CN101703684A - Medicament for treating allergic purpura and preparation method thereof - Google Patents
Medicament for treating allergic purpura and preparation method thereof Download PDFInfo
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- CN101703684A CN101703684A CN200910075890A CN200910075890A CN101703684A CN 101703684 A CN101703684 A CN 101703684A CN 200910075890 A CN200910075890 A CN 200910075890A CN 200910075890 A CN200910075890 A CN 200910075890A CN 101703684 A CN101703684 A CN 101703684A
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Abstract
The invention provides a medicament for treating allergic purpura, which is prepared from the following raw material medicaments in part by weight: 10 to 15 parts of Japanese thistle herb, 10 to 15 parts of common cephalanoplos herb, 5 to 10 parts of periostracum cicada, 10 to 15 parts of rehmannia root charcoal, 10 to 15 parts of baical skullcap root charcoal, 10 to 15 parts of garden burnet root charcoal,15 to 20 parts of lalang grass rhizome, 10 to 15 parts of the root bark of the peony tree, 10 to 15 parts of twotooth achyranthes root, 10 to 20 parts of poria, 15 to 20 parts of largehead atractylodes rhizome, 10 to 15 parts of red peony root, and 6 to 12 parts of raw liquorice. The raw material medicaments can be prepared into various conventional oral preparations by Chinese medicinal preparation conventional methods. The medicament has the functions of eliminating pathogenic heat from the blood, removing stasis to stop bleeding and resisting allergy, can treat both the symptoms and root causes of allergic purpura with perfect curative effect, and prevents relapse after healing. Clinical observation of 896 patients proves that the total effective rate of the medicament reaches 89.7 percent.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of anaphylactoid purpura, particularly relating to a kind of is the medicine and preparation method thereof of the treatment anaphylactoid purpura of crude drug preparation with Chinese medicine.
Background technology
Anaphylactoid purpura is comparatively common clinically, is the scorching disease of a kind of contingency blood capillary and tiny arteries, etiology unknown.Its characteristics are mucocutaneously all petechia can occur, or with joint, abdominal part and renal symptom.Primary disease is sent out well in child and teenager, and clinical symptoms can gently can weigh, and the petechia of the needle point size of diffusing shape appears in the lighter's skin, without visceral lesion; And weight person often merges purpura sample nephritis or intestinal bleeding.The traditional Chinese medical science thinks that its etiology and pathogenesis is because innate deficiency more, the heresy of affection of exogenous wind-cold wind heat, in have the poison of the long-pending heat of internal organs, pyretic toxicity to contain that then venation is impaired, escape of blood from meridians, the slime flux arteries and veins is subcutaneous forming outward.The heavy then multiple abscess joint of damp and hot poison, the inside fire attack internal organs, a little less than the sick decline of spleen-QI for a long time, the nutrient blood consumption is hindered, and involves in kidney.Because this cause of disease focus complexity, patient disorderly seeks medical advice again, and what have uses western medical treatment, as oral YUNNAN BAIYAO, takes VITAMIN C TABLET, prednisone, chlorphenamine; Also take rutin tablets, prednisone, happy power calcium, VITAMIN C TABLET; Also have hospitalization to use Western medicine penicillin, prednisone, VITAMIN C TABLET, chlorphenamine, etamsylate, troxerutin etc.These Therapeutic Method or in remission, i.e. recurrence again soon after the drug withdrawal, effect is undesirable, and is perhaps simply invalid.Though some patients have also used Chinese medicine, owing to do not suit the medicine to the illness poor effect.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of anaphylactoid purpura, this medicine has clearing away heat and cooling blood, removing stasis to stop bleeding and antianaphylactic effect, treatment anaphylactoid purpura curative effect ideal.
Another object of the present invention provides the preparation method of the medicine of this treatment anaphylactoid purpura treatment.
