CN107669775B - Novel method for processing fructus aurantii - Google Patents
Novel method for processing fructus aurantii Download PDFInfo
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- 244000236655 Diospyros kaki Species 0.000 claims abstract description 27
- 241001164374 Calyx Species 0.000 claims abstract description 20
- 235000008597 Diospyros kaki Nutrition 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 18
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 17
- 229930195725 Mannitol Natural products 0.000 claims abstract description 17
- 235000010355 mannitol Nutrition 0.000 claims abstract description 17
- 239000000594 mannitol Substances 0.000 claims abstract description 17
- 244000183685 Citrus aurantium Species 0.000 claims abstract description 10
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- 238000010438 heat treatment Methods 0.000 claims description 9
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- 238000009835 boiling Methods 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 6
- 238000000643 oven drying Methods 0.000 claims description 6
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 abstract description 8
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 8
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 abstract description 8
- 229940052490 naringin Drugs 0.000 abstract description 8
- 229930019673 naringin Natural products 0.000 abstract description 8
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 abstract description 8
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 abstract description 8
- 235000011511 Diospyros Nutrition 0.000 abstract description 7
- 238000003672 processing method Methods 0.000 abstract description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
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- 238000006731 degradation reaction Methods 0.000 abstract description 4
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
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- 241000607142 Salmonella Species 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
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- 235000013399 edible fruits Nutrition 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
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- 239000002994 raw material Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000792913 Ebenaceae Species 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241001093760 Sapindaceae Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
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- 239000002775 capsule Substances 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
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- 230000002085 persistent effect Effects 0.000 description 1
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- 208000026435 phlegm Diseases 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
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- 238000003825 pressing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- 235000010265 sodium sulphite Nutrition 0.000 description 1
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- 238000013112 stability test Methods 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
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- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention provides a novel method for processing fructus aurantii, and the obtained fructus aurantii contains active ingredients such as naringin and neohesperidin which are not easy to degrade, are more storage-resistant and have better antibacterial effect. Before conventional bran frying, the bitter orange is pretreated by processing liquid medicine prepared from mannitol, Shaosao and calyx kaki. Shaosao is sweet in flavor and warm in nature, and persimmon calyx is mild in nature, so that dryness of Zhi Qiao can be alleviated. Compared with the conventional bran frying method, the fructus aurantii treated by the liquid medicine processing method disclosed by the invention has the advantages that the content of naringin and neohesperidin is improved, the antibacterial effect is greatly enhanced, and the growth of strains such as salmonella and staphylococcus aureus can be remarkably inhibited. Meanwhile, the degradation rate of naringin and neohesperidin is low in the process of storing the fructus aurantii, and the stability is better compared with a bran stir-frying method. The inventor finds that the fructus aurantii is soaked in the mannitol solution before being treated by the processing liquid medicine, so that the treatment can further enhance the bacteriostatic property of the fructus aurantii and enlarge the diameter of a bacteriostatic circle.
Description
Technical Field
The invention relates to a method for processing traditional Chinese medicines, in particular to a novel method for processing bitter orange.
Background
Traditional Chinese medicine fructus aurantii is recorded in traditional Chinese herbal medicines, has the effects of removing food retention, activating stagnancy, soothing middle energizer and regulating qi, is used for treating the symptoms of indigestion, qi stagnation, chest and hypochondrium, phlegm and fluid retention, fullness and pain and the like, and is a common clinical traditional Chinese medicine. The action of raw bitter orange is very violent, so the bitter orange is easy to damage primordial qi, and the bitter orange is not suitable for patients with weak body. Moreover, the product has large stimulation to the gastrointestinal tract of a human body, and can cause uncomfortable adverse reactions such as nausea, vomiting and the like. Therefore, the processed products of fructus aurantii are emphasized to be used as the medicine, so far, the processing methods of fructus aurantii are as many as 23, and ancient people accumulate abundant processing experience, but the bran stir-frying method is the mainstream processing method, and the method is also adopted in the records of Chinese pharmacopoeia, and other methods are gradually eliminated. However, the pharmacological effects of fructus aurantii before and after being stir-fried with bran and the report on the content of part of components before and after being processed are not uniform in the prior art, so that the drug effect is unstable, and the loss of effective components is large along with the prolonging of the storage time.
Disclosure of Invention
The invention aims to provide a novel method for processing fructus aurantii, and the obtained fructus aurantii has the advantages of difficult degradation of active ingredients such as naringin and neohesperidin, better storage resistance and better antibacterial effect.
