CN102784307B - Traditional Chinese medicine for treating phthisis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating phthisis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating phthisis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine includes cordyceps sinensis, plantain herb, adenophora tetraphylla, dendrobe, lily, radix pseudostellariae, bighead atractylodes rhizome, angelica sinensis, ganoderma lucidum, great burdock achene, radix rehmanniae recen, gecko, rhizoma coptidis, commelina communis, radix euphorbiae lantu, paniculate swallowwort root, dandelion, poria cocos, rhizoma alismatis, ligusticum wallichii, rubia cordifolia and liquorice. The traditional Chinese medicine provided by the invention has the characteristics of little toxic and side effect, can not develop drug resistance easily, is low in cost, and can comprehensively adjust bodily functions; compared with Western medicine, the traditional Chinese medicine has the advantages of alleviating and resisting toxicity of the phthisis, and quickly improving the symptom of the phthisis so as to improve the curative effect.
Description
Technical field
The present invention relates to pharmaceutical technology, relate in particular to a kind of phthisical Chinese medicine that is used for the treatment of.
Background technology
Pulmonary tuberculosis is a kind of chronic infectious disease being caused by mycobacterium tuberculosis infection, belongs to motherland's medical science " consumptive disease " category, is one of mankind's Infectious Diseases, and doctor trained in Western medicine is dissected and found and change place nodosity, therefore be referred to as tuberculosis.According to World Health Organization (WHO), estimate, the whole world approximately has 1/3 population to infect tulase, approximately has every year 3000000 people to die from pulmonary tuberculosis, is that single courses of infection causes dead maximum infectious disease.
In recent years, adopt western medicine and chemotherapeutic treatment to play a great role controlling on pulmonary tuberculosis popular, make the more than 90% first lunger of controlling obtain healing.
Doctor trained in Western medicine be take chemotherapy sterilization as main, and sterilization will toxic side effect, just it is also noted that Human Tolerance ability, just must extend the period for the treatment of.So taking 6～9 months ability cures; The nonspecific immunity evoking with coryne bacterium parvum, bacillus calmette-guerin vaccine is limited in one's ability to the elimination of pulmonary bacillus, prevents all rightly, is used for the treatment of just unable to do what one wishes.
In addition, because irrational drug combination, mismanagement, irregular medication and immunity damage increasing of host etc., cause drug resistance person's proportion in China consumptive up to 28%～41%, to occur controlling again in a large number patient.There is data to show, recurrent tuberculosis accounts for 15%～20% of annual new registration tuberculosis patient, making to control again pulmonary tuberculosis becomes the subject matter in tuberculosis control, is also the root that resistant tuberculosis, especially resistance to multiple medicines tuberculosis produce, and global tuberculosis is controlled and caused serious threat.In addition, it is just to control 2～3 times of patient that required manpower, financial resources are managed in the treatment of controlling again lunger.Antituberculotics is to affect the major obstacles that chemotherapy completes smoothly on the infringement of liver, kidney always simultaneously.Some patients is on the one hand owing to forcing drug withdrawal to the untoward reaction of the conventional antimycobacterial drugs such as rifampicin is extremely sensitive, on the other hand again because financial difficulties can not afford antimycobacterial drug of new generation.
Chinese medicine is the magic weapon of motherland's traditional medicine when treatment disease, by the reasonable compatibility (monarch of various medicines, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, toxic side effect is little, be difficult for producing drug resistance, cheap, the feature that regulates all sidedly body function, can reach the effect for the treatment of both the principal and secondary aspects of a disease.Discovered in recent years, Chinese medicine has application more and more widely in treatment pulmonary tuberculosis, with respect to Western medicine, Chinese medicine is being alleviated the toxic action for the treatment of pulmonery tuberculosis, improve rapidly pulmonary tuberculosis symptom, and then improve the aspects such as curative effect and there are significant results, can prevent to greatest extent that pulmonary tuberculosis from developing into the degree of drug-tolerant pulmonary tuberculosis.
Therefore, the invention provides a kind of Chinese medicine that is used for the treatment of pulmonary tuberculosis, its have toxic and side effects little, be difficult for to produce drug resistance, cheap, the feature that regulates all sidedly body function, with respect to Western medicine, it is alleviating the toxic action for the treatment of pulmonery tuberculosis, improve rapidly pulmonary tuberculosis symptom, and then improve the aspects such as curative effect and there is advantage.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine that is used for the treatment of pulmonary tuberculosis is provided, its have toxic and side effects little, be difficult for to produce drug resistance, cheap, the feature that regulates all sidedly body function, with respect to Western medicine, it is alleviating the toxic action for the treatment of pulmonery tuberculosis, improve rapidly pulmonary tuberculosis symptom, and then improve the aspects such as curative effect and there is advantage.
In order to solve the problems of the technologies described above, the invention provides a kind of phthisical Chinese medicine that is used for the treatment of, it comprises Cordyceps, Herba Plantaginis, Radix Adenophorae, Herba Dendrobii, Bulbus Lilii, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Ganoderma, Fructus Arctii, Radix Rehmanniae, Gecko, Rhizoma Coptidis, Herba Commelinae, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Radix Cynanchi Paniculati, Herba Taraxaci, Poria, Rhizoma Alismatis, Rhizoma Chuanxiong, Radix Rubiae, Radix Glycyrrhizae.
