient treatment
Group Time Number of cases TC TG HDL-C LDL-C
Treatment group Before treatment 127 6.91±0.36 1.90±0.33 1.46±0.36 3.95±0.62
? After treatment 127 5.31±0.27 1.13±0.41 1.21±0.22 2.31±0.49
Matched group Before treatment 113 6.77±0.39 1.87±0.26 1.50±0.29 3.83±0.51
? After treatment 113 5.93±0.42 1.42±0.51 1.32±0.40 2.81±0.23
As can be seen from Table 8, adopt Chinese medicine composition of the present invention can reduce TC, T G, LDL-C, HDL-C level.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. a Chinese medicine composition that is used for the treatment of menopausal syndrome, is characterized in that: the crude drug of this Chinese medicine composition consists of Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae;
In described Chinese medicine composition, the weight portion of each crude drug is respectively Semen Nigellae 49 weight portion～59 weight portions, Rhizoma Curculiginis 36 weight portion～46 weight portions, Fructus Rosae Laevigatae 31 weight portion～41 weight portions, Semen Platycladi 17 weight portion～27 weight portions, Radix Polygalae 21 weight portion～31 weight portions, Herba Cistanches 42 weight portion～52 weight portions, Spica Prunellae 26 weight portion～36 weight portions, Semen Celosiae 23 weight portion～33 weight portions, Semen Sesami Nigrum 57 weight portion～67 weight portions, Herba Ecliptae 73 weight portion～83 weight portions, Cortex Phellodendri 43 weight portion～53 weight portions, Colla Plastri Testudinis 51 weight portion～61 weight portions, Rhizoma Curcumae 21 weight portion～31 weight portions, Pollen Typhae 33 weight portion～43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portion～29 weight portions, Rhizoma Dioscoreae 82 weight portion～92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portion～70 weight portions, Rhizoma Panacis Japonici 43 weight portion～53 weight portions, the Radix Paeoniae Alba 22 weight portion～32 weight portions, Radix Salviae Miltiorrhizae 31 weight portion～41 weight portions, Folium Apocyni Veneti 16 weight portion～26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portion～37 weight portions, Semen Phaseoli 16 weight portion～26 weight portions, Caulis Bambusae In Taenia 13 weight portion～23 weight portions, Concha Ostreae 9 weight portion～19 weight portions, Radix Achyranthis Bidentatae 39 weight portion～49 weight portions, Radix Changii 23 weight portion～33 weight portions, Pericarpium Citri Reticulatae 51 weight portion～61 weight portions, Semen Coicis 22 weight portion～32 weight portions, Radix Glycyrrhizae 27 weight portion～37 weight portions.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Semen Nigellae 51 weight portion～57 weight portions, Rhizoma Curculiginis 38 weight portion～44 weight portions, Fructus Rosae Laevigatae 33 weight portion～39 weight portions, Semen Platycladi 19 weight portion～25 weight portions, Radix Polygalae 23 weight portion～29 weight portions, Herba Cistanches 44 weight portion～50 weight portions, Spica Prunellae 28 weight portion～34 weight portions, Semen Celosiae 25 weight portion～31 weight portions, Semen Sesami Nigrum 59 weight portion～65 weight portions, Herba Ecliptae 75 weight portion～81 weight portions, Cortex Phellodendri 45 weight portion～51 weight portions, Colla Plastri Testudinis 53 weight portion～59 weight portions, Rhizoma Curcumae 23 weight portion～29 weight portions, Pollen Typhae 35 weight portion～41 weight portions, Lignum Dalbergiae Odoriferae 21 weight portion～27 weight portions, Rhizoma Dioscoreae 84 weight portion～90 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portion～68 weight portions, Rhizoma Panacis Japonici 45 weight portion～51 weight portions, the Radix Paeoniae Alba 24 weight portion～30 weight portions, Radix Salviae Miltiorrhizae 33 weight portion～39 weight portions, Folium Apocyni Veneti 18 weight portion～24 weight portions, Ramulus Uncariae Cum Uncis 29 weight portion～35 weight portions, Semen Phaseoli 18 weight portion～24 weight portions, Caulis Bambusae In Taenia 15 weight portion～21 weight portions, Concha Ostreae 11 weight portion～17 weight portions, Radix Achyranthis Bidentatae 41 weight portion～47 weight portions, Radix Changii 25 weight portion～31 weight portions, Pericarpium Citri Reticulatae 53 weight portion～59 weight portions, Semen Coicis 24 weight portion～30 weight portions, Radix Glycyrrhizae 29 weight portion～35 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: the dosage form of described Chinese medicine composition is tablet, powder, soft capsule, oral liquid, syrup, pill.
