CN104623354A - Traditional Chinese medicinal preparation for treating hypertension and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating hypertension and a preparation method thereof. The preparation is prepared from the following raw materials in parts by weight: 10-20 parts of apocynum venetum extract, 10-20 parts of corn stigma extract, 10-20 parts of celery extract, 10-20 parts of sophora japonica, 5-15 parts of radix polygoni multiflori, 5-15 parts of kudzu vine root, 1-5 parts of garlic, 5-15 parts of thalictrum robustum extract, 5-15 parts of selfheal, 10-20 parts of golden wave, 20-30 parts of lalang grass rhizome, 20-30 parts of saururus chinensis, 20-30 parts of polygonum cuspidatum, 5-10 parts of cirsium japonicum and 5-10 parts of herba cepbalanoplosis segeti. The preparation has the effects of removing toxicity, stopping bleeding, diminishing inflammation, improving blood hypercoagulability state, dredging micro-circulation, promoting blood circulation to remove stasis, reducing blood fat, nourishing yin, purging internal fire, smoothing blood circulation, stabilizing blood pressure without rebound, reinforcing body immunity and relieving occurrence of hypertensive complications, and has the advantages of small side effect, quick response, simple preparation process and convenience in popularization.

Description

One treats hypertensive Chinese medicine preparation and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, be specifically related to one and treat hypertensive Chinese medicine preparation and preparation method thereof.

Background technology

At present, the types of drugs of domestic and international application western medicine high blood pressure disease is more, if diuretic hypotensive agent hydrochlorothiazide, calcium ion antagonist are as nifedipine, angiotensin converting enzyme inhibitor captopril etc.But due to chemical drugs system synthetic, there is toxic and side effects in various degree, as drowsiness, dizzy, abdominal distention, feel sick, some drugs long-term taking even can cause angina pectoris, cytopenia etc., adds heavy patient's state of an illness.By contrast, Chinese medicine is from natural, and effect relaxes steadily, has integrally-regulated function, rare untoward reaction, and rely on phenomenon few, cost is low.But, market is used for the treatment of hypertensive Chinese medicine but very rare.

Summary of the invention

For solving the problem, the invention provides one and treat hypertensive Chinese medicine preparation and preparation method thereof, , there is toxin expelling, hemostasis, antiinflammatory, expel the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting, control oedema due to nephritis foot gas, anti-hypertension, anticancer, blood fat reducing, antioxidation, promote the multiple efficacies such as body waste discharge, and can high blood coagulation state be improved, dredging microcirculation, blood circulation promoting and blood stasis dispelling, by blood fat, nourishing yin and purging fire, blood is unimpeded, voltage stabilizing does not rebound, also there is enhancing human body immunity ability, alleviate the generation of hypertension complication, side effect is little, instant effect, preparation technology is simple, be convenient to promote.

For achieving the above object, the technical scheme that the present invention takes is:

One treats hypertensive Chinese medicine preparation, is prepared from by the raw material of following weight portion:

Herba Apocyni veneti extract 10 ~ 20 parts, Stigma Maydis extract 10 ~ 20 parts, Herba Apii graveolentis extract 10 ~ 20 parts, 10 ~ 20 parts, Flos Sophorae, the Radix Polygoni Multiflori 5 ~ 15 parts, Radix Puerariae 5 ~ 15 parts, 1 ~ 5 part, Bulbus Allii, sturdy Thalictrum extract 5 ~ 15 parts, Spica Prunellae 5 ~ 15 parts, Coreopsis basalis 10 ~ 20 parts, Rhizoma Imperatae 20 ~ 30 parts, Rhizoma Saururi (Herba Saururi) 20 ~ 30 parts, Rhizoma Polygoni Cuspidati 20 ~ 30 parts, Radix Cirsii Japonici 5 ~ 10 parts, Herba Cirsii 5 ~ 10 parts.

