CN104352569A - Trogopterus dung-containing traditional Chinese medicine composition for treating sprain - Google Patents
Trogopterus dung-containing traditional Chinese medicine composition for treating sprain Download PDFInfo
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- CN104352569A CN104352569A CN201410636913.2A CN201410636913A CN104352569A CN 104352569 A CN104352569 A CN 104352569A CN 201410636913 A CN201410636913 A CN 201410636913A CN 104352569 A CN104352569 A CN 104352569A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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Abstract
The invention relates to a traditional Chinese medicine composition and particularly relates to a traditional Chinese medicine composition for treating sprain, belonging to the technical field of medicines. The traditional Chinese medicine composition for treating sprain disclosed by the invention is prepared from the following medical raw materials in parts by weight: 10-15 parts of astragalus membranaceus, 10-15 parts of Chinese angelica, 5-12 parts of mulberry twigs and 5-12 parts of trogopterus dung. According to the traditional Chinese medicine composition disclosed by the invention, four medical raw materials are combined in proportion to have synergistic effects, so that the curative effects are remarkably improved, the medicament for treating the sprain is less in dosage, the course of treatment is short, the traditional Chinese medicine composition takes effect rapidly, and the side effects on the body of a patient are small.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to the Chinese medicine composition that a kind for the treatment of is sprained, belong to medical art.
Background technology
Spraining is pain because some meat fiber, ligament rapture or damage cause.Sprain and can be caused by wound, or come from the inappropriate use or overtired of muscle.Sprain and be common in all large joint parts of human body, as shoulder, wrist, knee joint, ankle, and the joint part such as hip, elbow.How cause because the external force swing of burst exceedes scope that respective joint can bear.Card is shown in that local swelling is livid purple, hurt like hell, dysfunction.
In the medicine sprained, Chinese medicine and western medicine is all applied, and Chinese medicine is little and occupy the larger market share with its toxic and side effects, but treatment by Chinese herbs is sprained, and there is slow, the problem such as medication dose is large that takes effect.
Summary of the invention
The object of the present invention is to provide the Chinese medicine composition that a kind for the treatment of is newly sprained, this traditional Chinese medicine composition for treating sprains instant effect, good effect and little to person side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
The Chinese medicine composition that treatment is sprained is be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Ramulus Mori 5 ~ 12 parts, Oletum Trogopterori 5 ~ 12 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by the Radix Astragali is 15 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Radix Angelicae Sinensis is 12 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Ramulus Mori is 10 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Oletum Trogopterori is 8 parts.
The Chinese medicine composition that treatment of the present invention is sprained, Traditional Chinese medicine extraction method conveniently can extract the active component of medicinal raw material, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc., the Chinese medicine composition that treatment of the present invention is sprained, can be applicable to various treatment of spraining.
Chinese medicine composition of the present invention can adopt but be not limited to following methods:
(1) medicinal raw material is got by formula proportion, the ethanol of 8 ~ 10 times of volumes or water reflux, extract, three times is added in medicinal raw material, extraction time is respectively 2.0h, 1.5h and 1.5h, collect and merge the extracting solution refluxed for three times, extracting solution is condensed into extractum, drying, obtains the extract of medicinal raw material of the present invention.
(2) said extracted thing is mixed with pharmaceutic adjuvant, make acceptable various pharmaceutical dosage form.
Compared with prior art, beneficial effect of the present invention: Chinese medicine composition of the present invention is be the medicament that raw material is made by the Radix Astragali, Radix Angelicae Sinensis, Ramulus Mori, Oletum Trogopterori 4 kinds of medicines, and wherein, the Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting; Radix Angelicae Sinensis has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes effect of laxation; Ramulus Mori controls anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen; Oletum Trogopterori promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.Through applicant's Chinese medicine compound medicine efficacy screening Platform Screening, after above-mentioned 4 kinds of medicinal raw materials press formula proportion combination, there is the effect having Synergistic, can be used for treating various spraining, it is little that dosage is sprained in treatment, instant effect, good effect, and without any side effects to patient body.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
In the embodiment of the present invention and comparative example, if no special instructions, the percentage composition of ethanol used, is volumn concentration, and ethanol is the aqueous solution of ethanol.