4. the preparation method of Chinese medicine composition described in claim 1 or 2, is characterized in that: when the dosage form of described Chinese medicine composition is syrup, this preparation method is specially,
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds with respect to 8～10 times of amount distilled water of mixture quality after pulverizing, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, stop heating, be down to room temperature, water extraction liquid is emitted, standing 1～2h, filter, obtain filtrate;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4～6 times of mixture qualities, boil 3～5h, filter, again add the distilled water with respect to 2～3 times of mixture qualities, boil 1～3h, filter, filtrate is merged, and the filtrate obtaining with second step mixes, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50%～70% (V/V), and standing over night is filtered, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution;
The 4th step, separately getting sucrose decocts with water, after dissolving, filter, concentrate and make syrup, mix with above-mentioned concentrated solution, boil, let cool, the volatile oil that adds antiseptic, second step to obtain, the powder that the first step obtains, by add or concentrated moisture to adjust volume to crude drug concentration be 3g/ml～4g/ml, subpackage, sterilizing, obtains described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portion～120 weight portions, and the addition of described antiseptic is 0.5 weight portion～1 weight portion.
5. the preparation method of Chinese medicine composition described in claim 1 or 2, is characterized in that: when the dosage form of described Chinese medicine composition is powder, this preparation method is specially,
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, after pulverizing, add with respect to 8～10 times of amount distilled water of mixture quality, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 1～2h, filters, obtain filtrate, filtrate concentrating under reduced pressure, obtains and gets dry extract, and is ground into powder;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4～6 times of mixture qualities, boil 3～5h, filter, again add the distilled water with respect to 2～3 times of mixture qualities, boil 1～3h, filter, filtrate is merged, and mix with the filtrate of second step acquisition, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50%～70% (V/V), standing over night, filter, filtrate decompression is concentrated, obtains and gets dry extract, and is ground into powder;
The 4th step, the volatile oil that second step is obtained is the dilution proportion with volume ratio 1:1～1:2 with ethanol, obtains volatile oil ethanol dilution liquid standby, takes beta-schardinger dextrin-and is placed in container, adding distil water is with the ratio heating for dissolving of 1:4～1:6, under 60 ℃ of constant temperature, stir, the volatile oil after dilution is slowly added in beta-schardinger dextrin-solution, stir 1～3h, put into 4 ℃ of cold preservation 12～24h of refrigerator, sucking filtration, dry 6～8h, obtain Benexate Hydrochloride, standby;
The 5th step, the Benexate Hydrochloride that the powder that the first step to the three steps are obtained and the 4th step obtain mixes, and is ground into 100 order～150 object powder, and vacuum drying obtains powder.