Wherein, in described Chinese medicine, the ratio of weight and number of each component is:
Cordyceps 50～60 weight portions, Herba Plantaginis 15～25 weight portions, Radix Adenophorae 30～40 weight portions, Herba Dendrobii 25～35 weight portions, Bulbus Lilii 10～20 weight portions, Radix Pseudostellariae 20～30 weight portions, the Rhizoma Atractylodis Macrocephalae 20～30 weight portions, Radix Angelicae Sinensis 35～45 weight portions, Ganoderma 15～25 weight portions, Fructus Arctii 20～30 weight portions, Radix Rehmanniae 15～25 weight portions, Gecko 10～20 weight portions, Rhizoma Coptidis 35～45 weight portions, Herba Commelinae 15～25 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 10～20 weight portions, Radix Cynanchi Paniculati 15～25 weight portions, Herba Taraxaci 20～30 weight portions, Poria 10～20 weight portions, Rhizoma Alismatis 10～20 weight portions, Rhizoma Chuanxiong 15～25 weight portions, Radix Rubiae 10～20 weight portions, Radix Glycyrrhizae 20～30 weight portions.
Wherein, in described Chinese medicine, the ratio of weight and number of each component is further:
Cordyceps 55～60 weight portions, Herba Plantaginis 20～25 weight portions, Radix Adenophorae 35～40 weight portions, Herba Dendrobii 30～35 weight portions, Bulbus Lilii 15～20 weight portions, Radix Pseudostellariae 25～30 weight portions, the Rhizoma Atractylodis Macrocephalae 25～30 weight portions, Radix Angelicae Sinensis 40～45 weight portions, Ganoderma 20～25 weight portions, Fructus Arctii 25～30 weight portions, Radix Rehmanniae 20～25 weight portions, Gecko 15～20 weight portions, Rhizoma Coptidis 40～45 weight portions, Herba Commelinae 20～25 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15～20 weight portions, Radix Cynanchi Paniculati 20～25 weight portions, Herba Taraxaci 25～30 weight portions, Poria 15～20 weight portions, Rhizoma Alismatis 15～20 weight portions, Rhizoma Chuanxiong 20～25 weight portions, Radix Rubiae 15～20 weight portions, Radix Glycyrrhizae 25～30 weight portions.
Wherein, in described Chinese medicine, the ratio of weight and number of each component is further:
Cordyceps 55 weight portions, Herba Plantaginis 20 weight portions, Radix Adenophorae 35 weight portions, Herba Dendrobii 30 weight portions, Bulbus Lilii 15 weight portions, Radix Pseudostellariae 25 weight portions, the Rhizoma Atractylodis Macrocephalae 25 weight portions, Radix Angelicae Sinensis 40 weight portions, Ganoderma 20 weight portions, Fructus Arctii 25 weight portions, Radix Rehmanniae 20 weight portions, Gecko 15 weight portions, Rhizoma Coptidis 40 weight portions, Herba Commelinae 20 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15 weight portions, Radix Cynanchi Paniculati 20 weight portions, Herba Taraxaci 25 weight portions, Poria 15 weight portions, Rhizoma Alismatis 15 weight portions, Rhizoma Chuanxiong 20 weight portions, Radix Rubiae 15 weight portions, Radix Glycyrrhizae 25 weight portions.
Wherein, can in described Chinese medicine, further add Flos Farfarae and Lignum Sappan, the weight fraction of described Flos Farfarae and Lignum Sappan to be respectively Flos Farfarae 15～25 weight portions and Lignum Sappan 10～20 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine, if when prepared dosage form is tablet, it comprises the following steps:
The first step, each component of described Chinese medicine is mixed in proportion, add the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 70～80%, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, filter the medicinal residues that obtain and add again the distilled water with respect to 4～8 times of described medicinal residues quality, decoct 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract,
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 600 order～800 object micropowders;
The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes 1000.
The present invention also provides the preparation method of above-mentioned Chinese medicine, if when prepared dosage form is capsule, it comprises the following steps:
The first step, each component of described Chinese medicine is mixed in proportion, add the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 70～80%, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, filter the medicinal residues that obtain and add again the distilled water with respect to 4～8 times of described medicinal residues quality, decoct 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract,
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 600 order～800 object micropowders;
The 3rd step, successively adds Pulvis Talci, magnesium stearate in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in housing, obtain capsule finished product.
Beneficial effect of the present invention:
Chinese medicine provided by the invention have toxic and side effects little, be difficult for to produce drug resistance, cheap, the feature that regulates all sidedly body function, with respect to Western medicine, it,, alleviating the toxic action for the treatment of pulmonery tuberculosis, improves rapidly pulmonary tuberculosis symptom, and then improves the aspects such as curative effect and have advantage.