Above-mentioned a kind of preparation method for the treatment of hypertensive Chinese medicine preparation, comprises the following steps:

S1, get Coreopsis basalis 10 ~ 20 parts, be ground into coarse granule, in the alcohol reflux 3 times that the ratio volume fraction of solid-liquid ratio 1: 8 is 75%, each 3h, merges the extracting solution of 3 times, after concentrating under reduced pressure recycling design, add chloroform extraction in the ratio of 1: 1, then add extraction into ethyl acetate in the ratio of 1: 1, merge twice extract, after concentrated, obtain Coreopsis basalis extractum;

S2, get Spica Prunellae 5 ~ 15 parts, add 5 ~ 20 times amount 10 ~ 90% alcohol reflux 2 ~ 4 times, each 0.5 ~ 3.0h, filter; Get filtrate reduced in volume, thickening temperature 55 ~ 65 DEG C, vacuum is 0.07 ~ 0.09Mpa, obtains Spica Prunellae extract;

S3, get 1 ~ 5 part, Bulbus Allii, remove the peel, clean, be crushed to granularity 6 ~ 7mm, load material barrel, be placed in extraction kettle and start extraction equipment, extraction temperature 35 DEG C, pressure 25Mpa, static extraction time 60min, circulation time 160min, separation temperature 45 DEG C, obtains Bulbus Allii extract;

S4, water intaking 82 parts, glycerol 4 parts, xanthan gum 1 part are mixed and heated to 80 degree, sterilizing;

S5, get emulsifying agent 4 parts, spermaceti stearyl alcohol 3 points, squalane 2 parts, Palmic acid isooctyl 2 parts, sad 2 parts, certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

S6, step S4 gained solution is spent homogeneous 30 ~ 35 minutes with step S5 gained solution mixing constant temperature to 80, be cooled to 60 degree, heat the Azelaic Acid of 1 part, stir and continue cooling, be cooled to less than 50 degree;

S7, get 10 ~ 20 parts, Flos Sophorae, the Radix Polygoni Multiflori 5 ~ 15 parts, Radix Puerariae 5 ~ 15 parts, 1 ~ 5 part, Bulbus Allii, Rhizoma Imperatae 20 ~ 30 parts, Rhizoma Saururi (Herba Saururi) 20 ~ 30 parts, Rhizoma Polygoni Cuspidati 20 ~ 30 parts, Radix Cirsii Japonici 5 ~ 10 parts, Herba Cirsii 5 ~ 10 parts be positioned in marmite, the water that at least can flood medical material is added in marmite, first with big fire by after water boil in marmite, use low baking temperature instead to decoct 0.5 ~ 2 hour, obtain decoction;

S8, the decoction of step S7 gained is cooled to 50 DEG C, add Herba Apocyni veneti extract 10 ~ 20 parts, Stigma Maydis extract 10 ~ 20 parts, Herba Apii graveolentis extract 10 ~ 20 parts, sturdy Thalictrum extract 5 ~ 15 parts, the Coreopsis basalis extractum of step S1 gained, the Spica Prunellae extract of step S2 gained, the Bulbus Allii extract of step S3 gained successively, stir;

S9, to be mixed by the mixture of step S8 gained continue to stir with the solution of step S6 gained, be cooled to 30 degree and stop stirring, leave standstill, inspection, fill, gets product.

The pharmacology of above-mentioned raw materials medical material is as follows:

Flos Sophorae: the traditional Chinese medical science thinks its bitter in the mouth, cold nature, returns liver, large intestine channel; Enter blood to hold back and fall, body slightly falls apart; There is cooling blood for hemostasis, effect of purging liver-fire; Cure mainly discharging fresh blood stool, hemorrhoidal bleeding, dysentery, hematuria, stranguria with blood, metrorrhagia, spit blood, epistaxis, liver-fire is had a headache, conjunctival congestion and swelling pain, sore throat, aphonia, ulcer sores.And from the angle of doctor trained in Western medicine, Flos Sophorae containing the material such as rutin (i.e. rutin, Rytub), Quercetin (Quercetin), tannin, sophoradiol (sophoradiol), vitamin A (specifically can see below contain scale).Rutin can improve the function of blood capillary, and keep the normal resistance of blood capillary, prevent because capillary fragility is excessive, too high hemorrhage, hypertension, the diabetes caused of permeability, can preventing of clothes is hemorrhage.

The Radix Polygoni Multiflori: blood fat reducing and arteriosclerosis: Radix Polygoni Multiflori ethanol extract 0.084,0.84,8.4g/kg gavage, continuous 6 weeks, high blood can be suppressed to refer to the rising of disease Carnis Coturnicis japonicae total plasma cholesterol, triglyceride, free cholesterol and cholesteryl ester, delay the atherosis formation and development that beats one's brains.

