CN104337758A - Preparation method and applications of veterinary injection of horse ketoprofen - Google Patents

Abstract

The invention belongs to the technical field of preparation methods and applications of veterinary analgesic drugs, and particularly relates to a preparation method of a veterinary injection of ketoprofen, and applications of the veterinary injection in poultry, pigs, dogs, cats and cattle. The formulation comprises (a) a ketoprofen bulk drug, (b) a solubilizing agent, (c) a stabilizing agent, (d) a preservative, and (e) an antioxidant agent. The ketoprofen injection is prepared by adopting the stirring method, is the colorless to pale yellow clear solution, has characteristics of good stability, rapid absorption, long elimination half life and high bioavailability, and can be used as the veterinary injection formulation.

Description

A kind of Injection for animals preparation method of horse ketoprofen and application thereof

Technical field

The invention belongs to the compound recipe preparation method of veterinary antibiotic medicine and the technical field of application, be specifically related to a kind of preparation method of Injection for animals of ketoprofen, and the application on poultry, pig, dog, cat, cattle.

 

Technical background

Along with advancing of disease, these softening cartilages will chap wearing and tearing, and lower floor's os osseum is exposed.Meanwhile, the cartilage changed can carry out re-organized and increase hardness, and remaining cartilage then can start to be worn.Finally, joint just has hyperosteogeny formation.After wearing and tearing, cartilage can be repaired, but chondrocyte has little time to produce enough cavernous transformation substrate, and therefore frayed cartilaginous tissue cannot self-healing.In fact, cartilaginous tissue does not have enough blood supplies to repair at all.

The main cause of osteoarthritis is caused to be unstability or the senescence in joint.Be old osteoarthritis in geriatric animals, then contain that wound, blood stasis, articulation structure are abnormal at young animals, ligamentum cruciatum fracture, Patella dislocation or breaking property chondritis.

Injection has great importance for the comprehensive infection of control antibacterial, can reduce antibiotic, reduces the generation of bacterial drug resistance, ensures human food's safety.At present, ketoprofen compound preparation is mainly pre-mixing agent, soluble powder etc., and the dosage of these two kinds of dosage forms is generally large compared with injection, and in daily use, easily cause escalated dose to use, and causes antibiotic abuse.Injection veterinary clinic uses comparatively common dosage form, has and absorb the advantage rapid, bioavailability is high, dosage is little.Therefore, ketoprofen is prepared into injection, effectively in conjunction with the antibacterial action of two kinds of medicines, the scope of application on veterinary clinic can be improved, play the object of whole body therapeutic.

Above-mentioned two patent documentations and this patent are forming and solvent and adjuvant are applied and had bigger difference.

Prominent features of the present invention is exactly preparation method ketoprofen being utilized mixed solvent, is prepared into Injection for animals.The Injection for animals good stability of the ketoprofen prepared by this method, nonirritant, and there is slow releasing function, the safety that tool is good, for China's veterinary clinic utilizes lincomycin hydrochloride and ketoprofen to provide a kind of new preparation better.

Summary of the invention

The object of the invention is to the Injection for animals developing a kind of ketoprofen, heighten the effect of a treatment, improve stability and the safety of medicine, tool long-acting.

The present invention, for achieving the above object, provides a kind of Injection for animals containing ketoprofen, it is characterized in that preparation specifically consists of:

(a) ketoprofen 8-20% (W/V);

(b) solubilizing agent 10-20% (W/V);

(c) antiseptic 0.05-0.50% (W/V);

(d) antioxidant 0.1-1% (W/V);

(e) stabilizing agent 0.2-0.6%(W/V)

Described a kind of injection containing ketoprofen, is characterized in that the preparation invented is based on water, and the polyhydric alcohol that can mix with water arbitrary proportion, as ethylene glycol, propylene glycol, glycerol, particularly preferably propylene glycol.

Described a kind of injection containing ketoprofen, is characterized in that the preferred poly yamanashi esters of described solubilizing agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferential poloxamer.

Described a kind of injection containing ketoprofen, is characterized in that described antiseptic is: benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate, sodium propionate, preferred sodium benzoate or sodium propionate.

Described a kind of injection containing ketoprofen, is characterized in that described stabilizing agent is: a certain in citrate (acid salt or normal salt), tartrate (acid salt or normal salt), phosphate, optimization citric acid.

Described a kind of injection containing ketoprofen, it is characterized in that described antioxidant is: a certain in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.

Described a kind of injection containing ketoprofen, is characterized in that preparation method is as follows:

Measure gentamycin sulfate and purified water, solvent and antiseptic, solubilizing agent agent according to prescription to stir formation suspension, separately get after recipe quantity stabilizing agent adds appropriate purified water, add in above-mentioned solution, with adding with stirring, add after antioxidant water dissolution, finally add water to recipe quantity, stir, obtained compound injection.

Detailed description of the invention

Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.

Example 1: ketoprofen injection

[prescription] ketoprofen 10% (W/V)

Propylene glycol 10% (W/V)

Poloxamer 0.3% (W/V)

Sodium benzoate 0.2% (W/V)

Sodium citrate 0.45% (W/V)

Pure water adds to 100% (V/V)

[preparation]

Get recipe quantity ketoprofen and above-mentioned various adjuvant is aseptically prepared according to aforementioned preparation process, i.e. ketoprofen injection processed.

Example 2: ketoprofen injection

[prescription] ketoprofen 20% (W/V)

Propylene glycol 20% (W/V)

Poloxamer 0.55% (W/V)

Sodium benzoate 0.45% (W/V)

Sodium citrate 0.80% (W/V)

Pure water adds to 100% (V/V)

[preparation]

Get recipe quantity ketoprofen and above-mentioned various adjuvant is aseptically prepared according to aforementioned preparation process, i.e. ketoprofen injection processed.

Claims (7)

1. a horse preparation method for ketoprofen injection, is characterized in that preparation specifically consists of:

(a) ketoprofen 8-20% (W/V);

(b) solubilizing agent 10-20% (W/V);

(c) antiseptic 0.05-0.50% (W/V);

(d) antioxidant 0.1-1% (W/V);

(e) stabilizing agent 0.2-0.6%(W/V)

By one according to claim 1 containing ketoprofen injection, it is characterized in that the preparation invented is based on water, and the polyhydric alcohol that can mix with water arbitrary proportion, as ethylene glycol, propylene glycol, glycerol, particularly preferably propylene glycol.

2., by a kind of injection containing ketoprofen according to claim 1, it is characterized in that the preferred poly yamanashi esters of described solubilizing agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferential poloxamer.

3., by a kind of ketoprofen injection according to claim 1, it is characterized in that the preferred poly yamanashi esters of described wetting agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferred poloxamer.

4. by a kind of ketoprofen injection according to claim 1, it is characterized in that described antiseptic is: benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate, sodium propionate, preferred sodium benzoate or sodium propionate.

5. by a kind of injection containing ketoprofen according to claim 1, it is characterized in that described stabilizing agent is: a certain in citrate (acid salt or normal salt), tartrate (acid salt or normal salt), phosphate, optimization citric acid.

6. by a kind of injection containing ketoprofen according to claim 1, it is characterized in that described antioxidant is: a certain in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.

7., by a kind of ketoprofen injection according to claim 1, it is characterized in that preparation method is as follows:

Measure gentamycin sulfate and purified water, solvent and antiseptic, solubilizing agent agent according to prescription to stir formation suspension, separately get after recipe quantity stabilizing agent adds appropriate purified water, add in above-mentioned solution, with adding with stirring, add after antioxidant water dissolution, finally add water to recipe quantity, stir, obtained compound injection.