CN103006674A - Compound sulfamonomethoxine sodium solution and preparation method thereof - Google Patents
Compound sulfamonomethoxine sodium solution and preparation method thereof Download PDFInfo
- Publication number
- CN103006674A CN103006674A CN2012105451465A CN201210545146A CN103006674A CN 103006674 A CN103006674 A CN 103006674A CN 2012105451465 A CN2012105451465 A CN 2012105451465A CN 201210545146 A CN201210545146 A CN 201210545146A CN 103006674 A CN103006674 A CN 103006674A
- Authority
- CN
- China
- Prior art keywords
- solution
- sulfamonomethoxine sodium
- sodium
- sodium solution
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention aims to disclose a compound sulfamonomethoxine sodium solution and a preparation method of the compound sulfamonomethoxine sodium solution. The compound sulfamonomethoxine sodium solution comprises 100ml of the following components: 5-20g of sulfamonomethoxine sodium, 1-5g of trimethoprim, 20-70ml of an organic solvent, 0.1-0.5g of an antioxidant and 0.1-0.5g of a metal complex. Compared with an injection liquid, the prepared compound sulfamonomethoxine sodium solution has the advantages of convenience for administration, resource economization, wide application, strong product activity, high bioavailability, stable efficacy, obvious effect, stable shape and properties, slow degradation of main drugs, capability of continuously keeping bioactivity and the like, and thus the aim of the invention is realized.
Description
Technical field
The present invention relates to a kind of solution and preparation method thereof, particularly composite sulfamonomethoxine sodium solution of a kind of animals for treating parasitic disease and preparation method thereof.
Background technology
Sulfamonomethoxine sodium from antibacterial action, ranks the first place of sulphonamides for sulfamethoxyplridazine class medicine more of new generation.Has double pharmacological action: can be antibiotic, again can protozoacide, gram positive bacteria and some negative bacterium there are stronger bacteriostasis, as: the sensitivities such as streptococcus, streptococcus pneumoniae, Salmonella, staphylococcus, Actinobacillus mallei, pasteurellosis bacillus, brucella, pneumobacillus, Bacillus proteus, dysentery bacterium, Listeria monocytogenes, Actinobacillus, swine dysentery spirillum; The protozoacide aspect has: this product is responsive to leucocyte protozoon, coccidiosis, the toxoplasma of chicken.Growth promoting function, the low dose of interpolation has the promotion growth, can obviously improve the egg production of laying hen, improves food conversion ratio.Clinically be mainly used in that treatment is yellow by the microbial baby pig edema of sensitivity, atrophic rhinitis, Actinobacillus property pleuropneumonia, piglet, Hakuri, swine toxoplasmosis, colibacillosis of pigs, Pullorum Disease, avian typhoid, avian colibacillosis, infectious coryza of chicken.Simultaneously white comb (chicken card Schwann Cells protozoacide), the chicken coccidiosis of fowl also there is specially good effect.
Trimethoprim is broad spectrum antibiotic, and antimicrobial spectrum and sulfa drugs seemingly the effect that suppresses dihydrofolate reductase is arranged, but antibacterial more easily produce drug resistance, use seldom separately.Sulphonamides then suppresses dihydrofolate synthetase.Both share, and can make the folic acid metabolism of antibacterial be subject to double blocking, thereby antibacterial action increases substantially (but potentiation several times to tens times), and kinetics is should product oral absorption complete, can reach more than 90% of dosage.
Therefore, need especially a kind of composite sulfamonomethoxine sodium solution and preparation method thereof, solved the problem of above-mentioned existing existence.
Summary of the invention
The advantages such as the object of the present invention is to provide a kind of composite sulfamonomethoxine sodium solution and preparation method thereof, for the deficiencies in the prior art, it is few to have use amount, and the medication number of times is few, and zest is good, and drug effect is definitely stable.
Technical problem solved by the invention can realize by the following technical solutions:
On the one hand, the invention provides a kind of composite sulfamonomethoxine sodium solution, it is characterized in that, it comprises the following component of every 100ml: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g.
In one embodiment of the invention, described organic solvent is the solution that propylene glycol and benzyl alcohol are mixed to get according to 30-60:5-30.
In one embodiment of the invention, described antioxidant is a kind of in sodium sulfite, sodium sulfite, the vitamin C.
In one embodiment of the invention, described complex is disodiumedetate.