Radix Puerariae: Compendium of Material Medica: " book on Chinese herbal medicine ten doses of clouds, expelling the excess with mild diaphoretic, the genus of Herba Ephedrae, Radix Puerariae.Lid Herba Ephedrae is Taiyang channel medicine, double enter lung meridian, lung governing skin and hair; Radix Puerariae is Yangming Channel medicine, double enter spleen channel, spleen governing muscles.Disperse so two taste medicines all lightly float, and institute enters also far different." " Bencao Jingshu ": " Radix Puerariae, dismisses the main medicine of positive bright epidemic febrile disease pathogenic heat also, therefore master quenches one's thirst, high fever of the body, and heat is stopped up chest and diaphragm and vomitted.Disperse and rise, the property of wind medicine also, therefore leads all numbness." " cold headache is held concurrently stiffness of the nape pain along the spinal column and bone pain person all over, and, it is bright that heresy does not still enter sun to the sufficient sun yet, therefore without thirsty card, should not take." " book on Chinese herbal medicine converges and says ": " Radix Puerariae, fresh breeze is trembled with fear, clean pathogenic factor in the exterior, expelling pathogenic factors from muscles heat, only excessive thirst.Rush down the medicine of stomach-fire also.Taste the medicine that loose heresy is delivered in sight, its product are also many, pull out sun battalion divide cold as Herba Ephedrae, the wind that Ramulus Cinnamomi Xie Taiyangwei divides, Radix Saposhnikoviae, Folium Perillae fall apart the wind and cold of the sun at table, and Rhizoma Ligustici, Rhizoma Et Radix Notopterygii fall apart the cold-damp of the sun at table, all claim to disperse medicine also, and dispersing of Radix Puerariae, also enter the sun, also dispersing wind and cold, different again, if non-numb, osmanthus, Soviet Union, anti-, pungent fragrant warm-dryness syndrome, disperse and damage middle gas mistake also; If non-Rhizoma Ligustici, Rhizoma Et Radix Notopterygii, disperse and have consumption nutrient blood anxiety also.", " herbal classic ": quench one's thirst, high fever of the body, vomiting, all numbness, rise cloudy gas, separate all poison., " not Lu ": excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles delivers perspiration, loosing the interspaces of skin and muscles, treats incised wound, only side of body wind pain

Bulbus Allii: removing toxic substances parasite killing, reducing swelling and alleviating pain, antidiarrheal dysentery relieving, controls lung, anthelmintic, also has warming the spleen warming the stomach in addition.Control swollen ulcer drug, white bald tinea skin ulcer, dysentery is had loose bowels, pulmonary tuberculosis pertussis, ascarid pinworm, eating accumulation, coldness and pain in the epigastrium, edema distension.Circulation of qi promoting removing food stagnancy, parasite killing detoxifies.For flu, bacillary dysentery, amebic dysentery, enteritis, eating accumulation, carbuncle skin infection.

Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.

Spica Prunellae: Compendium of Material Medica: " Li lay Buddhist " Yi Jianfang ", Spica Prunellae controls ophthalmalgia, and with granulated sugar water logging one ight, get it and can separate interior-heat, slow liver-fire also.Lou Quan is apt to cloud, Spica Prunellae control order pearl pain to night then notably, the magical effect or with bitter cold snack made with traditional Chinese medicines instead notably, the also magical effect.Lid order pearl connects order originally, and liver system also, belongs to the warp of the moon of fainting.Night very and some bitter and cold medicines anti-notably, night is with cold also cloudy therefore also.The gas of the pure sun of summer withered official report, mends cloudy blood vessels of fainting, therefore controls this as god, with Yang Zhiyin also." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, network of passing through.Control facial hemiparalysis, row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, loose scrofula, whole body tuberculosis.

Rhizoma Saururi (Herba Saururi): cure mainly edema, dysuria, drenches the puckery pain of drop, leukorrhagia; External treatment sore swollen toxin, eczema

Rhizoma Polygoni Cuspidati: for jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep plays damage, cough due to lung-heat.

Radix Cirsii Japonici: water logging agent, ethanol one water-leach liquor and alcohol leaching liquid, being applied to Canis familiaris L., cat, rabbit etc. all has the effect reduced blood pressure.Radix Cirsii Japonici water, Radix Cirsii Japonici fresh or dry root water decoction, root alkali liquor, acid alcohol extract and leaf water decoction all have hypotensive effect to anesthesia Canis familiaris L.

Herba Cirsii: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.

