CN102935159A - Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN102935159A CN102935159A CN2012105234891A CN201210523489A CN102935159A CN 102935159 A CN102935159 A CN 102935159A CN 2012105234891 A CN2012105234891 A CN 2012105234891A CN 201210523489 A CN201210523489 A CN 201210523489A CN 102935159 A CN102935159 A CN 102935159A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- treatment
- fracture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating fracture. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of asplenium antiquum makino, 15 to 25 parts of ground beeltle, 15 to 25 parts of angelica sinensis, 8 to 12 parts of peach kernel, 8 to 12 parts of radix angelicae pubescentis, 6 to 10 parts of resina draconis, 10 to 14 parts of rhizoma drynariae, 10 to 14 parts of cuscuta chinensis, 18 to 22 parts of lindera strychnifolium vill, and 15 to 25 parts of murraya paniculata. The traditional Chinese medicine composition has the effects of strengthening tendons and bones, dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis, and eliminating stagnation stop pain, so that the purpose of treating fracture can be achieved. The invention also discloses a preparation method and application of the traditional Chinese medicine composition.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that is used for the treatment of fracture and its preparation method and application.
Background technology
Fracture refers to a kind of disease of causing sclerotin partially or completely to rupture owing to reasons such as wound or pathology.Its main clinical manifestation is: fractures has limitation pain and tenderness, local swelling and ecchymosis occurs, and limb function position or completely lose, the completeness sclerotin still cacomelia and abnormal movement can occur.
Western medicine adopts transfusion to add anti-inflammation class medicine (such as penicillin) treatment more at present, and integration resets, mainly by self-recovery, and conservative treatment, very the person takes operative treatment to bring the hardship of broadsword play and burden economically to patient.Existing can invigorating blood circulation addiction, the treatment fracture herbal species of dredge the meridian passage, reducing swelling and alleviating pain is many, but because the difference of patient's the cause of disease, state of an illness weight, sick time length, and medicine is not equal to the effect of absorption of human body, performance, can't reach in actual applications the preferably effect of collateral dredging, blood stasis dispelling, pain relieving, thereby can not in time alleviate the slight illness of Most patients, can not obtain good therapeutic effect.Be better treatment disease, pain and alleviation, make patient's body tissue early recovery, people in the urgent need to a kind of effective, oneself is by most people confirms to play that strengthening the tendons and bones, invigorating blood circulation are tired, the treatment of the good result of dredge the meridian passage, reducing swelling and alleviating pain is fractured Chinese medicine composition.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of Chinese medicine composition that is used for the treatment of fracture and its preparation method and application.
Technical scheme: the objective of the invention is to realize by following scheme:
A kind of Chinese medicine composition that is used for the treatment of fracture, it is prepared by the raw material of following parts by weight: ferrum Hirudo 20-30 part, Eupolyphaga Seu Steleophaga 15-25 part, Radix Angelicae Sinensis 15-25 part, Semen Persicae 8-12 part, Radix Angelicae Pubescentis 8-12 part, Sanguis Draxonis 6-10 part, Rhizoma Drynariae 10-14 part, Semen Cuscutae 10-14 part, Radix Linderae 18-22 part, Folium Et Cacumen Murrayae 15-25 part.
The above-mentioned Chinese medicine composition that is used for the treatment of fracture, it is prepared by the raw material of following parts by weight: 25 parts of ferrum Hirudoes, 20 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Persicae, 10 parts of Radix Angelicae Pubescentiss, 8 parts of Sanguis Draxonis, 12 parts of Rhizoma Drynariae, 12 parts of Semen Cuscutae, 20 parts of the Radixs Linderae, 20 parts of Folium Et Cacumen Murrayae.
The above-mentioned Chinese medicine composition that is used for the treatment of fracture, described raw material add adjuvant and make oral liquid, tablet, capsule or granule after extracting.
The above-mentioned Chinese medicine composition that is used for the treatment of fracture, described adjuvant are one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fracture, it comprises the steps: to get the ferrum Hirudo, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Radix Angelicae Pubescentis, Sanguis Draxonis, Rhizoma Drynariae, Semen Cuscutae, the Radix Linderae and Folium Et Cacumen Murrayae medical material merge, decoct with water twice, collecting decoction, relative density is the extractum of 1.15-1.20 when being evaporated to 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, leave standstill, filter, relative density was 1.25-1.30 when filtrate decompression was concentrated into 65 ℃, and Recycled ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fracture, in the step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, and decocts 1-2h, and the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of fracture, in the step, the spray drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
The above-mentioned application of Chinese medicine composition in the medicine of preparation treatment fracture that is used for the treatment of fracture.
