CN103006674B - A kind of compound sulfamonomethoxine sodium solution and preparation method thereof - Google Patents
A kind of compound sulfamonomethoxine sodium solution and preparation method thereof Download PDFInfo
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- CN103006674B CN103006674B CN201210545146.5A CN201210545146A CN103006674B CN 103006674 B CN103006674 B CN 103006674B CN 201210545146 A CN201210545146 A CN 201210545146A CN 103006674 B CN103006674 B CN 103006674B
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Abstract
The object of the invention is to open a kind of compound sulfamonomethoxine sodium solution and preparation method thereof, it comprises the following component of every 100ml: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g; The compound sulfamonomethoxine sodium solution prepared is compared with injection, there is convenient drug administration, economize on resources, be widely used, product are active strong, bioavailability is high, efficacy stability, successful, character is stablized, slowly, the advantages such as the maintenance biological activity that can continue, realize object of the present invention in principal agent degraded.
Description
Technical field
The present invention relates to a kind of solution and preparation method thereof, particularly a kind of compound sulfamonomethoxine sodium solution and preparation method thereof of animals for treating parasitic disease.
Background technology
Sulfamonomethoxine sodium is sulfamethoxyplridazine class medicine more of new generation, from antibacterial action, ranks the first place of sulphonamides.There is double pharmacological action: can be antibacterial, again can protozoacide, stronger bacteriostasis is had to gram positive bacteria and some negative bacterium, as: the sensitivities such as streptococcus, streptococcus pneumoniae, Salmonella, staphylococcus, Actinobacillus mallei, pasteurellosis bacillus, brucella, pneumobacillus, Bacillus proteus, dysentery bacterium, Listeria monocytogenes, Actinobacillus, swine dysentery spirillum; Protozoacide aspect has: this product is responsive to the leucocyte protozoon of chicken, coccidiosis, toxoplasma.Growth promoting function, low dose of interpolation, has growth promoting effects effect, can significantly improve the egg production of laying hen, improve food conversion ratio.Clinically be mainly used in that treatment is yellow by the microbial baby pig edema of sensitivity, atrophic rhinitis, Actinobacillus property pleuropneumonia, piglet, Hakuri, swine toxoplasmosis, colibacillosis of pigs, Pullorum Disease, avian typhoid, avian colibacillosis, infectious coryza of chicken.Also there is specially good effect to the white comb of fowl (chicken card Schwann Cells protozoacide), chicken coccidiosis simultaneously.
Trimethoprim is broad spectrum antibiotic, and antimicrobial spectrum and sulfa drugs seemingly, have the effect suppressing dihydrofolate reductase, but antibacterial more easily produce drug resistance, is seldom used alone.Sulphonamides then suppresses dihydrofolate synthetase.Both share, and the folic acid metabolism of antibacterial can be made to be subject to double blocking, and thus antibacterial action increases substantially (can potentiation several times to tens times), and this product oral absorption of kinetics is complete, can reach more than 90% of dosage.
Therefore, a kind of compound sulfamonomethoxine sodium solution of special needs and preparation method thereof, has solved above-mentioned existing Problems existing.
Summary of the invention
The advantages such as the object of the present invention is to provide a kind of compound sulfamonomethoxine sodium solution and preparation method thereof, for the deficiencies in the prior art, have use amount few, times for spraying is few, and zest is good, and drug effect is definitely stable.
Technical problem solved by the invention can realize by the following technical solutions:
On the one hand, the invention provides a kind of compound sulfamonomethoxine sodium solution, it is characterized in that, it comprises the following component of every 100ml: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g.
In one embodiment of the invention, described organic solvent is the solution that propylene glycol and benzyl alcohol carry out according to 30-60:5-30 being mixed to get.
In one embodiment of the invention, described antioxidant is the one in sodium sulfite, sodium sulfite, vitamin C.
In one embodiment of the invention, described complex is disodiumedetate.
On the other hand, the invention provides a kind of preparation method of compound sulfamonomethoxine sodium solution, it is characterized in that, it comprises the steps:
(1) organic solvent is placed in a beaker, heats in the water-bath of 60-70 degree Celsius, the sulfametoxydiazine sodium taken and trimethoprim are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in the water-bath of 30-70 degree Celsius, adds antioxidant and chelating agent, and constantly stirring makes it clarify;
(3) solution in (2) is joined in the solution in (1) slowly, and constantly stirring makes its mix homogeneously, obtain the solution clarified;
(4), after cooling, the water adding surplus, in the solution of (3) gained, is settled to 100ml.
