CN102947458B - 用于丝状真菌中c4-二羧酸的改善的产生的方法 - Google Patents

用于丝状真菌中c4-二羧酸的改善的产生的方法 Download PDF

Info

Publication number
CN102947458B
CN102947458B CN201180030913.2A CN201180030913A CN102947458B CN 102947458 B CN102947458 B CN 102947458B CN 201180030913 A CN201180030913 A CN 201180030913A CN 102947458 B CN102947458 B CN 102947458B
Authority
CN
China
Prior art keywords
seq
sequence
host cell
dicarboxylic acid
transporter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180030913.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN102947458A (zh
Inventor
S.卢特林格
D.亚维尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Inc
Original Assignee
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Inc filed Critical Novozymes Inc
Publication of CN102947458A publication Critical patent/CN102947458A/zh
Application granted granted Critical
Publication of CN102947458B publication Critical patent/CN102947458B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201180030913.2A 2010-06-21 2011-06-21 用于丝状真菌中c4-二羧酸的改善的产生的方法 Expired - Fee Related CN102947458B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35700710P 2010-06-21 2010-06-21
US61/357,007 2010-06-21
PCT/US2011/041301 WO2011163270A1 (en) 2010-06-21 2011-06-21 Methods for improved c4-dicarboxylic acid production in filamentous fungi

Publications (2)

Publication Number Publication Date
CN102947458A CN102947458A (zh) 2013-02-27
CN102947458B true CN102947458B (zh) 2016-05-04

Family

ID=44504321

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180030913.2A Expired - Fee Related CN102947458B (zh) 2010-06-21 2011-06-21 用于丝状真菌中c4-二羧酸的改善的产生的方法

Country Status (6)

Country Link
US (2) US8497103B2 (https=)
EP (1) EP2582829B1 (https=)
CN (1) CN102947458B (https=)
BR (1) BR112012028031A2 (https=)
IN (1) IN2013CN00459A (https=)
WO (1) WO2011163270A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2772695A1 (en) * 2009-09-01 2011-03-10 Novozymes, Inc. Methods for improving malic acid production in filamentous fungi
WO2014142647A1 (en) * 2013-03-14 2014-09-18 Wageningen Universiteit Fungals strains with improved citric acid and itaconic acid production
EP3161142A4 (en) * 2014-06-26 2018-05-16 Lygos, Inc. Recombinant host cells for the production of malonate
EP3257934B1 (en) * 2015-02-15 2024-10-23 Tianjin Institute Of Industrial Biotechnology, Chinese Academy of Sciences Dibasic organic acid producing strain and preparation and application of same
CN106148209B (zh) * 2015-03-23 2020-11-20 中国科学院天津工业生物技术研究所 新的二元有机酸生产菌株及其制备和应用
CN106148208B (zh) * 2015-03-23 2020-12-18 中国科学院天津工业生物技术研究所 新的二元有机酸生产菌株及其制备和应用
JP6637712B2 (ja) * 2015-10-13 2020-01-29 花王株式会社 Ｃ４ジカルボン酸の製造方法
CN105754963A (zh) * 2016-05-19 2016-07-13 江南大学 一种提高延胡索酸产量的方法
WO2018051837A1 (ja) * 2016-09-15 2018-03-22 花王株式会社 変異糸状菌、及びそれを用いたｃ４ジカルボン酸の製造方法
CN114806899B (zh) * 2022-04-14 2024-04-02 王玮 一种生产l-苹果酸的里氏木霉工程菌及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009011974A1 (en) * 2007-05-18 2009-01-22 Microbia Precision Engineering, Inc. Organic acid production by fungal cells
CN101365782A (zh) * 2005-11-21 2009-02-11 泰特&莱尔组分美国公司 重组酵母中的苹果酸生产

