CN103007204A - Chinese medicinal composition for treating hepatofibrosis - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for treating hepatofibrosis, which is mainly prepared from the following main raw materials: 10-20g of trionyx sinensis shell, 10-20g of tortoise shell, 9-15g of curcuma zedoary, 12-15g of rhizoma sparganii, 18-25g of black sesame seeds, 15-18g of glossy privet fruit and 30g of dry loach powder. The following raw materials of the Chinese medicinal composition can be added selectively to treat the I-type symptoms of hepatofibrosis: 6-12g of fructus aurantii, 10g of coked malt, 10g of coked hawthorn, 10g of coked medicated leaven, and in addition, 12-18g of oriental wormwood and 10-15g of cape jasmine can be added to treat internal dampness and heat and jaundice. The following raw materials of the Chinese medicinal composition can be added selectively to treat the II-type symptoms of hepatofibrosis: 20-30g of dandelion, 6-9g of pseudo-ginseng, 6-9g of red peony root, 8-12g of curcuma aromatica, and in addition, 6-9g of hairyvein agrimony and 9-12g of eclipta alba can be added to treat hemorrhage. The following raw materials of the Chinese medicinal composition can be added selectively to treat the III-type symptoms of hepatofibrosis: 12-18g of codonopsis pilosula, 8-10g of dogwood and 9-12g of caulis spatholobi. 9-15g of subprostrate sophora and 1.5g of cordyceps sinensis can be added and decocted together with the raw materials to treat the positive marker of hepatitis B virus. The Chinese medicinal composition has a significant effect on 502 patients (69.05%) of the total 727 patients with the hepatofibrosis, is effective to 189 patients (26.00%), and is invalid to 36 patients (4.95%), thereby having the total effective rate of 95.05%.

Description

A kind of Fibrotic Chinese medicine composition of liver cirrhosis that is used for the treatment of

Technical field

The present invention relates to treatment by Chinese herbs liver cirrhosis field, in particular a kind of Fibrotic Chinese medicine composition of liver cirrhosis that is used for the treatment of.

Background technology

In a single day viral hepatitis forms liver cirrhosis, and the one, canceration rate obviously improves, and annual hepatocarcinoma occurs about 1,000,000; The 2nd, western medicine and medical practitioners basic incomparably than system, the reasonable measure of curative effect, method, the serious threat human health.Therefore, academic exchange and discussion are regularly carried out in a research such as the prevention of annual group of huge sum of money support research liver cirrhosis of country and even viral hepatitis, diagnosis, treatment, drug development.Be intended to conquer in very fast period the demon who threatens human health.The major lesions of liver cirrhosis is the formation of pseudolobuli, and the crucial pathological changes of pseudolobuli is that fibrosis, fibrous septum are around cutting apart hepatocyte.Based on the phenomenon of pathogenesis, body basic function and the disorder of immune mechanism of liver cirrhosis complexity, up to the present, also not to the breakthrough research of liver cirrhosis fibrosis Therapeutic Method, measure.In China, liver cirrhosis is frequently-occurring disease, commonly encountered diseases, is mainly delayed and is caused by the in time incorrect diagnosis of viral hepatitis (second, third, fourth type), treatment.Patients with Viral Hepatitis and take carrier China and have 1.2 hundred million-1.8 hundred million.The chronicity of second, third, hepatitis D and hardening ratio are very high, and liver cirrhosis patient is at 0.9-1.5 10,000,000 according to a preliminary estimate.Seek a whole set of to fruitful scheme, the method for liver cirrhosis fibrosis treatment, its meaning will be far-reaching, timely, challenging.

Summary of the invention

High for the pathogenesis of cirrhosis rate, hepatic fibrosis is without desirable active drug treatment, and Western medicine class toxicity is larger, and curative effect is difficult for determining, it is clinical that Chinese medicine class treatment liver cirrhosis fibrosis has breakthrough medicine to be badly in need of seeking out to drop into, the more scientific and reasonable effective problems that solved of this prescription.