(5) PH is regulated to be 9.5-11.5 with sodium hydroxide solution.
In one embodiment of the invention, the compound sulfamonomethoxine sodium solution of preparation adopted 120 degrees Celsius of flowing steam sterilizations to carry out sterilizing in 15 minutes, also can adopt other suitable sterilization method.
Compound sulfamonomethoxine sodium solution of the present invention and preparation method thereof, compared with prior art, the compound sulfamonomethoxine sodium solution prepared is compared with injection, there is convenient drug administration, economize on resources, be widely used, product are active strong, bioavailability is high, efficacy stability, successful, character is stablized, slowly, the advantages such as the maintenance biological activity that can continue, realize object of the present invention in principal agent degraded.
The detailed description and obtaining that feature of the present invention can consult the better embodiment of this case is well understood to.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reach object and effect is easy to understand, below in conjunction with specifically setting forth the present invention further.
Compound sulfamonomethoxine sodium solution of the present invention, it comprises the following component of every 100ml: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g.
In the present invention, described organic solvent is the solution that propylene glycol and benzyl alcohol carry out according to 30-60:5-30 being mixed to get.Described antioxidant is the one in sodium sulfite, sodium sulfite, vitamin C.Described complex is disodiumedetate.
The preparation method of compound sulfamonomethoxine sodium solution of the present invention, it comprises the steps:
(1) organic solvent is placed in a beaker, heats in the water-bath of 60-70 degree Celsius, the sulfametoxydiazine sodium taken and trimethoprim are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in the water-bath of 30-70 degree Celsius, adds antioxidant and chelating agent, and constantly stirring makes it clarify;
(3) solution in (2) is joined in the solution in (1) slowly, and constantly stirring makes its mix homogeneously, obtain the solution clarified;
(4), after cooling, the water adding surplus, in the solution of (3) gained, is settled to 100ml.
(5) PH is regulated to be 9.5-11.5 with sodium hydroxide solution.
In the present invention, the compound sulfamonomethoxine sodium solution of preparation adopted 120 degrees Celsius of flowing steam sterilizations to carry out sterilizing in 15 minutes, also can adopt other suitable sterilization method.
Can by the compound sulfamonomethoxine sodium solution fill of preparation in brown vial, or in lighttight plastic bottle, loading amount comprises 50ml, 100ml, 200ml, 250ml, 500ml etc.
Embodiment 1:
Sulfamonomethoxine sodium 5g, trimethoprim 1g, organic solvent 25ml, antioxidant 0.1g, metal complex 0.1g; Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol carry out according to 3:2 being mixed to get, and described antioxidant is sodium sulfite, and described complex is disodiumedetate; Concrete steps are as follows:
(1) organic solvent is placed in a beaker, heats in the water-bath of 60-70 degree Celsius, the sulfametoxydiazine sodium taken and trimethoprim are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in the water-bath of 30-70 degree Celsius, adds antioxidant and chelating agent, and constantly stirring makes it clarify;
(3) solution in (2) is joined in the solution in (1) slowly, and constantly stirring makes its mix homogeneously, obtain the solution clarified;
(4), after cooling, the water adding surplus, in the solution of (3) gained, is settled to 100ml.
(5) PH is regulated to be 9.5-11.5 with sodium hydroxide solution.
The compound sulfamonomethoxine sodium solution of preparation adopted 120 degrees Celsius of flowing steam sterilizations to carry out sterilizing in 15 minutes, also can adopt other suitable sterilization method.
Embodiment 2:
Sulfamonomethoxine sodium 10g, trimethoprim 2g, organic solvent 50ml, antioxidant 0.2g, metal complex 0.2g; Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol carry out according to 4:1 being mixed to get, and described antioxidant is sodium sulfite, and described complex is disodiumedetate; Concrete steps are as follows:
(1) organic solvent is placed in a beaker, heats in the water-bath of 60-70 degree Celsius, the sulfametoxydiazine sodium taken and trimethoprim are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in the water-bath of 30-70 degree Celsius, adds antioxidant and chelating agent, and constantly stirring makes it clarify;
(3) solution in (2) is joined in the solution in (1) slowly, and constantly stirring makes its mix homogeneously, obtain the solution clarified;
(4), after cooling, the water adding surplus, in the solution of (3) gained, is settled to 100ml.