On the other hand, the invention provides a kind of preparation method of composite sulfamonomethoxine sodium solution, it is characterized in that it comprises the steps:
(1) organic solvent is placed in the beaker, in 60-70 degree centigrade water-bath, heats, the sulfametoxydiazine sodium and the trimethoprim that take by weighing are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in 30-70 degree centigrade water-bath adds antioxidant and chelating agent, and constantly stirring makes its clarification;
(3) solution in (2) is joined slowly in the solution in (1), and constantly stir and make its mix homogeneously, the solution that obtains clarifying;
(4) after the cooling, add the water of surplus in the solution of (3) gained, be settled to 100ml.
(5) regulating PH with sodium hydroxide solution is 9.5-11.5.
In one embodiment of the invention, 120 degrees centigrade of flowing steam sterilizations of composite sulfamonomethoxine sodium solution employing of preparation were sterilized in 15 minutes, also can adopt other suitable sterilization method.
Composite sulfamonomethoxine sodium solution of the present invention and preparation method thereof, compared with prior art, the composite sulfamonomethoxine sodium solution for preparing is compared with injection, have convenient drug administration, economize on resources, be widely used, product are active strong, bioavailability is high, efficacy stability, successful, character is stable, the principal agent degraded is slow, and the advantages such as the maintenance biological activity that can continue realize purpose of the present invention.
Characteristics of the present invention can be consulted the detailed description of the better embodiment of this case and be obtained to be well understood to.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, further set forth the present invention below in conjunction with concrete.
Composite sulfamonomethoxine sodium solution of the present invention, it comprises the following component of every 100ml: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g.
In the present invention, described organic solvent is the solution that propylene glycol and benzyl alcohol are mixed to get according to 30-60:5-30.Described antioxidant is a kind of in sodium sulfite, sodium sulfite, the vitamin C.Described complex is disodiumedetate.
The preparation method of composite sulfamonomethoxine sodium solution of the present invention, it comprises the steps:
(1) organic solvent is placed in the beaker, in 60-70 degree centigrade water-bath, heats, the sulfametoxydiazine sodium and the trimethoprim that take by weighing are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in 30-70 degree centigrade water-bath adds antioxidant and chelating agent, and constantly stirring makes its clarification;
(3) solution in (2) is joined slowly in the solution in (1), and constantly stir and make its mix homogeneously, the solution that obtains clarifying;
(4) after the cooling, add the water of surplus in the solution of (3) gained, be settled to 100ml.
(5) regulating PH with sodium hydroxide solution is 9.5-11.5.
In the present invention, 120 degrees centigrade of flowing steam sterilizations of composite sulfamonomethoxine sodium solution employing of preparation were sterilized in 15 minutes, also can adopt other suitable sterilization method.
Can with the preparation the fill of composite sulfamonomethoxine sodium solution in brown vial, perhaps in the lighttight plastic bottle, loading amount comprises 50ml, 100ml, 200ml, 250ml, 500ml etc.
Embodiment 1:
Sulfamonomethoxine sodium 5g, trimethoprim 1g, organic solvent 25ml, antioxidant 0.1g, metal complex 0.1g; Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol are mixed to get according to 3:2, and described antioxidant is sodium sulfite, and described complex is disodiumedetate; Concrete steps are as follows:
(1) organic solvent is placed in the beaker, in 60-70 degree centigrade water-bath, heats, the sulfametoxydiazine sodium and the trimethoprim that take by weighing are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in 30-70 degree centigrade water-bath adds antioxidant and chelating agent, and constantly stirring makes its clarification;
(3) solution in (2) is joined slowly in the solution in (1), and constantly stir and make its mix homogeneously, the solution that obtains clarifying;
(4) after the cooling, add the water of surplus in the solution of (3) gained, be settled to 100ml.
(5) regulating PH with sodium hydroxide solution is 9.5-11.5.
Adopt 120 degrees centigrade of flowing steam sterilizations to sterilize in 15 minutes the composite sulfamonomethoxine sodium solution of preparation, also can adopt other suitable sterilization method.
Embodiment 2:
Sulfamonomethoxine sodium 10g, trimethoprim 2g, organic solvent 50ml, antioxidant 0.2g, metal complex 0.2g; Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol are mixed to get according to 4:1, and described antioxidant is sodium sulfite, and described complex is disodiumedetate; Concrete steps are as follows:
(1) organic solvent is placed in the beaker, in 60-70 degree centigrade water-bath, heats, the sulfametoxydiazine sodium and the trimethoprim that take by weighing are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in 30-70 degree centigrade water-bath adds antioxidant and chelating agent, and constantly stirring makes its clarification;
(3) solution in (2) is joined slowly in the solution in (1), and constantly stir and make its mix homogeneously, the solution that obtains clarifying;
(4) after the cooling, add the water of surplus in the solution of (3) gained, be settled to 100ml.
