CN104721217A - Preparation method and application of lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid - Google Patents
Preparation method and application of lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid Download PDFInfo
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- CN104721217A CN104721217A CN201310707341.8A CN201310707341A CN104721217A CN 104721217 A CN104721217 A CN 104721217A CN 201310707341 A CN201310707341 A CN 201310707341A CN 104721217 A CN104721217 A CN 104721217A
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- lincomycin
- injection
- pyrantel tartrate
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- tartrate
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Abstract
The invention belongs to the technical field of veterinary drug compound formula preparation method and application, and particularly relates to a preparation method and application in poultry, pigs, dogs, cats and cows of a lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid. The lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid preparation comprises (a) lincomycin hydrochloride and pyrantel tartrate as raw material drugs; (b) a solubilizer; (c) a stabilizer; (d) a preservative; and (e) an antioxidant. The lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid is prepared by mixing method, and is colorless to slightly yellow transparent solution in character. The lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid has the advantages of good stability, quick absorption, long elimination half life, and high bioavailability, and can be used as a veterinary injection preparation.
Description
Technical field
The invention belongs to the compound recipe preparation method of veterinary antibiotic medicine and the technical field of application, be specifically related to the preparation method of Injection for animals of a kind of lincomycin hydrochloride, pyrantel tartrate, and the application on poultry, pig, dog, cat, cattle.
Technical background
Pyrantel is all a kind of Depolarizing neuromuscular blocker to parasitic nematode and vertebrate host.Polypide paralysis caused by medicine is caused by polypide muscle contraction, and it and acetylcholine impel the effect of muscle contraction similar.Though the muscular contraction caused by pyrantel, morantel is slower than acetylcholine, act on stronger than acetylcholine 100 times.The above-mentioned effect that it should be noted that acetylcholine is reversible, and pyrantel and morantel are irreversible.
Pyrantel is similar with diethylcarbamazine citrate to the pharmacological action of host and morantel, levamisole, all has the biological characteristics of acetylcholine.These medicines Main Function and neurotransmitter in body---the effect produced when acetylcholine is excessive is identical, make chemoreceptor and the Neuromuscular inner contact of vegetative ganglia, adrenal medulla, carotid body and aortic body exactly, first excited rear paralysis, similar with nicotinic action.
Prominent features of the present invention is exactly preparation method lincomycin hydrochloride, pyrantel tartrate being utilized mixed solvent, is prepared into Injection for animals.The Injection for animals good stability of the lincomycin hydrochloride prepared by this method, pyrantel tartrate, nonirritant, and there is slow releasing function, the safety that tool is good, for China's veterinary clinic utilizes lincomycin hydrochloride and lincomycin hydrochloride, pyrantel tartrate to provide a kind of new preparation better.
Summary of the invention
The object of the invention is to the Injection for animals developing a kind of lincomycin hydrochloride, pyrantel tartrate, heighten the effect of a treatment, improve stability and the safety of medicine, tool long-acting.
The present invention, for achieving the above object, provides the Injection for animals of a kind of hydrochloric lincomycin, pyrantel tartrate, it is characterized in that preparation specifically consists of:
(a) lincomycin hydrochloride, pyrantel tartrate 8-20% (W/V);
(b) solubilizing agent 10-20% (W/V);
(c) antiseptic 0.05-0.50% (W/V);
(d) antioxidant 0.1-1% (W/V);
(e) stabilizing agent 0.2-0.6%(W/V)
Described a kind of hydrochloric lincomycin, the injection of pyrantel tartrate, is characterized in that the preparation invented is based on water, and the polyhydric alcohol that can mix with water arbitrary proportion, as ethylene glycol, propylene glycol, glycerol, particularly preferably propylene glycol.
Described a kind of hydrochloric lincomycin, the injection of pyrantel tartrate, is characterized in that the preferred poly yamanashi esters of described solubilizing agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferential poloxamer.
Described a kind of hydrochloric lincomycin, the injection of pyrantel tartrate, it is characterized in that described antiseptic is: benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate, sodium propionate, preferred sodium benzoate or sodium propionate.
Described a kind of hydrochloric lincomycin, the injection of pyrantel tartrate, is characterized in that described stabilizing agent is: a certain in citrate (acid salt or normal salt), tartrate (acid salt or normal salt), phosphate, optimization citric acid.
Described a kind of hydrochloric lincomycin, the injection of pyrantel tartrate, it is characterized in that described antioxidant is: a certain in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.
