CN103041183A - Traditional Chinese medicine composition for curing nephritis of Schonlein-Henoch purpura and preparation method thereof - Google Patents

Traditional Chinese medicine composition for curing nephritis of Schonlein-Henoch purpura and preparation method thereof Download PDF

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CN103041183A
CN103041183A CN2012105852386A CN201210585238A CN103041183A CN 103041183 A CN103041183 A CN 103041183A CN 2012105852386 A CN2012105852386 A CN 2012105852386A CN 201210585238 A CN201210585238 A CN 201210585238A CN 103041183 A CN103041183 A CN 103041183A
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radix
ethanol
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CN103041183B (en
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不公告发明人
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Central health center of Honghua Town, Zijin Mountain
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Qingdao Hengbo Instrument Co Ltd
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Abstract

The invention provides a traditional Chinese medicine composition for curing nephritis of Schonlein-Henoch purpura. The bulk drugs are as follows: codonopsis pilosula, rhizoma polygonati, acanthopanax, moutan bark, cacumen biotae, leonurus, cortex lycii radicis, schisandra chinensis, honeysuckle stem, isatis roots, cortex phellodendri chinensis, changium smyrnioides, storax, semen euryales, pyrrosia lingua, notopterygium roots, poria cocos, morinda officinalis, liquorice, medicinal cyathula roots, picria fel-terrae, geranium wilfordii, coptis chinensis, dendrobe, eclipta, cistanche, rhizoma atractylodis, roots of fangji and sargentgloryvine stems. The traditional Chinese medicine composition shortens the course of treatment, improves the cure rate and has no toxic and side effect or drug tolerance.

Description

Be used for the treatment of Chinese medicine composition of anaphy lactoid purpura nephritis and preparation method thereof
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of anaphy lactoid purpura nephritis and preparation method thereof.
Background technology
Anaphylactoid purpura is the modal vasculitic disease of a kind of child, and principal character is erythra, arthralgia, stomachache and glomerular injury.Have 40% infant to develop into henoch Schonlein purpura nephritis in 4 to 6 weeks in the Purpura after typical purpura occurring, the order of severity of injury of kidney is the key that determines the Children With Anaphylactoid Purpura long-term prognosis.
The purple paralysed nephritis of anaphylaxis is the renal damage that the purple paralysis of anaphylaxis causes, it is the modal secondary glomerulopathy of department of pediatrics, also is the main cause of children's chronic renal failure.Primary disease is more common in child and teenager, and is common with 3 ~ 14 years old.A lot of sick anxious, there is the upper respiratory tract infection history in front 1 ~ 3 week of 50% ~ 90% infant disease, and most infant prognosis bonas get involved and serious journey but its long-term prognosis depends on that kidney has or not.
The purple paralysed nephritis of anaphylaxis is clinical in the purple paralysis of skin, naked eyes or microscopic hematuria simultaneously can be with performances such as albuminuria, edema, hypertension as main repeatedly, and severe one can develop into chronic renal insufficiency.Current during for the purple paralysis of anaphylaxis the impaired incidence rate bibliographical information of kidney differ, part Study shows that 20% ~ 80% the purple paralysed patient of anaphylaxis has kidney to get involved, if but with kidney Analysis of Biopsies 100% renal damage that has in various degree almost.And the degree that kidney is got involved is determining the prognosis of infant, and the generation of renal damage is mostly in 6 months of onset.Purple tired, hematuria, albuminuria Chang Fanfu occur in the course of disease, and touching difficulty is more brought great pain to infant and the head of a family.
The sickness rate of the purple fatigue nephritis of anaphylaxis is higher, treats thorny, the easy delay, clinical common with hematuria and Proteinuria Type.Doctor trained in Western medicine not yet forms harmonized programme for the treatment of the purple fatigue nephritis of anaphylaxis (hematuria and Proteinuria Type) at present, the main glucocorticoid that adopts, the treatment of immunosuppressant and cytotoxic drug is although obtained certain curative effect, the feelings recurrence of easily causing a disease after the large and decrement of side effect.
Anaphy lactoid purpura nephritis is when belonging to the categories such as " hematohidrosis ", " hematuria " in the Chinese medicine, " edema ".The primary disease frequently-occurring disease is hurried, and motherland's medical science thinks that primary disease is owing to have in the heat in blood and accumulate, diseases caused by exogenous pathogenic factor affection due to external wind and heat, the exopathogen such as wet, malicious, or the product of the scorching meat or fish wind symptom such as excessively ichthyophagy, shrimp, or because of drug allergy, grasp body not to be subjected to, so that wind heat fights mutually, the strongly fragrant and heat-transformation of evil poison, blood system latent heat, disturbance blood network, the absurd row of forcing blood, excessive skin then are purpura, send out speckle and form hematohidrosis, endosmosis in inner, in invade kidney, hyperactivity of fire caused by deficiency of YIN, damage kidney network and be hematuria, turbid urine.Pathological changes is positioned the internal organs such as skin, blood vessels, stomach, spleen, liver, kidney.Primary disease belongs to deficiency in origin and excess in superficiality more, the early stage card heat, true that belong to more.Delay with the passing of time, burning hot heresy consumption impairment of QI is cloudy, causes deficiency of both QI and YIN, many simulataneous insufficiency and excessive of later stage, every stasis of bloods of pressing from both sides more.In recent years, motherland's medical science is more and more for the research of primary disease, and a large amount of clinical practices proves that also the Chinese medicine primary disease is shortening the course of disease, having no side effect and drug resistance, raising cure rate, improve the aspect such as prognosis and have obvious curative effect with respect to Western medicine.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of anaphy lactoid purpura nephritis is provided, and compares with Western medicine, and it can shorten the course of disease, improves cure rate, have no side effect and drug resistance.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of anaphy lactoid purpura nephritis, its crude drug comprises Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae.
Wherein, the weight portion of each crude drug is respectively Radix Codonopsis 88 weight portions ~ 98 weight portions in the described Chinese medicine composition, Rhizoma Polygonati 46 weight portions ~ 56 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portions ~ 72 weight portions, Cortex Moutan 23 weight portions ~ 33 weight portions, Cacumen Platycladi 35 weight portions ~ 45 weight portions, Herba Leonuri 31 weight portions ~ 41 weight portions, Cortex Lycii 20 weight portions ~ 30 weight portions, Fructus Schisandrae Chinensis 43 weight portions ~ 53 weight portions, Caulis Lonicerae 13 weight portions ~ 23 weight portions, Radix Isatidis 37 weight portions ~ 47 weight portions, Cortex Phellodendri 20 weight portions ~ 30 weight portions, Radix Changii 23 weight portions ~ 33 weight portions, Benzoinum 16 weight portions ~ 26 weight portions, Semen Euryales 36 weight portions ~ 46 weight portions, Folium Pyrrosiae 51 weight portions ~ 61 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions ~ 27 weight portions, Poria 32 weight portions ~ 42 weight portions, Radix Morindae Officinalis 64 weight portions ~ 74 weight portions, Radix Glycyrrhizae 21 weight portions ~ 31 weight portions, Radix Cyathulae 29 weight portions ~ 39 weight portions, Radix Picriae felterrae 25 weight portions ~ 35 weight portions, Herba Erodii 20 weight portions ~ 30 weight portions, Rhizoma Coptidis 37 weight portions ~ 47 weight portions, Herba Dendrobii 55 weight portions ~ 65 weight portions, Herba Ecliptae 93 weight portions ~ 103 weight portions, Herba Cistanches 60 weight portions ~ 70 weight portions, Rhizoma Atractylodis 33 weight portions ~ 43 weight portions, Radix Stephaniae Tetrandrae 21 weight portions ~ 31 weight portions, Caulis Sargentodoxae 34 weight portions ~ 44 weight portions.
Wherein, the weight portion of each crude drug is respectively in the described Chinese medicine composition:
Radix Codonopsis 93 weight portions, Rhizoma Polygonati 51 weight portions, Radix Et Caulis Acanthopanacis Senticosi 67 weight portions, Cortex Moutan 28 weight portions, Cacumen Platycladi 40 weight portions, Herba Leonuri 36 weight portions, Cortex Lycii 25 weight portions, Fructus Schisandrae Chinensis 48 weight portions, Caulis Lonicerae 18 weight portions, Radix Isatidis 42 weight portions, Cortex Phellodendri 25 weight portions, Radix Changii 28 weight portions, Benzoinum 21 weight portions, Semen Euryales 41 weight portions, Folium Pyrrosiae 56 weight portions, Rhizoma Et Radix Notopterygii 22 weight portions, Poria 37 weight portions, Radix Morindae Officinalis 69 weight portions, Radix Glycyrrhizae 26 weight portions, Radix Cyathulae 34 weight portions, Radix Picriae felterrae 30 weight portions, Herba Erodii 25 weight portions, Rhizoma Coptidis 42 weight portions, Herba Dendrobii 60 weight portions, Herba Ecliptae 98 weight portions, Herba Cistanches 65 weight portions, Rhizoma Atractylodis 38 weight portions, Radix Stephaniae Tetrandrae 26 weight portions, Caulis Sargentodoxae 39 weight portions.