Embodiment 1
The Chinese medicine composition that the treatment of the present embodiment is sprained is be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 15 parts, Radix Angelicae Sinensis 12 parts, Ramulus Mori 10 parts, Oletum Trogopterori 8 parts.
The present embodiment treats the preparation method of the Chinese medicine composition sprained: get medicinal raw material by formula proportion, pulverizes, and crosses 100 mesh sieves, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Mori, Oletum Trogopterori is placed in respectively mortar grinds well, inclining; By above-mentioned powder mixing, grind well, consistent to color even, packaging, obtains embodiment 1 and treats the Chinese medicine composition sprained.
Embodiment 2
The Chinese medicine composition that the treatment of the present embodiment is sprained is be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 12 parts, Radix Angelicae Sinensis 15 parts, Ramulus Mori 12 parts, Oletum Trogopterori 12 parts.
The extracting method of above-mentioned medicinal raw material: get medicinal raw material by formula proportion, alcohol reflux is added three times in medicinal raw material, the ethanol consumption of three times is 10 times of medicinal raw material volume, and three extraction times are followed successively by 2.0h, 1.5h and 1.5h, filters and collects filtrate after each backflow; Merge 3 filtrates and be condensed into extractum, being dried to constant weight, obtaining extract; Obtain embodiment 2 treatment and sprain Chinese medicine composition.
Embodiment 3
The Chinese medicine composition that treatment prepared by the present embodiment is sprained is be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 10 parts, Radix Angelicae Sinensis 10 parts, Ramulus Mori 5 parts, Oletum Trogopterori 5 parts.
The extracting method of above-mentioned medicinal raw material: get medicinal raw material by formula proportion, water reflux, extract, is added three times in medicinal raw material, three times be medicinal raw material volume by water volume 8 times, three extraction times are followed successively by 2.0h, 1.0h and 0.5h, collect merging 3 extracting solution and be condensed into extractum, be dried to constant weight, obtain extract, obtain the extract of embodiment 3.
Comparative example
The Chinese medicine composition that treatment prepared by this comparative example is sprained is be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 15 parts, Radix Angelicae Sinensis 12 parts, Ramulus Mori 10 parts.
This comparative example treats the preparation method of the Chinese medicine composition sprained: get medicinal raw material by formula proportion, pulverizes, and crosses 100 mesh sieves, the Radix Astragali, Radix Angelicae Sinensis, Ramulus Mori is placed in respectively mortar grinds well, inclining; By above-mentioned powder mixing, grind well, consistent to color even, packaging, obtains comparative example and treats the Chinese medicine composition sprained.
Pharmacodynamics test proves:
The curative effect of medicine of the present invention and advantage thereof are proved by following clinical trial:
1, Subject Population:
Select to be diagnosed as patient 180 example of spraining, wherein man 90 example, female 90 example, be divided into A, B, C tri-experimental grouies by disease symptom, each experiment component is two groups, often organizes 30 people, and respectively comprise man 15 example, female 15 example, grouping situation is in table 1.
Table 1
2, drug administration method:
First group of Chinese medicine composition sprained with the treatment that the embodiment of the present invention 1 is obtained of each experimental group; Second group of Chinese medicine composition obtained by comparative example of the present invention of each experimental group;
Every day is after the meal early, middle and late, and external application is to affected part, and continuous 5 days, the drug of topical application total amount of each patient was 20g raw medicinal herbs/sky.
3, efficacy evaluation:
Symptom is invalid without alleviation or DeGrain; Symptom substantially disappears or disappears completely is effective.
