CN104721196A - Preparation method and application of enrofloxacin and sulfadiazine silver-containing veterinary injection liquid - Google Patents
Preparation method and application of enrofloxacin and sulfadiazine silver-containing veterinary injection liquid Download PDFInfo
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- CN104721196A CN104721196A CN201310707282.4A CN201310707282A CN104721196A CN 104721196 A CN104721196 A CN 104721196A CN 201310707282 A CN201310707282 A CN 201310707282A CN 104721196 A CN104721196 A CN 104721196A
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- enrofloxacin
- silver sulfadiazine
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Abstract
The invention belongs to the technical field of veterinary drug preparation method and application, and particularly relates to a preparation method and application in poultry, pigs, dogs, cats and cows of an enrofloxacin and sulfadiazine silver-containing veterinary injection liquid. The enrofloxacin and sulfadiazine silver-containing veterinary injection liquid preparation comprises (a) enrofloxacin and sulfadiazine silver as raw material drugs; (b) a solubilizer; (c) a stabilizer; (d) a preservative; and (e) an antioxidant. The enrofloxacin and sulfadiazine silver-containing veterinary injection liquid is prepared by mixing method, and is colorless to slightly yellow transparent solution in character. The enrofloxacin and sulfadiazine silver-containing veterinary injection liquid has the advantages of good stability, quick absorption, long elimination half life, and high bioavailability, and can be used as a veterinary injection preparation.
Description
Technical field
The invention belongs to the compound recipe preparation method of veterinary antibiotic medicine and the technical field of application, be specifically related to the preparation method of Injection for animals of a kind of enrofloxacin, silver sulfadiazine, and the application on poultry, pig, dog, cat, cattle.
Technical background
Enrofloxacin can be used as animal-use drug product, long half time in animal body, has good tissue distribution, belongs to broad-spectrum antibacterial, for gram positive bacteria, negative bacterium and Mycoplasma, there is bacteriostasis, be once used in the vibrio disease of cultured fishes and the control of escherichia coli disease.
This product is the third generation carbostyril family antibacterial drugs of synthesis, has another name called ENR, and obtaining FDA approval on October 4th, 1996, is poultry and the special carbostyril family antibacterial drugs of Aquatic product.Can be combined with Bacterial DNA gyrase subunit A, thus inhibit cutting and the linkage function of enzyme, prevent copying of DNA of bacteria, and present antibacterial action.There is broad spectrum antibiotic activity, there is very strong permeability, this product has very strong killing action to gram negative bacteria, also good antibacterial action is had to gram positive bacteria, oral absorption is good, blood drug level is high and stable, can be distributed widely in tissue, its metabolite is ciprofloxacin, still has powerful antibacterial action.Almost all stronger to the antibacterial activity of all pathogen of aquatic animal.Effective to the microbial severe infections that caused a disease by drug resistance, with other antibiotics without cross resistance.
Prominent features of the present invention is exactly preparation method enrofloxacin, silver sulfadiazine being utilized mixed solvent, is prepared into Injection for animals.The Injection for animals good stability of the enrofloxacin prepared by this method, silver sulfadiazine, nonirritant, and there is slow releasing function, the safety that tool is good, for China's veterinary clinic utilizes lincomycin hydrochloride and enrofloxacin, silver sulfadiazine to provide a kind of new preparation better.
Summary of the invention
The object of the invention is to the Injection for animals developing a kind of enrofloxacin, silver sulfadiazine, heighten the effect of a treatment, improve stability and the safety of medicine, tool long-acting.
The present invention, for achieving the above object, provides a kind of Injection for animals containing enrofloxacin, silver sulfadiazine, it is characterized in that preparation specifically consists of:
(a) enrofloxacin, silver sulfadiazine 8-20% (W/V);
(b) solubilizing agent 10-20% (W/V);
(c) antiseptic 0.05-0.50% (W/V);
(d) antioxidant 0.1-1% (W/V);
(e) stabilizing agent 0.2-0.6%(W/V)
Described a kind of injection containing enrofloxacin, silver sulfadiazine, is characterized in that the preparation invented is based on water, and the polyhydric alcohol that can mix with water arbitrary proportion, as ethylene glycol, propylene glycol, glycerol, particularly preferably propylene glycol.
Described a kind of injection containing enrofloxacin, silver sulfadiazine, is characterized in that the preferred poly yamanashi esters of described solubilizing agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferential poloxamer.
Described a kind of injection containing enrofloxacin, silver sulfadiazine, it is characterized in that described antiseptic is: benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate, sodium propionate, preferred sodium benzoate or sodium propionate.
Described a kind of injection containing enrofloxacin, silver sulfadiazine, is characterized in that described stabilizing agent is: a certain in citrate (acid salt or normal salt), tartrate (acid salt or normal salt), phosphate, optimization citric acid.
Described a kind of injection containing enrofloxacin, silver sulfadiazine, it is characterized in that described antioxidant is: a certain in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.
