CN103212037B - Traditional Chinese medicine for treating female endocrine disorder and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating female endocrine disorder and a preparation method of the traditional Chinese medicine. According to the traditional Chinese medicine, the problem of female endocrine disorder can be effectively solved. According to the preparation method, the traditional Chinese medicine is prepared by using groups A, B and C of raw materials, wherein the group A of raw materials comprises the following components in parts by weight: 10-16 parts of cinnamon, 8-10 parts of epimedium, 10-15 parts of Morinda officinalis, 15-20 parts of motherwort, 15-20 parts of Chinese angelica, 18-20 parts of Rehmannia glutinosa, 10-16 parts of curcuma aromatica, 10-15 parts of cortex albiziae, 15-20 parts of prepared nutgrass galingale rhizome, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of tuckahoe, 15-20 parts of desert cistanche processed with wine, 15-20 parts of fructus psoraleae and 15-20 parts of Semen cuscutae; the group B of raw materials comprises the following components in parts by weight: 20-25 parts of placenta hominis, 8-10 parts of cartialgenous and 4-6 parts of sea horse; and the group C of raw materials comprises the following components in parts by weight: 20-26 parts of deer-horn glue, 10-13 parts of chelonia glue and 15-20 parts of donkey-hide gelatin. The preparation method comprises the following steps of: adding water to the group A of raw materials, and decocting to concentrate decoction to form an extract; grinding the group B of the raw materials to form micropowder; and adding the group C of raw materials and the micropowder into the extract to uniformly mix, kneading the medicine mixture into a lump, and pelleting the lump. The traditional Chinese medicine is rich in raw materials, scientific and reasonable in formula, easy to produce and manufacture, low in cost and convenient to take and has a good effect and no side effect.

Description

A kind of Chinese medicine for the treatment of female incretion disorder and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly a kind of Chinese medicine for the treatment of female incretion disorder and preparation method thereof.

Background technology

Complexity, accuracy and the trickle property of human endocrine system is particularly outstanding women's performance, its special physiological function has determined that women is more subject to the torment of endocrine system disease, also more easily stand the disorder of hormonal system function, it is particularly outstanding that this point shows aspect gynecological's endocrine system disease.Since 20 century 70s " hypothalamic-pituitary-ovarian axle " are illustrated by Western Modern medical science, perfectly in harmony with " appoint-uterus axle of kidney-menses-punching " of Traditional Chinese Medicine, open new chapter for Chinese traditional treatment gynecological endocrinopathy, be more subject to high praise and the appreciation of international medical community.Especially the smooth enforcement of the Human Genome Project and completing, positive deep effect the every field of medical science.People never profoundly recognize the essence of disease as it is.Along with the continuous progress of Chinese medicine research, the cause of disease and the pathogenesis of some complex diseases are elucidated, and diagnosis can be thereupon clearer and more definite, and new, have more Therapeutic Method targetedly and also continue to bring out.

Female incretion disorder is because the nerve that a variety of causes causes-hormone secretion regulates feedback mechanism not normal, particularly not normal the and a series of morbid states that cause of the adjusting feedback function of " hypothalamic-pituitary-ovarian axis (HPOA) ".Can be divided into from etiology and pathogenesis: sex hormones secretion is not enough or certain single hormone secretion too much, the malfunctioning or hypofunction of nervus centralis dysregulation, target organ feedback mechanism.The disease that female incretion system disorders causes mainly comprises: property differentiation and abnormal development, dysfunctional uterine hemorrhage, amenorrhea, premature ovarian failure, ovarian cyst, polycystic ovarian syndrome, dysmenorrhea, female frigidity, infertility etc.

The clinical manifestation of female incretion disorder: Most patients shows as that menoxenia, hypo-ovaria, amenorrhea, dysmenorrhea, emotional lability, soreness of the waist and knees, palpitation and insomnia, tinnitus night sweat, libido are indifferent, sterility and infertility, chaeta are abnormal etc.Six mensuration of Diagnosis of Female endocrine regulation Main Basis patient's symptom and sign and hormone are made diagnosis.

At present, treatment doctor trained in Western medicine for female incretion disorder adopts Hormone Replacement Therapy more, as: estradiol benzoate (estradiolbenzoate), estradiol valerate (estradiolvalerate), nilestriol (nilestriol), ethinylestradiol (ethinylestradiol, EE) etc., the life-time service of this type of hormone medicine has the danger of bringing out mastopathy and gynecological tumor, improper use (is limited to various reasons, human body requirements dosage and actual dosage clinically Chang Wufa accurately mate) can aggravate the state of female incretion disorder, in addition, the side effect of exogenous hormones and dependence syndrome are also comparatively obvious.Hormone Replacement Therapy only can provide supplementing of exogenous hormones for the low endocrine regulation patient of estrogen, can not fundamentally nurse one's health and activate female incretion system (hypothalamic-pituitary-ovarian gonad axis, HPOA) neuro hormone regulates feedback function, also just cannot solve the root problem of female incretion disorder, the limitation that the side effect of exogenous estrogen and hormone dependence syndrome produce, the disorder of treated by hormone female incretion is often lost more than gain, bring new health problem.

