CN102961713A - Ginger and garlic enteric-coated tablet and preparation method thereof - Google Patents
Ginger and garlic enteric-coated tablet and preparation method thereof Download PDFInfo
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- CN102961713A CN102961713A CN2012104975355A CN201210497535A CN102961713A CN 102961713 A CN102961713 A CN 102961713A CN 2012104975355 A CN2012104975355 A CN 2012104975355A CN 201210497535 A CN201210497535 A CN 201210497535A CN 102961713 A CN102961713 A CN 102961713A
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Abstract
The invention provides a ginger and garlic enteric-coated tablet and a preparation method thereof. The ginger and garlic enteric-coated tablet is prepared from ginger and garlic essence as raw materials by a beta-cyclodextrin inclusion process, has broad-spectrum antibacterial action, and also the functions of reducing blood fat and blood sugar, resisting atherosclerosis, resisting tumor, improving the organism immunity, and the like, and is high in technical content, high in inclusion rate, accurate in product drug release position, and high in bioavailability, so that the medicine is high in effective ingredient content, and strong in antibacterial action, thus overcoming the shortcomings that the previous product is low in effective ingredient content, has unpleasant odor, is inconvenient to carry and the like, and ensuring the quality of the product.
Description
Technical field
The present invention relates to a kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets and preparation method thereof, belong to field of medicine preparations.
Background technology
The world today, the improving constantly of people's living standard, the continuous aging of population structure, the various diseases that thereupon brings because of overnutrition and nutritional disorder is perplexing always also that our are human, and human health in serious threat.Such as hypertension, hyperlipidemia, hypercholesterolemia etc.Healthy cause is all paid special attention in the whole world, therefore, has the balance the body physical function, and the research and development of prevent disease and sanatory nutritional health food just more and more cause concern and the attention of various countries scientific circles and industrial quarters.In recent years, people study Bulbus Allii, Rhizoma Zingiberis Recens is found, they are not only nutritious, and medical value is quite large; Therefore, the research and development of Rhizoma Zingiberis Recens Bulbus Allii goods will have value.At present, the product of worldwide treatment " three-hypers " is exactly Rhizoma Zingiberis Recens Bulbus Allii goods.Garlic health-care product listing both at home and abroad was various in style in recent years, substantially can be divided into Oleum Bulbus Allii and Bulbus Allii sheet two large classes.Ginger products mostly is sugared ginger, Sucus Zingberis, Rhizoma Zingiberis Recens buccal tablet, Rhizoma Zingiberis Recens electuary etc.And that the Rhizoma Zingiberis Recens Bulbus Allii share goods is few, and utilizes beta-schardinger dextrin-that Rhizoma Zingiberis Recens Bulbus Allii volatile oil is carried out enclose and it is developed into enteric coatel tablets then still less.
The shortcomings such as all there are some shortcomings in original Rhizoma Zingiberis Recens Bulbus Allii goods, and soft capsule and soft gelatin capsule all exist storage unstable, and be perishable; The limited component content of Bulbus Allii powder film-making is low, the garlicky shortcoming such as dense.
Summary of the invention
The purpose of this invention is to provide Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets and preparation method thereof, take Rhizoma Zingiberis Recens, Bulbus Allii quintessence oil as raw material, make Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets through beta-cyclodextrin inclusion compound technique, has broad-spectrum antibacterial action, improved quality and the curative effect of preparation, increased stability and the antibiotic property of preparation, and dosage has been little, produce, take, easy to carry, satisfy better the health care needs.
Technical solution of the present invention is as follows:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: Bulbus Allii quintessence oil 1-5 part, ginger essential oil 1-5 part, 95% ethanol 2-100 part.
Wherein Bulbus Allii quintessence oil is with garlic peeling, cleans, is crushed to granularity 6-7mm, the material barrel of packing into, place extraction kettle to start extraction equipment, extract and separate condition by setting: 35 ℃ of extraction temperature, pressure 25Mpa, static extraction time 60min, circulation time 160min, 45 ℃ of separation temperatures are tested; The extract Bulbus Allii quintessence oil is by collecting in the separating still.
Wherein ginger essential oil is that the fresh Rhizoma Zingiberis Recens that cuts is added an amount of water, smash 10min to pieces, regulating pH is 6, adds the cellulase of Rhizoma Zingiberis Recens weight 2.2%, under 46 ℃ of temperature, carry out enzymolysis 2h, then sucking filtration, filtrate is used petroleum ether extraction, vacuum distilling, reclaim solvent, collection has strong fragrance grease, uses anhydrous sodium sulfate drying, and get final product.