4, therapeutic effect is in table 2:
Table 2
Learnt by statistical data in table 2, take first group of patient of the medicine that the obtained treatment of the embodiment of the present invention 1 is sprained, continuous use 5 days, medication total amount is 20g raw medicinal herbs/sky only, the patient of more than 90%, sprains symptom and substantially disappears even completely, and the effective percentage for the treatment of is more than 90%; And take second group of patient of the medicine that treatment that comparative example of the present invention obtains is sprained, continuous use 5 days, the total effective rate of the treatment of spraining is all lower than 70%, and therapeutic effect is relatively poor.Chi-square criterion is adopted to above-mentioned first group and second group, result p < 0.05, after two groups of treatments, clinical effective rate has remarkable difference, the therapeutic effect of first group is better than second group, and in experimentation, do not find untoward reaction before and after patient medication, Chinese medicine composition of the present invention, has no side effect to patient body.
To sum up, the Chinese medicine composition that treatment of the present invention is sprained, 4 kinds of medicinal raw materials have the effect of Synergistic by formula proportion combination, treatment is sprained, and dosage is little, short treating period, instant effect, continuous use 5 days, medication total amount is 20g raw medicinal herbs/sky only, and treatment total effective rate reaches more than 90%.Lack the medicinal raw material of any component, the curative effect of Chinese medicine composition all can significantly reduce, and as first group relative second group, takes medicine under the same conditions, and the treatment total effective rate of second group is the highest is no more than 70%; Especially, in B experimental group and C experimental group, the treatment total effective rate of the second group total effective rate than first group is lower than more than 20%, and second group of relative first group of therapeutic effect obviously reduces.
Claims (5)
1., containing the Chinese medicine composition that the treatment of Oletum Trogopterori is sprained, it is characterized in that: it is made up of the medicinal raw material of following weight proportion: the Radix Astragali 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Ramulus Mori 5 ~ 12 parts, Oletum Trogopterori 5 ~ 12 parts.
2. the Chinese medicine composition sprained for the treatment of according to claim 1, is characterized in that: part by weight shared by the Radix Astragali is 15 parts.
3. the Chinese medicine composition sprained for the treatment of according to claim 1, is characterized in that: part by weight shared by Radix Angelicae Sinensis is 12 parts.
4. the Chinese medicine composition sprained for the treatment of according to claim 1, is characterized in that: part by weight shared by Ramulus Mori is 10 parts.
5. the Chinese medicine composition sprained for the treatment of according to claim 1, is characterized in that: part by weight shared by Oletum Trogopterori is 8 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410636913.2A CN104352569A (en) | 2014-11-11 | 2014-11-11 | Trogopterus dung-containing traditional Chinese medicine composition for treating sprain |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410636913.2A CN104352569A (en) | 2014-11-11 | 2014-11-11 | Trogopterus dung-containing traditional Chinese medicine composition for treating sprain |
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| CN104352569A true CN104352569A (en) | 2015-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410636913.2A Pending CN104352569A (en) | 2014-11-11 | 2014-11-11 | Trogopterus dung-containing traditional Chinese medicine composition for treating sprain |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112871664A (en) * | 2021-01-12 | 2021-06-01 | 杨丹 | A lingzhi piece and lingzhi rice sorting unit for research of wulingzhi material basis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317315A (en) * | 2000-04-11 | 2001-10-17 | 潘秋兰 | Tendon-comfortable analgesic |
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2014
- 2014-11-11 CN CN201410636913.2A patent/CN104352569A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317315A (en) * | 2000-04-11 | 2001-10-17 | 潘秋兰 | Tendon-comfortable analgesic |
Non-Patent Citations (3)
| Title |
|---|
| 刘继林等: "黄芪临床研究的新进展", 《成都中医学院学报》 * |
| 郭国华: "《实用袖珍中药辞典》", 30 June 1998, 湖南科学技术出版社 * |
| 陈文莉: "五灵脂药对配伍应用六则", 《山东中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112871664A (en) * | 2021-01-12 | 2021-06-01 | 杨丹 | A lingzhi piece and lingzhi rice sorting unit for research of wulingzhi material basis |
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