Medicine of the present invention selects Radix Cirsii Japonici, Herba Cirsii, Periostracum Cicadae, fresh rehmannia charcoal, charred Radix Scutellariae, charred Radix Sanguisorbae, Rhizoma Imperatae, Cortex Moutan, Radix Achyranthis Bidentatae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Rubra, Radix Glycyrrhizae to make up, with these drug regimens, can be so that each efficacy of drugs produce synergism, thus anaphylactoid purpura and prevention of recurrence can effectively be treated.
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each component all has curative effect preferably in the following weight parts scope:
Radix Cirsii Japonici 10-15, Herba Cirsii 10-15, Periostracum Cicadae 5-10, fresh rehmannia charcoal 10-15, charred Radix Scutellariae 10-15, charred Radix Sanguisorbae 10-15, Rhizoma Imperatae 15-20, Cortex Moutan 10-15, Radix Achyranthis Bidentatae 10-15, Poria 10-20, Rhizoma Atractylodis Macrocephalae 15-20, Radix Paeoniae Rubra 10-15, Radix Glycyrrhizae 6-12.
The further raw material medicines in portions by weight of medicine of the present invention is: Radix Cirsii Japonici 11-13, Herba Cirsii 11-13, Periostracum Cicadae 7-9, fresh rehmannia charcoal 11-13, charred Radix Scutellariae 11-13, charred Radix Sanguisorbae 11-13, Rhizoma Imperatae 16-18, Cortex Moutan 11-13, Radix Achyranthis Bidentatae 11-13, Poria 13-15, Rhizoma Atractylodis Macrocephalae 16-18, Radix Paeoniae Rubra 11-13, Radix Glycyrrhizae 8-10.
Preferably, the raw material medicines in portions by weight of medicine of the present invention is: Radix Cirsii Japonici 12, Herba Cirsii 12, Periostracum Cicadae 8, fresh rehmannia charcoal 12, charred Radix Scutellariae 12, charred Radix Sanguisorbae 12, Rhizoma Imperatae 18, Cortex Moutan 12, Radix Achyranthis Bidentatae 12, Poria 15, the Rhizoma Atractylodis Macrocephalae 18, Radix Paeoniae Rubra 12, Radix Glycyrrhizae 8.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the peroral dosage form of any routine, as powder, capsule or pill.
The concrete preparation method that the present invention treats the medicine of anaphylactoid purpura is, with the Radix Rehmanniae, Radix Scutellariae, Radix Sanguisorbae respectively the roasting carbonization make fresh rehmannia charcoal, charred Radix Scutellariae and charred Radix Sanguisorbae, get each crude drug pulverize separately according to described weight portion and become mixing behind the smalls, be ground into smalls after perhaps mixing, make powder.
Make capsule in above-mentioned powder can being incapsulated, also can in described powder, add the Mel of convention amount, mix thoroughly and make pill.
During the preparation capsule, adorn clean medicine 0.5g in every capsules.
In the medicament composing prescription of the present invention, Radix Cirsii Japonici, Herba Cirsii, fresh rehmannia charcoal, charred Radix Scutellariae, charred Radix Sanguisorbae, Rhizoma Imperatae combined effect have clearing away heat and cooling blood, hemostatic effect; Cortex Moutan, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra are used for blood stasis dispelling; Periostracum Cicadae, Poria, the Rhizoma Atractylodis Macrocephalae are used for spleen invigorating, system blood, antiallergic hemostasis.Wherein Radix Cirsii Japonici, Herba Cirsii, charred Radix Sanguisorbae, charred Radix Scutellariae are monarch drug, and fresh rehmannia charcoal, Rhizoma Imperatae are ministerial drug, play the effect of the cold-blooded hemostasis of heat clearing away jointly; Cortex Moutan, Radix Achyranthis Bidentatae, Radix Paeoniae Rubra are adjuvant drug, and removing stasis to stop bleeding plays hemostasis and do not stay the effect of the stasis of blood, and Periostracum Cicadae, Poria, the Rhizoma Atractylodis Macrocephalae are all adjuvant drug, play spleen invigorating, system blood, anti-allergic effects, and Radix Glycyrrhizae is a messenger drug, coordinating the actions of various ingredients in a prescription.All medicines share, and treating both the principal and secondary aspects of a disease is cured the general difficult recurrence in back.
