CN102949380B - Medicine composition for improving reproductive performance of sow - Google Patents
Medicine composition for improving reproductive performance of sow Download PDFInfo
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- CN102949380B CN102949380B CN201110412575.0A CN201110412575A CN102949380B CN 102949380 B CN102949380 B CN 102949380B CN 201110412575 A CN201110412575 A CN 201110412575A CN 102949380 B CN102949380 B CN 102949380B
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Abstract
The invention belongs to the technical field of animal breeding and particularly discloses a medicine composition for enhancing or improving a physiological function or production performance of sow breeding. The medicine composition comprises main components such as olive oil, squalene and wheat flour. The medicine composition disclosed by the invention is mainly used for improving the physiological function or sexual behavior, normal oestrus and breeding pregnancy rate of sow breeding, increasing the litter size, improving the nutrition environment at an embryonic stage, enhancing the immunity of piglets, and increasing the quantity of healthy piglets.
Description
Technical field
The invention belongs to animal reproduction technical field, specifically, be a kind of pharmaceutical composition that improves or improve sow breeding physiology function and fertility performance, this pharmaceutical composition is mainly used in improving sow breeding physiology function and sexual behaviour, normally oestruses, conception rate, increase litter size, improve embryo phase nutrient environment and strengthen pigling immunity and increase strong young number.
Background technology
The raising of pig kind quality, the particularly raising of fattening period daily gain and feed efficiency, the decline that has brought reproductive performance.Producer is noticed, applies Animal Genetics theory and germplasm and measures synchronous breeding technique, for improving efficiency of gain, lean meat pig output and improving quality and played important function.So simultaneously, owing to existing incompatible phenomenon between a plurality of character of organism, feeding and management exists too smart grain, too unification, excessively controlled feeding and too intensive in addition, causes kind of female livestock breed power to go down and resistance decline.There is data to show: the strong young number of China numerous sow of energy and wean number are on the low side, big porker 9-10 head/nest (average 12-13 head/nest of Denmark is on average provided, the average 11-12 head/nest of Holland, the average 11-11.5 head/nest of France, the average 11-11.5 head/nest in Ireland, the average 9.5-10.5 head/nest of Britain), economic loss is large, has seriously affected Swine Production benefit.There is no at present special use and improve sow breeding physiology and obtain green natural, have no side effect, derive from marine organisms or land plant extract.This research belongs to biological active substances-zamene for improving the significantly patented product of the strong young number of increase of sow breeding function and breeding function health care.
The fertility that improves boar is the problem of Swine Production Important.There is document announcement both at home and abroad: (domestic being translated as " leptin ", " leptin ", " the fat element ") that disappears is to bring into play its different physiological roles by Leptin receptor and through corresponding signal transducting system in boar body, the biological active substances of a kind of Leptin of being called as.Leptin and receptors bind are the keys of performance Leptin physiological function.Since the gene of the clone such as Friedman of U.S. Rokefeller university in 1994 Leptin, at its 26S Proteasome Structure and Function, be related to aspect research and obtained important research progress and application.Leptin is used for the treatment of obesity, raising pig lean meat rate, raising reproductive capacity etc. prospect widely.Leptin has and starts the youth and grow, promote Development of Reproductive System and sexual maturity, maintain gestation, increase the functions such as litter size (referring to Bjorbaek C etc., Leptin Signaling in the Central Nervous System and the Periphery, Recent Prog, Horm, Res.2004,59 (1): 305-331; Madej T etc., Threading analysis suggests that the obese gene product may be a helical cytokine, FEBS Lett, 1995,373:13-16), though the application of exogenous Leptin for improving pig lean meat rate, reproductive capacity has great significance and prospect widely, but the method for no matter using injection Leptin at present is still used the method for gene fusion, all exist and use the problem inconvenient, cost is high, and in body, have Leptin opposing phenomenon.Therefore, new technology, new method and new product must be applied and root problem could be solved.The present invention adopts the pharmaceutical compositions such as pure natural biological active substances zamene (safety, economic, effective) to replace exogenous Leptin (starting endogenous Leptin), regulation and control body is to the sensitivity of endogenous Leptin and increase Leptin by the effective percentage of blood brain barrier, separate kind Leptin opposing phenomenon, and raising breeding function, it will not change the hereditary basis of pig, for the germ plasm resource of pig, preserves and has positive role.