The technical scheme adopted by the invention is as follows:
a novel method for processing fructus aurantii comprises the following steps:
(1) removing impurities and inner flesh from fructus Aurantii raw medicinal materials to obtain fructus Aurantii pure medicinal material, adding mannitol solution 2-3 times of the weight of fructus Aurantii pure medicinal material, soaking for 2-3h, adding concocting medicinal liquid 1-3 times of the weight of fructus Aurantii pure medicinal material, soaking at 20-30 deg.C for 12-18h, filtering, removing filtrate, cutting fructus Aurantii into pieces with thickness of 1-3mm, and oven drying;
(2) heating a stir-frying container, adding bran when the bran is spread and smoked immediately, pouring the fructus Aurantii decoction pieces into a pot, rapidly turning over until the surface of the fructus Aurantii decoction pieces is yellow or deep yellow, taking out, sieving to remove the bran, and cooling to obtain the final product.
The mass fraction of the mannitol solution is 0.5-1.8%.
The preparation method of the concocting liquid medicine comprises the following steps: boiling Shaosao and calyx kaki with 5-8 times of water for 5-10min, cooling to 80-85 deg.C, extracting for 2-3 hr, and filtering to obtain filtrate;
the mass ratio of the Shaoshi and the kaki is that Shaoshi: persimmon calyx is 1: (6-8);
in the bran-frying process of the step (2), 10-15g of bran is used for every 100kg of fructus aurantii;
shaoshi is the dry fruit of Shaoshi genus of Sapindaceae family, and has the effects of dispelling cold, stopping dysentery, and removing toxic substance. It can be used for treating dysentery, heart and abdomen psychroalgia, and pyocutaneous disease.
Calyx kaki is dried persistent calyx of Diospyros kaki Thunb of Ebenaceae. Picking in winter when the fruits are ripe, collecting when eating, cleaning and drying in the sun. Has effects of lowering blood pressure and stopping hiccup.
Before conventional bran frying, the bitter orange is pretreated by processing liquid medicine prepared from mannitol, Shaosao and calyx kaki. Shaosao is sweet in flavor and warm in nature, and persimmon calyx is mild in nature, so that dryness of Zhi Qiao can be alleviated. Compared with the conventional bran frying method, the fructus aurantii treated by the liquid medicine processing method disclosed by the invention has the advantages that the content of naringin and neohesperidin is improved, the antibacterial effect is greatly enhanced, and the growth of strains such as salmonella and staphylococcus aureus can be remarkably inhibited. Meanwhile, the degradation rate of naringin and neohesperidin is low in the process of storing the fructus aurantii, and the stability is better compared with a bran stir-frying method. The inventor finds that the fructus aurantii is soaked in the mannitol solution before being treated by the processing liquid medicine, so that the treatment can further enhance the bacteriostatic property of the fructus aurantii and enlarge the diameter of a bacteriostatic circle.
The invention has the advantages that: compared with the prior art, the fructus aurantii prepared by the invention has better stability, and the contents of naringin and neohesperidin are not obviously reduced after the fructus aurantii is stored for two years. And the bacteriostatic effect is improved, and the bacteriostatic effect on pseudomonas aeruginosa, staphylococcus aureus and other bacteria is better.
Detailed Description
Example 1: a novel method for processing fructus aurantii comprises the following steps:
(1) removing impurities and inner flesh from fructus Aurantii raw medicinal materials to obtain fructus Aurantii pure medicinal material, adding mannitol solution 2 times of the weight of fructus Aurantii pure medicinal material, soaking for 2.5h, adding processing medicinal liquid 2 times of the weight of fructus Aurantii pure medicinal material, soaking at 25 deg.C for 15h, filtering, removing filtrate, cutting fructus Aurantii into pieces with thickness of 1-3mm, and oven drying;
(2) heating a stir-frying container, adding bran when the bran is spread and smoked immediately, pouring the fructus Aurantii decoction pieces into a pot, rapidly turning over until the surface of the fructus Aurantii decoction pieces is yellow or deep yellow, taking out, sieving to remove the bran, and cooling to obtain the final product.
The mass fraction of the mannitol solution is 1.2%.
The preparation method of the concocting liquid medicine comprises the following steps: boiling Shaosao and calyx kaki with 6 times of water for 8min, cooling to 82 deg.C, extracting for 2.5 hr, and filtering to obtain filtrate;
the mass ratio of the Shaoshi and the kaki is that Shaoshi: persimmon calyx is 1: 7;
example 2: a novel method for processing fructus aurantii comprises the following steps:
(1) removing impurities and inner flesh from fructus Aurantii raw medicinal materials to obtain fructus Aurantii pure medicinal material, adding mannitol solution 2 times of the weight of fructus Aurantii pure medicinal material, soaking for 2h, adding concocting medicinal liquid 1 times of the weight of fructus Aurantii pure medicinal material, soaking at 20 deg.C for 12h, filtering, removing filtrate, cutting fructus Aurantii into pieces with thickness of 1-3mm, and oven drying;
(2) heating a stir-frying container, adding bran when the bran is spread and smoked immediately, pouring the fructus Aurantii decoction pieces into a pot, rapidly turning over until the surface of the fructus Aurantii decoction pieces is yellow or deep yellow, taking out, sieving to remove the bran, and cooling to obtain the final product.
The mass fraction of the mannitol solution is 1.8%.
The preparation method of the concocting liquid medicine comprises the following steps: boiling Shaosao and calyx kaki in 8 times of water for 10min, cooling to 85 deg.C, extracting for 3 hr, and filtering to obtain filtrate;
the mass ratio of the Shaoshi and the kaki is that Shaoshi: persimmon calyx is 1: 8;
example 3: a novel method for processing fructus aurantii comprises the following steps:
(1) removing impurities and inner flesh from fructus Aurantii raw medicinal materials to obtain fructus Aurantii pure medicinal material, adding mannitol solution 3 times of the weight of fructus Aurantii pure medicinal material, soaking for 3h, adding processing liquid 3 times of the weight of fructus Aurantii pure medicinal material, soaking at 30 deg.C for 18h, filtering, removing filtrate, cutting fructus Aurantii into pieces with thickness of 1-3mm, and oven drying;
(2) heating a stir-frying container, adding bran when the bran is spread and smoked immediately, pouring the fructus Aurantii decoction pieces into a pot, rapidly turning over until the surface of the fructus Aurantii decoction pieces is yellow or deep yellow, taking out, sieving to remove the bran, and cooling to obtain the final product.
The mass fraction of the mannitol solution is 0.5%.
The preparation method of the concocting liquid medicine comprises the following steps: boiling Shaosao and calyx kaki with 5 times of water for 5min, cooling to 80 deg.C, extracting for 2 hr, and filtering to obtain filtrate;
the mass ratio of the Shaoshi and the kaki is that Shaoshi: persimmon calyx is 1: 6;
example 4: the difference from example 1 is that:
the mass ratio of the Shaoshi and the kaki is that Shaoshi: persimmon calyx is 1: 9;
the rest is the same as example 1.
Example 5: the difference from example 1 is that:
the preparation method of the concocting liquid medicine comprises the following steps: extracting Shaosao and calyx kaki with 6 times of water at 82 deg.C for 2.5 hr, and filtering to obtain filtrate as processing liquid medicine;
the rest is the same as example 1.
Example 6: the difference from example 1 is that:
the processing method of fructus Aurantii in step (1) is not soaked in mannitol solution, and is otherwise the same as in example 1.
Comparative example 1: CN 101780168, a chinese patent discloses a method for processing fructus aurantii, the method disclosed in example 1 of the present invention is: taking 10Kg of fructus aurantii raw material, digging off the inner capsule of the fructus aurantii raw material by a knife, cleaning silt, moistening with water for 6-12 hours, putting on a wooden frame after pressing, manually inoculating 1g of mucor, placing in an environment with the temperature of 28 ℃ and the relative humidity of 92 percent for 48 hours, slicing and drying to obtain the fructus aurantii decoction pieces.
Comparative example 2: CN 106606570, a chinese patent discloses a method for processing fructus aurantii, the method disclosed in example 1 of the present invention is: removing impurities from fructus Aurantii 1kg, adding water 2L, sodium sulfite 0.1g, and glutathione 0.05g, soaking at 10 deg.C for 2 hr, taking out, placing on a medicine moistening table, covering with wet cloth, moistening, spraying water once every 15 min, with total amount of water 1L, moistening for 1.5 hr, slicing with a slicing machine to obtain decoction pieces with thickness of 2mm, drying in an oven at 40 deg.C, and sieving to remove pulp and core. Uniformly spreading 100g of testa Tritici in a hot pan, timely pouring the fructus Aurantii slices into the pan when the testa Tritici is smoky, rapidly turning, parching to yellow surface, taking out, sieving to remove testa Tritici, air cooling, and packaging.
Comparative example 3: heating the semen Hoveniae in a parching container, adding testa Tritici when the testa Tritici is scattered and smoked, adding semen Hoveniae, rapidly turning, parching until the surface is yellow or dark yellow, taking out, sieving to remove testa Tritici, and cooling. 10-15kg of bran is used for every 100kg of fructus aurantii.
Test example 1: the bitter orange medicinal materials prepared in the examples 1-7 and the comparative examples 1-2 are packaged in medicinal high-density polyvinyl chloride packaging bags, 500g of the medicinal materials are placed in each bag, a stability test is carried out, the temperature is 25 +/-2 ℃, the relative humidity is 60% +/-5%, and the sampling and content detection are carried out in the 0 th month and the 24 th month respectively. The test results are shown in tables 1 and 2.