Wherein, the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, syrup.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was syrup, it was specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step, get the sucrose of 100 weight portion dried cream powders, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, 30 weight portions ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, packing after the sterilization namely gets syrup.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was powder, it was specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of crude drug quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into 100 orders ~ 200 purpose powder, ultraviolet sterilization, packing.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition was tablet, it was specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step with the dried cream powder spray drying, added 20% ~ 30% filler, 3% ~ 5% binding agent, 0.5% ~ 1.5% correctives, 0.5% ~ 1.5% lubricant subsequently, mixing, and tabletting dries, packing.
Wherein, described filler is one or more mixing in starch, beta-schardinger dextrin-, xylitol, the calcium carbonate, described binding agent is one or more mixing in polyvinylpyrrolidone, methylcellulose, the starch slurry, described correctives is one or more mixing in sucrose, the aspartame, and described lubricant is one or more mixing in magnesium stearate, Pulvis Talci, the micropowder silica gel.
The present invention also provides a kind of Chinese medicine composition syrup that is used for the treatment of anaphy lactoid purpura nephritis, the crude drug of described syrup comprises Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae
The preparation method of described syrup is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step, get the sucrose of 100 weight portion dried cream powders, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, 30 weight portions ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, packing after the sterilization namely gets syrup.
The present invention also provides a kind of Chinese medicine composition composition powders that is used for the treatment of anaphy lactoid purpura nephritis, the crude drug of described powder comprises Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae
The preparation method of described powder is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of crude drug quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into 100 orders ~ 200 purpose powder, ultraviolet sterilization, packing.
Beneficial effect of the present invention:
The Chinese medicine composition that is used for the treatment of anaphy lactoid purpura nephritis provided by the invention is compared with Western medicine, and it can shorten the course of disease, improves cure rate, have no side effect and drug resistance.
The specific embodiment
There is no the name of disease of " purple paralysed nephritis " in the Chinese medicine, but according to its clinical manifestation, when belonging to the categories such as " purpura ", " hemorrhagic disease with purpura ", " blood disorder ", " hematuria ".Wherein the purple paralysis of skin is common sympton, how to control from " purpura ", " hemorrhagic disease with purpura " opinion.Form and the characteristic distributions of having described the purple paralysis of primary disease in " Yizong Jinjian surgery heart method hemorrhagic disease with purpura " is that " big or small livid purple speckle, color shape such as Fructus Vitis viniferae are sent out in all over, and only the lower limb shin is in the majority." " Waike Zhengzong, Orthodox Manual of External Diseases hemorrhagic disease with purpura " say: " hemorrhagic disease with purpura, its trouble is born in children's more, experiences abnormal climates in four seasons, and is strongly fragrant loose in skin, forms big or small livid purple speckle, if the color Fructus Vitis viniferae is sent out and then spread all over women's head-ornaments, is to be syndrome of FU-organ." vividly described form, cause, ill crowd of purple paralysis etc.About the pathogenesis of primary disease, before the Tang of Sui, how to set forth one's views from diseases caused by exogenous pathogenic factor, " General Treatise on the Cause and Symptoms of Diseases " discusses its cause of disease at chapters and sections such as " typhoid fever YIN YANG toxin syndrome time ", " miscellaneous child diseases nobilities ", mainly sets forth one's views from diseases caused by exogenous pathogenic factor, thinks " this disease or typhoid fever, or seasonal epidemic pathogens or temperature poison ".
On pathogenesis, the traditional Chinese medical science thinks that " disease of speckle poison is that steam enters stomach, and stomach master muscle, is that heat is held poison under the arm and accumulate and amass in stomach, and poison is smoked to be sent out in muscle " forms.Since the Song Yuan, no longer arrested in the saying of diseases caused by exogenous pathogenic factor, set forth one's views from heat in blood again, think that heat in blood is this pathogenetic major reason, " the total little opinion side of children's's health blood oozing from the body openings or subcuta neous tissue opinion " said: " all hemorrhage persons of children's are taken advantage of in vim and vigour also by heat; the blood superficial heat is slime flux then ..., infiltrating small intestinal and descending the person is hematuria." Zhu Danxi proposes internal injury and sends out speckle, " danxi's experiential therapy speckle skin ulcer " said: " internal injury sends out speckle person, the gastric qi extreme deficiency, all over the body fire parade in outside due to." point out that " fire is contained ", " impairment of QI " they are the Basic disease causes that causes hemorrhage in the Jing-Yue Complete Works; " principal is cloudy smart, should not move also, and is moving then be disease, and blood main management gas should not decrease and also decrease then as sick, and the moving person of lid is many because fiery, and fiery Sheng is then forced the absurd row of blood; Damage person is many owing to gas, and impairment of QI then blood is difficult to deposit." to occurring kidney damage in the course of disease, oneself is on the books from ancient times, " Plain Questions lose consciousness opinion " said: " born of the same parents move heat in the wing moon bright, then the addiction hematuria." " Taiping Royal Prescriptions is controlled all sides of hematuria ": say that " husband hematuria person is that the wing skin has exopathogenic heat, and blood oozes in fat and hematuria." " miscellaneous diseases source and course rhinoceros candle five types of stranguria reddish and whitish turbid urine source and course " say: " hematuria, the key disease of drowning also, it is former owing to suffer from a deficiency of the kidney.”
The heresy of diseases caused by exogenous pathogenic factor six climate exopathogens is one of Etiological of the purple paralysis row of anaphylaxis nephritis.Children's's internal organs are tender and lovely, are subject to the exopathogen invasion and attack, and wherein especially take ailment said due to cold or exposure as main.Wind being the primary exopathogen is easily attacked people's flesh table and is caused a disease.Children's's the lung being usually insufficient, Teng Li are not close, and weakened defensive QI is easily invaded by six climate exopathogens.And children's " YANG often being in excess ',, have the pathological characteristic of " morbidity easily, the change of disease is rapid ", every easily heat being transformed from excessive YANG was lit a fire after sense was evil, and burning hot heresy fought mutually with QI and blood, injures venation, and the absurd row of forcing blood, excessive skin are that purple is paralysed.Ailment said due to cold or exposure can be separately disease both, can hold concurrently folder for sick with pathogenic heat, malicious heresy and damp again, and wind, poison, wet, heat are attacked the lung impairment of the spleen, invade and blood system, and damage kidney network is sent out and is primary disease.
In the carcinogenesis of human of disease, the modal hematuria that shows as, hyperactivity of fire caused by deficiency of YIN and QI failing to control blood are the pathological factor that causes bleeding, again the hemorrhage result who causes, after hemorrhage, blood circulating out of vessels is accumulated in the body and is blood stasis, and blood stasis affects again fresh blood growth and operation again, makes hemorrhage repeatedly difficult ending.So the Therapeutic Principle of promoting blood flow and remove blood stasis and stop bleeding should carry throughout.
Patient's element body deficiency or course of disease delay, temper is impaired, deficient qi and blood, elevate a turnable ladder is unable, QI failing to control blood, blood loses and has under one's command, overflows and see purpura, hematuria outside arteries and veins.Qi being the governor of blood, the capable then blood of gas, the stagnation of QI is blood stasis then, and treatment is not forgotten invigorating the spleen and benefiting QI simultaneously at the hemostasis dissipating blood stasis could Zhi Qiben.
Theoretical based on above-mentioned Chinese traditional treatment, Chinese medicine composition provided by the invention is turbid take tonifying speen and tonifying kidney, blood circulation promoting and blood stasis dispelling, diureticization, heat-clearing and toxic substances removing is as the Therapeutic Principle, by blood circulation promoting and blood stasis dispelling, can improve little blood flow: make the slowly blood flow acceleration of flowing, improve dense, glutinous, solidifying, the poly-tendency of blood; Improve the blood capillary form: alleviate the blood capillary spasm, alleviate in the microcirculation erythrocytic stasis and compile, blood capillary button loop top blood stasis reduces or disappears, the blood capillary clear-cut, and the form trend is normal; Reduce capillary permeability, reduce blood capillary oozing of blood on every side.Can promote nephropathy reparation and fibrin to absorb, alleviate edema or albuminuria, adjust immunologic function; Suppress or alleviate allergy to damage, suppress connective tissue metabolism, prevent the kidney proliferation of fibrous tissue, promote conversion and the absorption of preneoplastic lesions, can active cell immunity and antibody formation reaction by tonifying speen and tonifying kidney, improve cellular immune function, promote tonsil cell inducement interferon, improve the serum interferon level; Blood vessel dilating has obvious blood pressure lowering and improves the renal function effect, improves hemorheological property, reduces whole blood viscosity, Plasma Viscosity, obviously cholesterol reducing, triglyceride and phospholipid.
