CN102988283A - Terramycin injection and preparation method thereof - Google Patents
Terramycin injection and preparation method thereof Download PDFInfo
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- CN102988283A CN102988283A CN201210537589XA CN201210537589A CN102988283A CN 102988283 A CN102988283 A CN 102988283A CN 201210537589X A CN201210537589X A CN 201210537589XA CN 201210537589 A CN201210537589 A CN 201210537589A CN 102988283 A CN102988283 A CN 102988283A
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- injection
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- terramycin
- oxytetracycline
- organic solvent
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Abstract
The invention aims to disclose a terramycin injection and a preparation method thereof. The terramycin injection comprises the following components of, in every 100 mL, 10-50 g of terramycin, 10-60 g of an organic solvent, 0.1 g-1 g of an anti-oxidant, and the balance being injection water. Compared with a conventional terramycin injection, the terramycin injection provided by the invention has high bioavailability, good curative effect and definite therapeutic effect. Clinic experiments show that the curative effect of the terramycin injection is 3-5 times that of a common terramycin injection. The terramycin injection has stable property, and can keep relatively high biological activity for a long time. The product is simple and easy to prepare, and can be used for industrial large-scale production. The object of the invention is realized.
Description
Technical field
The present invention relates to a kind of injection and preparation method thereof, particularly a kind of Ursocycline injection for animals and preparation method thereof.
Background technology
Oxytetracycline belongs to tetracycline antibiotics.This product is broad-spectrum antibacterial agent, and many rickettsiaes, Mycoplasma, chlamydiaceae, spirillum, ameba and some plasmodium are also responsive to this product.Enterococcus is to its drug resistance.Tetracycline is to gonococcus and the certain antibacterial activity of meningococcus tool, but penicillin-fast gonococcus is to oxytetracycline also drug resistance.Owing to the extensive use of Tetracyclines, common clinical pathogenic bacteria is serious to oxytetracycline drug resistance phenomenon, comprises gram positive bacteria and most gram negative bacillis such as staphylococcus for many years.There is crossing drug resistant between the different cultivars of tetracycline antibiotics.Its mechanism of action is that medicine can be combined with the A position of bacterial ribosome 30S subunit specifically, suppresses the growth of peptide chain and affects the synthetic of bacterioprotein.
At present, oxytetracycline has become the most popular antibiotic of animal such as poultry, usually is added in the feedstuff or makes injection.Oxytetracycline is added in the feedstuff, can be used for prevention and the treatment of the various diseases of animal, and Ursocycline injection then more is used for the treatment of indication.
But existing product curative effect is relatively poor, and security performance is not high.
Therefore, need especially a kind of Ursocycline injection and preparation method thereof, solved the problem of above-mentioned existing existence.
Summary of the invention
The object of the present invention is to provide a kind of Ursocycline injection and preparation method thereof, for the deficiencies in the prior art, efficient and safety.
Technical problem solved by the invention can realize by the following technical solutions:
On the one hand, the invention provides a kind of Ursocycline injection, it is characterized in that, it comprises the following components by weight percent of every 100ml: oxytetracycline 10-50g, and organic solvent 10-60g, antioxidant 0.1g-1g, surplus is water for injection.
In one embodiment of the invention, described organic solvent comprises one or more the combination in alpha-pyrrolidone, propylene glycol, Polyethylene Glycol or the benzyl alcohol.
In one embodiment of the invention, described antioxidant comprises one or more the combination in sodium sulfite, sodium sulfite or the vitamin C.
On the other hand, the invention provides a kind of preparation method of Ursocycline injection, it is characterized in that, get an amount of water, add antioxidant and make dissolving, add again oxytetracycline, put in 50-60 degree centigrade the water-bath and heat, slowly add organic solvent and make the oxytetracycline dissolving, the solution becomes clarification, be placed to room temperature, add the water of surplus, regulate PH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution; Aseptic filtration is divided in the bottle of airtight, shading, preserves in cool dark place.
Ursocycline injection of the present invention and preparation method thereof, compared with prior art, bioavailability is high, good effect, determined curative effect proves through clinical trial, its curative effect is 3-5 times of common Ursocycline injection; Stable in properties can keep higher biological activity the long period; Product prepares simple, can be used for industrial mass production, realizes purpose of the present invention.
Characteristics of the present invention can be consulted the detailed description of the better embodiment of this case and be obtained to be well understood to.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, further set forth the present invention below in conjunction with concrete.
Ursocycline injection of the present invention, it comprises the following components by weight percent of every 100ml: oxytetracycline 10-50g, organic solvent 10-60g, antioxidant 0.1g-1g, surplus is water for injection.
In the present invention, described organic solvent comprises one or more the combination in alpha-pyrrolidone, propylene glycol, Polyethylene Glycol or the benzyl alcohol.
Described antioxidant comprises one or more the combination in sodium sulfite, sodium sulfite or the vitamin C.
The preparation method of Ursocycline injection of the present invention, get an amount of water, add antioxidant and make dissolving, add again oxytetracycline, put in 50-60 degree centigrade the water-bath and heat, slowly add organic solvent and make the oxytetracycline dissolving, the solution becomes clarification, be placed to room temperature, add the water of surplus, regulate PH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution; Aseptic filtration is divided in the bottle of airtight, shading, preserves in cool dark place.