The classic of TCM " Plain Questions innocent opinion in ancient times " is said: " woman seven years old, kidney qi is contained, and dental transition is sent out long; Two or seven (about 14 years old) and menarche, conception vessel is logical, and taichong channel is contained, and regular menstrual cycle, therefore there is son ... seventy-seven (49 years old before and after), conception vessel void, taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, menopause, therefore senile appearance and loss of fecundity are also." "Nei Jing" on to the basis of female pathology understanding, emphasize kidney storing essence, main reproduction, secretes menses, Si Eryin plays mastery reaction to female incretion; Blood stored in the liver, main catharsis, and department's sea of blood has important regulating action to woman's endocrine; Liver is the son of kidney, and The liver and the kidney have a common source, and female incretion is disorderly dirty closely related with Liver and kidney two.

In addition, emotional factors is also the major reason of female incretion disorder, can have influence on internal organs QI and blood, and feelings will is not smooth, zang-fu disharmony, and QI and blood retardance, causes female incretion imbalance, only has irritability bar to reach, and catharsis officials could female incretion system balmy and bracing.The treatment of female incretion disorder should be soothing the liver as method taking the kidney invigorating, makes kidney qi fill Sheng, and irritability bar reaches, internal organs and suitable, YIN and YANG in a relative equilibrium.In coition medicine monographs in ancient times " plain female's warp ", draw " beautiful room secret formula " cloud: " keep away the taboo of seven damages, Hang Bayizhi road, contrary 5 constant virtues, body is to protect.In healthy energy, fill, what disease is not gone! The dirty peacefulness of internal organs, gloss profit reason.Often connect and rise, strength Radix Achyranthis Bidentatae "." the large opinion of Plain Questions YIN YANG classification of natural phenomena " has the opinion of " negative and positive are adjustable to know seven harmful methods and eight favorable techniques in sexual life ".Internal organs equilibrium between yin and yang, kidney qi is vigorous, and QI and blood is in harmonious proportion, and recovers normal sexual function.In a word, the generation of primary disease is relevant to internal organs imbalance of YIN and YANG, suffers from a deficiency of the kidney basic into it, and irritability stasis is its mark, and treatment is taking the kidney invigorating and essence nourishing as main, and it is auxiliary nourishing blood soothing the liver.

Therefore, the traditional Chinese medical science is to start with from conditioning viscera function for the treatment of female incretion disorder, by YIN and YANG balance regulating balance, reach the object for the treatment of, the sale of the existing Chinese medicine for female incretion disorder except Western medicine in the market, these Chinese medicine function singlenesses, only lay particular stress on a kind of cause of disease and treat, the disease causing for various factors cannot produce a desired effect, and combined therapy effect is not good.

Summary of the invention

For above-mentioned situation, in order to overcome the defect of prior art, the object of this invention is to provide a kind of Chinese medicine for the treatment of female incretion disorder and preparation method thereof, can effectively solve unicity and the defect of current clinical application, avoid the side effect of exogenous hormones medicine generation and the hormonal dependent that long-term taking produces, by the conditioning of Chinese medicine, the pharmacological action that supplements, activates, improve the stability of therapeutic efficiency and treatment, fundamentally solve the problem of female incretion disorder.

The technical scheme that the present invention solves is, female incretion disorder, belong to " gynecological's endocrinopathy " category, according to the etiology and pathogenesis of primary disease, the traditional Chinese medical science is thought, should be with depressed liver-energy dispersing and QI regulating, warming the kidney to activate YANG, benefiting QI and nourishing blood, stomach function regulating spleen invigorating, Chong and Ren Meridians regulating is superintended and directed band for Therapeutic Principle, accordingly, Chinese medicine of the present invention is by A, B, tri-groups of raw materials of C are made, by weight, A group raw material is: Cortex Cinnamomi 10-16 part, Herba Epimedii 8-10 part, Radix Morindae Officinalis 10-15 part, Herba Leonuri 15-20 part, Radix Angelicae Sinensis 15-20 part, Radix Rehmanniae Preparata 18-20 part, Radix Curcumae 10-16 part, Cortex Albiziae 10-15 part, Rhizoma Cyperi (processed) 15-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Poria 10-15 part, wine Herba Cistanches 15-20 part, Fructus Psoraleae 15-20 part and Semen Cuscutae 15-20 part, B group raw material is: Placenta Hominis 20-25 part, Cornu Cervi Pantotrichum 8-10 part and Hippocampus 4-6 part, C group raw material is: Colla cornus cervi 20-26 part, Colla Plastri Testudinis 10-13 part and Colla Corii Asini 15-20 part, and its preparation method is:

(1), A is organized after raw material mixes and adds its weight 6-8 water doubly, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.20-1.30;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, according to a conventional method, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product.

Abundant raw material of the present invention, prescription science, reasonable, is easy to manufacture, and cost is relatively low, taking convenience, effective, the female incretion disorder causing for different pathogeny all can be carried out conditioning and treating, pure Chinese medicinal preparation, the generation that has no side effect, has actual clinical meaning.

Detailed description of the invention

Be described further below in conjunction with embodiment with to the specific embodiment of the present invention.