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets, preparation method is as follows: with Bulbus Allii quintessence oil, ginger essential oil and 95% ethanol mix homogeneously, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed the 14-20 mesh sieve, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is selected one in following method:
(1) saturated water solution method: by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, stirred 5 hours, let cool, putting in the freezer cold preservation spends the night, filter, with spray drying method dry 2-10 hour, inlet temperature was 100-200 ℃, and leaving air temp is 50-150 ℃.
(2) ultrasonic method: press beta-schardinger dextrin-: water weight ratio 1:5-20 mixes, shake up, heating in water bath dissolving lets cool to room temperature, and by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, supersound process 30-120 minute, cold preservation is spent the night, and filters, and uses spray drying method dry 2-10 hour, inlet temperature is 100-200 ℃, and leaving air temp is 50-150 ℃.
(3) colloid milling: take by weighing beta-schardinger dextrin-: water weight ratio 1:5-20, water is put into the colloid mill hopper, constantly stir, slowly add beta-schardinger dextrin-, ground 20 minutes, by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, grinds 1-3 hour, and cold preservation is spent the night, filter, with spray drying method dry 2-6 hour, inlet temperature was 100-200 ℃, and leaving air temp is 50-150 ℃.
(4) ball-milling method: take by weighing beta-schardinger dextrin-: in the water weight ratio 1:5-20 Place mill, ground 5-30 minute, by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, ground 0.5-3 hour, cold preservation is spent the night, and filters, and uses spray drying method dry 2-12 hour, inlet temperature is 100-200 ℃, and leaving air temp is 50-150 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: clathrate powder 0.5-2.0 part, polyvidone 0.1-0.2 part, low-substituted hydroxypropyl cellulose 0.1-0.2 part, polyvinylpolypyrrolidone 0.1-0.2 part, carboxymethyl starch are received 0.1-0.2 part, microcrystalline Cellulose 0.1-0.3 part, hydroxypropyl emthylcellulose 0.1-0.2 part, magnesium stearate 0.005-0.02 part.
The Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets that the present invention makes, production technology is more rational, adopted the preparation method of inclusion essential oil, with high content of technology, inclusion rate is high, product release position is accurate, bioavailability is high, makes effective ingredient high, and antibacterial action is strong, overcome the existing product active constituent content low, bad smell arranged, carry the shortcomings such as inconvenient, guaranteed the quality of product.
The specific embodiment:
Embodiment 1:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: 1 part of Bulbus Allii quintessence oil, 1 part of ginger essential oil, 2 parts of 95% ethanol.
Wherein Bulbus Allii quintessence oil is with garlic peeling, cleans, is crushed to granularity 6-7mm, the material barrel of packing into, place extraction kettle to start extraction equipment, extract and separate condition by setting: 35 ℃ of extraction temperature, pressure 25Mpa, static extraction time 60min, circulation time 160min, 45 ℃ of separation temperatures are tested; The extract Bulbus Allii quintessence oil is by collecting in the separating still.
Wherein ginger essential oil is that the fresh Rhizoma Zingiberis Recens that cuts is added an amount of water, smash 10min to pieces, regulating pH is 6, adds the cellulase of Rhizoma Zingiberis Recens weight 2.2%, under 46 ℃ of temperature, carry out enzymolysis 2h, then sucking filtration, filtrate is used petroleum ether extraction, vacuum distilling, reclaim solvent, collection has strong fragrance grease, uses anhydrous sodium sulfate drying, and get final product.
The preparation method of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets is as follows: with Bulbus Allii quintessence oil, ginger essential oil and the 95% ethanol mix homogeneously of formula ratio, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 14 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is saturated water solution method: by volatile oil: the volume ratio 1:1 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, stirred 5 hours, let cool, putting in the freezer cold preservation spends the night, filter, with spray drying method dry 2 hours, inlet temperature was 100 ℃, and leaving air temp is 50 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: 0.5 part in clathrate powder, 0.1 part of polyvidone, 0.1 part of low-substituted hydroxypropyl cellulose, 0.1 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.1 part, 0.1 part of microcrystalline Cellulose, 0.1 part of hydroxypropyl emthylcellulose, 0.005 part of magnesium stearate.
Embodiment 2:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: 3 parts of Bulbus Allii quintessence oils, 3 parts of ginger essential oils, 50 parts of 95% ethanol.