(5) regulating PH with sodium hydroxide solution is 9.5-11.5.
Adopt 120 degrees centigrade of flowing steam sterilizations to sterilize in 15 minutes the composite sulfamonomethoxine sodium solution of preparation, also can adopt other suitable sterilization method.
Embodiment 3:
Sulfamonomethoxine sodium 20g, trimethoprim 5g, organic solvent 70ml, antioxidant 0.5g, metal complex 0.5g; Wherein, described organic solvent is the solution that propylene glycol and benzyl alcohol are mixed to get according to 5:2, and described antioxidant is vitamin C, and described complex is disodiumedetate; Concrete steps are as follows:
(1) organic solvent is placed in the beaker, in 60-70 degree centigrade water-bath, heats, the sulfametoxydiazine sodium and the trimethoprim that take by weighing are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in 30-70 degree centigrade water-bath adds antioxidant and chelating agent, and constantly stirring makes its clarification;
(3) solution in (2) is joined slowly in the solution in (1), and constantly stir and make its mix homogeneously, the solution that obtains clarifying;
(4) after the cooling, add the water of surplus in the solution of (3) gained, be settled to 100ml.
(5) regulating PH with sodium hydroxide solution is 9.5-11.5.
Adopt 120 degrees centigrade of flowing steam sterilizations to sterilize in 15 minutes the composite sulfamonomethoxine sodium solution of preparation, also can adopt other suitable sterilization method.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and the claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (6)
1. a composite sulfamonomethoxine sodium solution is characterized in that, it comprises the following component of every 100ml: sulfamonomethoxine sodium 5-20g, trimethoprim 1-5g, organic solvent 20-70ml, antioxidant 0.1-0.5g, metal complex 0.1-0.5g.
2. composite sulfamonomethoxine sodium solution as claimed in claim 1 is characterized in that, described organic solvent is the solution that propylene glycol and benzyl alcohol are mixed to get according to 30-60:5-30.
3. composite sulfamonomethoxine sodium solution as claimed in claim 1 is characterized in that, described antioxidant is a kind of in sodium sulfite, sodium sulfite, the vitamin C.
4. composite sulfamonomethoxine sodium solution as claimed in claim 1 is characterized in that, described complex is disodiumedetate.
5. the preparation method of a composite sulfamonomethoxine sodium solution is characterized in that, it comprises the steps:
(1) organic solvent is placed in the beaker, in 60-70 degree centigrade water-bath, heats, the sulfametoxydiazine sodium and the trimethoprim that take by weighing are poured into wherein, and constantly stirring makes clarification;
(2) get another beaker, add suitable quantity of water, preheating in 30-70 degree centigrade water-bath adds antioxidant and chelating agent, and constantly stirring makes its clarification;
(3) solution in (2) is joined slowly in the solution in (1), and constantly stir and make its mix homogeneously, the solution that obtains clarifying;
(4) after the cooling, add the water of surplus in the solution of (3) gained, be settled to 100ml.
(5) regulating PH with sodium hydroxide solution is 9.5-11.5.