Chinese medicine composition provided by the invention comprises following crude drug: Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae.
Preferably, described Chinese medicine composition only is made of the above-mentioned raw materials medicine.
In the side, Radix Codonopsis, Rhizoma Polygonati, the Radix Et Caulis Acanthopanacis Senticosi invigorating spleen and kidney, the convergence astringency inducing, reduce albuminuria, Cortex Moutan, Cacumen Platycladi suppresses telangiectasis, permeability is hyperfunction, ooze out and edema, the effect of antiinflammatory is arranged, Cortex Moutan can also suppress allergy, and anti-platelet aggregation and thrombotic effect arranged, Radix Codonopsis, the Radix Et Caulis Acanthopanacis Senticosi regulating immunological function, the enhancing body resistance against diseases, antioxidation, blood vessel dilating, increase renal blood flow, reduce thrombosis, the Herba Leonuri promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing, can improve renal microcirculation, reduce hematoblastic gathering, reduce blood viscosity, reduce the thrombosis of kidney, alleviate the damage of glomerular basement membrane, reduce albuminuria, improve renal function, the Cortex Lycii clearing away heat and cooling blood, the Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, obvious antiallergic is arranged, antiinflammatory action, can regulate immunity of organisms, antioxidation, remove free radical, the existing merit of invigorating blood circulation of Caulis Lonicerae rattan again can the dispelling wind collateral dredging, the Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, the Benzoinum promoting flow of QI and blood, the Semen Euryales supplementing the kidney to control the nocturnal, the spleen reinforcing dehumidifying, the Folium Pyrrosiae clearing away heat and promoting diuresis, promoting blood circulation and hemostasis, diuresis is arranged, antibiotic, improve the effects such as renal blood flow and renal microcirculation, notopterygium wind dispelling is antipruritic, has antiinflammatory, antiallergic, anticoagulation, has good effect to eliminating the reaction of kidney local inflammation, the Radix Glycyrrhizae detoxifcation is held concurrently and is transferred all medicines, Radix Cyathulae blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, the Radix Picriae felterrae heat-clearing and toxic substances removing, reducing swelling and alleviating pain, effect with antiinflammatory, Radix Changii yin nourishing stomach function regulating, the suppressing the hyperactive liver detoxifcation, the Herba Erodii expelling wind and removing dampness, promoting blood circulation and detumescence, the Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, the Radix Isatidis expelling pathogenic wind from the body surface, heat-clearing and toxic substances removing, the Herba Dendrobii nourishing the stomach of promoting the production of body fluid, the nourishing YIN for benefiting the kidney, the Herba Ecliptae liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, Herba Cistanches, the Radix Morindae Officinalis kidney-replenishing, benefiting essence-blood, Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, Poria, the Radix Stephaniae Tetrandrae promoting diuresis to eliminate damp pathogen, spleen invigorating and in, all medicines share, and play altogether tonifying speen and tonifying kidney, blood circulation promoting and blood stasis dispelling, diureticization is turbid, the effect of heat-clearing and toxic substances removing.
The weight portion of each crude drug is respectively in the described Chinese medicine composition:
Radix Codonopsis 88 weight portions ~ 98 weight portions, Rhizoma Polygonati 46 weight portions ~ 56 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portions ~ 72 weight portions, Cortex Moutan 23 weight portions ~ 33 weight portions, Cacumen Platycladi 35 weight portions ~ 45 weight portions, Herba Leonuri 31 weight portions ~ 41 weight portions, Cortex Lycii 20 weight portions ~ 30 weight portions, Fructus Schisandrae Chinensis 43 weight portions ~ 53 weight portions, Caulis Lonicerae 13 weight portions ~ 23 weight portions, Radix Isatidis 37 weight portions ~ 47 weight portions, Cortex Phellodendri 20 weight portions ~ 30 weight portions, Radix Changii 23 weight portions ~ 33 weight portions, Benzoinum 16 weight portions ~ 26 weight portions, Semen Euryales 36 weight portions ~ 46 weight portions, Folium Pyrrosiae 51 weight portions ~ 61 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions ~ 27 weight portions, Poria 32 weight portions ~ 42 weight portions, Radix Morindae Officinalis 64 weight portions ~ 74 weight portions, Radix Glycyrrhizae 21 weight portions ~ 31 weight portions, Radix Cyathulae 29 weight portions ~ 39 weight portions, Radix Picriae felterrae 25 weight portions ~ 35 weight portions, Herba Erodii 20 weight portions ~ 30 weight portions, Rhizoma Coptidis 37 weight portions ~ 47 weight portions, Herba Dendrobii 55 weight portions ~ 65 weight portions, Herba Ecliptae 93 weight portions ~ 103 weight portions, Herba Cistanches 60 weight portions ~ 70 weight portions, Rhizoma Atractylodis 33 weight portions ~ 43 weight portions, Radix Stephaniae Tetrandrae 21 weight portions ~ 31 weight portions, Caulis Sargentodoxae 34 weight portions ~ 44 weight portions.
The weight portion of each crude drug further preferably is respectively in the described Chinese medicine composition:
Radix Codonopsis 91 weight portions ~ 95 weight portions, Rhizoma Polygonati 49 weight portions ~ 53 weight portions, Radix Et Caulis Acanthopanacis Senticosi 65 weight portions ~ 69 weight portions, Cortex Moutan 26 weight portions ~ 30 weight portions, Cacumen Platycladi 38 weight portions ~ 42 weight portions, Herba Leonuri 34 weight portions ~ 38 weight portions, Cortex Lycii 23 weight portions ~ 27 weight portions, Fructus Schisandrae Chinensis 46 weight portions ~ 50 weight portions, Caulis Lonicerae 16 weight portions ~ 20 weight portions, Radix Isatidis 40 weight portions ~ 44 weight portions, Cortex Phellodendri 23 weight portions ~ 27 weight portions, Radix Changii 26 weight portions ~ 30 weight portions, Benzoinum 19 weight portions ~ 23 weight portions, Semen Euryales 39 weight portions ~ 43 weight portions, Folium Pyrrosiae 54 weight portions ~ 58 weight portions, Rhizoma Et Radix Notopterygii 20 weight portions ~ 24 weight portions, Poria 35 weight portions ~ 39 weight portions, Radix Morindae Officinalis 67 weight portions ~ 71 weight portions, Radix Glycyrrhizae 24 weight portions ~ 28 weight portions, Radix Cyathulae 32 weight portions ~ 36 weight portions, Radix Picriae felterrae 28 weight portions ~ 32 weight portions, Herba Erodii 23 weight portions ~ 27 weight portions, Rhizoma Coptidis 40 weight portions ~ 44 weight portions, Herba Dendrobii 58 weight portions ~ 62 weight portions, Herba Ecliptae 96 weight portions ~ 100 weight portions, Herba Cistanches 63 weight portions ~ 67 weight portions, Rhizoma Atractylodis 36 weight portions ~ 40 weight portions, Radix Stephaniae Tetrandrae 24 weight portions ~ 28 weight portions, Caulis Sargentodoxae 37 weight portions ~ 41 weight portions.
The weight portion of each crude drug most preferably is respectively in the described Chinese medicine composition:
Radix Codonopsis 93 weight portions, Rhizoma Polygonati 51 weight portions, Radix Et Caulis Acanthopanacis Senticosi 67 weight portions, Cortex Moutan 28 weight portions, Cacumen Platycladi 40 weight portions, Herba Leonuri 36 weight portions, Cortex Lycii 25 weight portions, Fructus Schisandrae Chinensis 48 weight portions, Caulis Lonicerae 18 weight portions, Radix Isatidis 42 weight portions, Cortex Phellodendri 25 weight portions, Radix Changii 28 weight portions, Benzoinum 21 weight portions, Semen Euryales 41 weight portions, Folium Pyrrosiae 56 weight portions, Rhizoma Et Radix Notopterygii 22 weight portions, Poria 37 weight portions, Radix Morindae Officinalis 69 weight portions, Radix Glycyrrhizae 26 weight portions, Radix Cyathulae 34 weight portions, Radix Picriae felterrae 30 weight portions, Herba Erodii 25 weight portions, Rhizoma Coptidis 42 weight portions, Herba Dendrobii 60 weight portions, Herba Ecliptae 98 weight portions, Herba Cistanches 65 weight portions, Rhizoma Atractylodis 38 weight portions, Radix Stephaniae Tetrandrae 26 weight portions, Caulis Sargentodoxae 39 weight portions.