Technical scheme of the present invention is as follows:

A kind of Fibrotic Chinese medicine composition of liver cirrhosis (the Misgurni anguillicaudati Carapax Trionycis is loose) that is used for the treatment of, main formula forms: Carapax Trionycis 10-20g, Carapax Et Plastrum Testudinis 10-20 g, Rhizoma Curcumae 9-15g, rhizoma sparganic 12-15 g, Semen Sesami Nigrum 18-25 g, Fructus Ligustri Lucidi 15-18 g, Misgurni anguillicaudati dry powder 30 g; With card plus-minus: the I type adds Fructus Aurantii 6-12g, each 10g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), retention of damp-heat in the interior and jaundice person adds Herba Artemisiae Scopariae 12-18 g, Fructus Gardeniae 10-15 g; The II type adds Herba Taraxaci 20-30 g, Radix Notoginseng 6-9 g, Radix Paeoniae Rubra 6-9 g, Radix Curcumae 8-12 g, has bleeding tendency person to add Herba Agrimoniae 6-9 g, Herba Ecliptae 9-12 g; The III type adds Radix Codonopsis 12-18 g, Fructus Corni 8-10g, Caulis Spatholobi 9-12 g; The hepatitis b virus marker positive adds Radix Sophorae Tonkinensis 9-15 g and described main formula medicine is fried in shallow oil together, Cordyceps 1.5 g take after mixing it with water.

The Misgurni anguillicaudati Carapax Trionycis is loose to have fibrosis, anti-hbv replication, improve liver function, regulate the effects such as hepatic blood circulation, strong liver, softening the hard mass, spleen invigorating.Carapax Trionycis is longer than nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, and the inflammation-inhibiting reaction promotes hepatocyte reparation and regeneration, improves microcirculation in the liver, suppresses fibroplasia, promotes collagenolysis and again absorption, improves serum protein content; Radix Paeoniae Rubra clearing away heat and cooling blood eliminating stasis to stop pain; The circulation of qi promoting of Rhizoma Curcumae acrid in the mouth removing blood stasis, the removing food stagnancy pain relieving, but also antiviral, improve liver circulation, regulate immunity, suppress fibroblast proliferation, the Radix Astragali has similar hormone-like effect, suppress anaphylaxis, immunoreation, be nonspecific free radical scavenger, be aided with Radix Codonopsis, Cordyceps, enriching kidney essence, invigorating the spleen and benefiting QI, all medicines share and get final product strengthening vital QI to eliminate pathogenic factors, have again a merit of blood circulation promoting and blood stasis dispelling, thereby stop, reverse or delay hepatic fibrosis liver cirrhosis process, improve the effects such as the state of an illness.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is described in detail.

Be used for the treatment of the Fibrotic Chinese medicine composition of liver cirrhosis, namely loose (ball, the soup) flavour of a drug of Misgurni anguillicaudati Carapax Trionycis form: Carapax Trionycis 10-20g, Carapax Et Plastrum Testudinis 10-20 g, Rhizoma Curcumae 9-15g, rhizoma sparganic 12-15 g, Semen Sesami Nigrum 18-25 g, Fructus Ligustri Lucidi 15-18 g, Misgurni anguillicaudati dry powder 30 g.

With card plus-minus: I type (I type, II type, III type refer to following Chinese medical discrimination content) adds Fructus Aurantii 6-12g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), each 10 g of Massa Medicata Fermentata (parched to brown), retention of damp-heat in the interior and jaundice person adds Herba Artemisiae Scopariae 12-18 g, Fructus Gardeniae 10-15 g; The II type adds Herba Taraxaci 20-30 g, Radix Notoginseng 6-9 g, Radix Paeoniae Rubra 6-9 g, Radix Curcumae 8-12 g, has bleeding tendency person to add Herba Agrimoniae 6-9 g, Herba Ecliptae 9-12 g; The III type adds Radix Codonopsis 12-18 g, Fructus Corni 8-10g, Caulis Spatholobi 9-12 g; The hepatitis b virus marker positive adds Radix Sophorae Tonkinensis 9-15 g(and said medicine with frying in shallow oil), Cordyceps 1.5 g take after mixing it with water.

