CN104258400A - Sulfamonomethoxine sodium injection - Google Patents
Sulfamonomethoxine sodium injection Download PDFInfo
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- CN104258400A CN104258400A CN201410459827.9A CN201410459827A CN104258400A CN 104258400 A CN104258400 A CN 104258400A CN 201410459827 A CN201410459827 A CN 201410459827A CN 104258400 A CN104258400 A CN 104258400A
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- injection
- sulfamonomethoxine sodium
- sulfamonomethoxine
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Abstract
The invention belongs to the technical field of animal medicaments and in particular relates to a sulfamonomethoxine sodium injection. The sulfamonomethoxine sodium injection is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of sulfamonomethoxine sodium, 0.2-0.4 part of sulfonamide synergist, 2-4 parts of organic solvent, 6-8 parts of water for injection and 0.01-0.03 part of pH regulator. With the adoption of the sulfamonomethoxine sodium injection, as the organic solvent and the water for injection are matched to be used as a solvent, the problem that the property of the sulfamonomethoxine sodium soluble in water is not stable is solved, and thus the property of the prepared injection is stable. The sulfamonomethoxine sodium injection is high in yield, is effective and safe and is suitable for industrial mass production.
Description
technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of sulfamonomethoxine sodium injection.
background technology
Sulfamonomethoxine sodium is the sulphonamides that in sulfonamides for animals, antibacterial action is the strongest, especially has stronger inhibitory action to most of gram positive bacteria and negative bacterium, and it is slower that antibacterial produces drug resistance to this medicine.Be mainly used in the various diseases (as hyperpyrexia disease, streptococcicosis, Haemophilus parasuis, toxoplasmosis, bowel oedema disease, eperythrozoonosis, contagious pleuropneumonia, pasteurellosis bacillus pneumonia etc.) caused by sensitive organism, toxoplasma, Eperythrozoon and mixed infection thereof.
At present, also there are some defects when making injection in sulfamonomethoxine sodium, and the solubization matter of such as sulfamonomethoxine sodium is very unstable, and the drug effect affecting injection plays.
summary of the invention
The object of the present invention is to provide a kind of sulfamonomethoxine sodium injection had good stability.
The present invention is by the following technical solutions:
Sulfamonomethoxine sodium injection, is made up of the raw material of following weight portion: sulfamonomethoxine sodium 0.8-1.2 part, trimethoprim (TMP) 0.2-0.4 part, organic solvent 2-4 part, water for injection 6-8 part, pH adjusting agent 0.01-0.03 part.
Trimethoprim (TMP) is trimethoprim.
Organic solvent is ethanol (95V%) or propylene glycol.
PH adjusting agent is sodium hydroxide.
This injection comprises the following steps when preparing:
A. each raw material is got in proportion;
B. sodium hydroxide partial syringe water is mixed with 20% sodium hydroxide solution for subsequent use;
C. in organic solvent, add remaining water for injection stir, add sulfamonomethoxine sodium, trimethoprim (TMP) stirs, the sodium hydroxide solution adjust ph with 20% is to 9-11, and survey content, embedding, sterilizing, obtains sulfamonomethoxine sodium injection.
The mode that sulfamonomethoxine sodium injection of the present invention adopts organic solvent to match with water for injection is as solvent, solve the problem that the solubization matter of sulfamonomethoxine sodium is very unstable, make the injection stable in properties obtained, product yield is high, effective and safe, is applicable to industrialization large-scale production.
detailed description of the invention
Embodiment 1:
Sulfamonomethoxine sodium injection raw material: sulfamonomethoxine sodium 0.8 part, trimethoprim 0.2 part, 95V% ethanol 2 parts, water for injection 6 parts, sodium hydroxide 0.01 part.
Comprise the following steps during preparation:
A. each raw material is got in proportion;
B. sodium hydroxide partial syringe water is mixed with the solution for standby of 20%;
C. in ethanol, add remaining water for injection stir, add sulfamonomethoxine sodium, trimethoprim stirs, by the sodium hydroxide solution adjust ph to 9 of 20%, survey content, embedding, sterilizing, obtains sulfamonomethoxine sodium injection.
Embodiment 2:
Sulfamonomethoxine sodium injection raw material: sulfamonomethoxine sodium 1.0 parts, trimethoprim 0.3 part, 95V% ethanol 3 parts, water for injection 7 parts, sodium hydroxide 0.02 part.