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1047002A (en) 1911-04-03 1912-12-10 James S Diehl Scissors.
US3063910A (en) 1960-02-03 1962-11-13 Kyowa Hakko Kogyo Kk Method of producing l-malic acid by fermentation
US5536661A (en) 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
WO1995033836A1 (en) 1994-06-03 1995-12-14 Novo Nordisk Biotech, Inc. Phosphonyldipeptides useful in the treatment of cardiovascular diseases
ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
US5766439A (en) 1996-10-10 1998-06-16 A. E. Staley Manufacturing Co. Production and recovery of organic acids
US7504490B1 (en) * 1998-10-16 2009-03-17 Oscient Pharmaceuticals Corporation Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics
DK1124949T3 (da) 1998-10-26 2006-11-06 Novozymes As Konstruktion og screening af et DNA-bibliotek af interesse i trådformede svampeceller
CN100482801C (zh) 1999-03-22 2009-04-29 诺沃奇梅兹有限公司 用于在真菌细胞中表达基因的启动子
CN1938257A (zh) 2004-01-29 2007-03-28 齐凯姆公司 有机酸的回收
WO2008144626A1 (en) * 2007-05-18 2008-11-27 Microbia Precision Engineering, Inc. Malic acid production in recombinant yeast
EP2687602A1 (en) 2007-11-20 2014-01-22 DSM IP Assets B.V. Succinic acid production in a eukaryotic cell
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
ES2623932T3 (es) 2008-07-08 2017-07-12 Dsm Ip Assets B.V. Producción de ácido succínico por fermentación a bajo pH
WO2010111344A2 (en) 2009-03-24 2010-09-30 Microbia, Inc. Methods and microorganisms for production of c4-dicarboxylic acids
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
CA2772695A1 (en) 2009-09-01 2011-03-10 Novozymes, Inc. Methods for improving malic acid production in filamentous fungi
WO2011066304A2 (en) 2009-11-25 2011-06-03 Codexis, Inc. Engineered beta-class carbonic anhydrase polypeptides and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101365782A (zh) * 2005-11-21 2009-02-11 泰特&莱尔组分美国公司 重组酵母中的苹果酸生产
WO2009011974A1 (en) * 2007-05-18 2009-01-22 Microbia Precision Engineering, Inc. Organic acid production by fungal cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Aspergillus clavatus NRRL1 1099423829736 genomic scaffold,whole genome shotgun sequence,登录号：NW_001517111.1;Nierman W C;《Genbank》;20090202;全文 *
Aspergillus fumigatus Af293 chromosome 8,whole genome shotgun sequence,登录号：NC_007201.1;Nierman W C等;《Genbank》;20100414;全文 *
Sequence 41942 from patent US 7504490,登录号为ACQ09725.1;Weinstock K G等;《Genbank》;20090429;全文 *

Also Published As

Publication number Publication date
US20110312046A1 (en) 2011-12-22
IN2013CN00459A (https=) 2015-07-03
US8497103B2 (en) 2013-07-30
EP2582829A1 (en) 2013-04-24
US20130288321A1 (en) 2013-10-31
BR112012028031A2 (pt) 2019-09-24
WO2011163270A1 (en) 2011-12-29
EP2582829B1 (en) 2016-11-30
CN102947458A (zh) 2013-02-27

Similar Documents

Publication Publication Date Title
CN102947458B (zh) 用于丝状真菌中c4-二羧酸的改善的产生的方法
US8663956B2 (en) Recombinant microorganisms for production C4-dicarboxylic acids
JP5833553B2 (ja) 糸状菌におけるリンゴ酸生成の改良方法
US9447440B2 (en) Microorganisms for C4-dicarboxylic acid production
US10358664B2 (en) Mutant host cells for the production of 3-hydroxypropionic acid
CN103003298B (zh) 在丝状真菌中产生c4二羧酸
CN107109347A (zh) 用于生产3‑羟基丙酸的重组宿主细胞
CN103080126B (zh) 具有c4-二羧酸转运蛋白活性的多肽和编码该多肽的多核苷酸
US20180265902A1 (en) Beta-Alanine Aminotransferases For The Production of 3-Hydroxypropionic Acid

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160504

Termination date: 20170621

CF01 Termination of patent right due to non-payment of annual fee