The preparation method of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets is as follows: with Bulbus Allii quintessence oil, ginger essential oil and the 95% ethanol mix homogeneously of formula ratio, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 18 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is colloid milling: take by weighing beta-schardinger dextrin-: water weight ratio 1:12, water is put into the colloid mill hopper, constantly stir, slowly add beta-schardinger dextrin-, ground 20 minutes, by volatile oil: the volume ratio 1:10 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, grinds 2 hours, and cold preservation is spent the night, filter, with spray drying method dry 4 hours, inlet temperature was 150 ℃, and leaving air temp is 100 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: 1.2 parts in clathrate powder, 0.15 part of polyvidone, 0.15 part of low-substituted hydroxypropyl cellulose, 0.15 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.15 part, 0.2 part of microcrystalline Cellulose, 0.15 part of hydroxypropyl emthylcellulose, 0.01 part of magnesium stearate.
All the other are with embodiment 1.
Embodiment 3:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: 5 parts of Bulbus Allii quintessence oils, 5 parts of ginger essential oils, 100 parts of 95% ethanol.
The preparation method of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets is as follows: with Bulbus Allii quintessence oil, ginger essential oil and the 95% ethanol mix homogeneously of formula ratio, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 20 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is ultrasonic method: press beta-schardinger dextrin-: water weight ratio 1:20 mixes, shake up, heating in water bath dissolving lets cool to room temperature, and by volatile oil: the volume ratio 1:20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, supersound process 120 minutes, cold preservation is spent the night, and filters, and uses spray drying method dry 10 hours, inlet temperature is 200 ℃, and leaving air temp is 150 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: 2.0 parts in clathrate powder, 0.2 part of polyvidone, 0.2 part of low-substituted hydroxypropyl cellulose, 0.2 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.2 part, 0.3 part of microcrystalline Cellulose, 0.2 part of hydroxypropyl emthylcellulose, 0.02 part of magnesium stearate.
All the other are with embodiment 1.
Embodiment 4:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: 2 parts of Bulbus Allii quintessence oils, 2 parts of ginger essential oils, 80 parts of 95% ethanol.
The preparation method of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets is as follows: with Bulbus Allii quintessence oil, ginger essential oil and the 95% ethanol mix homogeneously of formula ratio, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 16 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is colloid milling: take by weighing beta-schardinger dextrin-: water weight ratio 1:10, water is put into the colloid mill hopper, constantly stir, slowly add beta-schardinger dextrin-, ground 20 minutes, by volatile oil: the volume ratio 1:15 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, grinds 2 hours, and cold preservation is spent the night, filter, with spray drying method dry 5 hours, inlet temperature was 80 ℃, and leaving air temp is 120 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: 1.0 parts in clathrate powder, 0.1 part of polyvidone, 0.2 part of low-substituted hydroxypropyl cellulose, 0.1 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.2 part, 0.3 part of microcrystalline Cellulose, 0.1 part of hydroxypropyl emthylcellulose, 0.015 part of magnesium stearate.
All the other are with embodiment 1.
Embodiment 5:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: 0.5 part of Bulbus Allii quintessence oil, 0.5 part of ginger essential oil, 1 part of 95% ethanol.
The preparation method of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets is as follows: with Bulbus Allii quintessence oil, ginger essential oil and the 95% ethanol mix homogeneously of formula ratio, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 12 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is ultrasonic method: press beta-schardinger dextrin-: water weight ratio 1:4 mixes, shake up, heating in water bath dissolving lets cool to room temperature, and by volatile oil: the volume ratio 1:0.8 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, supersound process 20 minutes, cold preservation is spent the night, and filters, and uses spray drying method dry 1 hour, inlet temperature is 80 ℃, and leaving air temp is 40 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: 0.4 part in clathrate powder, 0.08 part of polyvidone, 0.08 part of low-substituted hydroxypropyl cellulose, 0.08 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.08 part, 0.08 part of microcrystalline Cellulose, 0.08 part of hydroxypropyl emthylcellulose, 0.004 part of magnesium stearate.
All the other are with embodiment 1.
Embodiment 6:
A kind of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets comprise the raw material of following volume proportion: 6 parts of Bulbus Allii quintessence oils, 6 parts of ginger essential oils, 120 parts of 95% ethanol.
Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets preparation method is as follows: with Bulbus Allii quintessence oil, ginger essential oil and 95% ethanol mix homogeneously, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 22 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
Wherein: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is ball-milling method: take by weighing beta-schardinger dextrin-: in the water weight ratio 1:24 Place mill, ground 35 minutes, by volatile oil: the volume ratio 1:25 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, ground 4 hours, cold preservation is spent the night, and filters, and uses spray drying method dry 15 hours, inlet temperature is 250 ℃, and leaving air temp is 200 ℃.
Wherein clathrate powder and adjuvant are by following weight proportion: 2.5 parts in clathrate powder, 0.3 part of polyvidone, 0.3 part of low-substituted hydroxypropyl cellulose, 0.3 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.3 part, 0.4 part of microcrystalline Cellulose, 0.3 part of hydroxypropyl emthylcellulose, 0.03 part of magnesium stearate.
All the other are with embodiment 1.
Comparative Examples 1:
The patent No. is the ginger allicin immunity soft capsult of 200510034874.X, every gross weight 600mg of oval soft capsule, the heavy 400mg of the content liquid of soft capsule, Rhizoma Zingiberis Recens quintessence oil 16mg wherein, Bulbus Allii quintessence oil 16mg, soybean oil 368mg, gelatin 200mg.
Wherein Oleum Bulbus Allii preparation: pulverize with pulverizer behind the Bulbus Allii peeling stripping lobe that will clean, crushed material dropped in the aluminum boiler heat, to the pot pressure reach 147-196kpa, material is boiled rolling after, be depressurized to immediately 48kpa, keep 2-3h, whole pot Bulbus Allii oil distills, and carries out oil-water separation with separatory funnel again, and isolated oil is heated to 140 ℃, the vacuum pump distilling under reduced pressure of right position namely gets and contains the high Bulbus Allii quintessence oil of garlicin.
Wherein Rhizoma Zingiberis Recens quintessence oil preparation: with the Rhizoma Zingiberis Recens wash clean, dry, pulverize, put into the water of the iron pan injection capacity under the distillator internal partition above the dividing plate, heating makes the water boiling produce steam, steam enters the Rhizoma Zingiberis Recens material by porous barrier, make the oil of ginger gasification, and enter in the lump condenser with water vapour, after condensation, enter catcher and carry out oil-water separation, isolated oil of ginger is carried out refine again, be refined into and contain Rhizoma Zingiberis Recens and draw the high oil of ginger of element.
The ginger allicin immunity soft capsult preparation method is by formula for a product comparison Rhizoma Zingiberis Recens quintessence oil, Bulbus Allii quintessence oil, and soybean oil carries out weighing, and spice is made into capsule content material crude oil, with deployed gelatine size, produces at the fully-automatic capsule processing equipment, and get final product again.
The antibacterial effect test:
Tested strain: escherichia coli, staphylococcus aureus, bacillus subtilis, streptococcus pneumoniae, beta hemolytic streptococcus.Strain provides by Nat'l Pharmaceutical ﹠ Biological Products Control Institute.
Culture medium preparation: steamed beef soup 100 ml, peptone 1 g, sodium chloride 0.5g, phosphoric acid
The hydrogen dipotassium is g, agar 1.2 g O.1, transfer to pH 7.6,103.4kPa, and high pressure went out in 20 minutes
Behind the bacterium, pour plate.
The preparation of liquid filter paper: the Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets that embodiment 1-6 made with aseptic pocket knife and Comparative Examples make Rhizoma Zingiberis Recens Bulbus Allii cellulose capsule and are cut into small pieces respectively, grind to form the mud shape with mortar respectively. the centrifuging and taking supernatant, get respectively 1 ml supernatant and add 100 of 0.6 cm filter papers, it is for subsequent use to ooze bubble.
Method of testing: with above tested strain, be diluted to 1.5x10 with Sterile Saline
8The various bacterium liquid of CFU/ml.Get above test bacterium liquid, draw O.1 ml, place on the flat board, be uniformly coated on the flat board with cotton swab, the filter paper of embodiment 1-6 and Comparative Examples 1 will be speckled with respectively, be attached to planar surface, the standard filter paper sheet that will contain gentamycin, chloromycetin, cefradine, penicillin with pincet simultaneously is attached on the flat board, and each scraps of paper center is at a distance of should be greater than 2.4 cm.Scraps of paper anomaly plate inner edge should be greater than 1.5 cm, put 37 ℃ and cultivate 24 hours, and observed result is measured the diameter of antibacterial ring with slide gauge, and is as shown in the table:
The present invention and antibiotic are to the bacteriostasis (diameter cm) of antibacterial
As can be seen from the above table, the bacteriostasis of the embodiment 1-4 of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets in processing range that the present invention makes all is better than the embodiment 5,6 outside processing range, the bacteriostasis of Comparative Examples 1 and gentamycin, chloromycetin, cefradine, penicillin, wherein with the best results of embodiment 2, as seen to make Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets bacteriostasis strong in the present invention, guarantee quality, satisfied the needs of health care.