The pharmacology of each crude drug is as follows:
Radix Codonopsis: latin name Codonopsis Radix, sweet in the mouth, property is flat, enter lung, spleen channel, have the QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, cure mainly deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, the cards such as cough spontaneous perspiration, Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach, transfers regulating the function of middle-JIAO, has the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes intestinal to the absorption of nutrient substance.
Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has the yin nourishing of fostering the spirit of nobility, the spleen invigorating lung moistening, the effect of enriching kidney essence is used for the taste deficiency of qi and yin, and lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, yin asthenia generating intrinsic heat quench one's thirst the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, little sweet, warm in nature, enter spleen, kidney, heart channel, has replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, be used for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity soft, be slow in action, the card such as the body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Cortex Moutan: latin name Moutan Cortex, bitter in the mouth, suffering, cold nature enters the heart, liver, kidney channel, and the effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling is arranged, and is used for the cards such as the fever due to yin deficiency of excessive noxious heat, the acute appendicitis of damp and hot knot poison, depressed blood stasis, xerostomia, deep red tongue; And the liver-fire conjunctival congestion and swelling pain, stomach-fire gingiva pain.
Cacumen Platycladi: latin name Platycladi Cacumen, bitter in the mouth, puckery, cold in nature, return lung, liver, spleen channel, have cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, the effect of growing and blacking hair cures mainly haematemesis, and hemoptysis is had blood in stool, bleeding not during menses, lung-heat cough with asthma, heat in blood alopecia, the cards such as early whitening of beard and hair.
Herba Leonuri: latin name Leonuri Herba, bitter in the mouth, suffering, cold nature enters liver, pericardium channel, has promoting blood flow to regulate menstruation, and the effect of inducing diuresis to remove edema cures mainly menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria, the cards such as acute nephritis edema.
Cortex Lycii: latin name Lycii Cortex, cold in nature, sweet in the mouth has removing heat from blood except steaming, and the effect of lung heat clearing pathogenic fire reducing cures mainly the cards such as deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet is returned lung, the heart, kidney channel, have the convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming, be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, the cards such as palpitation and insomnia.
Caulis Lonicerae: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, have heat-clearing and toxic substances removing, the effect of dispelling wind collateral dredging cures mainly the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia, the cards such as redness and swelling of joints burning pain.
Radix Isatidis: latin name Isatidis Radix, bitter in the mouth, cold in nature enters the heart, liver, gallbladder, stomach warp, and the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving is arranged, and is used for the treatment of maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat the cards such as epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis, Radix Isatidis has inhibitory action to various bacteria. and infusion has in various degree inhibitory action to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will is congratulated, Fu Shi) bacillus, bacillus enteritidis etc.
Cortex Phellodendri: latin name Phellodendri Amurensis Cortex, cold in nature, bitter in the mouth, return kidney, urinary bladder channel, have heat clearing and damp drying, pathogenic fire purging is except steaming, the effect of skin ulcer is treated in detoxifcation, cures mainly the cards such as damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin.
Radix Changii: sweet in the mouth, little hardship, cold nature is returned lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, the yin nourishing stomach function regulating, the effect of suppressing the hyperactive liver detoxifcation is used for the cough due to lung-heat, vomiting regurgitation, the lack of appetite xerostomia, conjunctival congestion is dizzy, the cards such as furunculosis skin infection.
Benzoinum: latin name Benzoinum, acrid in the mouth, hardship, property is flat, and GUIXIN, spleen channel have the effect that dirty, promoting flow of QI and blood, pain relieving are warded off in the refreshment of having one's ideas straightened out, eliminating phlegm, are used for the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, trusted subordinate's pain, puerperal blood faints, the cards such as infantile convulsion.
Semen Euryales: sweet in the mouth, puckery, property is flat.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping cures mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine is with inferior card.
Folium Pyrrosiae: sweet in the mouth, hardship, cold nature is returned lung, urinary bladder channel, has relieving stranguria by diuresis, and the effect that lung heat clearing expels the heat-evil cures mainly and drenches pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, the cards such as carbuncle.
Rhizoma Et Radix Notopterygii: latin name Notopterygii Rhizoma et Radix, acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, have the effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, has the wet exterior syndrome of wind and cold folder, disease is seen fever with aversion to cold, headache as is wrapped up in, neck rigid back pain, and limbs are heavy, joint is ached, the cards such as anemofrigid-damp arthralgia.
Poria: sweet in the mouth, light, property is flat, enters spleen, lung, bladder, heart channel, and the effect of eliminating dampness and diuresis, spleen invigorating mind calming is arranged, and is mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the cards such as the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention stagnation, epilepsy.
Radix Morindae Officinalis: acrid in the mouth, sweet, warm in nature, return liver, kidney channel, have reinforcing the kidney and supporting YANG; Bone and muscle strengthening; The effect of expelling wind and removing dampness cures mainly impotence due to deficiency of the kidney; The seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; The cards such as rheumatism limb gas.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Radix Cyathulae: sweet in the mouth, little hardship, property is flat, enters liver, kidney channel, has the effect of blood circulation promoting and blood stasis dispelling, sharp joint, strong waist knee joint, inducing diuresis for treating stranguria syndrome, is used for the blood stasis amenorrhea, dysmenorrhea, treating swelling and pain by traumatic injury, Fengshi Guanjie pain, soreness of the waist and knees with the passing of time, the cards such as pyretic stranguria, stranguria with blood, hematuria.
Radix Picriae felterrae:
Herba Erodii: acrid in the mouth, hardship, property is flat, returns the liver,kidney,spleen warp, has wind-damp dispelling, the meridian dredging, the effect of antidiarrheal profit is used for rheumatic arthralgia, numbness contracture, muscles and bones is ached, the cards such as dysentery.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, the effect of cooling blood for improving eyesight is usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, the symptom such as vexed, thirsty.
Herba Dendrobii: latin name Dendrobii Caulis, cold nature, sweet in the mouth is returned stomach, kidney channel, has reinforcing stomach reg fluid, and the effect of nourishing YIN and clearing away heat cures mainly cloudy impairment of body fluid and loses, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, the cards such as poor vision.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis is used for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in the stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Herba Cistanches: sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation is used for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill.
Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, the effect that makes eye bright is mainly used in the stomachache dysentery of retention of dampness in middle-JIAO, the abdominal distention pain of incoordination between the spleen and stomach is vomitted indigestion and loss of appetite; The abdomen side of body distending pain of incoordination between the liver and stomach, vomiting with acid regurgitation; And the cards such as anemofrigid-damp arthralgia of the outer strongly fragrant meridians of cold-damp.
Radix Stephaniae Tetrandrae: latin name Stephaniae Tetrandrae Radix, bitter in the mouth, suffering, cold in nature, enter bladder, kidney channel, have inducing diuresis to remove edema, the function of wind-expelling pain-stopping is used for edema due to the retention of water-damp in the body, dysuria, the cards such as rheumatic arthralgia.
Caulis Sargentodoxae: latin name Sargentodoxae Caulis, bitter in the mouth, property is flat, returns liver, large intestine channel, has the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.
Chinese medicine composition provided by the invention is oral traditional Chinese medicine composition, as required, can be prepared into any regular dosage forms such as tablet, soft capsule, powder, granule, pill, syrup, can be according to the conventional method preparation of each dosage form, preferably, the dosage form of Chinese medicine composition is syrup, tablet and powder.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is tablet, is specially:
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
In the 4th step, with the dried cream powder spray drying, add subsequently 20% ~ 30% filler, 3% ~ 5% binding agent, 0.5% ~ 1.5% correctives, 0.5% ~ 1.5% lubricant, mixing, tabletting dries, packing, every 0.5g, the mass percent sum of each composition is 100%.
Described filler is preferably one or more mixing in starch, beta-schardinger dextrin-, xylitol, the calcium carbonate, described binding agent is preferably one or more mixing in polyvinylpyrrolidone, methylcellulose, the starch slurry, described correctives is preferably one or more mixing in sucrose, the aspartame, and described lubricant is preferably one or more mixing in magnesium stearate, Pulvis Talci, the micropowder silica gel.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is syrup, is specially:
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step, get the sucrose of 100 weight portion dried cream powders, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, 30 weight portions ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, packing after the sterilization namely gets syrup.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, is specially:
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of crude drug quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into 100 orders ~ 200 purpose powder, ultraviolet sterilization, packing.