Usage: 1 dose of top every day, every dose of Chinese medicine adds water 300ml-350ml, fries in shallow oil to water boiling beginning timing, 30-40 minute.Every dose of decocting 2 times, each extracting juice 150ml-200ml, twice extracting juice is mixed to get 300ml-400ml,, each decoction being taken warmly minute sooner or later is each serving 150ml-200ml; Make loose or ball in we's (Carapax Trionycis 10-20g, Carapax Et Plastrum Testudinis 10-20 g, Rhizoma Curcumae 9-15g, rhizoma sparganic 12-15 g, Semen Sesami Nigrum 18-25 g, Fructus Ligustri Lucidi 15-18 g, Misgurni anguillicaudati dry powder 30 g) ratio after 1-3 month, Herba Taraxaci is fried in shallow oil water and is made water pill, every day 2-3 time, each 9-15 g, warm water delivery service.

Chinese medical discrimination:

The deficiency of YIN and damp and hot and deposit (I type): both liver and kidney deficiency, lustreless complexion, bitter taste, dull, poor appetite, abdominal distention, loose stool, yellowish urine, spiritlessness and weakness, indistinct tinnitus, two side of body distending pains, the white greasy or greasy little Huang of tongue fur, body of the tongue are deep red red, stringy and thready pulse; The rule for the treatment of: depressed liver-energy dispersing and QI regulating, damp eliminating spleen invigorating.

Heat in blood and blood stasis are tied (II type) mutually: soft unable, the low grade fever of dim complexion, limb, do not endure hardships time, dry mouth and tougue, anorexia, tongue fur white yellow or do, body of the tongue is dark reddish purple, the lower mass in the abdomen of the side of body, very person's epistaxis, bleeding from the gum, the dermal ecchymosis, hesitant pulse is thin; The rule for the treatment of: blood circulation promoting and blood stasis dispelling, nourishing YIN and clearing heat.

The liver spleen is with sick (III type): darkish complexion, gastral cavity abdominal distention are vexed, mouthful sticking nausea, belch anorexia, feelings will irritability, bass is hypologia, and the body of the tongue purple is dim, and stringy pulse moistens; Nourishing YIN for attracting YANG, the nourishing the liver of being amusing.

Misgurni anguillicaudati Carapax Trionycis loose (ball, soup) has fibrosis, suppresses HBV and copies, improves liver function, regulates the effects such as hepatic blood circulation, strong liver, softening the hard mass, spleen invigorating.Can suppress fibroplasia, promote collagenolysis and again absorption, inflammation-inhibiting reaction to promote hepatocyte reparation and regeneration, improve microcirculation in the liver such as Carapax Trionycis; Rhizoma Curcumae suppresses fibroblast proliferation, antiinflammatory, antiviral, improves liver circulation, regulates immunity, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, impel the degraded of established collagen fiber and heavily absorption, anti peroxidation of lipid and fibrosis etc., all medicines share, the clearing away heat-damp and promoting diuresis detoxifcation, the removing heat from blood and promoting blood circulation blood stasis dispelling, the tonify deficiency strengthening vital QI to eliminate pathogenic factors is regulated immunologic function, thereby reach reverse, stop or delay the liver cirrhosis process, improve the state of an illness etc.The Fibrotic generation of liver cirrhosis is synthetic with collagen, the dynamic equilibrium of degraded imbalance is relevant.Collagen is the important component part of extracellular matrix, liver cirrhosis fibrosis main manifestations is that abnormal deposition, the fiber of a large amount of extracellular matrixs regenerated every formation, the degeneration of hepatocyte diffusivity, necrosis, nodositas, if it is synthetic and/or promote the degraded of extracellular matrix to suppress the extracellular matrix such as collagen, all is blocking-up and the effective ways that reverse hepatic fibrosis.Perfect square compatibility monarch is complete, the efficacy of a drug is smart specially, applying flexible, has obvious tcm characteristic.Therefore, effect is clearly to Misgurni anguillicaudati Carapax Trionycis loose (ball, soup) to the liver cirrhosis treatment of fibrosis.