Described a kind of hydrochloric lincomycin, the injection of pyrantel tartrate, is characterized in that preparation method is as follows:
Measure gentamycin sulfate and purified water, solvent and antiseptic, solubilizing agent agent according to prescription to stir formation suspension, separately get after recipe quantity stabilizing agent adds appropriate purified water, add in above-mentioned solution, with adding with stirring, add after antioxidant water dissolution, finally add water to recipe quantity, stir, obtained compound injection.
Detailed description of the invention
Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example 1: lincomycin hydrochloride, pyrantel tartrate injection
[prescription] lincomycin hydrochloride, pyrantel tartrate 10% (W/V)
Propylene glycol 10% (W/V)
Poloxamer 0.3% (W/V)
Sodium benzoate 0.2% (W/V)
Sodium citrate 0.45% (W/V)
Pure water adds to 100% (V/V)
[preparation]
Get recipe quantity lincomycin hydrochloride, pyrantel tartrate and above-mentioned various adjuvant aseptically to prepare according to aforementioned preparation process, i.e. lincomycin hydrochloride processed, pyrantel tartrate injection.
Example 2: lincomycin hydrochloride, pyrantel tartrate injection
[prescription] lincomycin hydrochloride, pyrantel tartrate 20% (W/V)
Propylene glycol 20% (W/V)
Poloxamer 0.55% (W/V)
Sodium benzoate 0.45% (W/V)
Sodium citrate 0.80% (W/V)
Pure water adds to 100% (V/V)
[preparation]
Get recipe quantity lincomycin hydrochloride, pyrantel tartrate and above-mentioned various adjuvant aseptically to prepare according to aforementioned preparation process, i.e. lincomycin hydrochloride processed, pyrantel tartrate injection.
Claims (8)
1. a preparation method for hydrochloric lincomycin, pyrantel tartrate injection, is characterized in that preparation specifically consists of:
(a) lincomycin hydrochloride, pyrantel tartrate 8-20% (W/V);
(b) solubilizing agent 10-20% (W/V);
(c) antiseptic 0.05-0.50% (W/V);
(d) antioxidant 0.1-1% (W/V);
(e) stabilizing agent 0.2-0.6% (W/V).
2. by the hydrochloric lincomycin of one according to claim 1, pyrantel tartrate injection, it is characterized in that the preparation invented is based on water, and the polyhydric alcohol that can mix with water arbitrary proportion, as ethylene glycol, propylene glycol, glycerol, particularly preferably propylene glycol.
3., by the injection of a kind of hydrochloric lincomycin according to claim 1, pyrantel tartrate, it is characterized in that the preferred poly yamanashi esters of described solubilizing agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferential poloxamer.
4., by a kind of lincomycin hydrochloride according to claim 1, pyrantel tartrate injection, it is characterized in that the preferred poly yamanashi esters of described wetting agent, spans, glycerol, propylene glycol, polyoxyethylene castor oil, poloxamer, preferred poloxamer.
5. by a kind of lincomycin hydrochloride according to claim 1, pyrantel tartrate injection, it is characterized in that described antiseptic is: benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate, sodium propionate, preferred sodium benzoate or sodium propionate.
6. by the injection of a kind of hydrochloric lincomycin according to claim 1, pyrantel tartrate, it is characterized in that described stabilizing agent is: a certain in citrate (acid salt or normal salt), tartrate (acid salt or normal salt), phosphate, optimization citric acid.
7. by the injection of a kind of hydrochloric lincomycin according to claim 1, pyrantel tartrate, it is characterized in that described antioxidant is: a certain in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.
8., by a kind of lincomycin hydrochloride according to claim 1, pyrantel tartrate injection, it is characterized in that preparation method is as follows:
Measure gentamycin sulfate and purified water, solvent and antiseptic, solubilizing agent agent according to prescription to stir formation suspension, separately get after recipe quantity stabilizing agent adds appropriate purified water, add in above-mentioned solution, with adding with stirring, add after antioxidant water dissolution, finally add water to recipe quantity, stir, obtained compound injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310707341.8A CN104721217A (en) | 2013-12-20 | 2013-12-20 | Preparation method and application of lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310707341.8A CN104721217A (en) | 2013-12-20 | 2013-12-20 | Preparation method and application of lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104721217A true CN104721217A (en) | 2015-06-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310707341.8A Pending CN104721217A (en) | 2013-12-20 | 2013-12-20 | Preparation method and application of lincomycin hydrochloride and pyrantel tartrate-containing veterinary injection liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104721217A (en) |
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2013
- 2013-12-20 CN CN201310707341.8A patent/CN104721217A/en active Pending
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150624 |
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| WD01 | Invention patent application deemed withdrawn after publication |