The present invention has following beneficial effect:

There is toxin expelling, hemostasis, antiinflammatory, expel the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting, control the multiple efficacies such as oedema due to nephritis beriberi, anti-hypertension, anticancer, blood fat reducing, antioxidation, the discharge of promotion body waste, and can high blood coagulation state be improved, dredging microcirculation, blood circulation promoting and blood stasis dispelling, blood fat, nourishing yin and purging fire, blood is unimpeded, voltage stabilizing does not rebound, also there is enhancing human body immunity ability, alleviate the generation of hypertension complication, side effect is little, instant effect, preparation technology is simple, is convenient to promote.

Detailed description of the invention

In order to make objects and advantages of the present invention clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.

Embodiment 1

S11, get Coreopsis basalis 15 parts, be ground into coarse granule, in the alcohol reflux 3 times that the ratio volume fraction of solid-liquid ratio 1: 8 is 75%, each 3h, merges the extracting solution of 3 times, after concentrating under reduced pressure recycling design, add chloroform extraction in the ratio of 1: 1, then add extraction into ethyl acetate in the ratio of 1: 1, merge twice extract, after concentrated, obtain Coreopsis basalis extractum;

S12, get Spica Prunellae 10 parts, add 12.5 times amount 50% alcohol reflux 3 times, each 1.75h, filter; Get filtrate reduced in volume, thickening temperature 60 DEG C, vacuum is 0.08Mpa, obtains Spica Prunellae extract;

S13, get 3 parts, Bulbus Allii, remove the peel, clean, be crushed to granularity 6.5mm, load material barrel, be placed in extraction kettle and start extraction equipment, extraction temperature 35 DEG C, pressure 25Mpa, static extraction time 60min, circulation time 160min, separation temperature 45 DEG C, obtains Bulbus Allii extract;

S14, water intaking 82 parts, glycerol 4 parts, xanthan gum 1 part are mixed and heated to 80 degree, sterilizing;

S15, get emulsifying agent 4 parts, spermaceti stearyl alcohol 3 points, squalane 2 parts, Palmic acid isooctyl 2 parts, sad 2 parts, certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

S16, step S4 gained solution is spent homogeneous 30 ~ 35 minutes with step S5 gained solution mixing constant temperature to 80, be cooled to 60 degree, heat the Azelaic Acid of 1 part, stir and continue cooling, be cooled to less than 50 degree;

S17, get 15 parts, Flos Sophorae, the Radix Polygoni Multiflori 10 parts, Radix Puerariae 10 parts, 3 parts, Bulbus Allii, Rhizoma Imperatae 25 parts, Rhizoma Saururi (Herba Saururi) 25 parts, Rhizoma Polygoni Cuspidati 25 parts, Radix Cirsii Japonici 7.5 parts, Herba Cirsii 7.5 parts be positioned in marmite, the water that at least can flood medical material is added in marmite, first with big fire by after water boil in marmite, use low baking temperature instead and decoct 1.25 hours, obtain decoction;

S18, the decoction of step S17 gained is cooled to 50 DEG C, add Herba Apocyni veneti extract 15 parts, Stigma Maydis extract 15 parts, Herba Apii graveolentis extract 15 parts, sturdy Thalictrum extract 10 parts, the Coreopsis basalis extractum of step S11 gained, the Spica Prunellae extract of step S12 gained, the Bulbus Allii extract of step S13 gained successively, stir;

S19, to be mixed by the mixture of step S18 gained continue to stir with the solution of step S16 gained, be cooled to 30 degree and stop stirring, leave standstill, inspection, fill, gets product.

Embodiment 2

S21, get Coreopsis basalis 10 parts, be ground into coarse granule, in the alcohol reflux 3 times that the ratio volume fraction of solid-liquid ratio 1: 8 is 75%, each 3h, merges the extracting solution of 3 times, after concentrating under reduced pressure recycling design, add chloroform extraction in the ratio of 1: 1, then add extraction into ethyl acetate in the ratio of 1: 1, merge twice extract, after concentrated, obtain Coreopsis basalis extractum;

S22, get Spica Prunellae 5 parts, add 5 times amount 10% alcohol reflux 2 times, each 0.5h, filter; Get filtrate reduced in volume, thickening temperature 55 DEG C, vacuum is 0.07Mpa, obtains Spica Prunellae extract;

S23, get 1 part, Bulbus Allii, remove the peel, clean, be crushed to granularity 6mm, load material barrel, be placed in extraction kettle and start extraction equipment, extraction temperature 35 DEG C, pressure 25Mpa, static extraction time 60min, circulation time 160min, separation temperature 45 DEG C, obtains Bulbus Allii extract;

S24, water intaking 82 parts, glycerol 4 parts, xanthan gum 1 part are mixed and heated to 80 degree, sterilizing;

