CN102935119B - Method for preparing ointment for treating lumbar disc herniation - Google Patents
Method for preparing ointment for treating lumbar disc herniation Download PDFInfo
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Abstract
The invention discloses a method for preparing ointment for treating lumbar disc herniation, and belongs to the field of preparation methods of medicinal ointments. The ointment consists of clematis root, corydalis tuber and the like. The method comprises the following steps of: preparing beta-cyclodextrin covered volatile oil by adopting a grinding method; extracting clematis root, fructus gleditsiae and the like and residue of asarum and illicium verum for three times and 2 hours every time by adding 6 times of 60 percent ethanol, combining filtrate, and concentrating to obtain extract of which the relative density is 1.10 to 1.20; stirring borneol, diphenhydramine hydrochloride and the like, dissolving, mixing with zinc oxide, crushed rosin, rubber and the like uniformly, and standing for 15 to 20 hours in a rubber soaking basin; and extracting and concentrating the medicinal materials into the extract, mixing the extract, the beta-cyclodextrin covered volatile oil, the rubber and other matrix, thermally pressing to prepare paste, coating, bushing, slicing, and thus obtaining the ointment. The formula accords with the principle of a prescription formula, and the ointment has the effects of diminishing swelling, relieving pain, relaxing muscles and stimulating blood circulation; and the ointment effectively relieves various pains caused by the lumbar disc herniation, rheumatism or rheumatoid, strain or bruise, hyperostosis, cancers and the like.
Description
Technical field
The invention belongs to a kind of preparation method field of medicine unguentum, particularly relate to a kind of preparation method that can be used for treating the medicine unguentum of prolapse of lumbar intervertebral disc.
Background technology
Prolapse of lumbar intervertebral disc is because the lumbar intervertebral disc degeneration, Anular disruption, and a series of clinical symptoms and sign that the outstanding stimulation of vertebral pulp or pressuring neural root, cauda equina nerve show are commonly called as in " waist dash forward disease ".According to clinical statistics, prolapse of lumbar intervertebral disc is one of orthopaedics commonly encountered diseases, and approximately 1/5 lumbago and skelalgia patient is that prolapse of lumbar intervertebral disc causes.The most common symptom of this disease patient is pain, shows as lumbago and backache, sciatica more, typical sciatica.Pain is a kind of subjective symptom that human body comes to harm and produces behind the sexual stimulus, is threatening human health constantly.
The pain relieving Chinese herbal medicine is divided into the analgesic that induces sweat, wind-damp dispelling analgesic, promoting blood circulation, removing blood stasis and relieving pain medicine, promoting the circulation of QI to relieve pain medicine, warming the interior analgesic, narcotic analgesic medicine, clearing away heat to alleviate pain medicine 7 large classes.Applicating history is long, and clinical practice is very extensive, and it can not only alleviate and eliminate patient's misery, and the cause of disease of eliminate pain to a certain extent, treating both the principal and secondary aspects of a disease improves the rate of recovering, distinguished to the curative effect of some severe intractable pain especially, embodied the features and advantages of Chinese medicine.
The method that is used for the treatment of pain of injury disease in the middle of prior art is also more, but mainly is as main take external treatment.Domestic similar or like product generally adopts the treatment pattern of antiinflammatory, pain relieving, hormone medicine, though can control symptom to a certain extent, in case drug withdrawal, the phenomenon that namely has a rebound, even increase the weight of, and side effect is large, can not eradicate, easily recurrence.
In the middle of prior art, need badly in sum and want a kind of new medicament to solve this class problem.
Summary of the invention
Technical problem to be solved by this invention is: on the basis of traditional proved recipe, through the classical prescription that clinical summary draws, provide a kind of plaster of stable performance for treatment prolapse of lumbar intervertebral disc class illness.