The Misgurni anguillicaudati Carapax Trionycis falls apart (ball, soup) through for many years research, the thousands of routine patients of clinical observation, and clinical therapeutic efficacy is obvious.The Fibrotic curative effect of anti-liver cirrhosis is very sure, has the liver function of improvement, reduces portal vein pressure, improves liver function, the effect such as suppress HBV and copy.

The loose treatment of Misgurni anguillicaudati Carapax Trionycis liver cirrhosis 727 examples, produce effects 502 examples (69.05%), effective 189(26.00%), invalid 36 examples (4.95%).Total effective rate 95.05%.

Table 1 Misgurni anguillicaudati Carapax Trionycis loose (ball, soup) treatment liver cirrhosis Clinical analysis example (%)

The standard of curative effect evaluation: produce effects: cardinal symptom disappears, liver function recovery is normal, splenomegaly is dwindled in various degree or without dwindle, the obvious descender of hepatic fibrosis index; Effectively: cardinal symptom disappears substantially, liver function normal, splenomegaly stable, fibrosis indices in hepatic descender to some extent; It is invalid: even that symptom is eliminated is not obvious, liver function is not felt any better even ascensionist does not fall in deterioration, fibrosis indices in hepatic.

Syndrome Differentiation of Traditional Chinese Medicine and the rule for the treatment of:

The I type: both liver and kidney deficiency, lustreless complexion, bitter taste, dull, poor appetite, abdominal distention, loose stool, yellowish urine, spiritlessness and weakness, indistinct tinnitus, two side of body distending pains, the white greasy or greasy little Huang of tongue fur, body of the tongue are deep red red, stringy and thready pulse; The rule for the treatment of: depressed liver-energy dispersing and QI regulating, damp eliminating spleen invigorating.

The II type: soft unable, the low grade fever of dim complexion, limb, do not endure hardships time, dry mouth and tougue, anorexia, tongue fur white yellow or do, body of the tongue is dark reddish purple, the lower mass in the abdomen of the side of body, very person's epistaxis, bleeding from the gum, the dermal ecchymosis, hesitant pulse is thin; The rule for the treatment of: blood circulation promoting and blood stasis dispelling, nourishing YIN and clearing heat.

The III type: darkish complexion, gastral cavity abdominal distention are vexed, mouthful sticking nausea, belch anorexia, feelings will irritability, bass is hypologia, and the body of the tongue purple is dim, and stringy pulse moistens; Nourishing YIN for attracting YANG, the nourishing the liver of being amusing.

Should be understood that, for those of ordinary skills, can be improved according to the above description or conversion, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.

Claims (1)

1. one kind is used for the treatment of the Fibrotic Chinese medicine composition of liver cirrhosis, it is characterized in that, main formula forms: Carapax Trionycis 10-20g, Carapax Et Plastrum Testudinis 10-20 g, Rhizoma Curcumae 9-15g, rhizoma sparganic 12-15 g, Semen Sesami Nigrum 18-25 g, Fructus Ligustri Lucidi 15-18 g, Misgurni anguillicaudati dry powder 30 g; With card plus-minus: the I type adds Fructus Aurantii 6-12g, each 10g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), retention of damp-heat in the interior and jaundice person adds Herba Artemisiae Scopariae 12-18 g, Fructus Gardeniae 10-15 g; The II type adds Herba Taraxaci 20-30 g, Radix Notoginseng 6-9 g, Radix Paeoniae Rubra 6-9 g, Radix Curcumae 8-12 g, has bleeding tendency person to add Herba Agrimoniae 6-9 g, Herba Ecliptae 9-12 g; The III type adds Radix Codonopsis 12-18 g, Fructus Corni 8-10g, Caulis Spatholobi 9-12 g; The hepatitis b virus marker positive adds Radix Sophorae Tonkinensis 9-15 g and described main formula medicine is fried in shallow oil together, Cordyceps 1.5 g take after mixing it with water.