CN105250680A - Pharmaceutical preparation used for treating osteoporosis - Google Patents
Pharmaceutical preparation used for treating osteoporosis Download PDFInfo
- Publication number
- CN105250680A CN105250680A CN201510645464.2A CN201510645464A CN105250680A CN 105250680 A CN105250680 A CN 105250680A CN 201510645464 A CN201510645464 A CN 201510645464A CN 105250680 A CN105250680 A CN 105250680A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical preparation
- radix
- treatment
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of Chinese herbal preparations and particularly provides a pharmaceutical preparation used for treating osteoporosis. The pharmaceutical preparation is prepared from 25 parts of lindernia ruellioides, 28 parts of litsea glutinosa, 20 parts of desmos cochinchinensis, 25 parts of Chinese pholidota herbs, 18 parts of ground beeltles, 20 parts of pseudo-ginseng, 25 parts of Chinese starjasmine stems, 25 parts of Chinese yam, 20 parts of radix dipsaci, 20 parts of pyrola herbs, 20 parts of gynostemma pentaphylla, 25 parts of radix paeoniae alba, 20 parts of the roots of red-rooted salvia, 15 parts of eucommia ulmoides, 15 parts of semen plantaginis and 5 parts of licorice. The pharmaceutical preparation can treat osteoporosis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of osteoporotic pharmaceutical preparation and its preparation method and application.
Background technology
Osteoporosis and osteoporosis, be one group of osteopathia that many reasons causes, osseous tissue has normal calcification, and calcium salt and substrate are normal rates, and the metabolic osteopathy being reduced to feature with unit volume inner bone tissues amount becomes.In most osteoporosis, caused by the minimizing of osseous tissue increases mainly due to bone absorption.With skeleton pain, be easy to fracture for feature.For this reason, be bursting to develop and manyly treat the needs that osteoporotic medicine meets clinical treatment safely and effectively.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of bone loss disorders.In order to reach this object, adopt following technical scheme:
Technical scheme: one is used for the treatment of osteoporotic pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Lindernia ruellioides (Colsm.) Pennell 25 parts, purling 28 parts, withered tree, curled paralysis 20 parts, Pseudobulbus Pholidotae Chinensis 25 parts, Eupolyphaga Seu Steleophaga 18 parts, Radix Notoginseng 20 parts, Caulis Trachelospermi 25 parts, Rhizoma Dioscoreae 25 parts, Radix Dipsaci 20 parts, Herba Pyrolae 20 parts, Herb Gynostemmae Pentaphylli 20 parts, the Radix Paeoniae Alba 25 parts, Radix Salviae Miltiorrhizae 20 parts, the Cortex Eucommiae 15 parts, Semen Plantaginis 15 parts, 5 parts, Radix Glycyrrhizae.
Describedly be used for the treatment of osteoporotic pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.
Describedly be used for the treatment of osteoporotic pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
Described be used for the treatment of osteoporotic pharmaceutical preparation preparation treatment medicine for treating osteoporosis in application.
Lindernia ruellioides (Colsm.) Pennell, Latin is called Linderniaruellioides (Colsm) Pennell., Scrophulariaceae Vandellia annual herb, high 10-15cm.Stem is weak, few upright, multi-branched and long climing, and joint is taken root, near without hair.Leaf is to life; The long 3-20mm of handle, base portion how many armfuls of stems; Blade Long Circle, ellipticity tables, ovum shape Long Circle or circle, long 1-4cm, wide 0.6-2cm, tip circle is blunt or anxious sharp, the wide wedge shape of base portion, and edge is anxious tapering sawtooth significantly, and without prickle, two sides is by rough undercoat.Raceme top is raw, flower 2-10 piece; Bract drapes over one's shoulders needle-like bar shaped; Bennet is short, is gradually slightly connected in calyx, without hair to top; Calyx 5 drastic crack, sliver wire lanceolar, without hair; Corolla aubergine, corolla pipe is cylindric, and upper lip upright 2 splits, and lower lip is expanded, and 3 split, and sliver is several equal; Stamen 4,2 pieces, front is sterile, and 2 pieces, rear can be educated, without appurtenance; Style has wide and flat stigma.Capsule is cylindrical, long 1.5-2cm, is about 2 times than Constellation calyx.Seed is oval, brown.Florescence 6-9, the fruit phase 7-11 month.Vital energy regualting and blood circulation-promoting, reducing swelling and alleviating pain.For amenorrhea, dysmenorrhea, stomachache, mastitis, lymphoid tuberculosis; Traumatic injury is controlled in external, carbuncle pain, venom, lyssodexis.The present invention is with all herbal medicine.