6. the preparation method of composite sulfamonomethoxine sodium solution as claimed in claim 5 is characterized in that, 120 degrees centigrade of flowing steam sterilizations of composite sulfamonomethoxine sodium solution employing of preparation were sterilized in 15 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210545146.5A CN103006674B (en) | 2012-12-14 | 2012-12-14 | A kind of compound sulfamonomethoxine sodium solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210545146.5A CN103006674B (en) | 2012-12-14 | 2012-12-14 | A kind of compound sulfamonomethoxine sodium solution and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103006674A true CN103006674A (en) | 2013-04-03 |
| CN103006674B CN103006674B (en) | 2015-12-02 |
Family
ID=47956140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210545146.5A Active CN103006674B (en) | 2012-12-14 | 2012-12-14 | A kind of compound sulfamonomethoxine sodium solution and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103006674B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356663A (en) * | 2013-06-28 | 2013-10-23 | 浙江省农业科学院 | Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof |
| CN103450095A (en) * | 2013-09-11 | 2013-12-18 | 尹爱萍 | Mercuric sulfamonomethoxine and preparation method thereof |
| CN103550226A (en) * | 2013-11-12 | 2014-02-05 | 崔合芳 | Compound sulfamonomethoxine sodium injection as well as preparation method thereof |
| CN104224806A (en) * | 2014-09-11 | 2014-12-24 | 河南迪冉生物科技有限公司 | Preparation method of sulfamonomethoxine sodium injection |
| CN104274472A (en) * | 2014-09-12 | 2015-01-14 | 安徽天安动物药业有限公司 | Compound sulfamonomethoxine sodium injection and preparation method thereof |
| CN104324036A (en) * | 2014-11-04 | 2015-02-04 | 重庆泰通动物药业有限公司 | Drug composition of sulfamonomethoxine sodium with synergistic antibacterial effect for injection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053568A (en) * | 2007-04-28 | 2007-10-17 | 成青兰 | Compound and its processing technology for compound sulfamonomethoxine sodium injection |
-
2012
- 2012-12-14 CN CN201210545146.5A patent/CN103006674B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053568A (en) * | 2007-04-28 | 2007-10-17 | 成青兰 | Compound and its processing technology for compound sulfamonomethoxine sodium injection |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356663A (en) * | 2013-06-28 | 2013-10-23 | 浙江省农业科学院 | Sulfamonomethoxine-ciprofloxacin-fosfomycin combined injection for veterinary use and preparation method thereof |
| CN103450095A (en) * | 2013-09-11 | 2013-12-18 | 尹爱萍 | Mercuric sulfamonomethoxine and preparation method thereof |
| CN103550226A (en) * | 2013-11-12 | 2014-02-05 | 崔合芳 | Compound sulfamonomethoxine sodium injection as well as preparation method thereof |
| CN104224806A (en) * | 2014-09-11 | 2014-12-24 | 河南迪冉生物科技有限公司 | Preparation method of sulfamonomethoxine sodium injection |
| CN104274472A (en) * | 2014-09-12 | 2015-01-14 | 安徽天安动物药业有限公司 | Compound sulfamonomethoxine sodium injection and preparation method thereof |
| CN104324036A (en) * | 2014-11-04 | 2015-02-04 | 重庆泰通动物药业有限公司 | Drug composition of sulfamonomethoxine sodium with synergistic antibacterial effect for injection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103006674B (en) | 2015-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103006674B (en) | A kind of compound sulfamonomethoxine sodium solution and preparation method thereof | |
| CN100548305C (en) | Compound vibramycin injection for animals and preparation method thereof | |
| CN104840426A (en) | Amoxicillin soluble powder as well as preparation method and application of amoxicillin soluble powder | |
| CN102038643A (en) | Enrofloxacin soluble powder and preparation method and application thereof | |
| CN101810627B (en) | Compound sulfamonomethoxine/compound sulfamonomethoxine sodium injection and preparation method | |
| CN102008490A (en) | Compound florfenicol injection for animal | |
| CN102119919B (en) | Preparation method of valnemulin oily injection | |
| CN104095871A (en) | Veterinary injection containing lincomycin hydrochloride and spectinomycin sulfate | |
| CN106727578A (en) | Compound Sulfachorpyrdazine Sodium Powder and preparation method thereof | |
| CN103222978A (en) | Compound sulphamethoxazole injection and preparation method thereof | |
| CN101874773B (en) | Long-acting ceftiofur hydrochloride injection and preparation method thereof | |
| CN104586777A (en) | Ceftiofur hydrochloride powder injection as well as preparation method and application thereof | |
| CN102861100A (en) | Compound injection for treating animal respiratory tracts and preparation method thereof | |
| CN101525360B (en) | Hydrates of macrolides organic acid salts, preparation and application thereof | |
| CN103006551A (en) | Tiamulin injection and preparation method thereof | |
| CN102335136B (en) | Meropenem medicinal composition for injection and preparation method thereof | |
| CN101837118B (en) | Compound chicken colibacillosis resisting veterinary drug preparation | |
| CN101829129B (en) | Veterinary compound gentamycin sulfate injection and preparation method thereof | |
| CN104161761A (en) | Compound terramycin injection and preparation method thereof | |
| CN112089693A (en) | Penicillin composition for injection and preparation method thereof | |
| CN105125483A (en) | Florfenicol injection solution for veterinary use and preparation method of injection solution | |
| CN102988283A (en) | Terramycin injection and preparation method thereof | |
| CN104258400A (en) | Sulfamonomethoxine sodium injection | |
| CN104224806A (en) | Preparation method of sulfamonomethoxine sodium injection | |
| CN104127431A (en) | Veterinary ciprofloxacin-lincomycin long-acting injection liquid and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |