CN101822817A - Compound doxycycline hydrochloride injection for treating intestinal diseases of animals and preparation method thereof - Google Patents
Compound doxycycline hydrochloride injection for treating intestinal diseases of animals and preparation method thereof Download PDFInfo
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- CN101822817A CN101822817A CN200910115012A CN200910115012A CN101822817A CN 101822817 A CN101822817 A CN 101822817A CN 200910115012 A CN200910115012 A CN 200910115012A CN 200910115012 A CN200910115012 A CN 200910115012A CN 101822817 A CN101822817 A CN 101822817A
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- injection
- doxycycline hydrochloride
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention discloses compound doxycycline hydrochloride injection for treating intestinal diseases of animals, and the injection comprises principle agent, addition agent and solvent, wherein the principle agent is prepared by the following raw materials in parts by weight: 10-100 parts of doxycycline hydrochloride and 25-250 parts of sulfamethoxazole, or 10-100 parts of mequindox, or 10-100 parts of colistin sulfate, the addition agent is prepared by the following materials in parts by weight: 1-2 parts of antioxidant and 0.1-0.2 part of ethylene diamine tetraacetic acid-2Na, and the solvent is prepared by 650-980 parts of solvent for injection by weight. Clinical tests prove that the compound doxycycline hydrochloride injection for treating intestinal diseases of animals has better treating effects than unilateral preparations which respectively include each medicine and has the characteristics of wide antimicrobial spectrum, strong antibacterial activity, safe use and approval treating effects.
Description
Technical field
The present invention relates to a kind of compound doxycycline hydrochloride injection and preparation method for the treatment of intestinal diseases of animals.
Background technology
Livestock and poultry intestinal canal diseases is a regular incidence, treats untimelyly, has a strong impact on its growth, causes very big loss to aquaculture.It is various to be used for the livestock and poultry intestinal canal diseases product in the market, but most curative effect is not satisfied.
Summary of the invention
Purpose of the present invention just provides the compound doxycycline hydrochloride injection and the preparation method of the treating intestinal diseases of animals of a kind of safe in utilization, determined curative effect, has a broad antifungal spectrum.
The compound doxycycline hydrochloride injection for the treatment of intestinal diseases of animals of the present invention comprises principal agent, additives and solvent, wherein principal agent is formulated by weight portion raw material doxycycline hydrochloride 10～100 and Sulfamethoxazole 25～250 or Mequindox 10～100 or sulphuric acid colistin 10～100, additives are formulated with disodiumedetate 0.1～0.2 by the antioxidant 1～2 of weight portion, and solvent is formulated by solvent for injection 650～980.
Described antioxidant is one or more combinations in anhydrous sodium sulfite, sodium sulfite, sodium formaldehyde sulphoxylate, the sodium thiosulfate; Solvent for injection is a kind of or many combination in ethanol, propylene glycol, glycerol, alpha-pyrrolidone, glycerin methylal, dimethyl formamide, the water for injection.
The compound doxycycline hydrochloride injection preparation method for the treatment of intestinal diseases of animals of the present invention is: with doxycycline hydrochloride and Sulfamethoxazole or Mequindox or sulphuric acid colistin, add an amount of solvent for injection, stirring and dissolving; Add antioxidant, disodiumedetate, stirring and dissolving more respectively; Add solvent for injection afterwards to full dose, promptly.
Doxycycline hydrochloride is semi-synthetic tetracycline antibiotics in the compound doxycycline hydrochloride injection for the treatment of intestinal diseases of animals of the present invention, antibacterial activity is better than oxytetracycline and tetracycline, is used for the treatment of colibacillosis, salmonellosis, treponematosis of poultry etc.; Sulfamethoxazole is a sulfonamides, and antibacterial activity is strong than sulfadiazine, is mainly used to the infection that escherichia coli, Salmonella etc. cause; Mequindox is better than gram positive bacteria to the effect of gram negative bacteria, stronger to the treponema effect especially, to yellow scour of piglet, Hakuri, swine dysentery, calf diarrhea, paratyphoid fever, fowl pasteurellosis, the white scour of chicken, chicken colibacillosis etc. all have good curative effect; The sulphuric acid colistin is mainly used to prevent and treat the intestinal infection due to pig, the chicken gram negative bacteria.
The compound doxycycline hydrochloride injection for the treatment of intestinal diseases of animals of the present invention shows through clinical trial, and curative effect is better than including the single preparations of ephedrine of each medicine, and its advantage is: (1) develops the new veterinary drug compound preparation of treatment livestock and poultry intestinal canal diseases for veterinary clinic; (2) the serier compound preparation has further expanded intestinal antimicrobial spectrum range, strengthens antibacterial activity, and curative effect is better than including the single preparations of ephedrine of each medicine; (3) reasonable recipe, the raw material of employing are the efficient medicine that anti-intestinal infects; (4) production technology advanced person, preparation stabilization, storage period is long; (5) safe in utilization, determined curative effect, quality controllable; (6) dosage is accurate, and is easy to use.
