CN104857299A - Traditional Chinese medicine granular preparation for treating osteoporosis - Google Patents
Traditional Chinese medicine granular preparation for treating osteoporosis Download PDFInfo
- Publication number
- CN104857299A CN104857299A CN201510261366.9A CN201510261366A CN104857299A CN 104857299 A CN104857299 A CN 104857299A CN 201510261366 A CN201510261366 A CN 201510261366A CN 104857299 A CN104857299 A CN 104857299A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- extraction
- ethanol
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a traditional Chinese medicine granular preparation for treating osteoporosis and belongs to the field of traditional Chinese medicine preparations. The traditional Chinese medicine granular preparation is prepared by extracting traditional Chinese medicines as follows: 18 parts of caulis tinosporae sinensis, 20 parts of campylotropis rockii schindl, 15 parts of all-grass of irisleaf oberonia, 10 parts of flueggea virosa and 20 parts of philippine violet herb. The traditional Chinese medicine granular preparation can increase the bone mineral density and treat osteoporosis.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to one and treat osteoporotic Chinese medicine granules and preparation method thereof and application.
Background technology
Osteoporosis and osteoporosis, be one group of osteopathia that many reasons causes, osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, be easy to fracture for feature.Market lacks effective medicine.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide one to treat osteoporotic Chinese medicine granules and preparation method thereof and application.
Technical scheme: the object of the invention is by following scheme realize:
One treats osteoporotic Chinese medicine granules, is prepared from by the Chinese medicine extraction of following component: Herba Lycopodii 18 parts, harms clovershrub root 20 parts, Herba Oberoniae iridifoliae 15 parts, plain rice set 10 parts, little Lan flower Herba Violae 20 parts.
The osteoporotic Chinese medicine of described treatment, preparation method is: go above-mentioned Chinese medicine to join in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 4-6%, extracting pressure 15-30MPa, temperature 30-50 DEG C, CO2 flow 1-3m1/g crude drug min, extraction time 150-180min, obtain supercritical extract, add 70% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, the amount of 70% ethanol at every turn added is 2 times of medical material weight, obtain extract, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, add adjuvant and be prepared into granule.
The osteoporotic Chinese medicine of described treatment, the percent by volume that the entrainer of CO2 supercritical extraction described in preparation method extracting method accounts for total extractant is 5%, the extracting pressure 20MPa of described CO2 supercritical extraction, temperature 40 DEG C, CO2 flow 2ml/g crude drug min, extraction time 160min, described microwave extracting power 500W, each extraction 6 minutes.
A kind of treat osteoporotic Chinese medicine granules preparation treatment osteoporotic Chinese medicine granules in application.
Herba Lycopodii is the dry ratan of menispermaceae plant Tinospora sinensis Tinosporasinensis (Lour.) Merr..Relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping.For rheumatic arthralgia, sciatica, lumbar muscle strain, traumatic injury.
Harms clovershrub root, latin name: Campylotropis rockii Schindl..The distribution ground such as Yunnan, Guizhou.For the root of leguminous plant harms clovershrub root.Warm in nature, sweet in the mouth.Stasis-dispelling and pain-killing, clearing away heat-damp and promoting diuresis.
Herba Oberoniae iridifoliae is the orchid family cowherb white orchid platymiscium Rhizoma Iridis Tectori Rhizoma Tupistrae Wattii Oberonia iridifolia Lindl., with all herbal medicine.The four seasons can adopt, and boiled water dries after scalding.Regulate the flow of vital energy and help digestion, clearing away heat and promoting diuresis, cough-relieving pain relieving.For dyspepsia, stomachache, enteritis, urinary tract infection, cough, bronchitis, asthma, traumatic injury, fracture, venom.
Plain rice tree is Euphorbiaceae, and plain rice Pterostyrax plant plain rice tree Fluggea virosa (Roxb.ex Willd.) Baill. [F.microcarpa Bl.], is used as medicine with Herb.With with adopting, many using fresh herbs.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, antipruritic hemostasis.Eczema is controlled in external, impetigo, allergic dermatitis, furuncle, burn and scald.
Little Lan flower Herba Violae is Polygalaceae polygala little Radix Polygalae Polygala sibirica L.var.megalopha Franch., is used as medicine with Herb.The whole year can adopt, and chopping is dried.Antiinflammatory, pain relieving, draws out pus by applying a plaster to the affected part, granulation promoting.For parotitis, infantile pneumonia, gastroenteritis, stomachache, furuncle, toothache, bones and muscles pain due to rheumatism; Skin ulcer, furuncle are controlled in external, stremma, traumatic injury impairment caused by overstrain.