Beneficial effect:
1, from theory of Chinese medical science, ferrum Hirudo bone and muscle strengthening among the we; Blood circulation promoting and blood stasis dispelling, with drug for invigorating blood circulation and eliminating stasis compatibilities such as Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Radix Angelicae Pubescentis, Sanguis Draxonis, strengthening the tendons and bones, tired, the dredge the meridian passage of invigorating blood circulation, six is monarch drug, and Rhizoma Drynariae, Semen Cuscutae, the Radix Linderae are ministerial drug, the merit of principal drug assistance collateral dredging, reducing swelling and alleviating pain, Folium Et Cacumen Murrayae is adjuvant, all medicines are harmonious, and play altogether that strengthening the tendons and bones, invigorating blood circulation are tired, dredge the meridian passage, reducing swelling and alleviating pain effect, are used for the treatment of fracture.Theory of Chinese medical science is thought injury blood stasis swelling, blockage of main and collateral channels, and the QI and blood retardance, treatment should be with blood circulation promoting and blood stasis dispelling, and circulation of qi promoting is dissipated as the master.
2, Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, determined curative effect.
3, the present invention consists of Chinese crude drug, has no side effect low price.
The specific embodiment
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, in conjunction with the specific embodiment, the present invention is further described as follows:
Listed weight proportion takes by weighing raw material required for the present invention in the according to the form below, unit: part
| The ferrum Hirudo | Eupolyphaga Seu Steleophaga | Radix Angelicae Sinensis | Semen Persicae | Radix Angelicae Pubescentis | Sanguis Draxonis | Rhizoma Drynariae | Semen Cuscutae | The Radix Linderae | Folium Et Cacumen Murrayae | |
| 1 | 20 | 25 | 15 | 12 | 8 | 10 | 10 | 14 | 18 | 15 |
| 2 | 25 | 20 | 20 | 10 | 10 | 8 | 12 | 12 | 20 | 20 |
| 3 | 30 | 15 | 25 | 8 | 12 | 6 | 14 | 10 | 22 | 25 |
Among the present invention, the ferrum Hirudo is herb or the rhizome of Aspleniaceae plant Neottopteris nidus (L.) J. Smith.Latin plant animal mineral name: Neottopteris nidus(L.) J.Smith[Asplenium nidus L.] Folium Et Cacumen Murrayae is the herb of rutaceae Folium Et Cacumen Murrayae Murraya exotica L., all the other are the pharmacopeia kind.
2. Preparation Example
More than table Raw proportioning is example, may further comprise the steps:
Embodiment 1: get ferrum Hirudo 20g, Eupolyphaga Seu Steleophaga 25g, Radix Angelicae Sinensis 15g, Semen Persicae 12g, Radix Angelicae Pubescentis 8g, Sanguis Draxonis 10g, Rhizoma Drynariae 10g, Semen Cuscutae 14g, Radix Linderae 18g, Folium Et Cacumen Murrayae 15g medical material merges, decoct with water twice, add for the first time 8 times of amounts that water is medical material weight, decoct 1h, add for the second time 6 times of amounts that water is medical material weight, decoct 1h, collecting decoction, 0.07MPa, relative density is 1.10 when being evaporated to 65 ℃ under 60-70 ℃, adds 95% (v/v) ethanol and makes the alcohol amount of containing reach 85% (v/v), stirs, left standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, relative density was 1.30 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and (condition is that inlet temperature is 120 ℃ to spray drying, leaving air temp is 100 ℃, temperature of charge is 90 ℃, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.), adding starch, mix homogeneously with the moistening of an amount of 80% (v/v) ethanol, soft material processed, is crossed 30 mesh sieves and is granulated, and in 70 ~ 80 ℃ of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, packing, outer package, censorship is qualified, gets tablet.
Embodiment 2: get ferrum Hirudo 25g, Eupolyphaga Seu Steleophaga 20g, Radix Angelicae Sinensis 20g, Semen Persicae 10g, Radix Angelicae Pubescentis 10g, Sanguis Draxonis 8g, Rhizoma Drynariae 12g, Semen Cuscutae 12g, Radix Linderae 20g, Folium Et Cacumen Murrayae 20g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 when being evaporated to 65 ℃ under 60-70 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, left standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and (condition is that inlet temperature is 100 ℃ to spray drying, leaving air temp is 80 ℃, temperature of charge is 80 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), adding dextrin etc., dry granulation is crossed 60 mesh sieves, and No. 1 capsule of packing into gets final product to get capsule.