TABLE 1 Change in Naringin content
TABLE 2 Neohesperidin content variation
| Group of | 0 month (mg/g) | 24 months (mg/g) | Degradation Rate (%) |
| Example 1 | 38.07 | 37.76 | 0.81 |
| Example 2 | 37.85 | 37.48 | 0.98 |
| Example 3 | 37.43 | 37.09 | 0.91 |
| Example 4 | 33.95 | 29.65 | 12.67 |
| Example 5 | 34.29 | 29.28 | 14.61 |
| Example 6 | 36.56 | 35.65 | 2.49 |
| Comparative example 1 | 38.82 | 34.57 | 10.95 |
| Comparative example 2 | 36.47 | 32.90 | 9.79 |
| Comparative example 3 | 34.16 | 29.34 | 14.11 |
Test example 2: the bitter orange medicinal materials prepared in the examples 1 to 6 and the comparative examples 1 to 3 are respectively crushed and sieved by a 26-mesh sieve, 50g of powder sample is taken and placed in a 1000mL round bottom flask, and 500mL of distilled water is added for soaking overnight. Installing a steam distillation device, introducing condensed water, heating to boil, and stopping heating after keeping boiling for 6 hours; condensing, collecting volatile oil, drying with anhydrous sodium sulfate, and filtering to obtain fructus Aurantii volatile oil. The bacteriostatic activity was determined and the results are shown in table 3.
TABLE 3 bacteriostatic activity of the essential oil of bitter orange in each example
Claims (2)
1. A novel method for processing bitter orange is characterized in that: the method comprises the following steps:
(1) removing impurities and inner flesh from fructus Aurantii raw medicinal materials to obtain fructus Aurantii pure medicinal material, adding mannitol solution 2-3 times of the weight of fructus Aurantii pure medicinal material, soaking for 2-3h, adding concocting medicinal liquid 1-3 times of the weight of fructus Aurantii pure medicinal material, soaking at 20-30 deg.C for 12-18h, filtering, removing filtrate, cutting fructus Aurantii into pieces with thickness of 1-3mm, and oven drying;
(2) heating a stir-frying container, adding bran when the bran is scattered and immediately smoked, immediately pouring the fructus aurantii decoction pieces into a pot, quickly turning over until the surface of the fructus aurantii decoction pieces is yellow or deep yellow, taking out, sieving to remove the bran, and cooling to obtain the fructus aurantii decoction pieces;
the mass fraction of the mannitol solution is 0.5-1.8%;
the preparation method of the concocting liquid medicine comprises the following steps: boiling Shaosao and calyx kaki with 5-8 times of water for 5-10min, cooling to 80-85 deg.C, extracting for 2-3 hr, and filtering to obtain filtrate; the mass ratio of the Shaoshi and the kaki is that Shaoshi: calyx kaki = 1: (6-8).
2. The novel method for processing fructus aurantii as claimed in claim 1, wherein: the method comprises the following steps:
(1) removing impurities and inner flesh from fructus Aurantii raw medicinal materials to obtain fructus Aurantii pure medicinal material, adding mannitol solution 2 times of the weight of fructus Aurantii pure medicinal material, soaking for 2.5h, adding processing medicinal liquid 2 times of the weight of fructus Aurantii pure medicinal material, soaking at 25 deg.C for 15h, filtering, removing filtrate, cutting fructus Aurantii into pieces with thickness of 1-3mm, and oven drying;
(2) heating a stir-frying container, adding bran when the bran is scattered and immediately smoked, immediately pouring the fructus aurantii decoction pieces into a pot, quickly turning over until the surface of the fructus aurantii decoction pieces is yellow or deep yellow, taking out, sieving to remove the bran, and cooling to obtain the fructus aurantii decoction pieces;
the mass fraction of the mannitol solution is 1.2%;
the preparation method of the concocting liquid medicine comprises the following steps: boiling Shaosao and calyx kaki with 6 times of water for 8min, cooling to 82 deg.C, extracting for 2.5 hr, and filtering to obtain filtrate; the mass ratio of the Shaoshi and the kaki is that Shaoshi: calyx kaki = 1: 7.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780168A (en) * | 2010-03-08 | 2010-07-21 | 江西中医学院 | Processing method of Fructus Aurantii |
| CN106606570A (en) * | 2015-10-22 | 2017-05-03 | 重庆庆达药业有限公司 | Processing method of bitter orange decoction piece |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101780168A (en) * | 2010-03-08 | 2010-07-21 | 江西中医学院 | Processing method of Fructus Aurantii |
| CN106606570A (en) * | 2015-10-22 | 2017-05-03 | 重庆庆达药业有限公司 | Processing method of bitter orange decoction piece |
Non-Patent Citations (1)
| Title |
|---|
| 枳壳炮制历史沿革研究;蒋以号等;《中华中医药杂志》;20110228;第26卷(第2期);第387-391页 * |
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