Embodiment 1

The present invention is in concrete enforcement, made by A, B, tri-groups of raw materials of C, by weight, A group raw material: 10 parts of Cortex Cinnamomis, 8 parts of Herba Epimedii, 10 parts of Radix Morindae Officinaliss, 15 parts of Herba Leonuri, 15 parts of Radix Angelicae Sinensis, 18 parts, Radix Rehmanniae Preparata, 10 parts of Radix Curcumaes, 10 parts of Cortex Albiziaes, 15 parts of Rhizoma Cyperi (processed), 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 15 parts of wine Herba Cistanchess, 15 parts of Fructus Psoraleaes, 15 parts of Semen Cuscutae; B organizes raw material: 20 parts of Placenta Hominiss, 8 parts, Cornu Cervi Pantotrichum, 4 parts of Hippocampus; C organizes raw material: 20 parts of Colla cornus cervis, 10 parts of Colla Plastri Testudinis, 15 parts, Colla Corii Asini, and preparation method is:

(1), A is organized after raw material mixes and adds the water of 6 times of weight, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.20;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product;

The manufacture method of pill is: dry pill is put in coating pan, rotate pot, add appropriate syrup, stir, in the time that pill surface is burr shape and the ball heart and soaks into, add appropriate Pulvis Talci, stir, Pulvis Talci is all wrapped up in and invested pill surface, add again syrup, Pulvis Talci, so repeatedly, pill is dried up with hair-dryer, then stop blowing, add again syrup to stir, pill surface uniform is unanimously as the criterion, in the time that pill surface is slightly dry, ball is dried up adding blowing hot wind, then add wax powder, pivoting friction is to pill surface very till light, take the dish out of the pot, (manufacture method of pill is routine techniques to place room temperature preservation in clean container, the technical characterictic of not protecting as claim).

Embodiment 2

The present invention is in concrete enforcement, made by A, B, tri-groups of raw materials of C, by weight, A group raw material: 16 parts of Cortex Cinnamomis, 10 parts of Herba Epimedii, 15 parts of Radix Morindae Officinaliss, 20 parts of Herba Leonuri, 20 parts of Radix Angelicae Sinensis, 20 parts, Radix Rehmanniae Preparata, 16 parts of Radix Curcumaes, 15 parts of Cortex Albiziaes, 20 parts of Rhizoma Cyperi (processed), 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 20 parts of wine Herba Cistanchess, 20 parts of Fructus Psoraleaes, 20 parts of Semen Cuscutae; B organizes raw material: 25 parts of Placenta Hominiss, 10 parts, Cornu Cervi Pantotrichum, 6 parts of Hippocampus; C organizes raw material: 26 parts of Colla cornus cervis, 13 parts of Colla Plastri Testudinis, 20 parts, Colla Corii Asini, and preparation method is:

(1), A is organized after raw material mixes and adds the water of 8 times of weight, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.30;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product; Method for preparing pills is with embodiment 1.

Embodiment 3

The present invention is in concrete enforcement, made by A, B, tri-groups of raw materials of C, by weight, A group raw material: 13 parts of Cortex Cinnamomis, 9 parts of Herba Epimedii, 13 parts of Radix Morindae Officinaliss, 17 parts of Herba Leonuri, 19 parts of Radix Angelicae Sinensis, 19 parts, Radix Rehmanniae Preparata, 13 parts of Radix Curcumaes, 13 parts of Cortex Albiziaes, 17 parts of Rhizoma Cyperi (processed), 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria, 16 parts of wine Herba Cistanchess, 18 parts of Fructus Psoraleaes, 18 parts of Semen Cuscutae; B organizes raw material: 22 parts of Placenta Hominiss, 9 parts, Cornu Cervi Pantotrichum, 5 parts of Hippocampus; C organizes raw material: 23 parts of Colla cornus cervis, 21 parts of Colla Plastri Testudinis, 18 parts, Colla Corii Asini, and preparation method is:

(1), A is organized after raw material mixes and adds the water of 7 times of weight, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.20;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product, method for preparing pills is with embodiment 1.

In said medicine, wherein:

Cortex Cinnamomi, function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, the card of YANG-depletion collapse.

Herba Epimedii, function cures mainly: kidney invigorating and YANG supporting, expelling wind and removing dampness, strong muscle key bone, control that waist knee joint flaccidity is soft, cold extremities with aversion to cold, cold womb be infertile.

Radix Morindae Officinalis, function cures mainly: reinforcing the kidney and supporting YANG, bone and muscle strengthening, expelling wind and removing dampness.Control suffer from a deficiency of the kidney, few abdomen cold type of pain, cold womb are infertile, soreness of the waist and knees.

Herba Leonuri, function cures mainly: invigorates blood circulation, blood stasis dispelling, regulating menstruation.Control menoxenia, dysmenorrhea, amenorrhea.

Radix Angelicae Sinensis, function cures mainly: enrich blood, invigorate blood circulation, regulating menstruation, moisturizes laxation.Control all cards of blood deficiency.

Radix Rehmanniae Preparata, function cures mainly: the yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Control all diseases of blood deficiency.

Radix Curcumae, function cures mainly: invigorates blood circulation, circulation of qi promoting, resolving depression, the removing heat from blood that clears away heart-fire, controls amenorrhea dysmenorrhea, the liver failing to maintain the normal flow of QI, feelings will is not smooth.

Cortex Albiziae, function cures mainly: resolving stagnation for tranquilization, promoting blood circulation and detumescence, controls melancholy insomnia, irritability.