6. a Chinese medicine composition syrup that is used for the treatment of menopausal syndrome, is characterized in that: the crude drug of described syrup consists of Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae;
In described Chinese medicine composition syrup, the weight portion of each crude drug is respectively Semen Nigellae 49 weight portion～59 weight portions, Rhizoma Curculiginis 36 weight portion～46 weight portions, Fructus Rosae Laevigatae 31 weight portion～41 weight portions, Semen Platycladi 17 weight portion～27 weight portions, Radix Polygalae 21 weight portion～31 weight portions, Herba Cistanches 42 weight portion～52 weight portions, Spica Prunellae 26 weight portion～36 weight portions, Semen Celosiae 23 weight portion～33 weight portions, Semen Sesami Nigrum 57 weight portion～67 weight portions, Herba Ecliptae 73 weight portion～83 weight portions, Cortex Phellodendri 43 weight portion～53 weight portions, Colla Plastri Testudinis 51 weight portion～61 weight portions, Rhizoma Curcumae 21 weight portion～31 weight portions, Pollen Typhae 33 weight portion～43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portion～29 weight portions, Rhizoma Dioscoreae 82 weight portion～92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portion～70 weight portions, Rhizoma Panacis Japonici 43 weight portion～53 weight portions, the Radix Paeoniae Alba 22 weight portion～32 weight portions, Radix Salviae Miltiorrhizae 31 weight portion～41 weight portions, Folium Apocyni Veneti 16 weight portion～26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portion～37 weight portions, Semen Phaseoli 16 weight portion～26 weight portions, Caulis Bambusae In Taenia 13 weight portion～23 weight portions, Concha Ostreae 9 weight portion～19 weight portions, Radix Achyranthis Bidentatae 39 weight portion～49 weight portions, Radix Changii 23 weight portion～33 weight portions, Pericarpium Citri Reticulatae 51 weight portion～61 weight portions, Semen Coicis 22 weight portion～32 weight portions, Radix Glycyrrhizae 27 weight portion～37 weight portions.
7. syrup as claimed in claim 6, is characterized in that: the preparation method of described syrup is specially,
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, is mixed in proportion Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum, adds with respect to 8～10 times of amount distilled water of mixture quality after pulverizing, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, stop heating, be down to room temperature, water extraction liquid is emitted, standing 1～2h, filter, obtain filtrate;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4～6 times of mixture qualities, boil 3～5h, filter, again add the distilled water with respect to 2～3 times of mixture qualities, boil 1～3h, filter, filtrate is merged, and the filtrate obtaining with second step mixes, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50%～70% (V/V), and standing over night is filtered, filtrate decompression is concentrated into without alcohol taste, obtains concentrated solution;
The 4th step, separately getting sucrose decocts with water, after dissolving, filter, concentrate and make syrup, mix with above-mentioned concentrated solution, boil, let cool, the volatile oil that adds antiseptic, second step to obtain, the powder that the first step obtains, by add or concentrated moisture to adjust volume to crude drug concentration be 3g/ml～4g/ml, subpackage, sterilizing, obtains described syrup, with respect to the crude drug quality summation of 100 weight portions, the addition of described sucrose is 100 weight portion～120 weight portions, and the addition of described antiseptic is 0.5 weight portion～1 weight portion.