Beneficial effect: Herba Lycopodii, harms clovershrub root, Herba Oberoniae iridifoliae relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping is monarch drug, plain rice tree heat-clearing and toxic substances removing, and reducing swelling and alleviating pain is ministerial drug, and little Lan flower Herba Violae is adjuvant, and full side increases bone density, treatment osteoporosis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: get Herba Lycopodii 18g, harms clovershrub root 20g, Herba Oberoniae iridifoliae 15g, plain rice tree 10g, little Lan flower Herba Violae 20g, above-mentioned Chinese medicine joins in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20MPa, temperature 40 DEG C, CO2 flow 2m1/g crude drug min, extraction time 160min, obtain supercritical extract, add 70% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 500W, extract 2 times, each 6 minutes, the amount of 70% ethanol at every turn added is 2 times of medical material weight, obtain extract, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, add starch 20g, be prepared into granule.
Embodiment 2: get Herba Lycopodii 18g, harms clovershrub root 20g, Herba Oberoniae iridifoliae 15g, plain rice tree 10g, little Lan flower Herba Violae 20g, above-mentioned Chinese medicine joins in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 4%, extracting pressure 30MPa, temperature 30 DEG C, CO2 flow 3m1/g crude drug min, extraction time 150min, obtain supercritical extract, add 70% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power-600W, extract 2 times, each 4 minutes, the amount of 70% ethanol at every turn added is 2 times of medical material weight, obtain extract, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, add dextrin 20g, be prepared into granule.
Embodiment 3: get Herba Lycopodii 18g, harms clovershrub root 20g, Herba Oberoniae iridifoliae 15g, plain rice tree 10g, little Lan flower Herba Violae 20g, above-mentioned Chinese medicine joins in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 15MPa, temperature 50 C, CO2 flow 1m1/g crude drug min, extraction time 150min, obtain supercritical extract, add 70% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 600W, extract 2 times, each 4 minutes, the amount of 70% ethanol at every turn added is 2 times of medical material weight, obtain extract, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, add dextrin 20g, be prepared into granule.
Embodiment 4: the present invention is on the pharmacodynamic study of the impact of the bone density of laboratory animal
Sample preparation: prepare by embodiment 3 method.Precious strong SHENGU JIAONANG, Shandong meeting elixir industry Group Co., Ltd, lot number: 20130711.Tretinoin sheet, Shandong Liang Fu pharmaceutical Co. Ltd, lot number: 120120
Animal: Wistar rat, male, body weight 180-240g, Shanghai Slac Experimental Animal Co., Ltd. provides.
Experiment grouping and the foundation of model rat with osteoporosis: get normal Wistar rats 30 and be divided into 5 groups at random, get wherein 6 be NS group; Get wherein 6 as model group, press tretinoin 70mg/kg gavage two weeks merely; Get wherein 6 precious strong SHENGU JIAONANG matched groups of conduct; Remaining 12 rats are as high low dose group of the present invention.Gavage corresponding medicine while gavaging tretinoin as ZHENMUSHENGU JIAONANG matched group and high and low dose group of the present invention by the dosage of 70mg/kg, withdraw tretinoin after gavaging two weeks and continue two weeks mensuration indices.Rat sacrificed by decapitation, gets its femur by group arrangement, uses X-line mammary gland video camera production mating plate, with black and white densimeter on the greater trochanter of femur, femoral head, neck of femur, intertrochanteric line and under intertrochanteric line 5 positions fixed points measure and record bone density value.
The present invention is on the impact of rat bone density
Note: compare with model group, * P<0.05; * P<0.01
Experimental result: the present invention compares with model group, has significant difference, illustrates that the present invention can improve bone density, treatment fracture, and effect is better than precious strong SHENGU JIAONANG, can be used for preparing the application increased in bone density medicine.
Claims (3)
1. treat an osteoporotic Chinese medicine granules, it is characterized in that being prepared from by the Chinese medicine extraction of following component: Herba Lycopodii 18 parts, harms clovershrub root 20 parts, Herba Oberoniae iridifoliae 15 parts, plain rice set 10 parts, little Lan flower Herba Violae 20 parts.
2. treat osteoporotic Chinese medicine according to claim 1, it is characterized in that preparation method is: get above-mentioned Chinese medicine and join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 4-6%, extracting pressure 15-30MPa, temperature 30-50 DEG C, CO
2flow 1-3m1/g crude drug min, extraction time 150-180min, obtains supercritical extract, add 70% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, the amount of 70% ethanol at every turn added is 2 times of medical material weight, obtain extract, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, add adjuvant and be prepared into granule.