Rhizoma Cyperi (processed), function cures mainly: depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving, the treating the liver stagnation of QI is stagnant, menoxenia, dysmenorrhea.

The Rhizoma Atractylodis Macrocephalae, function cures mainly: invigorating the spleen and benefiting QI, moisturize dampness removing, increase appetite.

Poria, function cures mainly: promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming.Control dysuria, insufficiency of the spleen lack of appetite, palpitation and restlessness, insomnia forgetfulness.

Wine Herba Cistanches, function cures mainly: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation, controls insufficiency of kidney-YANG, essence and blood void thanks to, infertile, soreness of the waist and knees, muscles and bones is unable.

Fructus Psoraleae, function cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.Control chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, have loose bowels.

Semen Cuscutae, function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the solid tire of spleen invigorating.Control lumbago tinnitus, sterile, stranguria with turbid discharge leukorrhagia, the head is dim.

Placenta Hominis, function cures mainly: QI invigorating, nourish blood, benefit essence, controls deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency.

Cornu Cervi Pantotrichum, function cures mainly: invigorating kidney-YANG, mend marrow, bone and muscle strengthening, adjusts punching to appoint.Control the disease such as suffer from a deficiency of the kidney, dizzy, deaf, order is dark, sexual impotence, spermatorrhea, cold womb are infertile, Mental fatigue, fear of cold, spinal column cold type of pain, muscles and bones flaccidity are soft and prolonged illness is deficient.

Hippocampus, function cures mainly: kidney invigorating and YANG supporting, control suffer from a deficiency of the kidney, the disease such as difficult labour, lump in the abdomen, furuncle swelling toxin.

Colla cornus cervi, function cures mainly: temperature compensation Liver and kidney, beneficial intensive culture blood.Control blood deficiency dizziness, the acid of waist knee joint is cold, and asthenia is become thin.

Colla Plastri Testudinis, function cures mainly: YIN nourishing, enriches blood, hemostasis.Control deficiency of YIN anemia, consumptive fever hectic fever due to YIN-deficiency, dysphoria with smothery sensation palpitation with fear, lumbago due to renal deficiency, flaccidity of feet and knees, metrorrhagia, leukorrhagia.

Colla Corii Asini, function cures mainly: the YIN nourishing of enriching blood, moisturize hemostasis.Control blood deficiency and yellow complexion, dizzy cardiopalmus, dysphoria and insomnia, xeropulmonary cough.

The effective compatibility of said medicine, supports mutually, has the kidney invigorating and essence nourishing, a soothing the liver effect that nourishes blood, and is effective to treat female incretion disorder, and has obtained satisfied technique effect through clinical trial, and interrelated data is as follows:

One, clinical data

(1) physical data: this group patient is clinical case during in December, 2009～2010 year December.Choose at random the disorderly patient of 100 routine female incretion, 14～50 years old age, average 31.5 years old: the course of disease 0.5～8 year.

(2) clinical manifestation: menoxenia, hypo-ovaria, amenorrhea, dysmenorrhea, emotional lability, soreness of the waist and knees, palpitation and insomnia, tinnitus night sweat, libido are indifferent, infertile, insomnia forgetfulness, think much and kindly consider etc.; Spirit is gloomy not easypro or vexed not peaceful, the breast side of body, distending pain of the breast etc.; Pale tongue or red, white and thin fur, deep-thready pulse or string etc.

(3) Standards of Chinese Medical Syndrome Differentiation: " traditional Chinese medical science disease Standardization of diagnosis and curative effect " and " the new Chinese medicine guideline of clinical investigations " formulated according to State Administration of Traditional Chinese Medicine.

(4) exclusion standard: suffer from gynecological inflammation, organic disease, congenital abnormal development etc. and by endocrine regulation person due to above-mentioned disease; Take impact or the endocrine medicine of suspicious impact (as depressor, tranquilizer, thyroid class medicine etc.) person; Within nearly 6 months, accept hormone medicine therapist.

(5) observation index: the variation of front and back Diagnostic Scale scoring is treated in observation, treats front and treats and respectively record 1 time for latter 3 months.

Two, therapeutic scheme

Patient takes Chinese medicine of the present invention, and each 6 grams, every day 3 times is oral, within the 5th day, start to take medicine from menstruation, and continuous 21 days.Within 2 months, be a course for the treatment of, add up therapeutic outcome three courses for the treatment of.

Three, efficacy assessment standard

" traditional Chinese medical science disease Standardization of diagnosis and curative effect " and " the new Chinese medicine guideline of clinical investigations " formulated with reference to State Administration of Traditional Chinese Medicine, formulate in conjunction with the disorderly Diagnostic Scale of female incretion.

1. effective: recover normal menstrual cycle, the symptoms such as amenorrhea, dysmenorrhea, palpitation and insomnia, sign disappear or obviously alleviate;

2. effective: recover normal menstrual cycle, symptom, the signs such as amenorrhea, dysmenorrhea, palpitation and insomnia all alleviate before treatment;

3. invalid: symptom, sign are without improving or improving not obvious.

Four, statistical procedures

According to diagnostic criteria and therapeutic scheme, through the disorderly patients of randomly draw 100 routine female incretions are observed, person's 78 examples that have remarkable result, the person's of having clear improvement 14 examples, nonresponder's 8 examples, total effective rate 92%, and have good long-term effect.