The present invention also provide above-mentioned Chinese medicine composition for the preparation of the treatment anaphy lactoid purpura nephritis medicine in application.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The concrete preparation of embodiment 1 syrup 1
With Radix Codonopsis 93g, Rhizoma Polygonati 51g, Radix Et Caulis Acanthopanacis Senticosi 67g, Semen Euryales 41g, Folium Pyrrosiae 56g, Herba Dendrobii 60g, Herba Ecliptae 98g, Radix Morindae Officinalis 69g and Herba Cistanches 65g mix, obtain mixture, the determining alcohol that adds 600g is 90% ethanol, stir 4h, drop into percolate pot, the determining alcohol that continues adding 1.8kg is 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70L per hour, constantly adding determining alcohol by this speed simultaneously is 90% ethanol, remain in the percolation process that ethanol is not less than powder, collect percolate 5.4kg, with Cortex Moutan 28g, Cacumen Platycladi 40g, Herba Leonuri 36g, Cortex Lycii 25g, Fructus Schisandrae Chinensis 48g, Caulis Lonicerae 18g, Radix Isatidis 42g, Cortex Phellodendri 25g, Radix Changii 28g, Benzoinum 21g, Rhizoma Et Radix Notopterygii 22g, Poria 37g, Radix Glycyrrhizae 26g, Radix Cyathulae 34g, Radix Picriae felterrae 30g, Herba Erodii 25g, Rhizoma Coptidis 42g, Rhizoma Atractylodis 38g, Radix Stephaniae Tetrandrae 26g, Caulis Sargentodoxae 39g mixes, obtain mixture, the determining alcohol that adds 2.5kg is 90% ethanol, heating and refluxing extraction 5h, filter, obtain extracting solution, the determining alcohol that filtering residue adds 2.5kg again is 90% ethanol, heating and refluxing extraction 3h, again filter, obtain extracting solution, said extracted liquid is merged, obtain total extracting solution, the percolate that obtains is previously joined in total extracting solution of acquisition, obtain solution, leave standstill 24h, filter, filtrate decompression is concentrated, desolventizing obtains and gets dry extract, and is ground into dried cream powder, get the 1kg dried cream powder, the 40g sodium carboxymethyl cellulose, 500g sucrose, the sodium benzoate of 7g is dispersed in the 250g water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 4g/ml, boils to make dissolving, filter, packing after the sterilization namely gets syrup, every bottle of 10ml.
The concrete preparation of embodiment 2 syrups 2
With Radix Codonopsis 91g, Rhizoma Polygonati 49g, Radix Et Caulis Acanthopanacis Senticosi 65g, Semen Euryales 39g, Folium Pyrrosiae 54g, Herba Dendrobii 58g, Herba Ecliptae 96g, Radix Morindae Officinalis 67g and Herba Cistanches 63g mix, obtain mixture, the determining alcohol that adds 600g is 80% ethanol, stir 4h, drop into percolate pot, the determining alcohol that continues adding 1.8kg is 80% ethanol, dipping 24h, percolation, the percolate flow velocity is 70L per hour, constantly adding determining alcohol by this speed simultaneously is 80% ethanol, remain in the percolation process that ethanol is not less than powder, collect percolate 5kg, with Cortex Moutan 26g, Cacumen Platycladi 38g, Herba Leonuri 34g, Cortex Lycii 23g, Fructus Schisandrae Chinensis 46g, Caulis Lonicerae 16g, Radix Isatidis 40g, Cortex Phellodendri 23g, Radix Changii 26g, Benzoinum 19g, Rhizoma Et Radix Notopterygii 20g, Poria 35g, Radix Glycyrrhizae 24g, Radix Cyathulae 32g, Radix Picriae felterrae 28g, Herba Erodii 23g, Rhizoma Coptidis 40g, Rhizoma Atractylodis 36g, Radix Stephaniae Tetrandrae 24g, Caulis Sargentodoxae 37g mixes, obtain mixture, the determining alcohol that adds 2.4kg is 90% ethanol, heating and refluxing extraction 5h, filter, obtain extracting solution, the determining alcohol that filtering residue adds 2.4kg again is 90% ethanol, heating and refluxing extraction 3h, again filter, obtain extracting solution, said extracted liquid is merged, obtain total extracting solution, the percolate that obtains is previously joined in total extracting solution of acquisition, obtain solution, leave standstill 24h, filter, filtrate decompression is concentrated, desolventizing obtains and gets dry extract, and is ground into dried cream powder, get the 1kg dried cream powder, the 40g sodium carboxymethyl cellulose, 500g sucrose, the sodium benzoate of 7g is dispersed in the 200g water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 5g/ml, boils to make dissolving, filter, packing after the sterilization namely gets syrup, every bottle of 10ml.
The concrete preparation of embodiment 3 syrups 3
With Radix Codonopsis 95g, Rhizoma Polygonati 53g, Radix Et Caulis Acanthopanacis Senticosi 69g, Semen Euryales 43g, Folium Pyrrosiae 58g, Herba Dendrobii 62g, Herba Ecliptae 100g, Radix Morindae Officinalis 71g and Herba Cistanches 67g mix, obtain mixture, the determining alcohol that adds 600g is 90% ethanol, stir 4h, drop into percolate pot, the determining alcohol that continues adding 1.8kg is 80% ethanol, dipping 24h, percolation, the percolate flow velocity is 70L per hour, constantly adding determining alcohol by this speed simultaneously is 90% ethanol, remain in the percolation process that ethanol is not less than powder, collect percolate 5.4kg, with Cortex Moutan 30g, Cacumen Platycladi 42g, Herba Leonuri 38g, Cortex Lycii 27g, Fructus Schisandrae Chinensis 50g, Caulis Lonicerae 20g, Radix Isatidis 44g, Cortex Phellodendri 27g, Radix Changii 30g, Benzoinum 23g, Rhizoma Et Radix Notopterygii 24g, Poria 39g, Radix Glycyrrhizae 28g, Radix Cyathulae 36g, Radix Picriae felterrae 32g, Herba Erodii 27g, Rhizoma Coptidis 44g, Rhizoma Atractylodis 40g, Radix Stephaniae Tetrandrae 28g, Caulis Sargentodoxae 41g mixes, obtain mixture, the determining alcohol that adds 2.8kg is 90% ethanol, heating and refluxing extraction 5h, filter, obtain extracting solution, the determining alcohol that filtering residue adds 2.8kg again is 90% ethanol, heating and refluxing extraction 3h, again filter, obtain extracting solution, said extracted liquid is merged, obtain total extracting solution, the percolate that obtains is previously joined in total extracting solution of acquisition, obtain solution, leave standstill 24h, filter, filtrate decompression is concentrated, desolventizing obtains and gets dry extract, and is ground into dried cream powder, get the 1kg dried cream powder, the 40g sodium carboxymethyl cellulose, 500g sucrose, the sodium benzoate of 7g is dispersed in the 250g water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 4g/ml, boils to make dissolving, filter, packing after the sterilization namely gets syrup, every bottle of 10ml.
The concrete preparation of embodiment 4 powders 1
With Radix Codonopsis 93g, Rhizoma Polygonati 51g, Radix Et Caulis Acanthopanacis Senticosi 67g, Semen Euryales 41g, Folium Pyrrosiae 56g, Herba Dendrobii 60g, Herba Ecliptae 98g, Radix Morindae Officinalis 69g and Herba Cistanches 65g mix, obtain mixture, the determining alcohol that adds 600g is 90% ethanol, stir 4h, drop into percolate pot, the determining alcohol that continues adding 1.8kg is 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70L per hour, constantly adding determining alcohol by this speed simultaneously is 90% ethanol, remain in the percolation process that ethanol is not less than powder, collect percolate 5.4kg, with Cortex Moutan 28g, Cacumen Platycladi 40g, Herba Leonuri 36g, Cortex Lycii 25g, Fructus Schisandrae Chinensis 48g, Caulis Lonicerae 18g, Radix Isatidis 42g, Cortex Phellodendri 25g, Radix Changii 28g, Benzoinum 21g, Rhizoma Et Radix Notopterygii 22g, Poria 37g, Radix Glycyrrhizae 26g, Radix Cyathulae 34g, Radix Picriae felterrae 30g, Herba Erodii 25g, Rhizoma Coptidis 42g, Rhizoma Atractylodis 38g, Radix Stephaniae Tetrandrae 26g, Caulis Sargentodoxae 39g mixes, obtain mixture, the determining alcohol that adds 2.5kg is 90% ethanol, heating and refluxing extraction 5h, filter, obtain extracting solution, the determining alcohol that filtering residue adds 2.5kg again is 90% ethanol, heating and refluxing extraction 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution, the percolate that obtains is previously joined in total extracting solution of acquisition, obtain solution, leave standstill 24h, filter, filtrate decompression is concentrated, desolventizing, obtain and get dry extract, be ground into 150 purpose powder, ultraviolet sterilization, packing.