Ursocycline injection of the present invention, its applicable to as if various poultry and livestocks; Its route of administration is intramuscular injection, also can subcutaneous injection, and oral or other route of administration.Its character is amber clear liquid, and the Ph value is 8.3-8.8.
Embodiment 1:
Take by weighing the 10g oxytetracycline, 0.1g vitamin C, the water that adds about 20ml, put in 50-60 degree centigrade the water-bath and heat, slowly add alpha-pyrrolidone 10ml, and constantly stir and make the solution becomes clarification, be placed to room temperature, add the water of surplus to 100ml, regulate PH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution, and get final product.
Embodiment 2
Take by weighing the 20g oxytetracycline, 0.1g sodium sulfite, the water that adds about 20ml is put in 50-60 degree centigrade the water-bath and is heated, and slowly adds alpha-pyrrolidone 10ml, propylene glycol 25ml, and constantly stirring makes the solution becomes clarification, is placed to room temperature, adds the water of surplus to 100ml, regulate PH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution, and get final product.
Embodiment 3
Take by weighing the 30g oxytetracycline, 0.2g sodium sulfite, the water that adds about 20ml is put in 50-60 degree centigrade the water-bath and is heated, and slowly adds alpha-pyrrolidone 30ml, benzyl alcohol 10ml, and constantly stirring makes the solution becomes clarification, is placed to room temperature, adds the water of surplus to 100ml, regulate PH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution, and get final product.
Embodiment 4
Take by weighing the 50g oxytetracycline, 1.0g sodium sulfite adds the water of about 20ml, puts in 50-60 degree centigrade the water-bath and heats, slowly add PEG400 10ml, propylene glycol 20ml, alpha-pyrrolidone 30ml, and constantly stirring makes the solution becomes clarification, be placed to room temperature, add the water of surplus to 100ml, regulate PH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution, and get final product.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications; these changes and improvements all fall in the claimed scope of the invention, and the claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (4)
1. a Ursocycline injection is characterized in that, it comprises the following components by weight percent of every 100mL: oxytetracycline 10-50g, and organic solvent 10-60g, antioxidant 0.1g-1g, surplus is water for injection.
2. Ursocycline injection as claimed in claim 1 is characterized in that, described organic solvent comprises one or more the combination in alpha-pyrrolidone, propylene glycol, Polyethylene Glycol or the benzyl alcohol.
3. Ursocycline injection as claimed in claim 1 is characterized in that, described antioxidant comprises one or more the combination in sodium sulfite, sodium sulfite or the vitamin C.
4. the preparation method of a Ursocycline injection, it is characterized in that, get an amount of water, add antioxidant and make dissolving, add again oxytetracycline, put in 50-60 degree centigrade the water-bath and heat, slowly add organic solvent and make the oxytetracycline dissolving, the solution becomes clarification is placed to room temperature, the water that adds surplus is regulated pH to 8.3-8.8 with hydrochloric acid solution or sodium hydroxide solution; Aseptic filtration is divided in the bottle of airtight, shading, preserves in cool dark place.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210537589XA CN102988283A (en) | 2012-12-13 | 2012-12-13 | Terramycin injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210537589XA CN102988283A (en) | 2012-12-13 | 2012-12-13 | Terramycin injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN102988283A true CN102988283A (en) | 2013-03-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210537589XA Pending CN102988283A (en) | 2012-12-13 | 2012-12-13 | Terramycin injection and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104095810A (en) * | 2014-07-17 | 2014-10-15 | 江苏农牧科技职业学院 | Oxytetracycline injection and preparation method thereof |
| CN109674745A (en) * | 2019-01-23 | 2019-04-26 | 河北远征药业有限公司 | A kind of veterinary compound hydrochloric acid injection and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185635A (en) * | 2007-12-14 | 2008-05-28 | 四川喜亚动物药业有限公司 | Ursocycline injection composition |
| CN102247318A (en) * | 2010-09-28 | 2011-11-23 | 佛山市南海东方澳龙制药有限公司 | Oxytetracycline uterus injectant and preparation method thereof |
-
2012
- 2012-12-13 CN CN201210537589XA patent/CN102988283A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185635A (en) * | 2007-12-14 | 2008-05-28 | 四川喜亚动物药业有限公司 | Ursocycline injection composition |
| CN102247318A (en) * | 2010-09-28 | 2011-11-23 | 佛山市南海东方澳龙制药有限公司 | Oxytetracycline uterus injectant and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104095810A (en) * | 2014-07-17 | 2014-10-15 | 江苏农牧科技职业学院 | Oxytetracycline injection and preparation method thereof |
| CN109674745A (en) * | 2019-01-23 | 2019-04-26 | 河北远征药业有限公司 | A kind of veterinary compound hydrochloric acid injection and preparation method thereof |
| CN109674745B (en) * | 2019-01-23 | 2022-01-04 | 河北远征药业有限公司 | Veterinary compound oxytetracycline hydrochloride injection and preparation method thereof |
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Application publication date: 20130327 |