The specific embodiment
It is more that the traditional Chinese medical science thinks that pulmonary tuberculosis patient pathological changes relates to, even mainly pass and other vital organs of the human body at lung, kidney, spleen.Old people, internal organs are weak, positive QI-insufficiency, equilibrium between yin and yang is disorderly, and QI and blood is suitable becomes estranged, and then pathogenic factor gathers attached haunting, and is subject to the invasion and attack of consumptive disease worm.QI and blood side is empty, is not enough to resist consumptive disease worm, and pulmonary tuberculosis easily changes again, by a dirty void, develops into how dirty virtual loss, and the state of an illness is heavier, and touching difficulty more, rear bad.
Body void is the major reason of Incidence of Pulmonary Tuberculosis, tonify deficiency is one of Chinese traditional treatment means lungy, the traditional Chinese medical science is according to the syndrome performance in Incidence of Pulmonary Tuberculosis process, distinguish the different phases such as its damage and exhaustion of lung-YIN, hyperactivity of fire caused by deficiency of YIN, deficiency of both QI and YIN, deficiency of both YIN and YANG, often impose nourishing YIN and moistening the lung, nourishing YIN and clearing away fire, supplementing QI and nourishing YIN, fill up the different method for the treatment of such as essence and blood, warming and recuperating the spleen and kidney.Modern medicine thinks that immunity of organisms reduces, tubercle bacillus affection, brings out pulmonary tuberculosis.Chinese medicine passes through himself inhibition or kill bacteria and the comprehensive regulating action to body's immunity thereof, and plays the therapeutical effect to pulmonary tuberculosis.
In addition, Chinese medicine, to the inhibition of tubercule bacillus or killing action, has determined the using value of Chinese medicine in treatment tuberculosis.
Based on above-mentioned theory of Chinese medical science, the invention provides and a kind ofly take tonifying the lung, kidney tonifying, spleen invigorating and strengthening the body resistance as main, being aided with parasite killing reduces phlegm as principle, treat phthisical Chinese medicine, it comprises Cordyceps, Herba Plantaginis, Radix Adenophorae, Herba Dendrobii, Bulbus Lilii, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Ganoderma, Fructus Arctii, Radix Rehmanniae, Gecko, Rhizoma Coptidis, Herba Commelinae, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Radix Cynanchi Paniculati, Herba Taraxaci, Poria, Rhizoma Alismatis, Rhizoma Chuanxiong, Radix Rubiae, Radix Glycyrrhizae.
In described Chinese medicine, the ratio of weight and number of each component is:
Cordyceps 50～60 weight portions, Herba Plantaginis 15～25 weight portions, Radix Adenophorae 30～40 weight portions, Herba Dendrobii 25～35 weight portions, Bulbus Lilii 10～20 weight portions, Radix Pseudostellariae 20～30 weight portions, the Rhizoma Atractylodis Macrocephalae 20～30 weight portions, Radix Angelicae Sinensis 35～45 weight portions, Ganoderma 15～25 weight portions, Fructus Arctii 20～30 weight portions, Radix Rehmanniae 15～25 weight portions, Gecko 10～20 weight portions, Rhizoma Coptidis 35～45 weight portions, Herba Commelinae 15～25 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 10～20 weight portions, Radix Cynanchi Paniculati 15～25 weight portions, Herba Taraxaci 20～30 weight portions, Poria 10～20 weight portions, Rhizoma Alismatis 10～20 weight portions, Rhizoma Chuanxiong 15～25 weight portions, Radix Rubiae 10～20 weight portions, Radix Glycyrrhizae 20～30 weight portions.
In described Chinese medicine, the ratio of weight and number of each component is further:
Cordyceps 55～60 weight portions, Herba Plantaginis 20～25 weight portions, Radix Adenophorae 35～40 weight portions, Herba Dendrobii 30～35 weight portions, Bulbus Lilii 15～20 weight portions, Radix Pseudostellariae 25～30 weight portions, the Rhizoma Atractylodis Macrocephalae 25～30 weight portions, Radix Angelicae Sinensis 40～45 weight portions, Ganoderma 20～25 weight portions, Fructus Arctii 25～30 weight portions, Radix Rehmanniae 20～25 weight portions, Gecko 15～20 weight portions, Rhizoma Coptidis 40～45 weight portions, Herba Commelinae 20～25 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15～20 weight portions, Radix Cynanchi Paniculati 20～25 weight portions, Herba Taraxaci 25～30 weight portions, Poria 15～20 weight portions, Rhizoma Alismatis 15～20 weight portions, Rhizoma Chuanxiong 20～25 weight portions, Radix Rubiae 15～20 weight portions, Radix Glycyrrhizae 25～30 weight portions.
In described Chinese medicine, the ratio of weight and number of each component is further:
Cordyceps 55 weight portions, Herba Plantaginis 20 weight portions, Radix Adenophorae 35 weight portions, Herba Dendrobii 30 weight portions, Bulbus Lilii 15 weight portions, Radix Pseudostellariae 25 weight portions, the Rhizoma Atractylodis Macrocephalae 25 weight portions, Radix Angelicae Sinensis 40 weight portions, Ganoderma 20 weight portions, Fructus Arctii 25 weight portions, Radix Rehmanniae 20 weight portions, Gecko 15 weight portions, Rhizoma Coptidis 40 weight portions, Herba Commelinae 20 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15 weight portions, Radix Cynanchi Paniculati 20 weight portions, Herba Taraxaci 25 weight portions, Poria 15 weight portions, Rhizoma Alismatis 15 weight portions, Rhizoma Chuanxiong 20 weight portions, Radix Rubiae 15 weight portions, Radix Glycyrrhizae 25 weight portions.