The concrete preparation of embodiment 5 tablets 1
With Radix Codonopsis 93g, Rhizoma Polygonati 51g, Radix Et Caulis Acanthopanacis Senticosi 67g, Semen Euryales 41g, Folium Pyrrosiae 56g, Herba Dendrobii 60g, Herba Ecliptae 98g, Radix Morindae Officinalis 69g and Herba Cistanches 65g mix, obtain mixture, the determining alcohol that adds 600g is 90% ethanol, stir 4h, drop into percolate pot, the determining alcohol that continues adding 1.8kg is 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70L per hour, constantly adding determining alcohol by this speed simultaneously is 90% ethanol, remain in the percolation process that ethanol is not less than powder, collect percolate 5.4kg, with Cortex Moutan 28g, Cacumen Platycladi 40g, Herba Leonuri 36g, Cortex Lycii 25g, Fructus Schisandrae Chinensis 48g, Caulis Lonicerae 18g, Radix Isatidis 42g, Cortex Phellodendri 25g, Radix Changii 28g, Benzoinum 21g, Rhizoma Et Radix Notopterygii 22g, Poria 37g, Radix Glycyrrhizae 26g, Radix Cyathulae 34g, Radix Picriae felterrae 30g, Herba Erodii 25g, Rhizoma Coptidis 42g, Rhizoma Atractylodis 38g, Radix Stephaniae Tetrandrae 26g, Caulis Sargentodoxae 39g mixes, obtain mixture, the determining alcohol that adds 2.5kg is 90% ethanol, heating and refluxing extraction 5h, filter, obtain extracting solution, the determining alcohol that filtering residue adds 2.5kg again is 90% ethanol, heating and refluxing extraction 3h, again filter, obtain extracting solution, said extracted liquid is merged, obtain total extracting solution, the percolate that obtains is previously joined in total extracting solution of acquisition, obtain solution, leave standstill 24h, filter, filtrate decompression is concentrated, desolventizing, obtain and get dry extract, be ground into dried cream powder, with dried cream powder 700g spray drying, the filler starch that adds subsequently 200g, the binding agent methylcellulose of 35g, the correctives sucrose of 9g, the magnesium stearate lubricant of 9g, mixing, tabletting dries, packing, every 0.5g.
Embodiment 6 Chinese medicine composition toxicity tests detect
Laboratory animal
60 of kunming mices (being provided by Qingdao City's laboratory animal and zoopery center), female half and half, body weight 18～22g, be divided into 6 groups, every group 10,60 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight is 250g ~ 300g, in 14 ages in week, be divided into 6 groups, 10 every group, experimental animal enters the cleaner assay chamber and raises 7d, observes animal activity, feed, defecation and all begins test without after unusual.(50cm * 32cm * 22.5cm) raise, male and female are divided cage with all steel rat breeding cage.Feed with the Mus full-valence pellet feed, by the keeper special messenger's feeding and management through training.Animal housing's illumination is sufficient, and heating ventilation and air-conditioning equipment is good, 18～25 ℃ of room temperatures, and relative humidity 50%～70%, test chamber is regularly sterilization routinely.
Experimental agents
The syrup 1 of the 1st group to the 3rd group gavage embodiment of the invention of kunming mice 1 to embodiment 3 preparation is to syrup 3, syrup 1 to syrup 3 is diluted with water to 1g/ml, the powder 1 of the 4th group of gavage embodiment of the invention of kunming mice 4 preparations, powder 1 is dissolved in the water, dissolve complete, be prepared into the solution of 1g/ml, the tablet 1 of the 5th group of gavage embodiment of the invention of kunming mice 5 preparations, tablet 1 is dissolved in the water, dissolve complete, be prepared into the solution of 1g/ml, the syrup 1 of the 1st group to the 3rd group gavage embodiment of the invention of Cavia porcellus 1 to embodiment 3 preparation is diluted with water to 1g/ml to syrup 3 with syrup 1 to syrup 3, the powder 1 of the 4th group of gavage embodiment of the invention of Cavia porcellus 4 preparations, powder 1 is dissolved in the water, and dissolve complete is prepared into the solution of 1g/ml, the tablet 1 of the 5th group of gavage embodiment of the invention of Cavia porcellus 5 preparations, tablet 1 is dissolved in the water, and dissolve complete is prepared into the solution of 1g/ml.
The kunming mice acute toxicity testing
With the 1st group to the 5th group of kunming mice respectively according to top method administration, each 0.4ml/10g, blank group gavage equivalent normal saline, behind front fasting (the can't help water) 12h of test, the 1st group to the 5th group every day 1 gastric infusion, 14d records the situations such as tested mice behavior, activity, food ration, body weight, feces, death continuously, and not dead mice is put to death behind 14d and performs an autopsy on sb．.
The 1st group of mice to the 5th group of 40g (crude drug)/kg dosed administration of Chinese medicine composition, saw that the mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity, food ration, body weight gain, feces etc. all recover normally after the 2nd day, compare no significant difference with the blank group; And without dead and other unusual generations, two groups perform an autopsy on sb． after putting to death simultaneously in the 14d, and each main organs (heart, liver, spleen, lung, kidney) is no abnormality seen by the naked eye.
Cavia porcellus repetitively administered toxicity test
With the 1st group to the 5th group of Cavia porcellus respectively according to top method administration, each 0.4ml/10g, blank group gavage equivalent normal saline, behind front fasting (the can't help water) 12h of test, the 1st group to the 5th group every day 1 gastric infusion, continuous 5 weeks, record the situations such as tested Cavia porcellus behavior, activity, food ration, body weight, feces, death, Guinea Pigs Died is not put to death after 5 weeks and is performed an autopsy on sb．.
Experimental animal behavior activity within whole experimental period, diet, defecation and shown no obvious abnormalities by situations such as hair color pools have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.Duration of test has individual animal dead, takes up Anatomical Observation through cage, and dead animal shows no obvious abnormalities, and causes death for administration is improper.
Growth promoter is good after each treated animal administration, and body weight gain and blank group relatively show no obvious abnormalities.
Put to death animal after the off-test, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.
Heart: the myocardial cell band is clear, and nuclear is placed in the middle, and a matter has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without unusually.Liver: hepatocyte is arranged and is strand, and the lobules of liver structure is clear, and the portal area has no cell infiltration and fibrous connective tissue hypertrophy, the hepatocyte polygon, and slurry is abundant, and nuclear is justified greatly.Spleen: fibrous capsule is complete, and without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: the bronchioles structural integrity, be methodically arranged, the alveolar wall structural integrity, lung interval and bronchus are excellent, and intracavity has no degeneration, necrosis and cell infiltration without obvious exudate.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and the messangial cell number does not increase, and the blood capillary tube chamber is without expansion, matter no abnormality seen between renal cells, kidney.Brain: organizational structure is normal, and neurocyte, neurogliocyte form are normal, each layer neuronal cell Non Apparent Abnormality.
Embodiment 7 zooperies
Laboratory animal
60 of healthy guinea pigs, (being provided by Qingdao City's laboratory animal and zoopery center), male and female half and half, body weight is 250g ~ 300g, all rats took acidifying water front 3 days, all did urine protein, ERY (test paper method) inspection, thereby had got rid of the impact of laboratory animal on experimental result.
Experimental agents and reagent
The BSA bovine serum albumin: Science and Technology Ltd. provides by source, Shanghai consor thing; Staphylococcal enterotoxin B (SEB): Shandong Medical University provides; Nitric oxide (NO), nitricoxide synthase (NOS) test kit: the Hai Bo thing Engineering Co., Ltd that supports one's family in Qingdao provides; The 12nd weekend, adopt the carotid artery blood collection method to gather rat blood, separation of serum.
Experimental group uses the syrup of embodiment 1 preparation.
Instrument
Automatic clinical chemistry analyzer: the Linda of Qingdao City medical science and technology company limited is produced; 7550 spectrophotometers: Qingdao precision instrument reagent company limited is produced.