Five, model case

Not certain, female, 33 years old, people from Xichuan, Nanyang, Zhengzhou insurance company manager, on June 26th, 2011 examines.Cause massive hemorrhage because of placental retention puerperal, amenorrhea more than eight months, and whole body alopecia, companion sees tired weak, disease, pale tongue, white and thin fur, the thready and soft pulse such as libido is indifferent of polyuria, polydipsia, god.Card belongs to QI and blood deficiency, amenorrhea due to blood depletion.Control suitable benefiting QI and nourishing blood, Chong and Ren Meridians regulating.After diagnosis, take 7 doses, Chinese medicine of the present invention.Further consultation: July 3, still suitable after medicine, spirit takes a turn for the better, receives and sleeps also goodly, then keeps 14 doses of former sides and continues to take.Three examine: July 20, rise through water, only measure lessly, with coming, husband is other to tell with its spouse, and after taking medicine, libido is also recovered to some extent, and patient's self-induction is as the same, and no more side effects continues to take more than the moon.The four diagnostic methods: August 26, have rosy cheeks, spirit is all good, conscious without morbid state, in talk leak and love life as before harmonious, then continue to take a course for the treatment of by three sides of examining.

Bian so-and-so, female, 33 years old, Zhengzhou private entrepreneur.First visit on May 24 in 2011.More than the private prosecution whole body is sent out cool month, puerperal in 2010 conscious malasia, the whole body is weak, sends out cool aversion to wind and like to warm up, complexion is intense darkness without light, and podomere is miserable, uneasy sleeping at night, and libido is indifferent, goodwill as between spouses is absorbed in low ebb, once takes multiple female health product invalid, examines with indifferent being chief complaint of libido.Examine quarter: face (white light) is micro-swollen, spontaneous perspiration, and red tongue tongue is white, deficient pulse.Belong to losing puerperal and support, female incretion disorder due to hypo-ovaria, controlling should consolidating superficial resistance arresting sweating, nourishes cloudy blood, depressed liver-energy dispersing and QI regulating.After diagnosis, take 20 doses, Chinese medicine of the present invention.Two examine: June 20, after 20 doses of clothes medicine-feedings, antiperspirant subtracts greatly, unconsciously cool skin, and slightly sexy, tongue fur is white, and moderate pulse still continues to take a course for the treatment of (2 months) with front.Three examine JIUYUE 10, and subjective symptoms alleviates, and spirit sleep is all good, and face is improved, and libido is clearly better, and continues to take, and separately opens micro-powder of Chinese herbs, advises it gently to decoct every night rear fumigation and wash method, and medication heals more than the moon.

High mountain so-and-so, female, 27 years old, people from Huzhou, Zhejiang, bank clerk.First visit on July 2 in 2011.Private prosecution hyperhidrosis, osteopyrexia and fever, shiver all overs with cold, lower abdomen perineum more so, more than March, Hypomenorrhea darkish complexion over the past half year, libido is indifferent, does not think sexual life.Once saw a doctor in many places, examines as estrogen lowly, takes to estrogens medicine, slightly effect, but after clothes, body weight increases obviously, occasionally have feel sick dizzy, drug withdrawal then.After take certain brand health product, nearly unavailable, through colleague introduce, its household accompanies to examine.Examine quarter: dim complexion, and slight perspiration, cold hand and foot, body of the tongue thin coating is white, thready and rapid pulse without strength.Card belongs to deficiency of kidney-YIN, kidney yang deficiency.Control suitable enriching yin and nourishing kidney, warming the kidney to activate YANG.After diagnosis, take continuously 20 doses, Chinese medicine of the present invention.Two examine: August 5, after 20 doses of clothes medicine-feedings, sweating reduces, and lower abdomen perineum is conscious slightly warm, and arteries and veins is slightly strong.Front is adjusted slightly: Radix Astragali 60g, Radix Angelicae Sinensis 12g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 15g.Three examine: JIUYUE 1 day, and incoming call claims: take two and examine after 7 doses of medicines, discomfort is eliminated from head to foot, still tidal heat, sexuality is slightly recovered.Advise it still according to former side for the first time, continue to take January.The four diagnostic methods: October 5 examined, complexion is improved, and look joyful, knows that it is almost recovered.10 doses of consolidations of administration are dealt with problems arising from an accident.

Field, female, 27 years old, the supervisor of Zhengzhou enterprise.First visit on July 16 in 2012.Feel cold in the private prosecution whole body, taking two lower limb as work is more than 2 years.After within 2011, bearing child, sweating is frequent, and libido is indifferent, examines as anemia through doctor, slightly take a favorable turn after taking hematonic, but below waist and two lower limb send out cool, very cold, duration summer, wear thick clothing and also do not know to warm up, through in many ways failing to respond to any medical treatment.Examine quarter: pale complexion, lassitude, wears the thick trousers of sweater, touches skin of lower extremity profit and not warm, pale tongue with white fur, deep-thready pulse and slow (52 beats/min).Card belongs to antiperspirant impairment of YIN of a specified duration, and deficiency of YIN affecting YANG causes deficiency of kidney yang, controls suitable warming and recuperating the kidney-YANG, spleen reinforcing arresting sweating.After diagnosis, continue to take 14 doses, Chinese medicine of the present invention.Two examine: August 2, after 14 doses of clothes medicine-feedings, conscious two lower limb have warming, and tongue fur pulse condition is the same, no more side effects, and Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Poria are drunk and added to 20 grams in top, one course for the treatment of of tool medicine.Three examine: October 6, patient tells two lower limb and do not send out cool completely, though time early autumn, anti-thick trousers are changed, love life is as before harmonious, witness all removes, body constitution takes a turn for the better, and opens the medicine of nourishing kidney QI invigorating to be apt to thereafter, advises its sick disease just more must note warming.