Purling withered tree is purling withered tree Litseaglutinosa (Lour.) C.B.Rob. of Lauraceae Litsea plant, is used as medicine with root, skin, leaf.Xia Qiu gathers, and root is cleaned section and dried; The many using fresh herbs of leaf, skin.Clearing away damp-heat, detumescence poison, hemostasis, pain relieving.Root: take orally and control diarrhoea, traumatic injury, parotitis, diabetes.Skin, leaf: parotitis is controlled in external, furuncle carbuncle, mastitis from the beginning of, traumatic injury, traumatic hemorrhage.The present invention adopts root to be used as medicine.
Curled paralysis is annonaceae Desmos Lour Desmos chinensis DesmoscochinchinensisLour., is used as medicine with root and Herb.The whole year can adopt, and clean chopping is dried.Expelling wind and removing dampness, spleen invigorating is regulated the flow of vital energy, stasis-dispelling and pain-killing.For rheumatic arthritis, puerperal exposure to wind pain, puerperal abdonimal pain, bleed more than, dysmenorrhea, stomachache, stomachache, abdominal distention, dyspepsia, diarrhoea, oedema due to nephritis, traumatic injury.The present invention is used as medicine with Herb.
Pseudobulbus Pholidotae Chinensis is herb or the pseudobulb of monocotyledon medicine the orchid family peach family plant seed Pseudobulbus Pholidotae Chinensis.Clearing away heat and nourishing YIN, preventing phlegm from forming and stopping coughing.For cough due to lung-heat, pulmonary tuberculosis hemoptysis, tuberculous lymphadenitis, infantile malnutrition, taste-blindness rate; Chronic osteomyelitis is controlled in external.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science belongs to " atrophic debility of bones, bone withered, rheumatism involving the bone " category osteoporosis, thinks that its pathogeny is for suffer from a deficiency of the kidney and insufficiency of the spleen, therefore adopts the therapeutic rules of invigorating the kidney and strengthening the bones, replenishing QI to invigorate the spleen for pathogenesis.Lindernia ruellioides (Colsm.) Pennell of the present invention, purling withered tree, curled paralysis, Pseudobulbus Pholidotae Chinensis, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Caulis Trachelospermi strengthening the tendons and bones, nourishing the liver and kidney are monarch drug, Rhizoma Dioscoreae, Radix Dipsaci, Herba Pyrolae, Herb Gynostemmae Pentaphylli, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Semen Plantaginis replenishing QI to invigorate the spleen are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment osteoporosis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, the preparation of granule embodiment: get Lindernia ruellioides (Colsm.) Pennell 25g, purling withered tree 28g, curled paralysis 20g, Pseudobulbus Pholidotae Chinensis 25g, Eupolyphaga Seu Steleophaga 18g, Radix Notoginseng 20g, Caulis Trachelospermi 25g, Rhizoma Dioscoreae 25g, Radix Dipsaci 20g, Herba Pyrolae 20g, Herb Gynostemmae Pentaphylli 20g, Radix Paeoniae Alba 25g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae 15g, Semen Plantaginis 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
Embodiment 2, the preparation of Tablets Example: get Lindernia ruellioides (Colsm.) Pennell 25g, purling withered tree 28g, curled paralysis 20g, Pseudobulbus Pholidotae Chinensis 25g, Eupolyphaga Seu Steleophaga 18g, Radix Notoginseng 20g, Caulis Trachelospermi 25g, Rhizoma Dioscoreae 25g, Radix Dipsaci 20g, Herba Pyrolae 20g, Herb Gynostemmae Pentaphylli 20g, Radix Paeoniae Alba 25g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae 15g, Semen Plantaginis 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
Embodiment 3, the preparation of capsule embodiment: get Lindernia ruellioides (Colsm.) Pennell 25g, purling withered tree 28g, curled paralysis 20g, Pseudobulbus Pholidotae Chinensis 25g, Eupolyphaga Seu Steleophaga 18g, Radix Notoginseng 20g, Caulis Trachelospermi 25g, Rhizoma Dioscoreae 25g, Radix Dipsaci 20g, Herba Pyrolae 20g, Herb Gynostemmae Pentaphylli 20g, Radix Paeoniae Alba 25g, Radix Salviae Miltiorrhizae 20g, Cortex Eucommiae 15g, Semen Plantaginis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