Summary of the invention
The object of the invention is to overcome the defect that prior art exists, develop a kind of convenient drug administration, efficient, safety, the pharmaceutical composition that is applicable to improve sow reproductive performance of noresidue, to improve or to improve the reproductive performance of sow.
Realize technical solution of the present invention as described below:
Improve a pharmaceutical composition for sow reproductive performance, its component is as follows:
To prepare 10kg finished medicines:
Olive oil 2500ml;
Zamene 3000g;
Water content is lower than 13% wheat flour 4500g;
According to the following step, prepare:
1) using olive oil as diluent, zamene is dissolved in olive oil and mixed, obtain head product;
2) to step 1) head product in add wheat flour, mix and become graininess powder oil preparation.
The application process of pharmaceutical composition of the present invention in sow diets is: concrete consumption adds pharmaceutical composition 10g of the present invention by every sow (body weight 150-200 kilogram), and give once every day.
Pharmaceutical composition main component of the present invention is zamene (English name: Squalene, referring to document: Healthy Nature Rehource, U.S.A, Inc, Walnut.CA 91789U.S.A) be hydrocarbons, belong to terpenoid, can activate Leptin and receptors bind, performance Leptin starts youth growth, promotes Development of Reproductive System and sexual maturity, maintains gestation, increases the functions such as litter size indirectly, and then improve its reproductive capacity, can also make kind of poultry have healthy and lasting physiological activity, activate systemic cell, strengthen and extend breeding stock breeding function.Pharmaceutical composition mouthfeel of the present invention is good, and effect is remarkable, and curative effect is fast, curative effect is long, has no side effect, and (oral) easy to use, cost low (product cost can be reduced to 2～3 yuan/day/head after batch production), and safe and reliable.
The invention has the beneficial effects as follows:
The drawback that the present invention's oral (feeding) pharmaceutical composition (containing any hormone or chemicals) has avoided adopting the method for injectivity hormone to bring in the past, improve the breeding function of sow (or other breeding stocks), extend sow and utilize the time limit, there is effect significantly and the safe and reliable outstanding advantages that waits.
The applicant's inventor, through overtesting, raises and shows administration in the daily ration of 19 sows, uses pharmaceutical composition of the present invention can significantly improve sow breeding function, strengthens pigling immunity, increases strong young several 2～3/nests; Large-scale cultivation is had to significant economic benefit and social benefit.
The specific embodiment
Embodiment 1 (Preparation Example)
The formula of 10 kilograms of final drug compositionss of preparation is as follows:
Olive oil is (purchased from Greece product of Greece company; Acidity≤1%), 2500ml;
Zamene is (purchased from the U.S. Healthy Nature Rehource 3000g of company;
Water content is lower than 12% wheat flour 4500g;
According to the following step, prepare:
1) using olive oil as diluent, zamene is dissolved in olive oil and mixed, obtain head product;
2) to step 1) head product in add wheat flour, mix and become graininess powder oil preparation.
3) by step 2) described finished medicines is by every bottle of 500g, 50 part score dresses, keep in Dark Place standby.
Pharmaceutical composition medication of the present invention is:
According to every sow (body weight 150-200 kilogram) every day, 1 part, use the dosage of pharmaceutical composition 10g of the present invention, pharmaceutical composition of the present invention is sneaked in the daily ration of sow a meal, even feeding 2 weeks is a course for the treatment of, within 1 year, amounts to 2-3 the course for the treatment of, can reach obvious effect.