8. a Chinese medicine composition composition powders that is used for the treatment of menopausal syndrome, is characterized in that: the crude drug of described powder consists of Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Semen Platycladi, Radix Polygalae, Herba Cistanches, Spica Prunellae, Semen Celosiae, Semen Sesami Nigrum, Herba Ecliptae, Cortex Phellodendri, Colla Plastri Testudinis, Rhizoma Curcumae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Folium Apocyni Veneti, Ramulus Uncariae Cum Uncis, Semen Phaseoli, Caulis Bambusae In Taenia, Concha Ostreae, Radix Achyranthis Bidentatae, Radix Changii, Pericarpium Citri Reticulatae, Semen Coicis, Radix Glycyrrhizae;
In described Chinese medicine composition composition powders, the weight portion of each crude drug is respectively Semen Nigellae 49 weight portion～59 weight portions, Rhizoma Curculiginis 36 weight portion～46 weight portions, Fructus Rosae Laevigatae 31 weight portion～41 weight portions, Semen Platycladi 17 weight portion～27 weight portions, Radix Polygalae 21 weight portion～31 weight portions, Herba Cistanches 42 weight portion～52 weight portions, Spica Prunellae 26 weight portion～36 weight portions, Semen Celosiae 23 weight portion～33 weight portions, Semen Sesami Nigrum 57 weight portion～67 weight portions, Herba Ecliptae 73 weight portion～83 weight portions, Cortex Phellodendri 43 weight portion～53 weight portions, Colla Plastri Testudinis 51 weight portion～61 weight portions, Rhizoma Curcumae 21 weight portion～31 weight portions, Pollen Typhae 33 weight portion～43 weight portions, Lignum Dalbergiae Odoriferae 19 weight portion～29 weight portions, Rhizoma Dioscoreae 82 weight portion～92 weight portions, Radix Et Caulis Acanthopanacis Senticosi 60 weight portion～70 weight portions, Rhizoma Panacis Japonici 43 weight portion～53 weight portions, the Radix Paeoniae Alba 22 weight portion～32 weight portions, Radix Salviae Miltiorrhizae 31 weight portion～41 weight portions, Folium Apocyni Veneti 16 weight portion～26 weight portions, Ramulus Uncariae Cum Uncis 27 weight portion～37 weight portions, Semen Phaseoli 16 weight portion～26 weight portions, Caulis Bambusae In Taenia 13 weight portion～23 weight portions, Concha Ostreae 9 weight portion～19 weight portions, Radix Achyranthis Bidentatae 39 weight portion～49 weight portions, Radix Changii 23 weight portion～33 weight portions, Pericarpium Citri Reticulatae 51 weight portion～61 weight portions, Semen Coicis 22 weight portion～32 weight portions, Radix Glycyrrhizae 27 weight portion～37 weight portions.
9. powder as claimed in claim 8, is characterized in that: the preparation method of described powder is specially,
The first step is ground into powder after lyophilization by Colla Plastri Testudinis at the temperature of-10 ℃～-14 ℃ of degree;
Second step, Semen Nigellae, Rhizoma Curculiginis, Fructus Rosae Laevigatae, Herba Cistanches, Herba Ecliptae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Panacis Japonici, Radix Achyranthis Bidentatae, Semen Sesami Nigrum are mixed in proportion, after pulverizing, add with respect to 8～10 times of amount distilled water of mixture quality, after jolting mixes, soak 30～40min, be placed in volatile oil extractor, be heated to boiling, and keep 100 ℃～110 ℃ micro-6～8h that boil, collecting volatile oil is not increasing, and stops heating, be down to room temperature, water extraction liquid is emitted, and standing 1～2h, filters, obtain filtrate, filtrate concentrating under reduced pressure, obtains and gets dry extract, and is ground into powder;
The 3rd step, is mixed in proportion remaining component, adds the distilled water with respect to 4～6 times of mixture qualities, boil 3～5h, filter, again add the distilled water with respect to 2～3 times of mixture qualities, boil 1～3h, filter, filtrate is merged, and mix with the filtrate of second step acquisition, adding determining alcohol is that 70%～80% ethanol to alcohol volume content is 50%～70% (V/V), standing over night, filter, filtrate decompression is concentrated, obtains and gets dry extract, and is ground into powder;
The 4th step, the volatile oil that second step is obtained is the dilution proportion with volume ratio 1:1～1:2 with ethanol, obtains volatile oil ethanol dilution liquid standby, takes beta-schardinger dextrin-and is placed in container, adding distil water is with the ratio heating for dissolving of 1:4～1:6, under 60 ℃ of constant temperature, stir, the volatile oil after dilution is slowly added in beta-schardinger dextrin-solution, stir 1～3h, put into 4 ℃ of cold preservation 12～24h of refrigerator, sucking filtration, dry 6～8h, obtain Benexate Hydrochloride, standby;
The 5th step, the Benexate Hydrochloride that the powder that the first step to the three steps are obtained and the 4th step obtain mixes, and is ground into 100 order～150 object powder, and vacuum drying obtains powder.
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