Patient for cough thin sputum can further add Flos Farfarae and Lignum Sappan, the weight fraction of described Flos Farfarae and Lignum Sappan to be respectively Flos Farfarae 15～25 weight portions and Lignum Sappan 10～20 weight portions in described Chinese medicine.
The present invention also provides the preparation method of above-mentioned Chinese medicine, if when prepared dosage form is tablet, it comprises the following steps:
The first step, each component of described Chinese medicine is mixed in proportion, add the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 70～80%, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, filter the medicinal residues that obtain and add again the distilled water with respect to 4～8 times of described medicinal residues quality, decoct 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract,
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 600 order～800 object micropowders;
The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes 1000.
The present invention also provides the preparation method of above-mentioned Chinese medicine, if when prepared dosage form is capsule, it comprises the following steps:
The first step, each component of described Chinese medicine is mixed in proportion, add the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 70～80%, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, filter the medicinal residues that obtain and add again the distilled water with respect to 4～8 times of described medicinal residues quality, decoct 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract,
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 600 order～800 object micropowders;
The 3rd step, successively adds Pulvis Talci, magnesium stearate in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15～0.5: 0.15～0.5, and described capsule 's content is incapsulated in housing, obtain capsule finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Tablet 1 prepared by embodiment 1 the present invention
By Cordyceps 55g, Herba Plantaginis 20g, Radix Adenophorae 35g, Herba Dendrobii 30g, Bulbus Lilii 15g, Radix Pseudostellariae 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Angelicae Sinensis 40g, Ganoderma 20g, Fructus Arctii 25g, Radix Rehmanniae 20g, Gecko 15g, Rhizoma Coptidis 40g, Herba Commelinae 20g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15g, Radix Cynanchi Paniculati 20g, Herba Taraxaci 25g, Poria 15g, Rhizoma Alismatis 15g, Rhizoma Chuanxiong 20g, Radix Rubiae 15g, Radix Glycyrrhizae 25g mixes, the ethanol that the determining alcohol that adds 1700g is 80%, reflux 2 hours, extract 3 times, merge extractive liquid,, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste, filters the distilled water that the medicinal residues that obtain add 500g again, decoct 2 hours, decoct 2 times, filter respectively, merging filtrate obtains water extraction liquid, and water extraction liquid concentrating under reduced pressure mixes with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, the dry cream obtaining is placed in super micron mill and is pulverized 2 hours, pulverize, sieve, obtain 800 object micropowders, by the micropowders obtaining, add the microcrystalline Cellulose of 60g, 55g lactose, the starch of 65g, sieves, and mix homogeneously is granulated, dry, adds the magnesium stearate with respect to micropowders quality 12g, granulate, and tabletting, makes 1000.
Toxicity test
60 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity testing.Mice is divided into two groups at random, be matched group and administration group, before experiment, fasting is 12 hours, and the Chinese medicinal tablet of embodiments of the invention 1 preparation is dissolved in water, (concentration is 6.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (being that single-dose dosage is 31.4g crude drug/kg), matched group gives equivalent normal saline, administration in 1 day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mice overall health of patients, ingest, drinking-water, body weight gain is all normal.Mice oral administration gavage capsule LD of the present invention
50> 31.4g crude drug/kg, every day, maximum dosage-feeding was 62.8g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention is 2.1g crude drug/day/people, becomes body weight for humans in 60kg, and average dosage is 0.035g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese medicine of the present invention is quantity 897 times.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
Tablet 2 prepared by embodiment 2 the present invention
By Cordyceps 60g, Herba Plantaginis 20g, Radix Adenophorae 37g, Herba Dendrobii 35g, Bulbus Lilii 18g, Radix Pseudostellariae 28g, Rhizoma Atractylodis Macrocephalae 25g, Radix Angelicae Sinensis 43g, Ganoderma 25g, Fructus Arctii 25g, Radix Rehmanniae 22g, Gecko 15g, Rhizoma Coptidis 45g, Herba Commelinae 22g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 18g, Radix Cynanchi Paniculati 20g, Herba Taraxaci 25g, Poria 15g, Rhizoma Alismatis 15g, Rhizoma Chuanxiong 23g, Radix Rubiae 20g, Radix Glycyrrhizae 29g mixes, the ethanol that the determining alcohol that adds 1700g is 80%, reflux 2 hours, extract 3 times, merge extractive liquid,, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste, filters the distilled water that the medicinal residues that obtain add 500g again, decoct 2 hours, decoct 2 times, filter respectively, merging filtrate obtains water extraction liquid, and water extraction liquid concentrating under reduced pressure mixes with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, the dry cream obtaining is placed in super micron mill and is pulverized 2 hours, pulverize, sieve, obtain 800 object micropowders, by the micropowders obtaining, add the microcrystalline Cellulose of 60g, 55g lactose, the starch of 65g, sieves, and mix homogeneously is granulated, dry, adds the magnesium stearate with respect to micropowders quality 12g, granulate, and tabletting, makes 1000.