Money so-and-so, female, 14 years old, people from Zhengzhou City, student.First visit: on July 29th, 2012.Menophania in this year, passes through 4 times, and flood tide is still accurate.This time, through turning duration midsummer, enter water swimming so that menstrual blood volume menstrual period as punching, 10 days are not clean, wrap with sanitary towel 3, and lower abdominal distention pain discomfort, a little clot, can adjust just receive, thready and rolling pulse band, tongue is dark red, thin fur.It is stagnant that card belongs to the blood clotting stasis of blood, the debility of CHONG and REN meridians, and controlling should promoting tissue regeneration by removing blood stasis.After diagnosis, continue to take 4 doses, Chinese medicine of the present invention.Two examine: August 4.Menses subtract, and slightly (without sanitary towel) under the stasis of blood, only feels the soreness of waist, and Mental fatigue is indigestion and loss of appetite, constipation, and thready and rapid pulse without strength, tongue is partially red, thin fur, root is greasy in vain.QI and blood consume, asthenia of both the spleen and kidney, controls plan invigorating the spleen and regulating the stomach, and punching is taken the photograph in the kidney invigorating.Three examine: August 9.Under the stasis of blood, stop, energy gradually fills, and defecates also smooth, and food is received still few, thready and soft pulse, and tongue is partially red, thin fur.Menses are clean, continue and take the photograph punching with tonifying speen and tonifying kidney, consolidate being apt to.

Goldenrain tree so-and-so, 27 years old, married, Zheng Dong new district schoolman.First visit: on June 5th, 2011.17 years old menarches, the cycle successively, without fixed, turns for 20～40 days one, on the high side through measuring, and once Chinese medicine medical treatment, reduces to normal through amount.Within 26 years old, marry, pregnant after marriage, artificial abortion for some reason pregnant latter 42 days time.Without regularly, medium through measuring through row, painless warp.Accompany sagging distention in the smaller abdomen menstrual period, waist is aching and limp, through front and back easy catching a cold.Last menstrual period May 6, the present faces the phase and does not turn.Gynecologial examination: anteversion of uterus, compared with normal is smaller.Body of the tongue is partially red, greasy fur, thready and stringy pulse.Card belongs to deficiency of the liver and kindey, QI and blood deficiency, and Chong and Ren channel disorder, controls suitable liver-nourishing kidney-boosting, tonifying Chong and Ren channels.After diagnosis, continue to take 7 doses, Chinese medicine of the present invention.Two examine: June 29.Fall behind and turn for 10 days through water, happen the 4th day, medium through measuring, companion's spiritlessness and weakness, soreness of the loins and weakness of the limbs, xerostomia is just hard.Red tongue, greasy and thin fur, thready pulse.The hepatic and renal YIN deficiency, punching is appointed not enough.Controlling should nourishing the liver and kidney.Top adds Fructus Ligustri Lucidi 12g, Fructus Mori 12g, Herba Taxilli 12g, Semen Platycladi 12g, 8 doses.Three examine: June 26.Within 6 days, turn through water, energy is front abundant.Tongue tip side of red, greasy and thin fur, thready and soft pulse.Control the former method of ancestor.Keep 14 doses of former sides.The four diagnostic methods: July 12., there is no the premonition of passing through menstrual period nearly.Red tongue, greasy and thin fur, stringy and thready pulse.Liver and kidney element is empty, and a stagnation of QI is appointed in punching, premenstrual give nourish blood soothing the liver, Ployglycosidium.Five examine: July 24.Within 20th, turn through water, will be clean in amount.After medical treatment, become accurate through the phase, companion's lower abdominal distention pain, lower limb are aching and limp, feel again exopathogen menstrual period, and nasal obstruction watery nasal discharge, receives and just still adjusts.Red tongue, the few Tianjin of yellow, greasy and thin fur, thready and stringy pulse band number.The hepatic and renal YIN deficiency, affection due to external wind and heat, first should discongest heresy, expelling wind and clearing away heat.Six examine: August 7.Flu is recovered, has been the 18th day menstrual period, without sufferings.Red tongue, thin fur, thready pulse.Miscarriage backlash is appointed impaired, Liver and kidney consumption wound, and controlling should nourishing the liver and kidney.After medicine, turned medium through measuring through water August 24, therefore still from original meaning increase and lose medical treatments, the cycle becomes accurate, through follow up a case by regular visits to obtain soon pregnant.