For showing the therapeutic effect of medicine of the present invention, select 896 routine patients to carry out clinical observation to anaphylactoid purpura.All MethodsThe cases enrolled all meet " practical internal medicine " (People's Press) diagnostic criteria about anaphylactoid purpura: 1) clinical manifestation: 1. fall ill 1-3 week, symptoms such as low grade fever, pharyngalgia, upper respiratory tract infection and general malaise are often arranged; 2. near the joint of the lower extremity and the buttocks papuloid purpura that in batches occurs being symmetrically distributed, differing in size be main, can be with urticaria or edema, erythema multiforme; 3. hemorrhagic enteritis or arthralgia can occur in the course of disease, small number of patients is suffered from abdominal pain or can be occurred taking place in preceding 2 weeks purpura, often with purpura renal.2) lab testing: platelet count is normal, and platelet function and clotting time are normal; 3) histological examination: the little blood vessel neutrophil accumulation of the position skin corium of getting involved, blood vessel wall can have the necrosis of kitchen range fiber-like, and epithelial hyperplasia and erythrocyte ooze out outside the blood vessel, and the immunofluorescence inspection shows that the vasculitis focus has IgA and complement C
3In skin corium blood vessel wall calmness; 4) get rid of the vasculitis that other diseases causes, as cryoglobulin syndrome, optimum high globulin purpura, annular blood capillary autgmentability purpura, pigmentation purpura lichenoid dermatitis etc.
Medical history, the state of an illness, age, sex and Therapeutic Method to MethodsThe cases enrolled carry out statistical analysis, male's 428 examples wherein, women's 468 examples, age reckling 2 years old, the maximum 68 years old, 12 years old with interior person's 298 examples, person's 598 examples more than 12 years old, above patient is 1 course of treatment with 1 first quarter moon all, totally 3 courses of treatment, 1 year follow-up observation phase.
Curative effect judging standard: 1) produce effects: all transference cures of treatment back, relevantly check normally, compare with other treatment and to reach cure time and significantly shorten, complication rate and in 1 year relapse rate significantly reduce; 2) effective: the treatment back state of an illness is clearly better, but recovers normal, compares with treatment not, and reach this degree required time and obviously shorten, or the recidivist in back 2 months that fully recovers; 3) invalid: the treatment back degree that sb.'s illness took a favorable turn and required time are compared no marked difference with treatment not.
Therapeutic Method: oral medicine capsule of the present invention, every day 3 times, each 3, the child is cut down according to the circumstance.
Take medicine of the present invention after 3 courses of treatment, according to curative effect judging standard conditions of patients is carried out statistical analysis, wherein produce effects 586 examples account for 65.4%; Effective 218 examples account for 24.3%; Invalid 92 examples account for 10.3%; Total effective rate 89.7%.
Clinical drug trial result of the present invention shows:
1. choice of drug natural plants of the present invention is a raw material, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment anaphylactoid purpura disease of the Chinese medicine of respectively distinguishing the flavor of, and no chemical addition agent is nontoxic to human body.
2. medicine of the present invention adapts to the anaphylactoid purpura disease, also adapts to purpura sample nephritis or intestinal bleeding.Light disease person can select to take medicine of the present invention; Purpura sample nephritis person can add the cooperation of promoting diuresis to eliminate damp pathogen medicine and take; The intestinal bleeding person can add the hot-tempered wet medicine cooperation of heat clearing away and take.
The specific embodiment
Embodiment 1
With the Radix Rehmanniae, Radix Scutellariae, Radix Sanguisorbae respectively the roasting carbonization make fresh rehmannia charcoal, charred Radix Scutellariae and charred Radix Sanguisorbae.