S25, get emulsifying agent 4 parts, spermaceti stearyl alcohol 3 points, squalane 2 parts, Palmic acid isooctyl 2 parts, sad 2 parts, certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

S26, step S4 gained solution is spent homogeneous 30 ~ 35 minutes with step S5 gained solution mixing constant temperature to 80, be cooled to 60 degree, heat the Azelaic Acid of 1 part, stir and continue cooling, be cooled to less than 50 degree;

S27, get 10 parts, Flos Sophorae, the Radix Polygoni Multiflori 5 parts, Radix Puerariae 5 parts, 1 part, Bulbus Allii, Rhizoma Imperatae 20 parts, Rhizoma Saururi (Herba Saururi) 20 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Cirsii Japonici 5 parts, Herba Cirsii 5 parts be positioned in marmite, the water that at least can flood medical material is added in marmite, first with big fire by after water boil in marmite, use low baking temperature instead and decoct 0.5 hour, obtain decoction;

S28, the decoction of step S27 gained is cooled to 50 DEG C, add Herba Apocyni veneti extract 10 parts, Stigma Maydis extract 10 parts, Herba Apii graveolentis extract 10 parts, sturdy Thalictrum extract 5 parts, the Coreopsis basalis extractum of step S21 gained, the Spica Prunellae extract of step S22 gained, the Bulbus Allii extract of step S23 gained successively, stir;

S29, to be mixed by the mixture of step S28 gained continue to stir with the solution of step S26 gained, be cooled to 30 degree and stop stirring, leave standstill, inspection, fill, gets product.

Embodiment 3

S31, get Coreopsis basalis 20 parts, be ground into coarse granule, in the alcohol reflux 3 times that the ratio volume fraction of solid-liquid ratio 1: 8 is 75%, each 3h, merges the extracting solution of 3 times, after concentrating under reduced pressure recycling design, add chloroform extraction in the ratio of 1: 1, then add extraction into ethyl acetate in the ratio of 1: 1, merge twice extract, after concentrated, obtain Coreopsis basalis extractum;

S32, get Spica Prunellae 15 parts, add 20 times amount 90% alcohol reflux 4 times, each 3.0h, filter; Get filtrate reduced in volume, thickening temperature 65 DEG C, vacuum is 0.09Mpa, obtains Spica Prunellae extract;

S33, get 5 parts, Bulbus Allii, remove the peel, clean, be crushed to granularity 7mm, load material barrel, be placed in extraction kettle and start extraction equipment, extraction temperature 35 DEG C, pressure 25Mpa, static extraction time 60min, circulation time 160min, separation temperature 45 DEG C, obtains Bulbus Allii extract;

S34, water intaking 82 parts, glycerol 4 parts, xanthan gum 1 part are mixed and heated to 80 degree, sterilizing;

S35, get emulsifying agent 4 parts, spermaceti stearyl alcohol 3 points, squalane 2 parts, Palmic acid isooctyl 2 parts, sad 2 parts, certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

S36, step S4 gained solution is spent homogeneous 35 minutes with step S5 gained solution mixing constant temperature to 80, be cooled to 60 degree, heat the Azelaic Acid of 1 part, stir and continue cooling, be cooled to less than 50 degree;

S37, get 20 parts, Flos Sophorae, the Radix Polygoni Multiflori 15 parts, Radix Puerariae 15 parts, 5 parts, Bulbus Allii, Rhizoma Imperatae 30 parts, Rhizoma Saururi (Herba Saururi) 30 parts, Rhizoma Polygoni Cuspidati 30 parts, Radix Cirsii Japonici 10 parts, Herba Cirsii 10 parts be positioned in marmite, the water that at least can flood medical material is added in marmite, first with big fire by after water boil in marmite, use low baking temperature instead to decoct 0.5 ~ 2 hour, obtain decoction;

S38, the decoction of step S37 gained is cooled to 50 DEG C, add Herba Apocyni veneti extract 20 parts, Stigma Maydis extract 20 parts, Herba Apii graveolentis extract 20 parts, sturdy Thalictrum extract 15 parts, the Coreopsis basalis extractum of step S31 gained, the Spica Prunellae extract of step S32 gained, the Bulbus Allii extract of step S33 gained successively, stir;

S39, to be mixed by the mixture of step S38 gained continue to stir with the solution of step S36 gained, be cooled to 30 degree and stop stirring, leave standstill, inspection, fill, gets product.

The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.