Zhao so-and-so, female, 50 years old, Zheng Dong people from new district, JIUYUE in 2011 first visit on the 21st.JIUYUE menstruation on the 15th is arrived, originally dripping hemorrhage, and bled profusely incessantly yesterday because of tired causing, and color is light red, and matter is rare, dirty along lower limb, dizziness order flower, and limb is blue or green nervous, 65 grams of hematochrome, complexion (white light) in vain, do not imitate by note hemostasis pin.Thready and rapid pulse, the thin matter of tongue is light red, and limit has tooth to print.Obvious QI and blood is lost greatly, and blood goes cloudy wound, and deficiency of YIN affecting YANG is rushed to appoint and lost solid resembling, and the anxious QI invigorating warming YANG of working as only collapses.After diagnosis, continue to take 7 doses, Chinese medicine of the present invention.The 2 doses of warps of taking medicine are only clean.Idealistic throb with fear sleep poor, spiritlessness and weakness, further consultation intend benefiting QI and nourishing blood, in case repeatedly.Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Preparatum are removed in top; Increase 15 grams of GANQIZI, 15 grams of Rhizoma Polygonati (processed), with clear its source, multiple it is old.Follow-up March, metrorrhagia has no recurrence.

The Meng so-and-so, 32 years old, married, reporter.First visit: on February 17th, 2010.The patient artificial abortion for some reason that becomes pregnant then after marriage for 2005.Natural labor in February, 2007 1 tire, marriage sentimental crisis in puerperal, since then, less through measuring all the time, 2008 to 2009 the two degree miscarriage row dilatation and curettage.

First visit: on February 17th, 2010.Hypomenorrhea more than 1 year, color crineous, 3～4 of sanitary towels only at every turn, companion's dizziness and fatigue.Last menstrual period January 22,2 days clean, just adjusts, and tongue is dark, and thin fur, a little less than deep-thready pulse.Card belongs to Liver and kidney consume, and essence and blood declines few, Chong and Ren channel disorder.And nourishing the liver and kidney, adjusts replenishing vital essence and blood.After diagnosis, continue to take 7 doses, Chinese medicine of the present invention.Two examine: February 26.Last menstrual period February 19, time feel dizziness and fatigue, sleep night and feel unwell, red tongue, thin fur, thready pulse.Deficiency of the liver and kindey, deficiency of both QI and YIN.Control suitable liver and kidney tonifying, tonifying Chong and Ren channels.Three examine: March 5.Happen the middle of the month, the tired soreness of waist of body, sleeps and feel unwell night, xerostomia taking fluids profusely.Red tongue, thin fur, thready pulse.Control the former method of ancestor, still come in and go out with top, remove Radix Morindae Officinalis, Herba Cistanches, add Cortex Eucommiae 12g, Radix Dipsaci 12g, Rhizoma Cibotii 12g, 14 doses.The four diagnostic methods: March 19.Menstrual period nearly, the tired soreness of waist of body, large loose stool is thin, sleeps night and feels unwell.Red tongue, thin fur, deep-thready pulse.Deficiency of the liver and kindey, deficiency of both QI and YIN.Control suitable supplementing QI and nourishing YIN, tonifying Chong and Ren channels.Five examine: March 26.In last menstrual period March 21, amount before increases, and approximately, with 1 bag sanitary towel, it is red that color also turns, and 4 days are only clean, companioned with headache, and lower abdomen dull pain, stool is owed in fact, and the dream of sleeping night is disturbed.Body of the tongue is light red, thin fur, thready pulse.Deficiency of the liver and kindey, uterus deficiency and coldness.Control suitable tonifying speen and tonifying kidney, tonifying Chong and Ren channels.Six examine: April 7.Disease, as aforementioned, before arteries and veins tongue is detailed, is still recuperated under medical treatment from original meaning.Top the defocus Rhizoma Atractylodis Macrocephalae, Fructus Rubi, Radix Dipsaci, Rhizoma Cibotii, add Huai wheat 30 Radix Glycyrrhizae Preparata 6g, bar halberd 12g, Herba Epimedii 12g, 7 doses.Seven examine: April 16.Few through row amount, medical treatment takes a turn for the better, half congealed just time, has faced premenstrual.Red tongue, thin fur, deficiency of kidney-QI, liver blood consume, venation is become estranged.Intend tonifying speen and tonifying kidney, nourish blood and network.Eight examine: April 23.Turned April 18 through water, amount increases closely normal, and 3 days only clean.Through after night sleep and feel unwell, mental weariness.Body of the tongue, thin fur, thready pulse.Still should benefiting QI and nourishing blood after clean.Nine examine to 11 and examine, and basic as front method increase and lose medical treatment, be also normal through amount at last menstrual period May 16, defecates real, and all cards are also put down.

In above-mentioned clinical data, find no untoward reaction, show drug safety, stable curative effect.