(5) PH is regulated to be 9.5-11.5 with sodium hydroxide solution.
The compound sulfamonomethoxine sodium solution of preparation adopted 120 degrees Celsius of flowing steam sterilizations to carry out sterilizing in 15 minutes, also can adopt other suitable sterilization method.
Embodiment 3:
Sulfamonomethoxine sodium 20g, trimethoprim 5g, organic solvent 70ml, antioxidant 0.5g, metal complex 0.5g; Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol carry out according to 5:2 being mixed to get, and described antioxidant is vitamin C, and described complex is disodiumedetate; Concrete steps are as follows:
(1) organic solvent is placed in a beaker, heats in the water-bath of 60-70 degree Celsius, the sulfametoxydiazine sodium taken and trimethoprim are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in the water-bath of 30-70 degree Celsius, adds antioxidant and chelating agent, and constantly stirring makes it clarify;
(3) solution in (2) is joined in the solution in (1) slowly, and constantly stirring makes its mix homogeneously, obtain the solution clarified;
(4), after cooling, the water adding surplus, in the solution of (3) gained, is settled to 100ml.
(5) PH is regulated to be 9.5-11.5 with sodium hydroxide solution.
The compound sulfamonomethoxine sodium solution of preparation adopted 120 degrees Celsius of flowing steam sterilizations to carry out sterilizing in 15 minutes, also can adopt other suitable sterilization method.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and application claims protection domain is defined by appending claims and equivalent thereof.
Claims (1)
1. a compound sulfamonomethoxine sodium solution, is characterized in that, described in every 100ml, solution is made up of following component: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g
Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol carry out according to 30-60:5-30 being mixed to get;
Described antioxidant is the one in sodium sulfite, vitamin C;
Described complex is disodiumedetate;
Its preparation method comprises the steps:
(1) organic solvent is placed in a beaker, heats in the water-bath of 60-70 degree Celsius, the sulfametoxydiazine sodium taken and trimethoprim are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in the water-bath of 30-70 degree Celsius, adds antioxidant and chelating agent, and constantly stirring makes it clarify;
(3) solution in (2) is joined in the solution in (1) slowly, and constantly stirring makes its mix homogeneously, obtain the solution clarified;
(4), after cooling, the water adding surplus, in the solution of (3) gained, is settled to 100ml;
(5) PH is regulated to be 9.5-11.5 with sodium hydroxide solution;
(6) 120 degrees Celsius of flowing steam sterilizations the compound sulfamonomethoxine sodium solution of preparation are adopted to carry out sterilizing in 15 minutes.
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| CN201210545146.5A CN103006674B (en) | 2012-12-14 | 2012-12-14 | A kind of compound sulfamonomethoxine sodium solution and preparation method thereof |
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| CN103006674B true CN103006674B (en) | 2015-12-02 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103356663A (en) * | 2013-06-28 | 2013-10-23 | 浙江省农业科学院 | Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof |
| CN103450095A (en) * | 2013-09-11 | 2013-12-18 | 尹爱萍 | Mercuric sulfamonomethoxine and preparation method thereof |
| CN103550226B (en) * | 2013-11-12 | 2014-12-17 | 崔合芳 | Compound sulfamonomethoxine sodium injection as well as preparation method thereof |
| CN104224806A (en) * | 2014-09-11 | 2014-12-24 | 河南迪冉生物科技有限公司 | Preparation method of sulfamonomethoxine sodium injection |
| CN104274472A (en) * | 2014-09-12 | 2015-01-14 | 安徽天安动物药业有限公司 | Compound sulfamonomethoxine sodium injection and preparation method thereof |
| CN104324036A (en) * | 2014-11-04 | 2015-02-04 | 重庆泰通动物药业有限公司 | Drug composition of sulfamonomethoxine sodium with synergistic antibacterial effect for injection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053568A (en) * | 2007-04-28 | 2007-10-17 | 成青兰 | Compound and its processing technology for compound sulfamonomethoxine sodium injection |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053568A (en) * | 2007-04-28 | 2007-10-17 | 成青兰 | Compound and its processing technology for compound sulfamonomethoxine sodium injection |
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