Claims (2)

1. treat a hypertensive Chinese medicine preparation, it is characterized in that, be prepared from by the raw material of following weight portion:

Herba Apocyni veneti extract 10 ~ 20 parts, Stigma Maydis extract 10 ~ 20 parts, Herba Apii graveolentis extract 10 ~ 20 parts, 10 ~ 20 parts, Flos Sophorae, the Radix Polygoni Multiflori 5 ~ 15 parts, Radix Puerariae 5 ~ 15 parts, 1 ~ 5 part, Bulbus Allii, sturdy Thalictrum extract 5 ~ 15 parts, Spica Prunellae 5 ~ 15 parts, Coreopsis basalis 10 ~ 20 parts, Rhizoma Imperatae 20 ~ 30 parts, Rhizoma Saururi (Herba Saururi) 20 ~ 30 parts, Rhizoma Polygoni Cuspidati 20 ~ 30 parts, Radix Cirsii Japonici 5 ~ 10 parts, Herba Cirsii 5 ~ 10 parts.

2. a kind of preparation method for the treatment of hypertensive Chinese medicine preparation as claimed in claim 1, is characterized in that, comprise the following steps:

S1, get Coreopsis basalis 10 ~ 20 parts, be ground into coarse granule, in the alcohol reflux 3 times that the ratio volume fraction of solid-liquid ratio 1: 8 is 75%, each 3h, merges the extracting solution of 3 times, after concentrating under reduced pressure recycling design, add chloroform extraction in the ratio of 1: 1, then add extraction into ethyl acetate in the ratio of 1: 1, merge twice extract, after concentrated, obtain Coreopsis basalis extractum;

S2, get Spica Prunellae 5 ~ 15 parts, add 5 ~ 20 times amount 10 ~ 90% alcohol reflux 2 ~ 4 times, each 0.5 ~ 3.0h, filter; Get filtrate reduced in volume, thickening temperature 55 ~ 65 DEG C, vacuum is 0.07 ~ 0.09Mpa, obtains Spica Prunellae extract;

S3, get 1 ~ 5 part, Bulbus Allii, remove the peel, clean, be crushed to granularity 6 ~ 7mm, load material barrel, be placed in extraction kettle and start extraction equipment, extraction temperature 35 DEG C, pressure 25Mpa, static extraction time 60min, circulation time 160min, separation temperature 45 DEG C, obtains Bulbus Allii extract;

S4, water intaking 82 parts, glycerol 4 parts, xanthan gum 1 part are mixed and heated to 80 degree, sterilizing;

S5, get emulsifying agent 4 parts, spermaceti stearyl alcohol 3 points, squalane 2 parts, Palmic acid isooctyl 2 parts, sad 2 parts, certain herbaceous plants with big flowers acid glycerol three fat, is mixed and heated to 80 degree, sterilizing;

S6, step S4 gained solution is spent homogeneous 30 ~ 35 minutes with step S5 gained solution mixing constant temperature to 80, be cooled to 60 degree, heat the Azelaic Acid of 1 part, stir and continue cooling, be cooled to less than 50 degree;

S7, get 10 ~ 20 parts, Flos Sophorae, the Radix Polygoni Multiflori 5 ~ 15 parts, Radix Puerariae 5 ~ 15 parts, 1 ~ 5 part, Bulbus Allii, Rhizoma Imperatae 20 ~ 30 parts, Rhizoma Saururi (Herba Saururi) 20 ~ 30 parts, Rhizoma Polygoni Cuspidati 20 ~ 30 parts, Radix Cirsii Japonici 5 ~ 10 parts, Herba Cirsii 5 ~ 10 parts be positioned in marmite, the water that at least can flood medical material is added in marmite, first with big fire by after water boil in marmite, use low baking temperature instead to decoct 0.5 ~ 2 hour, obtain decoction;

S8, the decoction of step S7 gained is cooled to 50 DEG C, add Herba Apocyni veneti extract 10 ~ 20 parts, Stigma Maydis extract 10 ~ 20 parts, Herba Apii graveolentis extract 10 ~ 20 parts, sturdy Thalictrum extract 5 ~ 15 parts, the Coreopsis basalis extractum of step S1 gained, the Spica Prunellae extract of step S2 gained, the Bulbus Allii extract of step S3 gained successively, stir;

S9, to be mixed by the mixture of step S8 gained continue to stir with the solution of step S6 gained, be cooled to 30 degree and stop stirring, leave standstill, inspection, fill, gets product.