Embodiment 3: get ferrum Hirudo 30g, Eupolyphaga Seu Steleophaga 15g, Radix Angelicae Sinensis 25g, Semen Persicae 8g, Radix Angelicae Pubescentis 12g, Sanguis Draxonis 6g, Rhizoma Drynariae 14g, Semen Cuscutae 10g, Radix Linderae 22g, Folium Et Cacumen Murrayae 25g medical material merges, decoct with water twice, add for the first time 12 times of amounts that water is medical material weight, decoct 2h, add for the second time 10 times of amounts that water is medical material weight, decoct 2h, collecting decoction, 0.07MPa, relative density is 1.15 when being evaporated to 65 ℃ under 60-70 ℃, adds 95% (v/v) ethanol and makes the alcohol amount of containing reach 75% (v/v), stirs, left standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, and (condition is that inlet temperature is 110 ℃ to spray drying, leaving air temp is 85 ℃, temperature of charge is 85 ℃, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5ml/s.), add above-mentioned Benexate Hydrochloride, pulverize, add again suitable lactose, with the moistening of an amount of 80% (v/v) ethanol, soft material processed, cross 14 mesh sieves and granulate, 50-80 ℃ of drying, 60 order granulate get granule.
Embodiment 4: get ferrum Hirudo 25g, Eupolyphaga Seu Steleophaga 20g, Radix Angelicae Sinensis 20g, Semen Persicae 10g, Radix Angelicae Pubescentis 10g, Sanguis Draxonis 8g, Rhizoma Drynariae 12g, Semen Cuscutae 12g, Radix Linderae 20g, Folium Et Cacumen Murrayae 20g medical material merges, decoct with water twice, add for the first time 10 times of amounts that water is medical material weight, decoct 1.5h, add for the second time 8 times of amounts that water is medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, relative density is 1.15 when being evaporated to 65 ℃ under 60-70 ℃, adding 95% (v/v) ethanol makes the alcohol amount of containing reach 75% (v/v), stir, left standstill 24 hours, decompression filtrate recycling ethanol is also concentrated, and filtrate is at 0.07MPa, relative density was 1.25 when concentrating under reduced pressure became to 65 ℃ under 65 ℃ of conditions, add water and sucrose, be prepared into oral liquid.
3. on the pharmacodynamic study of the impact of the bone density of laboratory animal
Sample preparation: press above-described embodiment 3 preparation clinical trial samples, specification is the 10g/ bag, and containing the crude drug amount is the 16.7g/ bag.Precious strong SHENGU JIAONANG, Shandong meeting elixir industry Group Co.,Ltd, lot number: 20100511.The tretinoin sheet, the good good fortune in Shandong pharmaceutical Co. Ltd, lot number: 110120
Animal: the Wistar rat, male, body weight 180-240g, Shanghai Slac Experimental Animal Co., Ltd. provides.
The foundation of experiment grouping and model rat with osteoporosis: get 30 of normal Wistar rats and be divided at random 5 groups, get wherein 6 and organize for NS; Get wherein 6 as model group, press merely two weeks of tretinoin 70mg/kg gavage; Get wherein 6 precious strong SHENGU JIAONANG matched groups of conduct; Remaining 12 rats are as the high low dose group of the present invention.Gavage corresponding medicine when gavaging tretinoin as ZHENMUSHENGU JIAONANG matched group and high and low dose group of the present invention by the dosage of 70mg/kg, gavage and withdraw tretinoin after two weeks and continue two weeks and measure indices.The rat sacrificed by decapitation is got its femur and is arranged by group, uses X-line mammary gland video camera production mating plate, with the black and white densimeter on the greater trochanter of femur, femoral head, neck of femur, intertrochanteric line and under the intertrochanteric line 5 positions fixed point measure and the record bone density value.
Impact on rat bone density
Compare * 1P＜0.01, * 2P＜0.05 with model group
Experimental result shows that the present invention and model group relatively have significant difference, illustrate that the present invention can improve bone density, the treatment fracture, and also effect is better than precious strong SHENGU JIAONANG.
4. model case
Case 1: Lee, man, 40 years old.Injured be in hospital, clinical diagnosis are the right lower extremity fracture, and the therapeutic scheme of employing is as follows: take the above embodiment of the present invention 3 preparation clinical trial samples, each 10g, is discharged from hospital after recovery after serveing on for six weeks at every day 2 times.
Case 2: Zhang, woman, 48 years old.The patient is injured to be in hospital, and clinical diagnosis is that right chi is scratched the bone fracture, takes the above embodiment of the present invention 3 preparation clinical trial samples, and each 10g is discharged from hospital after recovery after the bimester of serveing on.
