CN107441171A - A kind of relaxing muscles and tendons capsule for treating fracture and preparation method thereof - Google Patents
A kind of relaxing muscles and tendons capsule for treating fracture and preparation method thereof Download PDFInfo
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- CN107441171A CN107441171A CN201710926540.6A CN201710926540A CN107441171A CN 107441171 A CN107441171 A CN 107441171A CN 201710926540 A CN201710926540 A CN 201710926540A CN 107441171 A CN107441171 A CN 107441171A
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- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The present invention provides a kind of relaxing muscles and tendons capsule for treating fracture, is prepared by following bulk drugs extraction：The 1400g of earthworm 600, the 210g of Semen Strychni (processed) 140, the 1000g of safflower 600, the 90g of vinegar-fried frankincense 60, the 90g of the root of fangji 60, the 90g of myrrh 60, the 90g of cortex periplocae 60, the 90g of Rhizoma drynariae preparata 60, using specific preparation method, obtained relaxing muscles and tendons capsule hydroxyl radical carthamin yellow carthamus A content is high, and finds that relaxing muscles and tendons capsule treatment fracture positive effect is better than original prescription.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, and in particular to a kind of relaxing muscles and tendons capsule for treating fracture and its preparation side
Method.
Background technology
Fracture is that the continuity of bone structure is broken completely or partially.Be more common in children and the elderly, young people also when
There is generation.Patient is often-individual position fracture, and minority is multiple fracture.Through appropriate processing in time, most patients can recover former
The function of coming, a few patients can leave different degrees of sequelae.Relaxing muscles and tendons capsule is recorded in《Chinese Pharmacopoeia》Version in 2010
One, channels sootheing and network vessel quickening, promoting blood circulation, swelling and pain relieving, using effect is not very good at present, and technique is coarse, falls behind, impurity
More, active constituent content is low, causes patient's dosage excessive, it has not been convenient to takes, has had a strong impact on that this product is clinically applied.
The content of the invention
Goal of the invention：In order to solve the above problems, it is an object of the invention to provide a kind of SHENJIN DAN glue for treating fracture
Capsule and preparation method thereof.
Technical scheme：The purpose of the present invention is realized by following scheme：
A kind of relaxing muscles and tendons capsule for treating fracture, it is prepared by following bulk drugs extraction：Earthworm 600-1400g, horse processed
Money 140-210g, safflower 600-1000g, vinegar-fried frankincense 60-90g, root of fangji 60-90g, myrrh 60-90g, cortex periplocae 60-90g,
Rhizoma drynariae preparata 60-90g.
The relaxing muscles and tendons capsule of the treatment fracture, is prepared by following bulk drugs extraction：Earthworm 800-1200g, horse processed
Money 150-200g, safflower 700-900g, vinegar-fried frankincense 65-85g, root of fangji 65-85g, myrrh 65-85g, cortex periplocae 65-85g,
Rhizoma drynariae preparata 65-85g.
The relaxing muscles and tendons capsule of the treatment fracture, is prepared by following bulk drugs extraction：Earthworm 1000g, Semen Strychni (processed)
175g, safflower 800g, vinegar-fried frankincense 75g, root of fangji 75g, myrrh 75g, cortex periplocae 500g, Rhizoma drynariae preparata 75g.
The relaxing muscles and tendons capsule of the treatment fracture, preparation method comprise the following steps：Above-mentioned medicinal material is taken, is measured with 6-10 times
70%-95% alcohol reflux extracts 1.5 hours, extracts 2 times, filtration, is concentrated under reduced pressure, obtains alcohol-extracted extract, then use frequency for
20~50kHz, voltage are 60V ultrasonic extraction 10min, filtration, are concentrated under reduced pressure, and are dried, and are pelletized, and sieving is filling to obtain SHENJIN DAN glue
Capsule.
Beneficial effect：The unique physical characteristic of ultrasonic wave can promote plant cell tissue's broken wall or deformation, make Chinese medicine effective
Constituents extraction is more abundant, and recovery rate is significantly improved up to 50-500% than traditional handicraft, and intensified by ultrasonic wave traditional Chinese medicine extraction is generally in 10-
Optimum extraction rate can be obtained within 40 minutes, extraction time greatly shortens more than 2/3 compared with conventional method, medicinal material raw material disposal amount
Greatly, the optimum temperature of ultrasonic extraction Chinese medicine is at 40-60 DEG C, in case of thermal instability, facile hydrolysis or the medicinal material of oxidation effectively into
Dividing has protective effect, while energy-conservation energy consumption significantly, ultrasonic extraction Chinese medicine are not limited by compositional polarity, molecular size range,
Suitable for the extraction of most species Chinese medicines and each constituents, extraction decoction impurity is few, and active ingredient is easily isolated, is pure
Change, extraction process operating cost is low, and overall economic efficiency is notable, and operation is simple, plant maintenance, easy maintenance.Existing skill
In art, relaxing muscles and tendons capsule is using the method for alcohol extracting, and technique is coarse, falls behind, and impurity is more, causes patient's dosage excessive, it has not been convenient to take
With hydroxyl radical carthamin yellow carthamus A yield increase in relaxing muscles and tendons capsule prepared by the present invention, content is high, and it is good to treat fracture effect.
