CN102985406B - 制备取代的1,3-二氢-2h-吲哚-2-酮的方法 - Google Patents

制备取代的1,3-二氢-2h-吲哚-2-酮的方法 Download PDF

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Publication number
CN102985406B
CN102985406B CN201180034200.3A CN201180034200A CN102985406B CN 102985406 B CN102985406 B CN 102985406B CN 201180034200 A CN201180034200 A CN 201180034200A CN 102985406 B CN102985406 B CN 102985406B
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China
Prior art keywords
formula
compounds
preparation
reaction mixture
indol
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CN201180034200.3A
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English (en)
Chinese (zh)
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CN102985406A (zh
Inventor
K·西格尔
G·凯里格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Bayer CropScience AG
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Bayer Pharma AG
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Publication of CN102985406A publication Critical patent/CN102985406A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201180034200.3A 2010-05-10 2011-05-06 制备取代的1,3-二氢-2h-吲哚-2-酮的方法 Active CN102985406B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33294910P 2010-05-10 2010-05-10
US61/332,949 2010-05-10
EP10162381 2010-05-10
EP10162381.7 2010-05-10
PCT/EP2011/057276 WO2011141364A1 (de) 2010-05-10 2011-05-06 Verfahren zur herstellung von substituierten 1,3-dihydro-2h-indol-2-onen

Publications (2)

Publication Number Publication Date
CN102985406A CN102985406A (zh) 2013-03-20
CN102985406B true CN102985406B (zh) 2015-04-29

Family

ID=42537445

Family Applications (1)

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CN201180034200.3A Active CN102985406B (zh) 2010-05-10 2011-05-06 制备取代的1,3-二氢-2h-吲哚-2-酮的方法

Country Status (12)

Country Link
US (1) US8563749B2 (enExample)
EP (1) EP2569283B1 (enExample)
JP (1) JP5815679B2 (enExample)
KR (1) KR101783471B1 (enExample)
CN (1) CN102985406B (enExample)
BR (1) BR112012028767B1 (enExample)
DK (1) DK2569283T3 (enExample)
ES (1) ES2523226T3 (enExample)
IL (1) IL222929A (enExample)
MX (1) MX2012012959A (enExample)
TW (1) TWI499583B (enExample)
WO (1) WO2011141364A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3643210A1 (de) 2018-10-25 2020-04-29 Jura Elektroapparate AG Verfahren zum erzeugen eines kaffeegetränks in einem kaffeeautomaten

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160032A (en) * 1973-11-21 1979-07-03 Sandoz, Inc. Oxindoles as sleep-inducers
US4503073A (en) * 1981-01-07 1985-03-05 A. H. Robins Company, Incorporated 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids
CN1056875A (zh) * 1990-05-31 1991-12-11 美国氰胺公司 芳氧基螺烷基二氢吲哚酮除草剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI80270C (fi) * 1984-09-19 1990-05-10 Pfizer Foerfarande foer framstaellning av analgetiska och anti-inflammatoriska 1,3-diacyl-2-oxoindol-foereningar och mellanprodukter.
US5124347A (en) * 1991-07-31 1992-06-23 Warner-Lambert Co. 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents
FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160032A (en) * 1973-11-21 1979-07-03 Sandoz, Inc. Oxindoles as sleep-inducers
US4503073A (en) * 1981-01-07 1985-03-05 A. H. Robins Company, Incorporated 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids
CN1056875A (zh) * 1990-05-31 1991-12-11 美国氰胺公司 芳氧基螺烷基二氢吲哚酮除草剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Non-reductive desulfenylation of 3-thioalkyl-2-oxindoles;Terrence J .connolly，等;《synlett》;19960701;第663-664页 *
Rsgioselective Alkylation of Phenoxy-Substituted 3- (Met hylt hio)indolin-2 (3H)-ones. Preparation of 3-, 1,3-, and 1,3,3-Substituted Indolin-2(3H)-ones;Gary M. Karp;《J. Org. Chem.》;19921231;第57卷(第17期);第4765-4772页 *
Synthesis of 6,7-Dihydroxyoxindole (A Subunit of Paraherquamide A);Brad M. Savall，等;《J. Org. Chem.》;19961231;第61卷(第24期);第8696-8697页 *

Also Published As

Publication number Publication date
ES2523226T3 (es) 2014-11-24
DK2569283T3 (en) 2014-12-01
JP2013526498A (ja) 2013-06-24
BR112012028767A2 (pt) 2015-09-15
TW201206884A (en) 2012-02-16
BR112012028767B1 (pt) 2021-04-27
WO2011141364A1 (de) 2011-11-17
US20110275832A1 (en) 2011-11-10
CN102985406A (zh) 2013-03-20
IL222929A (en) 2015-06-30
EP2569283B1 (de) 2014-08-27
US8563749B2 (en) 2013-10-22
TWI499583B (zh) 2015-09-11
IL222929A0 (en) 2012-12-31
JP5815679B2 (ja) 2015-11-17
MX2012012959A (es) 2012-12-17
KR101783471B1 (ko) 2017-09-29
EP2569283A1 (de) 2013-03-20
KR20130100913A (ko) 2013-09-12

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Address after: 50 Alfred Nobel Street, Monheim, Rhine, Germany 40789

Patentee after: BAYER INTELLECTUAL PROPERTY GmbH

Address before: Germany

Patentee before: BAYER INTELLECTUAL PROPERTY GmbH

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Effective date of registration: 20240116

Address after: 50 Alfred Nobel Street, Monheim, Rhine, Germany 40789

Patentee after: BAYER CROPSCIENCE AG

Address before: 50 Alfred Nobel Street, Monheim, Rhine, Germany 40789

Patentee before: BAYER INTELLECTUAL PROPERTY GmbH