Embodiment 4: the present invention is on the pharmacodynamic study of the impact of the bone density of laboratory animal
Sample preparation: prepare by embodiment 1 method.Precious strong SHENGU JIAONANG, Shandong meeting elixir industry Group Co., Ltd, lot number: 20140713.Tretinoin sheet, Shandong Liang Fu pharmaceutical Co. Ltd, lot number: 130110
Animal: Wistar rat, male, body weight 180-240g, Shanghai Slac Experimental Animal Co., Ltd. provides.
Experiment grouping and the foundation of model rat with osteoporosis: get normal Wistar rats 30 and be divided into 5 groups at random, get wherein 6 be NS group; Get wherein 6 as model group, press tretinoin 70mg/kg gavage two weeks merely; Get wherein 6 precious strong SHENGU JIAONANG matched groups of conduct; Remaining 12 rats are as high low dose group of the present invention.Gavage corresponding medicine while gavaging tretinoin as ZHENMUSHENGU JIAONANG matched group and high and low dose group of the present invention by the dosage of 70mg/kg, withdraw tretinoin after gavaging two weeks and continue two weeks mensuration indices.Rat sacrificed by decapitation, gets its femur by group arrangement, uses X-line mammary gland video camera production mating plate, with black and white densimeter on the greater trochanter of femur, femoral head, neck of femur, intertrochanteric line and under intertrochanteric line 5 positions fixed points measure and record bone density value.
The present invention is on the impact of rat bone density
Note: compare with model group, * P<0.05; * P<0.01
Experimental result: the present invention compares with model group, has significant difference, illustrates that the present invention can improve bone density, treatment fracture, and effect is better than precious strong SHENGU JIAONANG, can be used for preparing the application increased in bone density medicine.
Claims (4)
1. one kind is used for the treatment of osteoporotic pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Lindernia ruellioides (Colsm.) Pennell 25 parts, purling 28 parts, withered tree, curled paralysis 20 parts, Pseudobulbus Pholidotae Chinensis 25 parts, Eupolyphaga Seu Steleophaga 18 parts, Radix Notoginseng 20 parts, Caulis Trachelospermi 25 parts, Rhizoma Dioscoreae 25 parts, Radix Dipsaci 20 parts, Herba Pyrolae 20 parts, Herb Gynostemmae Pentaphylli 20 parts, the Radix Paeoniae Alba 25 parts, Radix Salviae Miltiorrhizae 20 parts, the Cortex Eucommiae 15 parts, Semen Plantaginis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of osteoporotic pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of osteoporotic pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of osteoporotic pharmaceutical preparation in treatment medicine for treating osteoporosis according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510645464.2A CN105250680A (en) | 2015-10-05 | 2015-10-05 | Pharmaceutical preparation used for treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510645464.2A CN105250680A (en) | 2015-10-05 | 2015-10-05 | Pharmaceutical preparation used for treating osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250680A true CN105250680A (en) | 2016-01-20 |
Family
ID=55090808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510645464.2A Withdrawn CN105250680A (en) | 2015-10-05 | 2015-10-05 | Pharmaceutical preparation used for treating osteoporosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250680A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468829A (en) * | 2017-10-07 | 2017-12-15 | 南京正宽医药科技有限公司 | A kind of externally-applied ointment for being used to treat osteoporosis |