Clinical trial:
The compound doxycycline hydrochloride injection for the treatment of intestinal diseases of animals of the present invention carries out curative effect relatively by the single preparations of ephedrine with this product prescription medication,
The experimental animal grouping:
(1) 1 group of (doxycycline hydrochloride+Sulfamethoxazole) injection of drug test group
(2) 2 groups of (doxycycline hydrochloride+Mequindox) injection of drug test group
(3) 3 groups of (doxycycline hydrochloride+sulphuric acid colistin) injection of drug test group
(4) 1 group of doxycycline hydrochloride injection of medicine matched group
(5) 2 groups of Sulfamethoxazole injection of medicine matched group
(6) 3 groups of mequindox injections of medicine matched group
(7) 4 groups of sulphuric acid colistins of medicine matched group injection
(8) positive controls infects not administration
(9) the blank group does not infect not administration
Show by clinical trial, veterinary doxycycline hydrochloride respectively with Sulfamethoxazole, Mequindox, sulphuric acid colistin in the compound injection made of a kind of medicine, with matched group relatively, drug test group curative effect of the present invention strengthens, each folk prescription medicine matched group of the medication that is better than writing out a prescription.
The specific embodiment
Embodiment 1
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 10, Sulfamethoxazole 25, sodium sulfite 1, disodiumedetate 0.1, propylene glycol 950.
Its preparation method is: take by weighing the principal agent of recipe quantity respectively, add in an amount of solvent for injection, stirring and dissolving adds recipe quantity antioxidant, disodiumedetate again, and stirring and dissolving is added the surplus solvent for injection to full dose, promptly.
Embodiment 2
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 50, Sulfamethoxazole 125, sodium formaldehyde sulphoxylate 1, disodiumedetate 0.2, glycerin methylal 900.
Its preparation method is identical with embodiment 1.
Embodiment 3
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 100, Sulfamethoxazole 250, sodium thiosulfate 2, disodiumedetate 0.1, dimethyl formamide 700.
Its preparation method is identical with embodiment 1.
Embodiment 4
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 10, Mequindox 10, sodium thiosulfate 2,7 edetate disodium 0.2, dimethyl formamide 750.
Its preparation method is identical with embodiment 1.
Embodiment 5
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 50, Mequindox 50, anhydrous sodium sulfite 1, disodiumedetate 0.1, water for injection 680.
Its preparation method is identical with embodiment 1.
Embodiment 6
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 100, Mequindox 100, anhydrous sodium sulfite 1, disodiumedetate 0.1, ethanol 900.
Its preparation method is identical with embodiment 1.
Embodiment 7
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 10, sulphuric acid colistin 10, sodium thiosulfate 2, disodiumedetate 0.1, glycerol 800.
Its preparation method is identical with embodiment 1.
Embodiment 8
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 50, sulphuric acid colistin 50, sodium thiosulfate 1,7 edetate disodium 0.1, glycerin methylal 750.
Its preparation method is identical with embodiment 1.
Embodiment 9
A kind of compound doxycycline hydrochloride injection, formulated by weight portion raw material doxycycline hydrochloride 100, sulphuric acid colistin 100, sodium formaldehyde sulphoxylate 1, disodiumedetate 0.2, glycerol 650.
Its preparation method is identical with embodiment 1.
Claims (2)
1. the compound doxycycline hydrochloride injection of a treating intestinal diseases of animals, comprise principal agent, additives and solvent, it is characterized in that: wherein principal agent is formulated by weight portion raw material doxycycline hydrochloride 10～100 and Sulfamethoxazole 25～250 or Mequindox 10～100 or sulphuric acid colistin 10～100, additives are formulated with disodiumedetate 0.1～0.2 by the antioxidant 1～2 of weight portion, and solvent is formulated by solvent for injection 650～980;
Described antioxidant is one or more combinations in anhydrous sodium sulfite, sodium sulfite, sodium formaldehyde sulphoxylate, the sodium thiosulfate; Solvent for injection is a kind of or many combination in ethanol, propylene glycol, glycerol, alpha-pyrrolidone, glycerin methylal, dimethyl formamide, the water for injection.
2. the compound doxycycline hydrochloride injection for the treatment of intestinal diseases of animals as claimed in claim 1, its preparation method is: with doxycycline hydrochloride and Sulfamethoxazole or Mequindox or sulphuric acid colistin, add an amount of solvent for injection, stirring and dissolving; Add antioxidant, disodiumedetate, stirring and dissolving more respectively; Add solvent for injection afterwards to full dose, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910115012A CN101822817A (en) | 2009-03-06 | 2009-03-06 | Compound doxycycline hydrochloride injection for treating intestinal diseases of animals and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910115012A CN101822817A (en) | 2009-03-06 | 2009-03-06 | Compound doxycycline hydrochloride injection for treating intestinal diseases of animals and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101822817A true CN101822817A (en) | 2010-09-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910115012A Pending CN101822817A (en) | 2009-03-06 | 2009-03-06 | Compound doxycycline hydrochloride injection for treating intestinal diseases of animals and preparation method thereof |
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| CN (1) | CN101822817A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622976A (en) * | 2013-11-08 | 2014-03-12 | 江西新天地药业有限公司 | Long-acting compound doxycycline hydrochloride injection for animals and preparation method thereof |
-
2009
- 2009-03-06 CN CN200910115012A patent/CN101822817A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103622976A (en) * | 2013-11-08 | 2014-03-12 | 江西新天地药业有限公司 | Long-acting compound doxycycline hydrochloride injection for animals and preparation method thereof |
| CN103622976B (en) * | 2013-11-08 | 2015-09-16 | 江西新天地药业有限公司 | Long-acting veterinary compound doxycycline hydrochloride injection and preparation method thereof |
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Application publication date: 20100908 |