Capsule 1 prepared by embodiment 3 the present invention
By Cordyceps 55g, Herba Plantaginis 20g, Radix Adenophorae 35g, Herba Dendrobii 30g, Bulbus Lilii 15g, Radix Pseudostellariae 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Angelicae Sinensis 40g, Ganoderma 20g, Fructus Arctii 25g, Radix Rehmanniae 20g, Gecko 15g, Rhizoma Coptidis 40g, Herba Commelinae 20g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15g, Radix Cynanchi Paniculati 20g, Herba Taraxaci 25g, Poria 15g, Rhizoma Alismatis 15g, Rhizoma Chuanxiong 20g, Radix Rubiae 15g, Radix Glycyrrhizae 25g mixes, the ethanol that the determining alcohol that adds 1700g is 80%, reflux 2 hours, extract 3 times, merge extractive liquid,, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste, filters the distilled water that the medicinal residues that obtain add 500g again, decoct 2 hours, decoct 2 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mixes with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, the dry cream obtaining is placed in super micron mill and is pulverized 2 hours, pulverize, sieve, obtain 800 object micropowders, in the micropowders obtaining, add successively 120g Pulvis Talci, 100g magnesium stearate, mixes processing, obtains capsule 's content, and described capsule 's content is incapsulated in housing, obtains capsule finished product.
Capsule 2 prepared by embodiment 4 the present invention
By Cordyceps 60g, Herba Plantaginis 20g, Radix Adenophorae 37g, Herba Dendrobii 35g, Bulbus Lilii 18g, Radix Pseudostellariae 28g, Rhizoma Atractylodis Macrocephalae 25g, Radix Angelicae Sinensis 43g, Ganoderma 25g, Fructus Arctii 25g, Radix Rehmanniae 22g, Gecko 15g, Rhizoma Coptidis 45g, Herba Commelinae 22g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 18g, Radix Cynanchi Paniculati 20g, Herba Taraxaci 25g, Poria 15g, Rhizoma Alismatis 15g, Rhizoma Chuanxiong 23g, Radix Rubiae 20g, Radix Glycyrrhizae 29g mixes, the ethanol that the determining alcohol that adds 1700g is 80%, reflux 2 hours, extract 3 times, merge extractive liquid,, filters and obtains alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste, filters the distilled water that the medicinal residues that obtain add 500g again, decoct 2 hours, decoct 2 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mixes with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, the dry cream obtaining is placed in super micron mill and is pulverized 2 hours, pulverize, sieve, obtain 800 object micropowders, in the micropowders obtaining, add successively 120g Pulvis Talci, 100g magnesium stearate, mixes processing, obtains capsule 's content, and described capsule 's content is incapsulated in housing, obtains capsule finished product.
Embodiment 5 clinical experiments
Clinical data
Lunger's 190 examples of choosing my 2007～2010 years outpatient clinics of institute, are expectorant smear-positive patient.Phthisical diagnosis and treatment are all by the standard of < < China tuberculosis control program implementation guide (2002) > >.Male 112 examples in 190 routine patients, female's 78 examples, 40～68 years old age.Case is divided into treatment group 120 example and matched group 70 examples at random.Treatment group man 70 examples, female's 50 examples, just control 92 examples, control again 28 examples, 52.6 years old mean age.Matched group man 50 examples, female's 28 examples, 57.9 years old mean age, just control 60 examples, control again 18 examples.Two groups of equal not statistically significants of difference aspect age, sex and clinical manifestation, have comparability (P > 0.05).
Therapeutic scheme
Matched group: adopt WHO specified standard short distance scheme, with the anti-consumptive disease treatment of Western medicine.Just control and be coated with sun employing 2H
3r
3z
3e
3(S
3)/4H
3r
3scheme, in this scheme, isoniazid (H), rifampicin (R), ethambutol (E), pyrazinamide (P) or streptomycin (S), strengthening phase 1 time every other day, 1 totally month, consolidation 1 time every other day, 3 totally months.Control again and be coated with sun employing 2H
3r
3z
3e
3s
3/ 6H
3r
3e
3chemotherapy regimen, in this scheme, strengthening phase 1 time every other day, 1 totally month, consolidation 1 time every other day, 4 totally months.Drug dose: decoction being taken at a draught H0.6g every other day, P0.6g, R2.0g, E1.25g or every other day intramuscular injection S0.75g.
Treatment group: take the tablet of the embodiment of the present invention 1 preparation, take altogether 9 months, each 3, take every 0.5g every day 4 times.
Observation item
2,5,6 (8) the individual the end of month are respectively looked into expectorant 1 time in treatment, within every 2 months, look into rabat 1 time, monthly look into liver function 1 time.Observe clinical symptoms recovery situation, drug side effect etc.
Therapeutic effect
Curative effect judging standard
Expectorant bacterium is turned out cloudy: after finishing the course for the treatment of, (just control full 4 months, control again full 5 months) expectorant smear acid-fast bacilli check result negative for turning out cloudy.