The structure of anaphy lactoid purpura nephritis model
The next day oral 0.1% the acidifying water that contains, add regular tail vein injection BSA after 6 weeks, 8 all recurrence of disease at the same time next year add tail vein injection SEB, then observe to the 12nd weekend.The preparation of acidifying water: freshly boil the method that adds hydrochloric acid in the distilled water that strokes (every 500ml adds 10% hydrochloric acid 1.6ml preparation, uses after the airtight cooling.The 0.1%BSA acidifying water adds the preparation of 1000ml acidifying water by BAS.Tail vein injection BSA dosage: 10mg/kg during 6 week, once a day, continuous three days.Tail vein injection SEB dosage during 8 week: the 0.4mg/kg body weight, weekly, continuous three weeks.Occur hematuria, albuminuria after 12 weeks, the modeling success is described.
Experiment grouping and administration
Experiment is divided into 3 groups, and 20 every group, be divided into treatment group, model group and blank group, treatment group gavages the syrup of the embodiment of the invention 1 preparation, in the 8th week beginning gavage, once a day, continuous 5 weeks; Blank group and model group gavage respectively the distilled water of equivalent, the blank distilled water that gavages respectively equivalent with model group of organizing.
Detection method
The 24h urine protein quantitation was measured 8w (before the administration), the 12nd weekend (administration 5w), collected rat 24h urine with the metabolic cage method, and record urine amount and mensuration urine protein concentration are calculated the 24h excretion quantity of urinary protein, urine erythrocyte counting urinary sediment microscopy.Get the determination of serum renal function the 12nd weekend, detect nephridial tissue NO, NOS content by nitrate reductase method.Light microscopy specimen is put to death rat the 12nd weekend, take out kidney, fixes with 10% neutral formalin.Electron microscope specimen is fixed with 3% glutaraldehyde solution.
Statistical method
Carry out statistical disposition with 10.0 editions softwares of SPSS for Windows.Measurement data adopts the t check, and enumeration data adopts χ 2Check.
Experimental result
Variation to Cavia porcellus 24h urine protein quantitation the results are shown in Table 1.
The variation of three groups of Cavia porcellus 24h of table 1 urine protein quantitation
Figure BDA00002683217300211
As can be seen from Table 1, after modeling, the urine protein quantitation of Cavia porcellus significantly raises, and through taking traditional Chinese medicine composition for treating provided by the invention, the urine albumen amount for the treatment of group significantly descends.
Variation to the Cavia porcellus urine erythrocyte the results are shown in Table 2.
The variation of three groups of Cavia porcellus urine of table 2 Lactoferrin
Figure BDA00002683217300212
As can be seen from Table 2, after modeling, the urine erythrocyte of Cavia porcellus counting significantly raises, and through taking traditional Chinese medicine composition for treating provided by the invention, the urine erythrocyte counting for the treatment of group significantly descends.
The variation of three groups of guinea pig serum BUN, Cr the results are shown in Table 3.
The variation of table 3 three groups of guinea pig serum BUN, Cr
Group Blood urea nitrogen (g/L) Creatinine (g/L)
Treatment group 7.63±0.73 56.03±6.85
Model group 8.91±0.60 80.17±9.03
Blank group 7.37±0.91 55.49±8.21
As can be seen from Table 3, the blood urea nitrogen of model group and creatinine significantly rise with respect to the blank group, and through adopting the treatment of Chinese medicine composition of the present invention, blood urea nitrogen and creatinine significantly descend.
The variation of three groups of Cavia porcellus nephridial tissue NO, NOS content the results are shown in Table 4.
The variation of three groups of Cavia porcellus nephridial tissues of table 4 NO, NOS content
Group NO(μmol/L) NOS(U/ml)
Treatment group 0.192±0.062 0.801±0.106
Model group 0.427±0.091 1.103±0.195
Blank group 0.173±0.051 0.762±0.113
As can be seen from Table 4, the Cavia porcellus nephridial tissue NO of model group, NOS content significantly rise, and take the Chinese medicine composition of the present invention's preparation, can significantly reduce Cavia porcellus nephridial tissue NO, NOS content.
Embodiment 8 clinical experiments
Physical data
All cases derive from medical infant in year June in October, 2008 to 2011, selection meets infant totally 159 examples of the standard of 2009 " TCM Pediatrics clinical research " of publishing (except nephrotic syndrome and renal dysfunction state), be divided into treatment group and matched group, treatment group infant 83 examples, man's 49 examples, woman's 34 examples, 2～14 years old age, average (9.63 ± 1.27) year; The course of disease 3～45d, matched group 76 examples, male 41 examples, women 35 examples; 3～12 years old age, average (10.03 ± 1.55) year; The course of disease 4～38d.2 groups of infant sexes, age, course of disease etc. be Epidemiological Analysis by statistics, and difference no statistical significance (P＞0.05) has comparability.
Therapeutic Method
Matched group is taken prednisone 2mg/ (kgd), begins decrement after taking for 4 weeks, and decoction being taken at a draught 2mg/ (kgd) took for 4 weeks next day of making into, later decrement gradually, the 0.5mg/ next day that maintenance dose being (kgd), total course for the treatment of 4.
Treatment group is taken the syrup 1 of the embodiment of the invention 1 preparation, and 3 doses of every days, each 1 dose, 1 dose of 10ml, takes 4 courses for the treatment of at 1 month 1 course for the treatment of.
The clinical efficacy standard
Draft with reference to relevant criterion in " new Chinese medicine guideline of clinical investigations ".Recovery from illness: symptom, sign disappear, and urine erythrocyte disappears, and occult blood is negative, and the qualitative feminine gender of urine protein or 24h urine protein quantitation are lower than 100mg, normal renal function.Produce effects: symptom, sign disappear, and urine erythrocyte is no more than 6/HP, and the Urine sediments analyzer red blood cell count(RBC) reduces by 〉=3/HP, and occult blood reduces 〉=" ++ ", and the 24h urine protein quantitation continues to be down to below the 300mg, normal renal function.Effectively: symptom, sign are improved, and the Urine sediments analyzer red blood cell count(RBC) reduces by＜3/HP, and occult blood reduces＜"+", normal renal function.Invalid: symptom, sign are improved not obvious, and routine urianlysis is without improving or increasing the weight of.
Statistical method
Carry out statistical disposition with 10.0 editions softwares of SPSS for Windows.Measurement data adopts the t check, and enumeration data adopts χ 2Check.
Cardinal symptom, sign disappear routine number relatively
Main observation and comparison is hematuria (microscopic hematuria), the routine number of albuminuretic disappearance in 4 courses for the treatment of.
The result
2 groups of Clinical efficacy comparisons the results are shown in Table 5.
2 groups of curative effects of table 5 relatively
Group n Recovery from illness Produce effects Effectively Invalid Total effective rate (%)
Treatment group 83 41 23 14 5 93.98%
Matched group 76 15 22 20 19 75%
As can be seen from Table 5, employing Chinese medicine composition of the present invention will be significantly better than western medicine group on therapeutic effect.
2 groups of hematurias, albuminuria disappear routine number relatively, the results are shown in Table 6.