Claims (8)
1. Chinese medicine composition that is used for the treatment of fracture, it is characterized in that it is prepared by the raw material of following parts by weight: ferrum Hirudo 20-30 part, Eupolyphaga Seu Steleophaga 15-25 part, Radix Angelicae Sinensis 15-25 part, Semen Persicae 8-12 part, Radix Angelicae Pubescentis 8-12 part, Sanguis Draxonis 6-10 part, Rhizoma Drynariae 10-14 part, Semen Cuscutae 10-14 part, Radix Linderae 18-22 part, Folium Et Cacumen Murrayae 15-25 part.
2. the Chinese medicine composition that is used for the treatment of fracture according to claim 1, it is characterized in that it is prepared by the raw material of following parts by weight: 25 parts of ferrum Hirudoes, 20 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Angelicae Sinensis, 10 parts in Semen Persicae, 10 parts of Radix Angelicae Pubescentiss, 8 parts of Sanguis Draxonis, 12 parts of Rhizoma Drynariae, 12 parts of Semen Cuscutae, 20 parts of the Radixs Linderae, 20 parts of Folium Et Cacumen Murrayae.
3. the Chinese medicine composition that is used for the treatment of fracture according to claim 1 and 2 is characterized in that, described raw material adds adjuvant and makes oral liquid, tablet, capsule or granule after extracting.
4. the Chinese medicine composition that is used for the treatment of fracture according to claim 3, it is characterized in that described adjuvant is one or more of dextrin, lactose, starch, sucrose, glucose, microcrystalline Cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose and stevioside.
5. claim 1 or the 2 described preparation methoies that are used for the treatment of the Chinese medicine composition of fracture, it is characterized in that, it comprises the steps: to get the ferrum Hirudo, Eupolyphaga Seu Steleophaga, Radix Angelicae Sinensis, Semen Persicae, Radix Angelicae Pubescentis, Sanguis Draxonis, Rhizoma Drynariae, Semen Cuscutae, the Radix Linderae and Folium Et Cacumen Murrayae medical material merge, decoct with water twice, collecting decoction, relative density is the extractum of 1.15-1.20 when being evaporated to 65 ℃, adding ethanol makes the percent by volume that contains the alcohol amount reach 75-85%, stir, leave standstill, filter, relative density was 1.25-1.30 when filtrate decompression was concentrated into 65 ℃, and Recycled ethanol, get concentrated solution, concentrated solution is added water and adjuvant is mixed with oral liquid, or with the concentrated solution spray drying, add adjuvant and make capsule, tablet, granule.
6. the preparation method that is used for the treatment of the Chinese medicine composition of fracture according to claim 5 is characterized in that, in the step, decocting condition is: the 8-12 that adds for the first time water and be medical material weight doubly measures, decoct 1-2h, the 6-10 that adds water for the second time and be medical material weight doubly measures, and decocts 1-2h.
7. the preparation method that is used for the treatment of the Chinese medicine composition of fracture according to claim 5, it is characterized in that, in the step, the spray drying condition is: inlet temperature is 100-120 ℃, leaving air temp is 80-90 ℃, temperature of charge is 70-90 ℃, and atomizing pressure is the 0.2-0.4 MPa, and spray velocity is 5-10ml/s.