Focus absorbing state: the < < chemotherapy of pulmonary tuberculosis > > appraisal standards of drafting according to nineteen eighty-two national tuberculosis control academic conference are judged.It is effective that focus absorbs >=1/2, and it is effectively that focus absorbs < 1/2, and focus is without changing or worsening as invalid.
Table 1 liang group sputum negative conversion rate comparison
| Group | Number of cases | Turn out cloudy | Do not turn out cloudy | Negative conversion rate (%) |
| Treatment group | 120 | 116 | 4 | 96.7％ |
| Matched group | 70 | 52 | 18 | 74.3％ |
A table 2 liang group x-ray rabat changes relatively
| Group | Number of cases | Effective | Effectively | Invalid | Effective percentage |
| Treatment group | 120 | 98 | 18 | 4 | 96.7％ |
| Matched group | 70 | 32 | 17 | 21 | 70％ |
Model case
Case 1: Wei, man, 39 years old, find after pulmonary tuberculosis, whole family's generaI investigation, tuberculin experiment is strong positive, coughs, becomes thin, and lip is pale, and brothers are cold, and rabat has no obvious pathological changes.The tablet of taking the embodiment of the present invention 2 preparations, each 3, every day 3 times, after one week, it is warm that brothers turn, and it is ruddy that lip turns.Take altogether January, so far without recurrence sign.
Case 2: Wu, man, 46 years old, suffer from pulmonary tuberculosis because of chemotherapy side effect too large, its second son comes to seek medical advice.The tablet of taking the embodiment of the present invention 1 preparation, each 3, every day 3 times, 15 talentes take.After the Spring Festival, follow up a case by regular visits to, drug withdrawal is cured in readme.The recurrence of 2009 winters, in medication on January 21 in 2010.After 20 days, add synergist, after 35 days, through Hedong District, chest hospital makes a definite diagnosis as CT, cures.
In described Chinese medicine, the pharmacology of each component is as follows:
Cordyceps: sweet in the mouth, property is flat, enters lung, kidney channel, has kidney invigorating and YANG supporting, tonifying the lung is relievingd asthma, the effect of hemostasis and phlegm, and the traditional Chinese medical science thinks, Cordyceps enters lung kidney two warps, can tonifying the lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint, weak after being ill, chronic cough is weak, phthisical cough expectorant blood, spontaneous sweatings etc., are unique a kind of balance simultaneously, the Chinese medicine composition of adjusting negative and positive, cure mainly senile chronic bronchitis, emphysema, pulmonary tuberculosis, bronchial asthma, cough is breathed hard, dyspnea due to deficiency spitting of blood; The empty hyperhidrosis of body, spontaneous perspiration, night sweat; Weak after being ill, prolonged deficiency is not multiple, or the labor that declines is weak, and various chronic expendable; Deficiency of kidney-QI, soreness of waist and knee joint, impotence and seminal emission; Cancer; Diabetes patient, lupus erythematosus, the cards such as chronic nephritis and aplastic anemia and leukopenia, the several amino acids that Cordyceps contains and multivitamin, trace element are the compositions of needed by human, can strengthen lymphocyte activity, DNA repair ability, thereby enhancing human body immunity power and the patient toleration to medicine, to preventing that hepatic injury from having obvious curative effect, has good curative effect aspect treatment pulmonary tuberculosis.
Herba Plantaginis: sweet in the mouth, light, cold nature, returns lung, liver, kidney, urinary bladder channel, has the effect that clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, improving eyesight are eliminated the phlegm, and cures mainly dysuria, stranguria with turbid discharge leukorrhagia, edema distension, heat-damp in summer dysentery, conjunctival congestion is hidden from view, and expectorant heat syndrome cough such as breathes heavily at the card.
Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, the dry cough that cures mainly thermal burn lung yin or lung-dryness syndrome due to deficiency of YIN is lacked expectorant, consumptive lung disease cough, the apoplexy due to phlegm blood streak, and calentura injures the withered cards such as thirsty and dry pharynx of stomach-Yin or prolonged illness deficiency of YIN Tianjin.
Herba Dendrobii: cold nature, sweet in the mouth, enters stomach, kidney channel, has reinforcing stomach reg fluid, the effect of nourishing YIN and clearing away heat, for consumption of body fluid by heat, low grade fever excessive thirst, the few tongue of red tongue; Deficiency of stomach-Yin, thirsty and dry pharynx, vomiting is eaten less, vague epigastralgia, the few tongue of tongue light; Deficiency of kidney yin, the cards such as blurring of vision.
Bulbus Lilii: sweet in the mouth, cold nature, enters the heart, lung meridian, has nourishing YIN and moistening the lung, and the effect of clearing away heart-fire for tranquillization cures mainly deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, the cards such as absentminded.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is flat, returns spleen, lung meridian, has the effect of air making-up and spleen enlivening, the lung moistening and production of body fluid promoting, cures mainly the inappetence due to deficiency-weakness of spleen-QI, fatigue and weakness, deficiency of the lung cough caused by dryness, dyspnea with rapid and short breath is breathed hard, the convalescent stage of febrile disease, gas Tianjin two wounds, the thirsty card that waits of interior-heat.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had to regulating action.
Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature, enter liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation, is mainly used in having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood; The sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, and dysmenorrhoea, produce or stomachache, and other blood stasis is had a pain and the symptoms such as constipation of deficiency of YIN insufficiency of blood dryness of the intestine.