Comprise the following steps during preparation:
A. each raw material is got in proportion;
B. sodium hydroxide partial syringe water is mixed with the solution for standby of 20%;
C. in ethanol, add remaining water for injection stir, add sulfamonomethoxine sodium, trimethoprim stirs, and by the sodium hydroxide solution adjust ph to 11 of 20%, survey content, embedding, sterilizing, obtains sulfamonomethoxine sodium injection.
Embodiment 3:
Sulfamonomethoxine sodium injection raw material: sulfamonomethoxine sodium 1.2 parts, trimethoprim 0.4 part, propylene glycol 4 parts, water for injection 8 parts, sodium hydroxide 0.03 part.
Comprise the following steps during preparation:
A. each raw material is got in proportion;
B. sodium hydroxide partial syringe water is mixed with the solution for standby of 20%;
C. in propylene glycol, add remaining water for injection stir, add sulfamonomethoxine sodium, trimethoprim stirs, and by the sodium hydroxide solution adjust ph to 10 of 20%, survey content, embedding, sterilizing, obtains sulfamonomethoxine sodium injection.
Number in embodiment 1-3 is parts by weight.
Titrimetry examination content and product yield examination are carried out to the product of example 1-3.
Titrimetry is examined or check: often prop up the content of medicine and the ratio of labelled amount; Product yield: the ratio of paid number and receivable number.Result is as follows:
Embodiment 1 product: gained sulfamonomethoxine sodium injection content is 98.6%, yield 96.1%.
Embodiment 2 product: gained sulfamonomethoxine sodium injection content is 100.9%, yield 96.8%.
Embodiment 3 product: gained sulfamonomethoxine sodium injection content is 102.2%, yield 96.7%.
Stability data
(1) accelerated test
Embodiment 1
Packaging: low borosilicate glass ampoule bottle
Investigation condition: temperature 40 ± 2 DEG C, relative humidity 75 ± 5%; Result is as following table:
(2) experiment for long-term stability
Embodiment 2
Packaging: low borosilicate glass ampoule bottle
Investigation condition: temperature 25 ± 2 DEG C, relative humidity 60 ± 5%, the results are shown in following table:
Found out by data in table, in accelerated test and long term test, in injection, the content of the effective ingredient sulfamonomethoxine sodium of side is basicly stable, does not significantly reduce, the short-term of the florfenicol injection that the present invention obtains and long-time stability good.
Claims (4)
1. sulfamonomethoxine sodium injection, is characterized in that: be made up of the raw material of following weight portion: sulfamonomethoxine sodium 0.8-1.2 part, trimethoprim (TMP) 0.2-0.4 part, organic solvent 2-4 part, water for injection 6-8 part, pH adjusting agent 0.01-0.03 part.
2. sulfamonomethoxine sodium injection as claimed in claim 1, is characterized in that: trimethoprim (TMP) is trimethoprim.
3. sulfamonomethoxine sodium injection as claimed in claim 1 or 2, is characterized in that: organic solvent is ethanol or propylene glycol.
4. sulfamonomethoxine sodium injection as claimed in claim 1 or 2, is characterized in that: pH adjusting agent is sodium hydroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410459827.9A CN104258400A (en) | 2014-09-11 | 2014-09-11 | Sulfamonomethoxine sodium injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410459827.9A CN104258400A (en) | 2014-09-11 | 2014-09-11 | Sulfamonomethoxine sodium injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104258400A true CN104258400A (en) | 2015-01-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410459827.9A Pending CN104258400A (en) | 2014-09-11 | 2014-09-11 | Sulfamonomethoxine sodium injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104258400A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114452251A (en) * | 2021-12-17 | 2022-05-10 | 四川志邦生物科技有限公司 | Sulfamonomethoxine sodium injection and preparation method thereof |
-
2014
- 2014-09-11 CN CN201410459827.9A patent/CN104258400A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114452251A (en) * | 2021-12-17 | 2022-05-10 | 四川志邦生物科技有限公司 | Sulfamonomethoxine sodium injection and preparation method thereof |
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| C06 | Publication | ||
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150107 |
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| WD01 | Invention patent application deemed withdrawn after publication |