Inclusion rate is measured:
With the prepared dry clathrate precise weighing of each embodiment, to put in the round-bottomed flask that zeolite is housed, adding distil water connects volatile oil determination apparatus, 1 h, one 2h that seethes with excitement, stopped heating when no longer increasing to oil mass.After placing lh, be limpid or reading during glassy yellow to oil.Be converted to actual oil content in the clathrate.Be calculated as follows inclusion rate and clathrate productive rate:
Volatile oil quality in inclusion rate (%)=clathrate/input quintessence oil quality * 100%
Measurement result is as shown in the table:
Can find out that from upper table result the inclusion rate of the embodiment 1-4 of Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets in processing range that the present invention makes is all greater than the embodiment 5,6 outside processing range, the enclose effect is high, wherein with the best results of embodiment 2, has satisfied the needs of producing.
Claims (8)
1. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets is characterized by: the raw material that comprises following volume proportion: Bulbus Allii quintessence oil 1-5 part, ginger essential oil 1-5 part, 95% ethanol 2-100 part; Bulbus Allii quintessence oil is with garlic peeling, cleans, is crushed to granularity 6-7mm, the material barrel of packing into, place extraction kettle to start extraction equipment, extract and separate condition by setting: 35 ℃ of extraction temperature, pressure 25Mpa, static extraction time 60min, circulation time 160min, 45 ℃ of separation temperatures are tested; The extract Bulbus Allii quintessence oil is by collecting in the separating still; Ginger essential oil is that the fresh Rhizoma Zingiberis Recens that cuts is added an amount of water, smash 10min to pieces, regulating pH is 6, adds the cellulase of Rhizoma Zingiberis Recens weight 2.2%, under 46 ℃ of temperature, carry out enzymolysis 2h, then sucking filtration, filtrate is used petroleum ether extraction, vacuum distilling, reclaim solvent, collection has strong fragrance grease, uses anhydrous sodium sulfate drying, and get final product.
2. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 1, it is characterized by: preparation method is as follows: with Bulbus Allii quintessence oil, ginger essential oil and 95% ethanol mix homogeneously, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed the 14-20 mesh sieve, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
3. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 2, it is characterized by: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is selected one in following method:
(1) saturated water solution method: by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, stirred 5 hours, let cool, putting in the freezer cold preservation spends the night, filter, with spray drying method dry 2-10 hour, inlet temperature was 100-200 ℃, and leaving air temp is 50-150 ℃;
(2) ultrasonic method: press beta-schardinger dextrin-: water weight ratio 1:5-20 mixes, shake up, heating in water bath dissolving lets cool to room temperature, and by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, supersound process 30-120 minute, cold preservation is spent the night, and filters, and uses spray drying method dry 2-10 hour, inlet temperature is 100-200 ℃, and leaving air temp is 50-150 ℃;
(3) colloid milling: take by weighing beta-schardinger dextrin-: water weight ratio 1:5-20, water is put into the colloid mill hopper, constantly stir, slowly add beta-schardinger dextrin-, ground 20 minutes, by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, grinds 1-3 hour, and cold preservation is spent the night, filter, with spray drying method dry 2-6 hour, inlet temperature was 100-200 ℃, and leaving air temp is 50-150 ℃;
(4) ball-milling method: take by weighing beta-schardinger dextrin-: in the water weight ratio 1:5-20 Place mill, ground 5-30 minute, by volatile oil: the volume ratio 1:1-20 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, ground 0.5-3 hour, cold preservation is spent the night, and filters, and uses spray drying method dry 2-12 hour, inlet temperature is 100-200 ℃, and leaving air temp is 50-150 ℃.
4. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 2 is characterized by: clathrate powder and adjuvant are by following weight proportion: clathrate powder 0.5-2.0 part, polyvidone 0.1-0.2 part, low-substituted hydroxypropyl cellulose 0.1-0.2 part, polyvinylpolypyrrolidone 0.1-0.2 part, carboxymethyl starch are received 0.1-0.2 part, microcrystalline Cellulose 0.1-0.3 part, hydroxypropyl emthylcellulose 0.1-0.2 part, magnesium stearate 0.005-0.02 part.
5. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 1 is characterized by: the raw material that comprises following volume proportion: 3 parts of Bulbus Allii quintessence oils, 3 parts of ginger essential oils, 50 parts of 95% ethanol; Bulbus Allii quintessence oil is with garlic peeling, cleans, is crushed to granularity 6-7mm, the material barrel of packing into, place extraction kettle to start extraction equipment, extract and separate condition by setting: 35 ℃ of extraction temperature, pressure 25Mpa, static extraction time 60min, circulation time 160min, 45 ℃ of separation temperatures are tested; The extract Bulbus Allii quintessence oil is by collecting in the separating still; Ginger essential oil is that the fresh Rhizoma Zingiberis Recens that cuts is added an amount of water, smash 10min to pieces, regulating pH is 6, adds the cellulase of Rhizoma Zingiberis Recens weight 2.2%, under 46 ℃ of temperature, carry out enzymolysis 2h, then sucking filtration, filtrate is used petroleum ether extraction, vacuum distilling, reclaim solvent, collection has strong fragrance grease, uses anhydrous sodium sulfate drying, and get final product.
6. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 5, it is characterized by: preparation method is as follows: with Bulbus Allii quintessence oil, ginger essential oil and the 95% ethanol mix homogeneously of formula ratio, add beta-schardinger dextrin-and carry out enclose, clathrate is crossed 18 mesh sieves, the clathrate powder adds that polyvidone, low-substituted hydroxypropyl cellulose, polyvinylpolypyrrolidone, carboxymethyl starch are received again, microcrystalline Cellulose, hydroxypropyl emthylcellulose, magnesium stearate, mix homogeneously, compacting is in blocks, and tablet uses the enteric Opadry enteric coated again.
7. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 6, it is characterized by: the inclusion method of Rhizoma Zingiberis Recens Bulbus Allii volatile oil is colloid milling: take by weighing beta-schardinger dextrin-: water weight ratio 1:12, put into the colloid mill hopper with water, constantly stir, slowly add beta-schardinger dextrin-, ground 20 minutes, by volatile oil: the volume ratio 1:10 of the enclose aqueous solution of beta-schardinger dextrin-slowly adds volatile oil, ground 2 hours, cold preservation is spent the night, and filters, and uses spray drying method dry 4 hours, inlet temperature is 150 ℃, and leaving air temp is 100 ℃.
8. Rhizoma Zingiberis Recens Bulbus Allii enteric coatel tablets as claimed in claim 6 is characterized by: clathrate powder and adjuvant are by following weight proportion: 1.2 parts in clathrate powder, 0.15 part of polyvidone, 0.15 part of low-substituted hydroxypropyl cellulose, 0.15 part of polyvinylpolypyrrolidone, carboxymethyl starch are received 0.15 part, 0.2 part of microcrystalline Cellulose, 0.15 part of hydroxypropyl emthylcellulose, 0.01 part of magnesium stearate.
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| CN104413409A (en) * | 2013-09-10 | 2015-03-18 | 贵州省务川华荣山食品厂 | Garlic tablet |
| CN104623354A (en) * | 2014-12-18 | 2015-05-20 | 青岛市中心医院 | Traditional Chinese medicinal preparation for treating hypertension and preparation method thereof |
| CN106924707A (en) * | 2017-05-04 | 2017-07-07 | 广东武大珞珈健康科技有限公司 | A kind of Ginger P.E and its preparation method and application |
| IT201800007395A1 (en) * | 2018-07-20 | 2020-01-20 | COMPOSITION BASED ON ESSENTIAL OILS |
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Cited By (5)
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| CN104413409A (en) * | 2013-09-10 | 2015-03-18 | 贵州省务川华荣山食品厂 | Garlic tablet |
| CN104623354A (en) * | 2014-12-18 | 2015-05-20 | 青岛市中心医院 | Traditional Chinese medicinal preparation for treating hypertension and preparation method thereof |
| CN106924707A (en) * | 2017-05-04 | 2017-07-07 | 广东武大珞珈健康科技有限公司 | A kind of Ginger P.E and its preparation method and application |
| CN106924707B (en) * | 2017-05-04 | 2020-09-04 | 广东武大珞珈健康科技有限公司 | Ginger extract and preparation method and application thereof |
| IT201800007395A1 (en) * | 2018-07-20 | 2020-01-20 | COMPOSITION BASED ON ESSENTIAL OILS |
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| CN102961713B (en) | 2014-05-28 |
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