Get Radix Cirsii Japonici 100g, Herba Cirsii 100g, Periostracum Cicadae 60g, fresh rehmannia charcoal 150g, charred Radix Scutellariae 150g, charred Radix Sanguisorbae 100g, Rhizoma Imperatae 150g, Cortex Moutan 100g, Radix Achyranthis Bidentatae 100g, Poria 150g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Rubra 120g, Radix Glycyrrhizae 100g is ground into the above smalls of 80 orders after the mixing, and mixing is made powder.
Embodiment 2
With the Radix Rehmanniae, Radix Scutellariae, Radix Sanguisorbae respectively the roasting carbonization make fresh rehmannia charcoal, charred Radix Scutellariae and charred Radix Sanguisorbae.
Get Radix Cirsii Japonici 120g, Herba Cirsii 120g, Periostracum Cicadae 80g, fresh rehmannia charcoal 120g, charred Radix Scutellariae 120g, charred Radix Sanguisorbae 120g, Rhizoma Imperatae 180g, Cortex Moutan 120g, Radix Achyranthis Bidentatae 120g, Poria 150g, Rhizoma Atractylodis Macrocephalae 180g, Radix Paeoniae Rubra 120g, Radix Glycyrrhizae 80g is ground into the above smalls of 80 orders, mixing after the mixing, in incapsulating, make the capsule that specification is 0.5g.
Embodiment 3
With the Radix Rehmanniae, Radix Scutellariae, Radix Sanguisorbae respectively the roasting carbonization make fresh rehmannia charcoal, charred Radix Scutellariae and charred Radix Sanguisorbae.
Get Radix Cirsii Japonici 150g, Herba Cirsii 150g, Periostracum Cicadae 60g, fresh rehmannia charcoal 100g, charred Radix Scutellariae 100g, charred Radix Sanguisorbae 150g, Rhizoma Imperatae 180g, Cortex Moutan 150g, Radix Achyranthis Bidentatae 150g, Poria 120g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Rubra 120g, Radix Glycyrrhizae 80g is ground into the above smalls of 80 orders, mixing after the mixing, add Mel as plasticizer, mix thoroughly and make honeyed pill.
Claims (8)
1. a medicine for the treatment of anaphylactoid purpura is characterized in that it being the medicament of being made by following raw medicaments in portion by weight: Radix Cirsii Japonici 10-15, Herba Cirsii 10-15, Periostracum Cicadae 5-10, fresh rehmannia charcoal 10-15, charred Radix Scutellariae 10-15, charred Radix Sanguisorbae 10-15, Rhizoma Imperatae 15-20, Cortex Moutan 1015, Radix Achyranthis Bidentatae 10-15, Poria 10-20, Rhizoma Atractylodis Macrocephalae 15-20, Radix Paeoniae Rubra 10-15, Radix Glycyrrhizae 6-12.
2. the medicine of treatment anaphylactoid purpura according to claim 1 is characterized in that the weight portion of described each crude drug of medicament is: Radix Cirsii Japonici 11-13, Herba Cirsii 11-13, Periostracum Cicadae 7-9, fresh rehmannia charcoal 11-13, charred Radix Scutellariae 11-13, charred Radix Sanguisorbae 11-13, Rhizoma Imperatae 16-18, Cortex Moutan 11-13, Radix Achyranthis Bidentatae 11-13, Poria 13-15, Rhizoma Atractylodis Macrocephalae 16-18, Radix Paeoniae Rubra 11-13, Radix Glycyrrhizae 8-10.
3. the medicine of treatment anaphylactoid purpura according to claim 1 is characterized in that the weight portion of described each crude drug of medicament is: Radix Cirsii Japonici 12, Herba Cirsii 12, Periostracum Cicadae 8, fresh rehmannia charcoal 12, charred Radix Scutellariae 12, charred Radix Sanguisorbae 12, Rhizoma Imperatae 18, Cortex Moutan 12, Radix Achyranthis Bidentatae 12, Poria 15, the Rhizoma Atractylodis Macrocephalae 18, Radix Paeoniae Rubra 12, Radix Glycyrrhizae 8.