Embodiment
Form by the following examples, the above of the present invention is described in further detail again, but should not be by this
The scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following example, and all technologies for being realized based on the above of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1：Take earthworm 600g, Semen Strychni (processed) 210g, safflower 600g, vinegar-fried frankincense 90g, root of fangji 60g, myrrh 90g,
Cortex periplocae 60g, Rhizoma drynariae preparata 90g, preparation method comprise the following steps：Above-mentioned medicinal material is taken, is returned with 70% ethanol of 10 times of amounts
Stream extraction 1.5 hours, is extracted 2 times, filtration, is concentrated under reduced pressure, is obtained alcohol-extracted extract, then uses frequency voltage surpasses for 60V for 20kHz
Sound extraction 10min, filtration, is concentrated under reduced pressure, dries, pelletize, and sieving is filling to obtain relaxing muscles and tendons capsule.
Embodiment 2：Take earthworm 1400g, Semen Strychni (processed) 140g, safflower 1000g, vinegar-fried frankincense 60g, root of fangji 90g, myrrh
60g, cortex periplocae 90g, Rhizoma drynariae preparata 60g, preparation method comprise the following steps：Above-mentioned medicinal material is taken, with 95% ethanol of 6 times of amounts
Refluxing extraction 1.5 hours, extract 2 times, filtration, be concentrated under reduced pressure, obtain alcohol-extracted extract, then use frequency as 50kHz, voltage 60V
Ultrasonic extraction 10min, filtration, is concentrated under reduced pressure, and dries, and pelletizes, and sieving is filling to obtain relaxing muscles and tendons capsule.
Embodiment 3：Take earthworm 1000g, Semen Strychni (processed) 175g, safflower 800g, vinegar-fried frankincense 75g, root of fangji 75g, myrrh
75g, cortex periplocae 500g, Rhizoma drynariae preparata 75g, preparation method comprise the following steps：Above-mentioned medicinal material is taken, with 85% second of 8 times of amounts
Alcohol reflux extracts 1.5 hours, extracts 2 times, filtration, is concentrated under reduced pressure, obtains alcohol-extracted extract, then uses frequency voltage is for 40kHz
60V ultrasonic extraction 10min, filtration, are concentrated under reduced pressure, and dry, and pelletize, and sieving is filling to obtain relaxing muscles and tendons capsule.
Comparative example 1：Take earthworm 250g, Semen Strychni (processed) 175g, safflower 175g, vinegar-fried frankincense 75g, root of fangji 75g, myrrh
75g, cortex periplocae 75g, Rhizoma drynariae preparata 75g, the taste of the above eight, are ground into fine powder, pelletize, and dry, and load capsule, are made 1000,
Produce.
Comparative example 2：Take earthworm 250g, Semen Strychni (processed) 175g, safflower 175g, vinegar-fried frankincense 75g, root of fangji 75g, myrrh
75g, cortex periplocae 75g, Rhizoma drynariae preparata 75g, preparation method comprise the following steps：Above-mentioned medicinal material is taken, with 85% ethanol of 8 times of amounts
Refluxing extraction 1.5 hours, extract 2 times, filtration, be concentrated under reduced pressure, obtain alcohol-extracted extract, then use frequency as 40kHz, voltage 60V
Ultrasonic extraction 10min, filtration, is concentrated under reduced pressure, and dries, and pelletizes, and sieving is filling to obtain relaxing muscles and tendons capsule.
Embodiment 4：Hydroxyl radical carthamin yellow carthamus A assay experimental study data in relaxing muscles and tendons capsule of the present invention
1.1 Experimental agents：Relaxing muscles and tendons capsule is prepared using comparative example 1 and 2.
1.2 instrument：High performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pumps；
The UV-detectors of Waters 2487 and GJ605 type high pressure six-way injection valves；Chromatographic column is ODS-C18 (diamond) chromatographic column
(250mm×4.6mm,5μm)；Data acquisition and processing are using HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determination：Determined according to high performance liquid chromatography (two D of annex V of Chinese Pharmacopoeia version in 2000).Using
ODS-C18 (diamond) chromatographic column (250mm × 4.6mm, 5 μm), mobile phase are the phosphate aqueous solution of methanol -0.5% (40：60)；Stream
Speed is 1.0mL/min, and Detection wavelength 400nm, sample size is 10 μ L.