Table 1 pharmaceutical composition of the present invention improves sow reproductive efficiency test data sheet (sow test group)
Test group is a brood of average 12.0, SE ± 0.263
* *
Test group two nests are average 13.0, SE ± 0.408
* *(test group two nests are more than test group brood
*)
Test group three nests are average 11.9, SE ± 0.262
* *(a brood of zero difference of test group three nests and test group)
Table 2 pharmaceutical composition of the present invention improves sow reproductive efficiency test data sheet (sow matched group)
Matched group is a brood of average 9.7, SE ± 0.153
Matched group two nests are average 9.0, and (matched group two nests are a brood of fewer than matched group in SE ± 0.258
*)
Matched group three nests are average 8.667, and (matched group three nests are a brood of fewer than matched group in SE ± 0.289
*)
Test effect conclusion of the present invention is as described below:
1. test group sow the first nest is than several 2.3 of the strong son of the many increases of matched group sow the first nest, and difference is (P < 0.001) extremely significantly;
2. test group sow the second nest is than several 4.0 of the strong son of the many increases of matched group sow the second nest, and difference is (P < 0.001) extremely significantly;
3. test group sow two nest averages are than several 3.0 of the strong son of the many increases of matched group sow two nest average, and difference is (P < 0.001) extremely significantly;
4. test group the second nest is than test group the first nest many 1.0, variant (P < 0.05);
5. matched group sow the second nest is than matched group the first nest few 0.7, variant (P < 0.05);
6. test group the 3rd nest is than many 3.2 of matched group the 3rd nest, and difference is (P < 0.001) extremely significantly;
7. test group the 3rd nest and test group the first nest zero difference;
8. matched group the 3rd nest is than matched group the first nest few 1.0, significant difference (P < 0.01);
After the first nest drug withdrawal of evidence test group sow, the second nest still plays a role, and after drug withdrawal, effect is also being strengthened, and test group the second nest is more than the strong young number of test group the first nest; And matched group sow the second nest is really few than matched group the first nest.
Claims (1)
1. the application of drug regimen in the pharmaceutical composition of preparation raising sow reproductive performance, is characterized in that, the component of this pharmaceutical composition is as follows:
To prepare 10kg finished medicines:
Olive oil 2500ml;
Zamene 3000g;
Water content is lower than 13% wheat flour 4500g;
According to the following step, prepare:
1) using olive oil as diluent;
2) zamene is dissolved in the diluent of step 1) and mix, obtain head product;
3) to step 2) head product in add wheat flour, mix and become graininess powder oil preparation;
The consumption of aforementioned pharmaceutical compositions in sow diets pressed 10g/150-200kg sow body weight, and give every day for 1 time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110412575.0A CN102949380B (en) | 2011-12-06 | 2011-12-06 | Medicine composition for improving reproductive performance of sow |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110412575.0A CN102949380B (en) | 2011-12-06 | 2011-12-06 | Medicine composition for improving reproductive performance of sow |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102949380A CN102949380A (en) | 2013-03-06 |
| CN102949380B true CN102949380B (en) | 2014-02-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110412575.0A Expired - Fee Related CN102949380B (en) | 2011-12-06 | 2011-12-06 | Medicine composition for improving reproductive performance of sow |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105394392A (en) * | 2015-11-24 | 2016-03-16 | 天津市中升挑战生物科技有限公司 | Feed additive capable of resisting swine viral diseases and preparation method for feed additive |
| CN107027983B (en) * | 2016-12-28 | 2018-03-02 | 广州市优百特饲料科技有限公司 | A kind of milking sow promotees the breeding ester composition of aliphatic acid three |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876011A (en) * | 2006-04-04 | 2006-12-13 | 华中农业大学 | A pharmaceutical composition capable of improving boar reproductive performance |
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2011
- 2011-12-06 CN CN201110412575.0A patent/CN102949380B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876011A (en) * | 2006-04-04 | 2006-12-13 | 华中农业大学 | A pharmaceutical composition capable of improving boar reproductive performance |
Non-Patent Citations (1)
| Title |
|---|
| Madej T 等.Leptin Signaling in the Central Nervous System and the Periphery.《Recent Prog，Horm，Res.2004》.2004,第59卷(第1期),第305-331页. * |
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| CN102949380A (en) | 2013-03-06 |
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Granted publication date: 20140219 Termination date: 20171206 |