8. claim 1 or the 2 described application of Chinese medicine composition in the medicine of preparation treatment fracture that are used for the treatment of fracture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210523489.1A CN102935159B (en) | 2012-12-08 | 2012-12-08 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210523489.1A CN102935159B (en) | 2012-12-08 | 2012-12-08 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102935159A true CN102935159A (en) | 2013-02-20 |
| CN102935159B CN102935159B (en) | 2014-09-10 |
Family
ID=47694106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210523489.1A Expired - Fee Related CN102935159B (en) | 2012-12-08 | 2012-12-08 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102935159B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274602A (en) * | 1999-12-13 | 2000-11-29 | 莫强林 | Externally applied medicated wine for treating traumatic injury and rheumatism |
| CN1339313A (en) * | 2001-09-30 | 2002-03-13 | 吴绍静 | Pure traditional Chinese medicine for relaxing muscles and tendons and promoting blood circulation |
| CN1457868A (en) * | 2003-05-19 | 2003-11-26 | 南明森 | Naturally curing fracture setting pill |
| CN1507892A (en) * | 2002-12-18 | 2004-06-30 | 潘荣秦 | Osteoproliferation medicine for external application |
| CN1824009A (en) * | 2005-02-22 | 2006-08-30 | 林立树 | Multipurpose medicinal composition capable of oral administration and external use |
| CN102793831A (en) * | 2012-08-27 | 2012-11-28 | 刘伟娟 | Preparation method for traditional Chinese medicine lotion for treatment of hypertension-type closed fracture |
-
2012
- 2012-12-08 CN CN201210523489.1A patent/CN102935159B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274602A (en) * | 1999-12-13 | 2000-11-29 | 莫强林 | Externally applied medicated wine for treating traumatic injury and rheumatism |
| CN1339313A (en) * | 2001-09-30 | 2002-03-13 | 吴绍静 | Pure traditional Chinese medicine for relaxing muscles and tendons and promoting blood circulation |
| CN1507892A (en) * | 2002-12-18 | 2004-06-30 | 潘荣秦 | Osteoproliferation medicine for external application |
| CN1457868A (en) * | 2003-05-19 | 2003-11-26 | 南明森 | Naturally curing fracture setting pill |
| CN1824009A (en) * | 2005-02-22 | 2006-08-30 | 林立树 | Multipurpose medicinal composition capable of oral administration and external use |
| CN102793831A (en) * | 2012-08-27 | 2012-11-28 | 刘伟娟 | Preparation method for traditional Chinese medicine lotion for treatment of hypertension-type closed fracture |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102935159B (en) | 2014-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101130030B (en) | Medicine composition for treating nephropathy and uses of the same | |
| CN102225138B (en) | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof | |
| CN102379941B (en) | A kind of compound Chinese medicinal preparation treating fracture and preparation method thereof | |
| CN105148019A (en) | Medicinal preparation used for treating fractures | |
| CN104001004A (en) | Traditional Chinese medicine composition for curing fractures and osteoporosis and preparation method and application thereof | |
| CN104013929A (en) | Rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and preparation method thereof | |
| CN101332268B (en) | Medicine for treating rhinitis, sinusitis | |
| CN102935159B (en) | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof | |
| CN111358906B (en) | Traditional Chinese medicine composition suitable for exogenous diseases | |
| CN102008635A (en) | Traditional Chinese medicine preparation for treating acute pancreatitis | |
| CN102283917A (en) | Deer bone medicated liquor for treating fracture | |
| CN101502583A (en) | Chinese medicament preparation for treating cholecystitis and gall-stone as well as preparation method thereof | |
| CN101732469B (en) | Application of Chinese medicinal composition in preparation of medicament for treating aphonia | |
| CN101239140A (en) | Chinese medicine for treating psoriasis | |
| CN100409892C (en) | Externally applied medicament for treating hyperplasia of mammary glands and preparation method thereof | |
| CN101194959B (en) | Capsule for treating headache and method for preparing the same | |
| CN101194963B (en) | Process for preparing medicine for treating headache | |
| CN104800339A (en) | Traditional Chinese medicine composition for treating bone fracture | |
| CN105267400A (en) | Medicine preparation for treating gynecological vaginitis | |
| CN104383263A (en) | Traditional Chinese medicine composition for treating bone fracture as well as preparation method and application thereof | |
| CN106853193A (en) | It is a kind of to treat Chinese medicine of rheumatoid arthritis and preparation method thereof | |
| CN104435149A (en) | Traditional Chinese medicine composition containing kadsura pepper stem for treating gout | |
| CN104352569A (en) | Trogopterus dung-containing traditional Chinese medicine composition for treating sprain | |
| CN101843695B (en) | Chinese medicament for treating chronic kidney failure | |
| CN103784706A (en) | Medicine composition for treating intestinal tympany of equus animals |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL Free format text: FORMER OWNER: NANJING ZHENGKUAN PHARMACEUTICAL SCIENCE AND TECHNOLOGY CO., LTD. Effective date: 20140815 |
|
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhao Jianhua Inventor after: Wang Chaowei Inventor after: Qin Xiuguang Inventor after: Li Qing Inventor after: Zhang Lijun Inventor before: The inventor has waived the right to be mentioned |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 211224 NANJING, JIANGSU PROVINCE TO: 453100 XINXIANG, HENAN PROVINCE Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: ZHAO JIANHUA WANG CHAOWEI QIN XIUGUANG LI QING ZHANG LIJUN |
|
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20140815 Address after: 453100 No. 88 health Road, Weihui, Henan, Xinxiang Applicant after: The First Affiliated Hospital of Xinxiang Medical University Address before: 211224 No. 1 Industrial Park, Jing Qiao Town, Lishui County, Jiangsu, Nanjing Applicant before: Nanjing Zhengkuan Pharmaceutical Science and Technology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140910 Termination date: 20151208 |
|
| EXPY | Termination of patent right or utility model |