CN102939074A - 稳定的眼科半乳甘露聚糖制剂 - Google Patents

稳定的眼科半乳甘露聚糖制剂 Download PDF

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Publication number
CN102939074A
CN102939074A CN2011800292803A CN201180029280A CN102939074A CN 102939074 A CN102939074 A CN 102939074A CN 2011800292803 A CN2011800292803 A CN 2011800292803A CN 201180029280 A CN201180029280 A CN 201180029280A CN 102939074 A CN102939074 A CN 102939074A
Authority
CN
China
Prior art keywords
formulation
galactomannan
concentration
diol
borate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800292803A
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English (en)
Chinese (zh)
Inventor
H·A·凯特尔森
J·W·达维斯
D·L·梅多斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Research LLC
Original Assignee
Alcon Research LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Research LLC filed Critical Alcon Research LLC
Priority to CN201610986410.7A priority Critical patent/CN106389325A/zh
Publication of CN102939074A publication Critical patent/CN102939074A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2011800292803A 2010-05-05 2011-05-04 稳定的眼科半乳甘露聚糖制剂 Pending CN102939074A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610986410.7A CN106389325A (zh) 2010-05-05 2011-05-04 稳定的眼科半乳甘露聚糖制剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33151110P 2010-05-05 2010-05-05
US61/331,511 2010-05-05
PCT/US2011/035165 WO2011140203A2 (en) 2010-05-05 2011-05-04 Stabilized ophthalmic galactomannan formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610986410.7A Division CN106389325A (zh) 2010-05-05 2011-05-04 稳定的眼科半乳甘露聚糖制剂

Publications (1)

Publication Number Publication Date
CN102939074A true CN102939074A (zh) 2013-02-20

Family

ID=44626461

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011800292803A Pending CN102939074A (zh) 2010-05-05 2011-05-04 稳定的眼科半乳甘露聚糖制剂
CN201610986410.7A Pending CN106389325A (zh) 2010-05-05 2011-05-04 稳定的眼科半乳甘露聚糖制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610986410.7A Pending CN106389325A (zh) 2010-05-05 2011-05-04 稳定的眼科半乳甘露聚糖制剂

Country Status (16)

Country Link
US (2) US20110275593A1 (https=)
EP (1) EP2566447B1 (https=)
JP (1) JP5794744B2 (https=)
KR (2) KR20180001587A (https=)
CN (2) CN102939074A (https=)
AR (1) AR081015A1 (https=)
AU (1) AU2011248129B2 (https=)
BR (1) BR112012028308B1 (https=)
CA (1) CA2798069C (https=)
ES (1) ES2809304T3 (https=)
MX (1) MX2012012826A (https=)
NZ (1) NZ603345A (https=)
SG (2) SG10201804305SA (https=)
TW (1) TWI606841B (https=)
WO (1) WO2011140203A2 (https=)
ZA (1) ZA201208199B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2009000985A1 (es) * 2008-04-26 2010-01-15 Alcon Res Ltd Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo.
TWI492769B (zh) * 2009-09-23 2015-07-21 Alcon Res Ltd 可注射的水性眼用組成物及其使用之方法
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
UA113434C2 (uk) * 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
RU2018145364A (ru) 2016-06-27 2020-07-28 Ачиллион Фармасьютикалс, Инк. Хиназолиновые и индольные соединения для лечения медицинских нарушений
CN110114119B (zh) * 2016-10-12 2022-05-31 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法
US11583496B2 (en) 2016-10-12 2023-02-21 PS Therapy Inc. Drug vehicle compositions and methods of use thereof
US11260035B2 (en) 2016-10-12 2022-03-01 Ps Therapies Ltd Topical compositions and methods of use thereof
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
EP3866773B1 (en) 2018-10-16 2024-08-28 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
WO2021168320A1 (en) 2020-02-20 2021-08-26 Achillion Pharmaceuticals, Inc. Heteroaryl compounds for treatment of complement factor d mediated disorders
WO2022066774A1 (en) 2020-09-23 2022-03-31 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
US20250277076A1 (en) 2024-03-04 2025-09-04 Alcon Inc. Mucoadhesive hydrophilic copolymers and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
CN1302201A (zh) * 1997-07-29 2001-07-04 阿尔康实验室公司 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
CN1802148A (zh) * 2003-06-13 2006-07-12 爱尔康公司 包含三种聚合物的协同组合的眼用组合物
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
CN101678140A (zh) * 2007-05-18 2010-03-24 爱尔康研究有限公司 用于隐形眼镜护理和防腐的药用组合物的磷脂组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8028A (en) * 1851-04-08 Hokse-poweb
DE3827561C1 (https=) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
GB9808461D0 (en) * 1998-04-22 1998-06-17 Innovative Tech Ltd Solid borate-diol interaction products
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
TWI434926B (zh) 2006-12-11 2014-04-21 Alcon Res Ltd 眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用
CL2009000985A1 (es) * 2008-04-26 2010-01-15 Alcon Res Ltd Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo.
MX2011007714A (es) 2009-02-05 2011-12-06 Alcon Res Ltd Proceso para purificar goma guar.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
CN1302201A (zh) * 1997-07-29 2001-07-04 阿尔康实验室公司 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
CN1802148A (zh) * 2003-06-13 2006-07-12 爱尔康公司 包含三种聚合物的协同组合的眼用组合物
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
CN101678140A (zh) * 2007-05-18 2010-03-24 爱尔康研究有限公司 用于隐形眼镜护理和防腐的药用组合物的磷脂组合物

Also Published As

Publication number Publication date
SG185422A1 (en) 2012-12-28
US20110275593A1 (en) 2011-11-10
JP5794744B2 (ja) 2015-10-14
US20130244971A1 (en) 2013-09-19
SG10201804305SA (en) 2018-06-28
MX2012012826A (es) 2013-01-28
JP2013525493A (ja) 2013-06-20
WO2011140203A3 (en) 2012-04-19
ES2809304T3 (es) 2021-03-03
AU2011248129A1 (en) 2012-11-29
EP2566447B1 (en) 2020-07-15
KR20130060228A (ko) 2013-06-07
TW201141524A (en) 2011-12-01
US8846641B2 (en) 2014-09-30
AU2011248129B2 (en) 2014-10-09
TWI606841B (zh) 2017-12-01
CN106389325A (zh) 2017-02-15
EP2566447A2 (en) 2013-03-13
BR112012028308B1 (pt) 2021-09-28
CA2798069A1 (en) 2011-11-10
KR20180001587A (ko) 2018-01-04
AR081015A1 (es) 2012-05-30
WO2011140203A2 (en) 2011-11-10
CA2798069C (en) 2016-07-05
ZA201208199B (en) 2014-01-29
NZ603345A (en) 2014-12-24
BR112012028308A2 (pt) 2016-11-01

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Application publication date: 20130220