| CN116832082A (en) * | 2023-07-13 | 2023-10-03 | 海南医学院 | A radix seu cortex Litseae Rubrae extract, its preparation method and application in preparing medicine for treating and/or preventing cardiovascular diseases |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864710A (en) * | 2005-05-19 | 2006-11-22 | 北京燕京中科生物技术有限公司 | A medicine for treating osteoporosis |
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
-
2015
- 2015-10-05 CN CN201510645464.2A patent/CN105250680A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864710A (en) * | 2005-05-19 | 2006-11-22 | 北京燕京中科生物技术有限公司 | A medicine for treating osteoporosis |
| CN104857299A (en) * | 2015-05-20 | 2015-08-26 | 南京华宽信息咨询中心 | Traditional Chinese medicine granular preparation for treating osteoporosis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468829A (en) * | 2017-10-07 | 2017-12-15 | 南京正宽医药科技有限公司 | A kind of externally-applied ointment for being used to treat osteoporosis |
| CN116832082A (en) * | 2023-07-13 | 2023-10-03 | 海南医学院 | A radix seu cortex Litseae Rubrae extract, its preparation method and application in preparing medicine for treating and/or preventing cardiovascular diseases |
| CN116832082B (en) * | 2023-07-13 | 2024-05-17 | 海南医学院 | A radix seu cortex Litseae Rubrae extract, its preparation method and application in preparing medicine for treating and/or preventing cardiovascular diseases |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102225138B (en) | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof | |
| CN104095091A (en) | Kidney nourishing and lung moisturizing health care tea and preparation method thereof | |
| CN105616356A (en) | Peach seed-safflower Siwu granule originated from peach seed-safflower Siwu decoction, and preparation method thereof | |
| CN105148019A (en) | Medicinal preparation used for treating fractures | |
| CN105250680A (en) | Pharmaceutical preparation used for treating osteoporosis | |
| CN1127967C (en) | Quick-acting hypertension capsule | |
| CN104001004A (en) | Traditional Chinese medicine composition for curing fractures and osteoporosis and preparation method and application thereof | |
| CN101890146A (en) | Traditional Chinese medicine pills for treating liver diseases | |
| CN104906366A (en) | Pharmaceutical preparation for treating delayed menorrhea | |
| CN105031106A (en) | Lavipeditum powder for relieving fatigue and preparation method thereof | |
| CN106511889A (en) | Traditional Chinese medicine potion for mainly treating follicular maldevelopment caused by polycystic ovary and preparation method thereof | |
| CN105693878A (en) | Method for extracting lentinan from shiitake mushrooms and shiitake mushroom product | |
| CN106860656A (en) | It is a kind of to treat Chinese medicine composition of osteoporosis and its preparation method and application | |
| CN107998211B (en) | Hair nourishing composition and preparation method and application thereof | |
| CN104857299A (en) | Traditional Chinese medicine granular preparation for treating osteoporosis | |
| CN105148240A (en) | Medicinal preparation used for treating chronic cardiac failure | |
| CN104083521A (en) | Traditional Chinese medicine preparation for treating hematemesis | |
| CN105311306A (en) | Medicine for treating severe body odor | |
| CN104027652A (en) | Traditional Chinese medicine preparation for decreasing blood sugar and preparation method of traditional Chinese medicine preparation | |
| CN102940762A (en) | Traditional Chinese medicine for treating gouty arthritis | |
| CN106729215A (en) | It is a kind of to treat Chinese medicine preparation of osteoarthritis and preparation method thereof | |
| CN102145119B (en) | Traditional Chinese medicinal composition for treating pulmonary heart diseases | |
| CN104383263A (en) | Traditional Chinese medicine composition for treating bone fracture as well as preparation method and application thereof | |
| CN105521384A (en) | Gynecological medicine for treating pregnancy complications, and preparation method thereof | |
| CN104800339A (en) | Traditional Chinese medicine composition for treating bone fracture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160120 |