4. according to the medicine of claim 1,2 or 3 described treatment anaphylactoid purpura, it is characterized in that described medicament is powder, capsule or pill.
5. the preparation method of the medicine of claim 1,2 or 3 described treatment anaphylactoid purpura, it is characterized in that with the Radix Rehmanniae, Radix Scutellariae, Radix Sanguisorbae respectively the roasting carbonization make fresh rehmannia charcoal, charred Radix Scutellariae and charred Radix Sanguisorbae, get each crude drug pulverize separately according to described weight portion and become mixing behind the smalls, be ground into smalls after perhaps mixing, make powder.
6. according to the preparation method of the medicine of the described treatment anaphylactoid purpura of claim 5, make capsule in it is characterized in that described powder incapsulated.
7. the preparation method of the medicine of treatment anaphylactoid purpura according to claim 6 is characterized in that every of described capsule adorns clean medicine 0.5g.
8. according to the preparation method of the medicine of the described treatment anaphylactoid purpura of claim 5, it is characterized in that in described powder, adding the Mel of convention amount, mix thoroughly and make pill.
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| CN2009100758901A CN101703684B (en) | 2009-11-05 | 2009-11-05 | Medicament for treating allergic purpura and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103041183A (en) * | 2012-12-30 | 2013-04-17 | 青岛恒波仪器有限公司 | Traditional Chinese medicine composition for curing nephritis of Schonlein-Henoch purpura and preparation method thereof |
| CN103330851A (en) * | 2013-06-14 | 2013-10-02 | 袁军清 | Traditional Chinese medicine for treating idiopathic thrombocytopenic purpura |
| CN104147160A (en) * | 2014-08-19 | 2014-11-19 | 李有花 | Compound sponge for eliminating swelling caused by cardiac coronary contrast agent extravasation, and preparation method thereof |
| CN104510942A (en) * | 2015-01-14 | 2015-04-15 | 刘小芳 | Traditional Chinese medicine for treating allergic purpura |
| CN108236680A (en) * | 2016-12-23 | 2018-07-03 | 郑州市天地人农副产品有限公司 | Disappear insane preparation |
| CN112843187A (en) * | 2021-03-29 | 2021-05-28 | 王有 | Traditional Chinese medicine composition for treating anaphylactoid purpura |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1240415C (en) * | 2001-09-04 | 2006-02-08 | 鲍少敏 | Tablets against allergic purpura |
| CN1689615A (en) * | 2004-04-21 | 2005-11-02 | 范崔生 | Bleeding arresting Chinese medicinal composition and its preparation method |
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2009
- 2009-11-05 CN CN2009100758901A patent/CN101703684B/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041183A (en) * | 2012-12-30 | 2013-04-17 | 青岛恒波仪器有限公司 | Traditional Chinese medicine composition for curing nephritis of Schonlein-Henoch purpura and preparation method thereof |
| CN103330851A (en) * | 2013-06-14 | 2013-10-02 | 袁军清 | Traditional Chinese medicine for treating idiopathic thrombocytopenic purpura |
| CN104147160A (en) * | 2014-08-19 | 2014-11-19 | 李有花 | Compound sponge for eliminating swelling caused by cardiac coronary contrast agent extravasation, and preparation method thereof |
| CN104147160B (en) * | 2014-08-19 | 2016-03-02 | 朱军 | Eliminate coronal artery angiography agent to exosmose the compound recipe sponge of caused swelling and preparation method |
| CN104510942A (en) * | 2015-01-14 | 2015-04-15 | 刘小芳 | Traditional Chinese medicine for treating allergic purpura |
| CN108236680A (en) * | 2016-12-23 | 2018-07-03 | 郑州市天地人农副产品有限公司 | Disappear insane preparation |
| CN112843187A (en) * | 2021-03-29 | 2021-05-28 | 王有 | Traditional Chinese medicine composition for treating anaphylactoid purpura |
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| CN101703684B (en) | 2011-07-20 |
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