CN106806474A - A kind of Anti-depressive traditional Chinese medicinal composition and preparation method thereof - Google Patents
A kind of Anti-depressive traditional Chinese medicinal composition and preparation method thereof Download PDFInfo
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- CN106806474A CN106806474A CN201510861098.4A CN201510861098A CN106806474A CN 106806474 A CN106806474 A CN 106806474A CN 201510861098 A CN201510861098 A CN 201510861098A CN 106806474 A CN106806474 A CN 106806474A
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Abstract
The invention provides a kind of Anti-depressive traditional Chinese medicinal composition, it is prepared from by bulk drugs such as radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizaes.Present invention also offers the preparation method of the pharmaceutical composition.
Description
Technical field
The invention belongs to the field of Chinese medicines, be related to a kind of Chinese medicine composition, it is more particularly to a kind of for prevent and treat depression by Chinese medicine compositions being prepared from such as radix bupleuri, Radix Angelicae Sinensis and preparation method thereof.
Background technology
Depression is a kind of common mental disease.In global range, have and suffer from depression more than 3.5 hundred million people, spread all over all age group.Showing as depression is sad, lose enjoyment, retardation of thinking, listless, social withdrawal, or even pessimistic and worldweary, there is suicidal thought or behavior.Not yet determine for the depressed cause of disease at present, it is related to biological, psychology, social environment many factors, and existing medicine has Western medicine Prozac, Fluvoxamine etc., and Chinese medicine has Danzhi Xiaoyao San, depression alleviating pills etc..
Melancholia category can be listed in the depression traditional Chinese medical science in, be mostly due to emotional discomfort, what depression and stagnation of QI caused, it is general it is dialectical is stagnation of liver qi, qi depression transforming into fire, mental disorder pent-up, the mind is lost and is supported, the insufficiency of heart and spleen, heart kidney-yin deficiency, fire excess from yin deficiency etc..
The easy recurrent exerbation of depression, extreme influence is brought to minimal invasive treatment, and depression has some Precursory Characters, prophylactic treatment should need to be carried out to patient, to repeatedly hair author, need long-term treatment, for the etiology and pathogenesis feature of depression, the new Chinese medicine for preventing and treating depression is developed extremely urgent.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition and its production and use, it has good antidepressant effect.
The present invention provides a kind of Chinese medicine composition, is prepared from by the raw material of following weight portion：
Radix bupleuri 10-14 portions of 8-12 parts of Radix Angelicae Sinensis 8-12 portions of root of herbaceous peony
Dried orange peel 6-10 parts of Ligusticum wallichii 1-3 parts of 6-10 parts of Radix Glycyrrhizae (honey is processed)
Further, above-mentioned Chinese medicine composition, it is characterised in that be prepared from by the raw material of following weight portion：
12 portions of radix bupleuri, 10 portions of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peony
8 parts of 8 parts of dried orange peel, 2 portions of Ligusticum wallichii Radix Glycyrrhizae (honey is processed)
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
Radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by weight, it is ground into fine powder, plus 60%-80% ethanol is extracted 2 times, 1-2 hours every time, 6-10 times is added every time and measures ethanol, merge extract solution, filtration, clear cream is concentrated into, is dried, the powder that gets dry extract is made required dosage formulation with pharmaceutically acceptable auxiliary material thereafter.
Further, above-mentioned preparation method, comprises the following steps：
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by weight, above Six-element is taken, and are ground into fine powder, plus 60%-80% ethanol is extracted 2 times, 1-2 hours every time, 6-10 times is added every time and measures ethanol, merge extract solution, filtration, clear cream is concentrated into, is dried, it is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol softwood, granulation is dried, whole grain, adds magnesium stearate, is well mixed, compressing tablet.
Further, above-mentioned preparation method, the relative density of clear cream is 1.24-1.26 (65 DEG C) in the step (1)；Drying temperature is 60-80 DEG C in the step (2).
The present invention also provides application of the above-mentioned Chinese medicine composition in preventing and treating antidepressant agents are prepared.
Beneficial effects of the present invention：Radix bupleuri soothing liver-qi stagnation in Chinese prescription provided by the present invention, is monarch, the soft liver blood-nourishing of the root of herbaceous peony, is minister, Chinese angelica blood supplementing blood-nourishing, promoting blood circulation and stopping pain, dried orange peel regulating qi-flowing for strengthening spleen, Ligusticum wallichii blood-activating and qi-promoting, Radix Glycyrrhizae coordinating the drug actions of a prescription, beneficial spleen and in；All medicines share, treats both principal and secondary aspect of disease, and makes equilibrium between yin and yang, qi and blood smooth, and long memorial liver and qi solution is strongly fragrant altogether, effect of invigorating the spleen clearing away the heart fire and tranquillizing.