Six, conclusion

Shown by above-mentioned data, in the Chinese medicine the present invention relates to, Colla cornus cervi, Cornu Cervi Pantotrichum, Herba Epimedii, wine Herba Cistanches, Radix Morindae Officinalis, Semen Cuscutae invigorating kidney-YANG are with emerging wish, wherein Herba Epimedii warming the kidney to invigorate YANG, modern pharmacological research shows, its contained Herba Epimedii total flavones, icariine, vitamin E etc., can promote nucleic acid, protein synthetic of yang deficiency animal, and have androgen-like action; Radix Morindae Officinalis energy warming the kidney to invigorate YANG benefit essence, Semen Cuscutae tonifying the kidney to consolidate the essence, all containing flavone compound etc., can strengthen Isolated Toad Heart contractility, the effect of excited isolated uterine; Radix Rehmanniae Preparata, Colla Plastri Testudinis nourishing kidney-yin, beneficial seminal fluid, tonifying deficiency, Radix Angelicae Sinensis, Colla Corii Asini nourishing blood nourishing the liver; Rhizoma Cyperi (processed), Radix Curcumae, Cortex Albiziae dispersing the stagnated live-QI to relieve the stagnation of QI, bar reaches mechanism of qi; The Rhizoma Atractylodis Macrocephalae, Poria spleen-benefiting mind-tranquilizing.Above drug regimen and preparation tonifying both YIN and YANG, make positive cloudy helping and biochemical infinite, YIN matched with sufficient YANG making living things fully vivid, and full side is taking the negative and positive of the kidney invigorating as main, and nourishing kidney-yin is with benefit essence, help kidney yang and excitement, be aided with and nourish blood soothing the liverly, kidney essense is filled, kidney qi is contained, essence and blood is full, and irritability is smooth, and punching is appointed and is full of, and all diseases more.

The organic compatibility of drug component of the present invention, there is depressed liver-energy dispersing and QI regulating, warming the kidney to activate YANG, benefiting QI and nourishing blood, stomach function regulating spleen invigorating, Chong and Ren Meridians regulating and superintend and direct band, improve effect of the sensitivity of female sexual response, can effectively treat female incretion disorder, inadequate sexual desire, menoxenia, taking convenience, simple, effective, safety, has actual clinical meaning.

Claims (3)

1. treat the preparation method of the Chinese medicine of female incretion disorder for one kind, it is characterized in that, made by A, B, tri-groups of raw materials of C, by weight, A group raw material is: Cortex Cinnamomi 10-16 part, Herba Epimedii 8-10 part, Radix Morindae Officinalis 10-15 part, Herba Leonuri 15-20 part, Radix Angelicae Sinensis 15-20 part, Radix Rehmanniae Preparata 18-20 part, Radix Curcumae 10-16 part, Cortex Albiziae 10-15 part, Rhizoma Cyperi (processed) 15-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Poria 10-15 part, wine Herba Cistanches 15-20 part, Fructus Psoraleae 15-20 part and Semen Cuscutae 15-20 part; B group raw material is: Placenta Hominis 20-25 part, Cornu Cervi Pantotrichum 8-10 part and Hippocampus 4-6 part; C group raw material is: Colla cornus cervi 20-26 part, Colla Plastri Testudinis 10-13 part and Colla Corii Asini 15-20 part, and its preparation method is:

(1), A is organized after raw material mixes and adds its weight 6-8 water doubly, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.20-1.30;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, according to a conventional method, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product.

2. the preparation method of the Chinese medicine for the treatment of female incretion according to claim 1 disorder, it is characterized in that, made by A, B, tri-groups of raw materials of C, by weight, A group raw material: 10 parts of Cortex Cinnamomis, 8 parts of Herba Epimedii, 10 parts of Radix Morindae Officinaliss, 15 parts of Herba Leonuri, 15 parts of Radix Angelicae Sinensis, 18 parts, Radix Rehmanniae Preparata, 10 parts of Radix Curcumaes, 10 parts of Cortex Albiziaes, 15 parts of Rhizoma Cyperi (processed), 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 15 parts of wine Herba Cistanchess, 15 parts of Fructus Psoraleaes, 15 parts of Semen Cuscutae; B organizes raw material: 20 parts of Placenta Hominiss, 8 parts, Cornu Cervi Pantotrichum, 4 parts of Hippocampus; C organizes raw material: 20 parts of Colla cornus cervis, 10 parts of Colla Plastri Testudinis, 15 parts, Colla Corii Asini, and preparation method is:

(1), A is organized after raw material mixes and adds the water of 6 times of weight, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.20;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product.

3. the preparation method of the Chinese medicine for the treatment of female incretion according to claim 1 disorder, it is characterized in that, made by A, B, tri-groups of raw materials of C, by weight, A group raw material: 16 parts of Cortex Cinnamomis, 10 parts of Herba Epimedii, 15 parts of Radix Morindae Officinaliss, 20 parts of Herba Leonuri, 20 parts of Radix Angelicae Sinensis, 20 parts, Radix Rehmanniae Preparata, 16 parts of Radix Curcumaes, 15 parts of Cortex Albiziaes, 20 parts of Rhizoma Cyperi (processed), 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 20 parts of wine Herba Cistanchess, 20 parts of Fructus Psoraleaes, 20 parts of Semen Cuscutae; B organizes raw material: 25 parts of Placenta Hominiss, 10 parts, Cornu Cervi Pantotrichum, 6 parts of Hippocampus; C organizes raw material: 26 parts of Colla cornus cervis, 13 parts of Colla Plastri Testudinis, 20 parts, Colla Corii Asini, and preparation method is:

(1), A is organized after raw material mixes and adds the water of 8 times of weight, decoct 1.5 hours, decocting liquid is concentrated into the extractum that 50 DEG C of relative densities are 1.30;

(2), by B organize raw material mix after be ground into powder, cross 300 mesh sieves, mix and obtain micropowder;

(3), C organized to gained micropowder in raw material and step (2) add mix homogeneously in the extractum that A group raw material makes, becomes to stick together with medicine, make the pill of Semen phaseoli radiati size, oven dry, to obtain final product.