Ganoderma: sweet in the mouth, property is flat, and GUIXIN, lung, liver, kidney channel, have benefiting qi and nourishing blood, tranquilizing by nourishing the heart, the flat effect of coughing of cough-relieving, cures mainly body void weak, and diet reduces, giddy; Deficiency of both the heart and spleen, severe palpitation, insomnia forgetfulness; Insufficiency of lung-QI, breathes with cough and loses heart; Hypertension, hyperlipidemia, coronary heart disease; Leukopenia; The cards such as chronic viral hepatitis.
Fructus Arctii: acrid in the mouth, hardship; Cold in nature, return lung, stomach warp, has dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, the lung qi dispersing sore-throat relieving swollen effect of faling apart, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; The card such as sore swollen toxin and mumps.
Radix Rehmanniae: sweet in the mouth, hardship, cold in nature, enter the heart, liver, kidney channel, there are clearing away heat and cooling blood, eliminating blood stasis to promote regeneration of blood, the effect of YIN nourishing and the production of body fluid promoting, is mainly used in the Kidney-Yin cards of being robbed such as fever of the body is thirsty of heat as battalion minute; Or calentura later stage low grade fever does not move back; Chronic disease card belongs to yin asthenia generating intrinsic heat person; The thirst and drinking of accumulated heat in the lung and stomach, quenches one's thirst vexed, thirsty few Tianjin that stomach-Yin is injured; The having blood in stool of bleeding due to blood-heat, metrostaxis; The purple black card that waits of a speckle of heat in blood poison Sheng.
Gecko: taste becomes, property is flat, returns lung, kidney channel, has the effect of invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence, cures mainly the cards such as lung kidney deficiency, dyspnea due to deficiency tachypnea, chronic cough hemoptysis, sexual impotence, seminal emission.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for improving eyesight, is usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, the symptom such as vexed, thirsty.
Commeline communis: sweet in the mouth, light, cold in nature, enter the heart, liver,spleen,kidney, intestine and small intestine warp, have heat-clearing and toxic substances removing, the effect of inducing diuresis to remove edema.Cure mainly edema, beriberi, dysuria, flu, erysipelas, parotitis, icterohepatitis, hematodiarrhoea, malaria, epistaxis, hematuria, metrorrhagia, leucorrhea, because larynx swells and ache, the cards such as carbuncle furuncle.
The Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae): bitter in the mouth; Pungent; Property is put down, and returns lung meridian, has removing fluid-retention by purgation; The effect of removing mass parasite killing.Cure mainly edema abdominal distention; Expectorant carnivorism is long-pending; Trusted subordinate's pain; Lump in the abdomen; Tuberculosis; The cards such as scabies.
Radix Cynanchi Paniculati: acrid in the mouth, warm in nature, return liver, stomach warp, there is the effect of the removing dampness of dispeling the wind, antalgesic-antipruritic, cure mainly rheumatic arthralgia, stomachache distension, toothache, lumbago, fall cards such as flutterring the pain of injury, rubella, eczema.
Herba Taraxaci: sweet in the mouth, hardship, cold in nature, enter liver, stomach warp, there is the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the treatment of the symptoms such as conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, also there is the effect of promoting urination to remove dampness, for controlling the treatment of the diseases such as jaundice due to damp-heat, dysuria, urinary system infection.
Poria: sweet in the mouth, light, property is flat, enters spleen, lung, bladder, heart channel, has the effect of eliminating dampness and diuresis, spleen invigorating mind calming, is mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the cards such as the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention stagnation, epilepsy.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enter kidney, urinary bladder channel, there are promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria, the lung that clears away heart-fire, rush down the effect of kidney fire, be mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of heresy of diseases caused by retention of fluid phlegm-damp, causes dizzy that clear YANG failing to ascend voiced sound does not fall; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, enter liver, gallbladder, pericardium channel, there is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping, for all cards of stagnation of QI and blood, headache, rheumatic arthralgia, the cards such as traumatic injury.
Radix Rubiae: cold in nature, bitter in the mouth, returns Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cures mainly: heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation stomachache; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; The swollen card that waits of hemorrhoid.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, by adding Radix Glycyrrhizae can play QI invigorating, neutralizes, and is in harmonious proportion the effect of each component.
Flos Farfarae: acrid in the mouth, hardship, warm in nature, enter lung meridian, there is nourishing the lung to arrest cough, the effect of the expectorant therapeutic method to keep the adverse QI flowing downwards, is mainly used in various cough and asthmas, the cards such as excessive phlegm and sputum mixed with blood.