1.4 experimental result
Hydroxyl radical carthamin yellow carthamus A assay result in relaxing muscles and tendons capsule prepared by each embodiment
| Sample source | Hydroxyl radical carthamin yellow carthamus A content (%) |
| Comparative example 1 | 0.12 |
| Comparative example 2 | 0.67 |
Hydroxyl radical carthamin yellow carthamus A contains in the relaxing muscles and tendons capsule prepared according to the results showed that comparative example 2 of upper table
Amount is apparently higher than 1 group of comparative example.
Embodiment 5：The pharmacodynamic study of influence of the present invention to the bone density of experimental animal
Sample preparation：Sample is prepared by embodiment 3 and the method for comparative example 1.Tretinoin piece, the good good fortune pharmacy in Shandong are limited
Company, lot number：150120
Animal：Wistar rats, male, body weight 180-240g, Shanghai Slac Experimental Animal Co., Ltd. provide.
The foundation of experiment packet and model rat with osteoporosis：Take normal Wistar rats 40 to be only randomly divided into 4 groups, take it
In 10 be NS groups；Take wherein 10 to be only used as model group, press Tretinoin 70mg/kg gavages merely two weeks；Wherein 20 are taken to be only used as reality
Apply sample sets prepared by 3 groups of example and the method for comparative example 1.Withdraw Tretinoin after gavaging two weeks and continue two weeks measure items
Index.Rat sacrificed by decapitation, take its femur by group arrangement, using X- line mammary gland video camera produce mating plate, with black and white densitometer in
The greater trochanter of femur, femoral head, neck of femur, 5 positions fixed point determines and records bone density value on intertrochanteric line and under intertrochanteric line.
Influence of the present invention to rat bone density
Note：Compared with model group, * P<0.05；**P<0.01
Experimental result：The present invention has significant difference, illustrates that the present invention can improve bone density, control compared with model group
Fracture is treated, and the positive effect of embodiment 3 is better than comparative example 1.
Claims (4)
1. a kind of relaxing muscles and tendons capsule for treating fracture, it is characterised in that be prepared by the bulk drug extraction of following weight：Earthworm
600-1400g, Semen Strychni (processed) 140-210g, safflower 600-1000g, vinegar-fried frankincense 60-90g, root of fangji 60-90g, myrrh 60-
90g, cortex periplocae 60-90g, Rhizoma drynariae preparata 60-90g.
2. the relaxing muscles and tendons capsule of fracture is treated according to claim 1, it is characterised in that extracted by the bulk drug of following weight
It is prepared：Earthworm 800-1200g, Semen Strychni (processed) 150-200g, safflower 700-900g, vinegar-fried frankincense 65-85g, root of fangji 65-
85g, myrrh 65-85g, cortex periplocae 65-85g, Rhizoma drynariae preparata 65-85g.
3. the relaxing muscles and tendons capsule of fracture is treated according to claim 2, it is characterised in that extracted by the bulk drug of following weight
It is prepared：Earthworm 1000g, Semen Strychni (processed) 175g, safflower 800g, vinegar-fried frankincense 75g, root of fangji 75g, myrrh 75g, cortex periplocae
500g, Rhizoma drynariae preparata 75g.
4. the relaxing muscles and tendons capsule of fracture is treated according to claim 1, it is characterised in that preparation method comprises the following steps：
Above-mentioned medicinal material is taken, is extracted 1.5 hours, extracted 2 times with the 6-10 times of 70%-95% measured alcohol reflux, filtration, is concentrated under reduced pressure,
Alcohol-extracted extract is obtained, then uses frequency as 20~50kHz, voltage is 60V ultrasonic extraction 10min, filtration, is concentrated under reduced pressure, and is dried, system
Grain, sieving are filling to obtain relaxing muscles and tendons capsule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710926540.6A CN107441171A (en) | 2017-10-07 | 2017-10-07 | A kind of relaxing muscles and tendons capsule for treating fracture and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710926540.6A CN107441171A (en) | 2017-10-07 | 2017-10-07 | A kind of relaxing muscles and tendons capsule for treating fracture and preparation method thereof |
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| CN107441171A true CN107441171A (en) | 2017-12-08 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293013A (en) * | 2007-04-26 | 2008-10-29 | 浙江新光药业有限公司 | Pharmaceutical composition for treating paralysis, preparation technique and quality testing method |
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
| CN105148019A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating fractures |
-
2017
- 2017-10-07 CN CN201710926540.6A patent/CN107441171A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293013A (en) * | 2007-04-26 | 2008-10-29 | 浙江新光药业有限公司 | Pharmaceutical composition for treating paralysis, preparation technique and quality testing method |
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
| CN105148019A (en) * | 2015-09-27 | 2015-12-16 | 南京晶云化工有限公司 | Medicinal preparation used for treating fractures |
Non-Patent Citations (2)
| Title |
|---|
| 吴亚山等: "伸筋丹胶囊治疗坐骨神经痛30例——附追风透骨丸治疗30例对照", 《浙江中医杂志》 * |
| 国家药典委员会编: "《中华人民共和国药典》", 30 June 2015 * |
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