Described a kind of injection containing enrofloxacin, silver sulfadiazine, is characterized in that preparation method is as follows:
Measure gentamycin sulfate and purified water, solvent and antiseptic, solubilizing agent agent according to prescription to stir formation suspension, separately get after recipe quantity stabilizing agent adds appropriate purified water, add in above-mentioned solution, with adding with stirring, add after antioxidant water dissolution, finally add water to recipe quantity, stir, obtained compound injection.
Detailed description of the invention
Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example 1: enrofloxacin, silver sulfadiazine injection
[prescription] enrofloxacin, silver sulfadiazine 10% (W/V)
Propylene glycol 10% (W/V)
Poloxamer 0.3% (W/V)
Sodium benzoate 0.2% (W/V)
Sodium citrate 0.45% (W/V)
Pure water adds to 100% (V/V)
[preparation]
Get recipe quantity enrofloxacin, silver sulfadiazine and above-mentioned various adjuvant aseptically to prepare according to aforementioned preparation process, i.e. enrofloxacin processed, silver sulfadiazine injection.
Example 2: enrofloxacin, silver sulfadiazine injection
[prescription] enrofloxacin, silver sulfadiazine 20% (W/V)
Propylene glycol 20% (W/V)
Poloxamer 0.55% (W/V)
Sodium benzoate 0.45% (W/V)
Sodium citrate 0.80% (W/V)
Pure water adds to 100% (V/V)
[preparation]
Get recipe quantity enrofloxacin, silver sulfadiazine and above-mentioned various adjuvant aseptically to prepare according to aforementioned preparation process, i.e. enrofloxacin processed, silver sulfadiazine injection.
Claims (8)
1. a preparation method for enrofloxacin for animals, silver sulfadiazine injection, is characterized in that preparation specifically consists of:
(a) enrofloxacin, silver sulfadiazine 8-20% (W/V);
(b) solubilizing agent 10-20% (W/V);
(c) antiseptic 0.05-0.50% (W/V);
(d) antioxidant 0.1-1% (W/V);
(e) stabilizing agent 0.2-0.6% (W/V).
2. contain enrofloxacin, silver sulfadiazine injection by one according to claim 1, it is characterized in that the preparation invented is based on water, and the polyhydric alcohol that can mix with water arbitrary proportion, as ethylene glycol, propylene glycol, glycerol, particularly preferably propylene glycol.
3., by a kind of injection containing enrofloxacin, silver sulfadiazine according to claim 1, it is characterized in that the preferred poly yamanashi esters of described solubilizing agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferential poloxamer.
4., by a kind of enrofloxacin according to claim 1, silver sulfadiazine injection, it is characterized in that the preferred poly yamanashi esters of described wetting agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferred poloxamer.
5. by a kind of enrofloxacin according to claim 1, silver sulfadiazine injection, it is characterized in that described antiseptic is: benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate, sodium propionate, preferred sodium benzoate or sodium propionate.
6. by a kind of injection containing enrofloxacin, silver sulfadiazine according to claim 1, it is characterized in that described stabilizing agent is: a certain in citrate (acid salt or normal salt), tartrate (acid salt or normal salt), phosphate, optimization citric acid.
7. by a kind of injection containing enrofloxacin, silver sulfadiazine according to claim 1, it is characterized in that described antioxidant is: a certain in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.
8., by a kind of enrofloxacin according to claim 1, silver sulfadiazine injection, it is characterized in that preparation method is as follows:
Measure gentamycin sulfate and purified water, solvent and antiseptic, solubilizing agent agent according to prescription to stir formation suspension, separately get after recipe quantity stabilizing agent adds appropriate purified water, add in above-mentioned solution, with adding with stirring, add after antioxidant water dissolution, finally add water to recipe quantity, stir, obtained compound injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310707282.4A CN104721196A (en) | 2013-12-20 | 2013-12-20 | Preparation method and application of enrofloxacin and sulfadiazine silver-containing veterinary injection liquid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310707282.4A CN104721196A (en) | 2013-12-20 | 2013-12-20 | Preparation method and application of enrofloxacin and sulfadiazine silver-containing veterinary injection liquid |
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| CN104721196A true CN104721196A (en) | 2015-06-24 |
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| CN201310707282.4A Pending CN104721196A (en) | 2013-12-20 | 2013-12-20 | Preparation method and application of enrofloxacin and sulfadiazine silver-containing veterinary injection liquid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394688A (en) * | 2018-11-01 | 2019-03-01 | 广东温氏大华农生物科技有限公司 | A kind of enrofloxacin injection and preparation method thereof |
-
2013
- 2013-12-20 CN CN201310707282.4A patent/CN104721196A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394688A (en) * | 2018-11-01 | 2019-03-01 | 广东温氏大华农生物科技有限公司 | A kind of enrofloxacin injection and preparation method thereof |
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Application publication date: 20150624 |