Table 62 groups of hematurias, albuminuria disappear routine number relatively
Figure BDA00002683217300231
Figure BDA00002683217300241
Embodiment 9 model cases
Song, man, 8 years old, first visit on August 27 in 2010.Infant the skin purpura occurs in May, 2010, during morbidity without heating and arthralgia, stomachache.Local hospital is diagnosed as anaphylactoid purpura.Purpura disappears behind the systematic treating in hospital.Hematuria occurs after 3 weeks, routine urinalysis shows urine protein (+), 40/HP of erythrocyte, occult blood (+++), first visit disease is seen: skin is without the petechia ecchymosis, without generating heat pharyngeal hyperemia, tonsil I degree hypertrophy, red tongue, yellow fur, thready and rapid pulse.Lab testing: routine urinalysis shows urine protein (+), occult blood (+++), 30～35/HP of erythrocyte, 2～4/HP of leukocyte, be diagnosed as anaphy lactoid purpura nephritis, the syrup of the oral embodiment of the invention 1 preparation, 3 doses of every days, each 1 dose, 1 dose of 10ml, check routine urinalysis after 1 month: urine protein (-), 6～8/HP of erythrocyte, 1～3/HP of leukocyte, period in a medicine is advised and is taken a good rest, avoid flu, continued to take 3 months, check routine urinalysis: 2～4/HP of erythrocyte, 0～1/HP of leukocyte, urine protein (-), stable disease is followed up a case by regular visits to and is not recurred June.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims (10)

1. Chinese medicine composition that is used for the treatment of anaphy lactoid purpura nephritis, it is characterized in that: the crude drug of described Chinese medicine composition comprises Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is respectively Radix Codonopsis 88 weight portions ~ 98 weight portions in the described Chinese medicine composition, Rhizoma Polygonati 46 weight portions ~ 56 weight portions, Radix Et Caulis Acanthopanacis Senticosi 62 weight portions ~ 72 weight portions, Cortex Moutan 23 weight portions ~ 33 weight portions, Cacumen Platycladi 35 weight portions ~ 45 weight portions, Herba Leonuri 31 weight portions ~ 41 weight portions, Cortex Lycii 20 weight portions ~ 30 weight portions, Fructus Schisandrae Chinensis 43 weight portions ~ 53 weight portions, Caulis Lonicerae 13 weight portions ~ 23 weight portions, Radix Isatidis 37 weight portions ~ 47 weight portions, Cortex Phellodendri 20 weight portions ~ 30 weight portions, Radix Changii 23 weight portions ~ 33 weight portions, Benzoinum 16 weight portions ~ 26 weight portions, Semen Euryales 36 weight portions ~ 46 weight portions, Folium Pyrrosiae 51 weight portions ~ 61 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions ~ 27 weight portions, Poria 32 weight portions ~ 42 weight portions, Radix Morindae Officinalis 64 weight portions ~ 74 weight portions, Radix Glycyrrhizae 21 weight portions ~ 31 weight portions, Radix Cyathulae 29 weight portions ~ 39 weight portions, Radix Picriae felterrae 25 weight portions ~ 35 weight portions, Herba Erodii 20 weight portions ~ 30 weight portions, Rhizoma Coptidis 37 weight portions ~ 47 weight portions, Herba Dendrobii 55 weight portions ~ 65 weight portions, Herba Ecliptae 93 weight portions ~ 103 weight portions, Herba Cistanches 60 weight portions ~ 70 weight portions, Rhizoma Atractylodis 33 weight portions ~ 43 weight portions, Radix Stephaniae Tetrandrae 21 weight portions ~ 31 weight portions, Caulis Sargentodoxae 34 weight portions ~ 44 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively in the described Chinese medicine composition: Radix Codonopsis 93 weight portions, Rhizoma Polygonati 51 weight portions, Radix Et Caulis Acanthopanacis Senticosi 67 weight portions, Cortex Moutan 28 weight portions, Cacumen Platycladi 40 weight portions, Herba Leonuri 36 weight portions, Cortex Lycii 25 weight portions, Fructus Schisandrae Chinensis 48 weight portions, Caulis Lonicerae 18 weight portions, Radix Isatidis 42 weight portions, Cortex Phellodendri 25 weight portions, Radix Changii 28 weight portions, Benzoinum 21 weight portions, Semen Euryales 41 weight portions, Folium Pyrrosiae 56 weight portions, Rhizoma Et Radix Notopterygii 22 weight portions, Poria 37 weight portions, Radix Morindae Officinalis 69 weight portions, Radix Glycyrrhizae 26 weight portions, Radix Cyathulae 34 weight portions, Radix Picriae felterrae 30 weight portions, Herba Erodii 25 weight portions, Rhizoma Coptidis 42 weight portions, Herba Dendrobii 60 weight portions, Herba Ecliptae 98 weight portions, Herba Cistanches 65 weight portions, Rhizoma Atractylodis 38 weight portions, Radix Stephaniae Tetrandrae 26 weight portions, Caulis Sargentodoxae 39 weight portions.
4. such as the described Chinese medicine composition of claims 1 to 3, it is characterized in that: the dosage form of described Chinese medicine composition is tablet, soft capsule, powder, granule, pill, syrup.
5. the preparation method of the described Chinese medicine composition of claim 1 to 4 is characterized in that: when the dosage form of described Chinese medicine composition is syrup, is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step, get the sucrose of 100 weight portion dried cream powders, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, 30 weight portions ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, packing after the sterilization namely gets syrup.
6. the preparation method of the described Chinese medicine composition of claim 1 to 4 is characterized in that: when the dosage form of described Chinese medicine composition is powder, is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of crude drug quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into 100 orders ~ 200 purpose powder, ultraviolet sterilization, packing.
7. the preparation method of the described Chinese medicine composition of claim 1 to 4 is characterized in that: when the dosage form of described Chinese medicine composition is tablet, is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step with the dried cream powder spray drying, added 20% ~ 30% filler, 3% ~ 5% binding agent, 0.5% ~ 1.5% correctives, 0.5% ~ 1.5% lubricant subsequently, mixing, and tabletting dries, packing.
8. preparation method as claimed in claim 7, it is characterized in that: described filler is preferably one or more mixing in starch, beta-schardinger dextrin-, xylitol, the calcium carbonate, described binding agent is preferably one or more mixing in polyvinylpyrrolidone, methylcellulose, the starch slurry, described correctives is preferably one or more mixing in sucrose, the aspartame, and described lubricant is preferably one or more mixing in magnesium stearate, Pulvis Talci, the micropowder silica gel.
9. Chinese medicine composition syrup that is used for the treatment of anaphy lactoid purpura nephritis, it is characterized in that: the crude drug of described syrup comprises Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae
The preparation method of described syrup is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae, Radix Morindae Officinalis and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of described mixture quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into dried cream powder;
The 4th step, get the sucrose of 100 weight portion dried cream powders, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, 30 weight portions ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, packing after the sterilization namely gets syrup.
10. Chinese medicine composition composition powders that is used for the treatment of anaphy lactoid purpura nephritis, it is characterized in that: the crude drug of described powder comprises Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Cortex Moutan, Cacumen Platycladi, Herba Leonuri, Cortex Lycii, Fructus Schisandrae Chinensis, Caulis Lonicerae, Radix Isatidis, Cortex Phellodendri, Radix Changii, Benzoinum, Semen Euryales, Folium Pyrrosiae, Rhizoma Et Radix Notopterygii, Poria, Radix Morindae Officinalis, Radix Glycyrrhizae, Radix Cyathulae, Radix Picriae felterrae, Herba Erodii, Rhizoma Coptidis, Herba Dendrobii, Herba Ecliptae, Herba Cistanches, Rhizoma Atractylodis, Radix Stephaniae Tetrandrae, Caulis Sargentodoxae
The preparation method of described powder is specially,
The first step, with Radix Codonopsis, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Folium Pyrrosiae, Herba Dendrobii, Herba Ecliptae and Herba Cistanches are mixed in proportion, obtain mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 1 ~ 2 times of this mixture quality, stir 2h ~ 4h, drop into percolate pot, continue to add determining alcohol with respect to 2 ~ 4 times of this mixture qualities and be 80% ~ 90% ethanol, dipping 24h, percolation, the percolate flow velocity is 70～85L per hour, and constantly adding determining alcohol by this speed simultaneously is 80% ~ 90% ethanol, remain in the percolation process that ethanol is not less than powder, the collection percolate is 7 ~ 9 times of crude drug quality;
Second step is mixed in proportion remaining component, obtains mixture, adding is 80% ~ 90% ethanol with respect to the determining alcohol of 3 ~ 5 times of this mixture qualities, heating and refluxing extraction 3 ~ 5h filters, and obtains extracting solution, it is 80% ~ 90% ethanol that filtering residue adds determining alcohol with respect to 2 ~ 3 times of this mixture qualities again, heating and refluxing extraction 1 ~ 3h filters again, obtains extracting solution, said extracted liquid is merged, obtain total extracting solution;
In the 3rd step, the percolate that the first step is obtained joins in total extracting solution that second step obtains, and obtains solution, leaves standstill 24h, filters, and filtrate decompression is concentrated, and desolventizing obtains and gets dry extract, and is ground into 100 orders ~ 200 purpose powder, ultraviolet sterilization, packing.
CN201210585238.6A 2012-12-30 2012-12-30 Traditional Chinese medicine composition for curing nephritis of Schonlein-Henoch purpura and preparation method thereof Expired - Fee Related CN103041183B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101095872A (en) * 2007-07-05 2008-01-02 北京艺信堂医药研究所 Chinese traditional medicine composition for treating anaphylactoid purpura nephritis
CN101703684A (en) * 2009-11-05 2010-05-12 贾高锁 Medicament for treating allergic purpura and preparation method thereof
CN102114163A (en) * 2011-02-19 2011-07-06 岳淑玲 Traditional Chinese medicine for treating Henoch-Schonlein purpura nephritis

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Publication number Priority date Publication date Assignee Title
CN101095872A (en) * 2007-07-05 2008-01-02 北京艺信堂医药研究所 Chinese traditional medicine composition for treating anaphylactoid purpura nephritis
CN101703684A (en) * 2009-11-05 2010-05-12 贾高锁 Medicament for treating allergic purpura and preparation method thereof
CN102114163A (en) * 2011-02-19 2011-07-06 岳淑玲 Traditional Chinese medicine for treating Henoch-Schonlein purpura nephritis

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