Specific embodiment
Embodiment 1
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by following weight portion：
Radix bupleuri 120g Radix Angelicae Sinensis 100g root of herbaceous peonys 100g
Dried orange peel 80g Ligusticum wallichii 20g Radix Glycyrrhizae (honey is processed) 80g
Above Six-element is taken, fine powder is ground into, plus 75% ethanol is extracted 2 times, 2 hours every time, 8 times of ethanol is added every time, merges extract solution, filtration is concentrated into 1.24-1.26 (65 DEG C) clear cream, and microwave drying is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol solution granulation, 60-80 DEG C of drying, whole grain adds magnesium stearate, is well mixed, compressing tablet.
Embodiment 2
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by following weight portion：
Radix bupleuri 140g Radix Angelicae Sinensis 120g root of herbaceous peonys 120g
Dried orange peel 60g Ligusticum wallichii 30g Radix Glycyrrhizae (honey is processed) 60g
Above Six-element is taken, fine powder is ground into, plus 80% ethanol is extracted 2 times, 1 hour every time, 10 times of amount ethanol is added every time, merges extract solution, filtration is concentrated into 1.24-1.26 (65 DEG C) clear cream, and microwave drying is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol solution granulation, 60-80 DEG C of drying, whole grain adds magnesium stearate, is well mixed, compressing tablet.
Embodiment 3
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by following weight portion：
Radix bupleuri 100g Radix Angelicae Sinensis 80g root of herbaceous peonys 80g
Dried orange peel 100g Ligusticum wallichii 10g Radix Glycyrrhizae (honey is processed) 100g
Above Six-element is taken, fine powder is ground into, plus 60% ethanol is extracted 2 times, 2 hours every time, 6 times of ethanol is added every time, merges extract solution, filtration is concentrated into 1.24-1.26 (65 DEG C) clear cream, and microwave drying is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol solution granulation, 60-80 DEG C of drying, whole grain adds magnesium stearate, is well mixed, compressing tablet.
Comparative example 1
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by following weight portion：
Radix bupleuri 100g Radix Angelicae Sinensis 180g root of herbaceous peonys 180g
Dried orange peel 100g Ligusticum wallichii 30g Radix Glycyrrhizae (honey is processed) 100g
Above Six-element is taken, fine powder is ground into, plus 75% ethanol is extracted 2 times, 2 hours every time, 6 times of ethanol is added every time, merges extract solution, filtration is concentrated into 1.24-1.26 (65 DEG C) clear cream, and microwave drying is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol solution granulation, 60-80 DEG C of drying, whole grain adds magnesium stearate, is well mixed, compressing tablet.
Comparative example 2
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by following weight portion：
Radix bupleuri 100g Radix Angelicae Sinensis 30g root of herbaceous peonys 60g
Dried orange peel 50g Ligusticum wallichii 30g Radix Glycyrrhizae (honey is processed) 80g
Above Six-element is taken, fine powder is ground into, plus 75% ethanol is extracted 2 times, 2 hours every time, 6 times of ethanol is added every time, merges extract solution, filtration is concentrated into 1.24-1.26 (65 DEG C) clear cream, and microwave drying is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol solution granulation, 60-80 DEG C of drying, whole grain adds magnesium stearate, is well mixed, compressing tablet.
For a better understanding of the present invention, embodiment 1-3 and comparative example 1-2 gained samples are carried out into following pharmacodynamic experiment.
First, Tail suspension test
Experimental animal and packet：ICR mouse (male, 20 ± 2g) 72, are randomly divided into 6 groups, every group 12.It is divided into blank group, 1 group of experiment, 2 groups of experiment, 3 groups of experiment, 1 group of contrast, 2 groups of contrast, experiment 1-3 groups are administered embodiment 1-3 gained samples respectively, contrast 1-2 groups are administered comparative example 1-2 groups gained sample respectively, blank group gives isometric physiological saline gastric infusion, and experimental group and contrast groups are by the dosage gastric infusion containing crude drug amount 35g/kg.
Experimental technique：Continuous gavage is administered 14 days, and 1h does Tail suspension test after administration, will be fixed in same level with glutinous cream bar at mouse tail end 2cm, makes it be in projecting state, and destage face 15cm, surrounding isolates animal sight line with plank, the mouse accumulation dead time in 5min after record.
Experimental result：Experimental result refers to table 1, and knowable to experimental result, administration group compares with blank group and is respectively provided with significant difference, to test 1 group of best results；The effect of contrast groups is good compared with blank group, has significant difference with administration group.