3. treat osteoporotic Chinese medicine according to claim 1, it is characterized in that CO described in preparation method extracting method
2the percent by volume that supercritical extraction entrainer accounts for total extractant is 5%, described CO
2the extracting pressure 20MPa of supercritical extraction, temperature 40 DEG C, CO
2flow 2ml/g crude drug min, extraction time 160min, described microwave extracting power 500W, each extraction 6 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510261366.9A CN104857299A (en) | 2015-05-20 | 2015-05-20 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510261366.9A CN104857299A (en) | 2015-05-20 | 2015-05-20 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104857299A true CN104857299A (en) | 2015-08-26 |
Family
ID=53903762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510261366.9A Pending CN104857299A (en) | 2015-05-20 | 2015-05-20 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104857299A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250680A (en) * | 2015-10-05 | 2016-01-20 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutical preparation used for treating osteoporosis |
| CN107441171A (en) * | 2017-10-07 | 2017-12-08 | 南京正宽医药科技有限公司 | A kind of relaxing muscles and tendons capsule for treating fracture and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225138A (en) * | 2011-06-24 | 2011-10-26 | 南京中医药大学 | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof |
| CN102935159A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
| CN103467480A (en) * | 2013-10-10 | 2013-12-25 | 南京正亮医药科技有限公司 | Method for extracting artemisinin and application of artemisinin |
-
2015
- 2015-05-20 CN CN201510261366.9A patent/CN104857299A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225138A (en) * | 2011-06-24 | 2011-10-26 | 南京中医药大学 | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof |
| CN102935159A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating fracture as well as preparation method and application thereof |
| CN103467480A (en) * | 2013-10-10 | 2013-12-25 | 南京正亮医药科技有限公司 | Method for extracting artemisinin and application of artemisinin |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250680A (en) * | 2015-10-05 | 2016-01-20 | 淄博齐鼎立专利信息咨询有限公司 | Pharmaceutical preparation used for treating osteoporosis |
| CN107441171A (en) * | 2017-10-07 | 2017-12-08 | 南京正宽医药科技有限公司 | A kind of relaxing muscles and tendons capsule for treating fracture and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hou et al. | Origin and concept of medicine food homology and its application in modern functional foods | |
| CN102178809B (en) | Externally-applied medicament for skin and method for processing medicament into preparation | |
| CN105031307A (en) | Chinese drugs preparation for curing headache and preparation method for Chinese drugs pharmaceutics | |
| CN103784622A (en) | Traditional Chinese medicine for treating hyperosteogeny arthritis and preparation method thereof | |
| CN104857299A (en) | Traditional Chinese medicine granular preparation for treating osteoporosis | |
| CN107802763A (en) | A kind of new medicine composition for treating gout and preparation method | |
| CN105055918A (en) | Traditional Chinese medicine for treating bone diseases and preparation method thereof | |
| CN104026670A (en) | Manyprickle acathopanax root soup with function of strengthening tendons and bones and production method thereof | |
| CN103301337A (en) | Traditional Chinese medicine for treating bovine puerperal fever | |
| CN112972557A (en) | Medicinal liquor for treating arthralgia and myalgia and preparation method thereof | |
| CN105250959A (en) | Traditional Chinese medicine preparation for repairing liver damage and preparation method | |
| CN104306784A (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof | |
| CN105311306A (en) | Medicine for treating severe body odor | |
| CN104083710A (en) | Traditional Chinese medicine preparation for treating scleroderma | |
| CN103720973A (en) | Chinese herbal medicine for treating lumbar disc herniation and preparation method thereof | |
| CN104173491A (en) | Traditional Chinese herbal medicine extract preparation for preventing and treating cow sunstroke and preparation method of traditional Chinese herbal medicine extract preparation | |
| CN104306706B (en) | A kind of strong drug composition for treating chronic pelvic inflammatory disease | |
| CN103784736A (en) | Medicine composition for treating pregnancy toxaemia of equus animals | |
| CN107029098A (en) | A kind of Chinese medicine preparation Asmeton"strong" Capsules capsule | |
| CN104225100A (en) | Drug for treating knee osteoarthritis | |
| CN107261058A (en) | A kind of medicament for treating sclerotin retrogression pathological changes and preparation method thereof | |
| CN105250680A (en) | Pharmaceutical preparation used for treating osteoporosis | |
| CN102327581A (en) | Chinese herbal medicine for curing rheumatism | |
| CN104383263A (en) | Traditional Chinese medicine composition for treating bone fracture as well as preparation method and application thereof | |
| CN105055613A (en) | Liquid for treating ostalgia and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150826 |