Lignum Sappan: sweet in the mouth, one-tenth, property is flat, enters the heart, liver, large intestine channel, has blood circulation promoting and blood stasis dispelling, the effect of reducing swelling and alleviating pain, for blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury, fracture, the cards such as carbuncle sore tumefacting virus.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (3)
1. one kind is used for the treatment of phthisical Chinese medicine, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Cordyceps 50～60 weight portions, Herba Plantaginis 15～25 weight portions, Radix Adenophorae 30～40 weight portions, Herba Dendrobii 25～35 weight portions, Bulbus Lilii 10～20 weight portions, Radix Pseudostellariae 20～30 weight portions, the Rhizoma Atractylodis Macrocephalae 20～30 weight portions, Radix Angelicae Sinensis 35～45 weight portions, Ganoderma 15～25 weight portions, Fructus Arctii 20～30 weight portions, Radix Rehmanniae 15～25 weight portions, Gecko 10～20 weight portions, Rhizoma Coptidis 35～45 weight portions, Herba Commelinae 15～25 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 10～20 weight portions, Radix Cynanchi Paniculati 15～25 weight portions, Herba Taraxaci 20～30 weight portions, Poria 10～20 weight portions, Rhizoma Alismatis 10～20 weight portions, Rhizoma Chuanxiong 15～25 weight portions, Radix Rubiae 10～20 weight portions and Radix Glycyrrhizae 20～30 weight portions,
The dosage form of described Chinese medicine is capsule, and it comprises the following steps,
The first step, each raw medicinal material of described Chinese medicine is mixed in proportion, add the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 70～80%, reflux 1～3 hour, extract 2～3 times, merge extractive liquid, filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, filter the medicinal residues that obtain and add again the distilled water with respect to 4～8 times of described medicinal residues quality, decoct 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate obtains water extraction liquid, water extraction liquid concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtaining above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract,
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 600 order～800 object micropowders;
The 3rd step, successively adds Pulvis Talci, magnesium stearate in the micropowders obtaining at second step, mixes processing, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100:0.15～0.5:0.15～0.5, and described capsule 's content is incapsulated in housing, obtain capsule finished product.
2. Chinese medicine as claimed in claim 1, is characterized in that: in described Chinese medicine, the ratio of weight and number of each raw medicinal material is:
Cordyceps 55～60 weight portions, Herba Plantaginis 20～25 weight portions, Radix Adenophorae 35～40 weight portions, Herba Dendrobii 30～35 weight portions, Bulbus Lilii 15～20 weight portions, Radix Pseudostellariae 25～30 weight portions, the Rhizoma Atractylodis Macrocephalae 25～30 weight portions, Radix Angelicae Sinensis 40～45 weight portions, Ganoderma 20-25 weight portion, Fructus Arctii 25～30 weight portions, Radix Rehmanniae 20～25 weight portions, Gecko 15～20 weight portions, Rhizoma Coptidis 40～45 weight portions, Herba Commelinae 20～25 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15～20 weight portions, Radix Cynanchi Paniculati 20～25 weight portions, Herba Taraxaci 25～30 weight portions, Poria 15～20 weight portions, Rhizoma Alismatis 15～20 weight portions, Rhizoma Chuanxiong 20～25 weight portions, Radix Rubiae 15～20 weight portions and Radix Glycyrrhizae 25～30 weight portions.
3. Chinese medicine as claimed in claim 1, is characterized in that: in described Chinese medicine, the ratio of weight and number of each raw medicinal material is:
Cordyceps 55 weight portions, Herba Plantaginis 20 weight portions, Radix Adenophorae 35 weight portions, Herba Dendrobii 30 weight portions, Bulbus Lilii 15 weight portions, Radix Pseudostellariae 25 weight portions, the Rhizoma Atractylodis Macrocephalae 25 weight portions, Radix Angelicae Sinensis 40 weight portions, Ganoderma 20 weight portions, Fructus Arctii 25 weight portions, Radix Rehmanniae 20 weight portions, Gecko 15 weight portions, Rhizoma Coptidis 40 weight portions, Herba Commelinae 20 weight portions, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 15 weight portions, Radix Cynanchi Paniculati 20 weight portions, Herba Taraxaci 25 weight portions, Poria 15 weight portions, Rhizoma Alismatis 15 weight portions, Rhizoma Chuanxiong 20 weight portions, Radix Rubiae 15 weight portions and Radix Glycyrrhizae 25 weight portions.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101850A (en) * | 1993-10-20 | 1995-04-26 | 刘纯一 | Tianfengjiehegao ointment for curing tuberculosis |
| CN102293970A (en) * | 2010-06-22 | 2011-12-28 | 刘凯峰 | Special Chinese patent medicine for resisting phthisis-astragalus fritillaria capsules |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1101850A (en) * | 1993-10-20 | 1995-04-26 | 刘纯一 | Tianfengjiehegao ointment for curing tuberculosis |
| CN102293970A (en) * | 2010-06-22 | 2011-12-28 | 刘凯峰 | Special Chinese patent medicine for resisting phthisis-astragalus fritillaria capsules |
Non-Patent Citations (4)
| Title |
|---|
| 何芳.有关肺结核中医古籍文献的初探.《中华中医药学刊》.2011,第29卷(第1期),52-54. |
| 有关肺结核中医古籍文献的初探;何芳;《中华中医药学刊》;20110131;第29卷(第1期);52-54 * |
| 滑东方.现有辅助抗结核中成药综述.《临床肺科杂志》.2010,第15卷(第9期),1286-1288. * |
| 邵艳新.中药在治疗结核病中的作用与临床应用.《现代中西医结合杂志》.2009,第18卷(第7期),830-832. * |
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