2nd, mouse forced swimming test
Experimental animal and packet：ICR mouse (male, 20 ± 2g) 72, are randomly divided into 6 groups, every group 12.It is divided into blank group, 1 group of experiment, 2 groups of experiment, 3 groups of experiment, 1 group of contrast, 2 groups of contrast, experiment 1-3 groups are administered embodiment 1-3 gained samples respectively, contrast 1-2 groups are administered comparative example 1-2 groups gained sample respectively, blank group gives isometric physiological saline gastric infusion, and experimental group and contrast groups are by the dosage gastric infusion containing crude drug amount 35g/kg.
Experimental technique：Continuous gavage is administered the 14th day, after last dose 1h, and mouse is placed in into 25cm high, and in the lucite cylinder of diameter 13cm, depth of water 12cm, water temperature is 22-25 DEG C.Dead time in 4min after observation 6min records (i.e. mouse to stop struggle or in floating state in water, only small limb motion to keep head to keep afloat).
Experimental result：Experimental result refers to table 1, and knowable to experimental result, administration group compares with blank group and is respectively provided with significant difference, to test 1 group of best results；The effect of contrast groups is good compared with blank group, has significant difference with administration group.
The each group Tail suspension test of table 1 and forced swim test result (N=12)
Note：With blank group contrast, * * P ＜ 0.01；Compared with 2 groups of contrast, △ △ P ＜ 0.01.
Claims (7)
1. a kind of Chinese medicine composition, it is characterised in that be prepared from by the raw material of following weight portion：
Radix bupleuri 10-14 portions of 8-12 parts of Radix Angelicae Sinensis 8-12 portions of root of herbaceous peony
Dried orange peel 6-10 parts of Ligusticum wallichii 1-3 parts of 6-10 parts of Radix Glycyrrhizae (honey is processed).
2. Chinese medicine composition according to claim 1, it is characterised in that be prepared from by the raw material of following weight portion：
12 portions of radix bupleuri, 10 portions of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peony
8 parts of 8 parts of dried orange peel, 2 portions of Ligusticum wallichii Radix Glycyrrhizae (honey is processed).
3. the preparation method of the Chinese medicine composition described in claim 1 or 2, is characterised by comprising the following steps：
Radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by weight, it is ground into fine powder, plus 60%-80% ethanol is extracted 2 times, 1-2 hours every time, 6-10 times is added every time and measures ethanol, merge extract solution, filtration, clear cream is concentrated into, is dried, the powder that gets dry extract is made required dosage formulation with pharmaceutically acceptable auxiliary material thereafter.
4. the preparation method of the Chinese medicine composition described in claim 1 or 2, it is characterised in that comprise the following steps：
(1) radix bupleuri, Radix Angelicae Sinensis, the root of herbaceous peony, dried orange peel, Ligusticum wallichii, Radix Glycyrrhizae Six-element raw material are weighed by weight, above Six-element is taken, and are ground into fine powder, plus 60%-80% ethanol is extracted 2 times, 1-2 hours every time, 6-10 times is added every time and measures ethanol, merge extract solution, filtration, clear cream is concentrated into, is dried, it is standby；
(2) dried cream powder, microcrystalline cellulose, hydroxypropyl cellulose, PVPP are taken, the clear cream obtained with step (1) is well mixed, adds ethanol softwood, granulation is dried, whole grain, adds magnesium stearate, is well mixed, and compressing tablet is obtained final product.
5. preparation method according to claim 4, it is characterised in that the relative density of clear cream is 1.24-1.26 (65 DEG C) in the step (1).
6. preparation method according to claim 4, it is characterised in that drying temperature is 60-80 DEG C in the step (2).
7. application of the Chinese medicine composition described in claim 1 or 2 in preventing and treating antidepressant agents are prepared.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772580A (en) * | 2019-11-21 | 2020-02-11 | 江西中医药大学 | Sleep-regulating composition, compound essential oil and application thereof |
| CN111671868A (en) * | 2020-05-11 | 2020-09-18 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for treating coronavirus pneumonia and insomnia |
-
2015
- 2015-12-01 CN CN201510861098.4A patent/CN106806474A/en active Pending
Non-Patent Citations (2)
| Title |
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| 何天富等: "《中药快速记忆法》", 30 April 2015, 金盾出版社 * |
| 李庆业等: "《传统方剂手册》", 28 February 2005, 福建科学技术出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772580A (en) * | 2019-11-21 | 2020-02-11 | 江西中医药大学 | Sleep-regulating composition, compound essential oil and application thereof |
| CN110772580B (en) * | 2019-11-21 | 2022-01-28 | 江西中医药大学 | Compound essential oil for adjusting sleep |
| CN111671868A (en) * | 2020-05-11 | 2020-09-18 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition for treating coronavirus pneumonia and insomnia |
| CN111671868B (en) * | 2020-05-11 | 2021-09-10 | 首都医科大学附属北京中医医院 | Novel traditional Chinese medicine composition for treating mild symptoms, namely coronavirus pneumonia and insomnia |
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