CN103012789A - 烟酸司维拉姆的制备方法 - Google Patents
烟酸司维拉姆的制备方法 Download PDFInfo
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- CN103012789A CN103012789A CN2011102868439A CN201110286843A CN103012789A CN 103012789 A CN103012789 A CN 103012789A CN 2011102868439 A CN2011102868439 A CN 2011102868439A CN 201110286843 A CN201110286843 A CN 201110286843A CN 103012789 A CN103012789 A CN 103012789A
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- nicotinic acid
- polyallylamine
- sevelamer
- reaction
- alkaline
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Abstract
Description
假手术组 | 慢性肾衰竭组 | 盐酸司维拉姆组 | 烟酸司维拉姆组 | |
2d | 2.91±0.22 | 4.21±0.31 | 3.89±0.29 | 3.76±0.34 |
7d | 3.01±0.28 | 4.26±0.38 | 3.23±0.26 | 3.01±0.16 |
14d | 2.89±0.23 | 4.33±0.34 | 3.12±0.29 | 2.97±0.18 |
慢性肾衰竭组 | 盐酸司维拉姆组 | 烟酸司维拉姆组 | |
2d | 12.04±1.34 | 11.03±1.01 | 10.96±1.23 |
7d | 11.98±1.41 | 9.88±0.99 | 9.08±0.91 |
14d | 12.01±1.38 | 8.93±0.89 | 8.34±0.78 |
假手术组 | 慢性肾衰竭组 | 盐酸司维拉姆组 | 烟酸司维拉姆组 | |
14d | 20.63±5.70 | 37.98±4.58 | 22.36±5.42 | 20.68±4.01 |
假手术组 | 慢性肾衰竭组 | 盐酸司维拉姆组 | 烟酸司维拉姆组 | |
2d | 33.58±3.85 | 68.21±6.45 | 30.19±3.23 | 29.89±3.07 |
7d | 34.01±3.72 | 68.46±6.18 | 29.97±3.42 | 28.94±3.21 |
14d | 33.78±3.21 | 68.18±6.29 | 29.76±3.37 | 28.56±3.17 |
Claims (15)
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CN201110286843.9A CN103012789B (zh) | 2011-09-23 | 2011-09-23 | 烟酸司维拉姆的制备方法 |
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CN201110286843.9A CN103012789B (zh) | 2011-09-23 | 2011-09-23 | 烟酸司维拉姆的制备方法 |
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CN103012789A true CN103012789A (zh) | 2013-04-03 |
CN103012789B CN103012789B (zh) | 2015-02-25 |
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CN201110286843.9A Expired - Fee Related CN103012789B (zh) | 2011-09-23 | 2011-09-23 | 烟酸司维拉姆的制备方法 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000069445A1 (en) * | 1999-05-13 | 2000-11-23 | Geltex Pharmaceuticals, Inc. | Combination therapy for treating hypercholesterolemia |
CN1278180A (zh) * | 1997-11-05 | 2000-12-27 | 吉尔特药品公司 | 用未取代的聚(二烯丙基胺)治疗血胆甾醇过多症的方法 |
CN101743012A (zh) * | 2007-07-17 | 2010-06-16 | 奇莫埃博利卡股份有限公司 | 制备交联聚(烯丙胺)聚合物的新型一步法 |
US20100331516A1 (en) * | 2008-04-08 | 2010-12-30 | Govind Dhananjay Sathe | Process for Preparation of Sevelamer Carbonate |
-
2011
- 2011-09-23 CN CN201110286843.9A patent/CN103012789B/zh not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1278180A (zh) * | 1997-11-05 | 2000-12-27 | 吉尔特药品公司 | 用未取代的聚(二烯丙基胺)治疗血胆甾醇过多症的方法 |
WO2000069445A1 (en) * | 1999-05-13 | 2000-11-23 | Geltex Pharmaceuticals, Inc. | Combination therapy for treating hypercholesterolemia |
CN101743012A (zh) * | 2007-07-17 | 2010-06-16 | 奇莫埃博利卡股份有限公司 | 制备交联聚(烯丙胺)聚合物的新型一步法 |
US20100331516A1 (en) * | 2008-04-08 | 2010-12-30 | Govind Dhananjay Sathe | Process for Preparation of Sevelamer Carbonate |
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CN103012789B (zh) | 2015-02-25 |
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Address after: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: PKUCARE PHARMACEUTICAL R&D CENTER Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: PKUCARE PHARMACEUTICAL R&D CENTER Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
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Effective date of registration: 20221014 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: PKUCARE PHARMACEUTICAL R&D CENTER Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: PKUCARE PHARMACEUTICAL R&D CENTER Patentee before: PKU HEALTHCARE INDUSTRY Group |
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Granted publication date: 20150225 |