A kind of preparation method for the treatment of the prolapse of lumbar intervertebral disc unguentum, it is characterized in that: prepare the raw material medicaments in part by weight number that this unguentum adopts and count 1800 parts～2200 parts of Radix Clematidis, 800 parts～1200 parts of Rhizoma Corydalis, 800 parts～1200 parts of Fructus Anisi Stellatis, 800 parts～1200 parts of Rhizoma Menispermis, 310 parts～350 parts of Fructus Gleditsiae Abnormalis, 310 parts～350 parts of Herba Asaris, 280 parts～320 parts of rubber, 25 parts～30 parts of Oleum Cinnamomi, 25 parts～30 parts of Borneolum Syntheticums, 10 parts～14 parts of diphhydramine hydrochlorides, 12 parts～16 parts of methyl salicylate, 430 parts～470 parts of zinc oxide, 100 parts～140 parts of Colophonium, 15 parts～25 parts of lanolines, 15 parts～25 parts in vaseline, 5 parts～15 parts of liquid Paraffin, the step of its preparation method is:
Step 1, the ratio in aforementioned according to preparation method take by weighing Herba Asari, Fructus Anisi Stellati, adding weight is 16 times the water yield, extract volatile oil, the each extraction 8 hours, the volatile oil beta-cyclodextrin inclusion compound, adopt polishing, and wherein (β-CD): (volatile oil)=6:1, water: (β-CD)=(6:1), at every turn ground 2 hours;
Step 2, the ratio in aforementioned according to preparation method take by weighing Radix Clematidis, Fructus Gleditsiae Abnormalis, Rhizoma Corydalis, Rhizoma Menispermi, with step 1 in Herba Asari, Fructus Anisi Stellati medicinal residues, be that 6 times of amount concentration are 60% ethanol with weight, extract three times, it is 2 hours at every turn, merging filtrate is concentrated to relative density and is 1.10～1.20 extractum under 70 ℃ of temperature;
Step 3, the ratio in aforementioned according to preparation method take by weighing Borneolum Syntheticum, diphhydramine hydrochloride, Oleum Cinnamomi, liquid Paraffin, methyl salicylate, mix and make it to reach altogether molten state, ratio during continuation is aforementioned according to preparation method takes by weighing Colophonium, lanoline, vaseline, zinc oxide and rubber, wherein Colophonium is the Colophonium after pulverizing, mix uniformly respectively one by one, then placed bubble glue basin static 15 hours～20 hours;
Step 4, the rubber mass for preparing in the medicinal material extract concentrated extract for preparing in the volatile oil of the beta-cyclodextrin inclusion compound for preparing in the step 1, the step 2 and the step 3 is mixed, and hot pressing mixing, then make and be coated with cream, be coated with again, cover lining, the slice process process had both prepared complete.
The dosage form of this unguentum is plaster.This unguentum is applied to treat prolapse of lumbar intervertebral disc.
By above-mentioned design, the present invention can bring following beneficial effect: this product mainly is comprised of Radix Clematidis, Rhizoma Corydalis, Fructus Anisi Stellati, Rhizoma Menispermi, Fructus Gleditsiae Abnormalis, Herba Asari, Borneolum Syntheticum etc.Adopt the plaster dosage form.Prescription meets China's traditional medicine prescription formulation principle, and is complementary and reach the effectiveness of detumescence, pain relieving, relaxing muscles and tendons to promote blood circulation; Can effectively alleviate prolapse of lumbar intervertebral disc, rheumatism, rheumatoid, sprain, contusion, hyperosteogeny, cancer etc. cause to class pain.
Take Radix Clematidis as monarch drug, Radix Clematidis is hot, salty, temperature in the side.Return urinary bladder channel, Liver Channel.Has expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain effect; Be used for rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness etc.Contain oleanolic acid (oleanoic acid) for the multiple saponin of aglycon, protoanemonin (protoanemonin) and often to see rattan ruscogenin (hederagenin), table hederagenin (epihede～ragenin).The preliminary study of anti-inflammatory and antalgic mechanism, the genesis of lymphocyte and rheumatoid arthritis (RA) has substantial connection.The ethanol extract of Radix Clematidis is to the propagation unrestraint effect of the spleen lymphocyte of mice, and the propagation of thymic lymphocytes is had good inhibitory action.Analgesic activity experiment showed, that the Radix Clematidis decoct can obviously improve pain value of explaining of mice to the pain reaction that thermostimulation causes, and the analgesic activity that wine is processed product is strong and lasting.Radix Clematidis injection and heavy dose of decoct thereof are inhibited to the mouse writhing reaction that glacial acetic acid causes, show significant analgesic activity, and have synergism at analgesic activity and Gentian macrophylla Pall..
Minister is with Rhizoma Corydalis promoting blood circulation, removing blood stasis and relieving pain, the loose stagnated fire of the logical all keys of Borneolum Syntheticum, reducing swelling and alleviating pain effect.Rhizoma Corydalis is hot, bitter; Temperature; Nontoxic.Have and invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.Be used for all pains of trusted subordinate's waist knee joint; Traumatic injury etc.The several formulations of Rhizoma Corydalis has obvious analgesia, calmness and syngignoscism.The powder analgesia is tired and is about 5% of morphine, and the Rhizoma Corydalis total alkaloids analgesic activity is about 60% of morphine, and the analgesic activity with the second element in alkaloid is the strongest, and obvious syngignoscism is arranged, and with barbiturate synergism is arranged.Can resist again the central excitation effect of amfetamine and caffeine, rat is had slight reduction body temperature effect.Confirmed that tetrahydropalmatine and rotundine all have good calmness, analgesic activity.Borneolum Syntheticum is hot, bitter, cold.Have logical all keys, loose stagnated fire, removing nebula makes eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, the calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is the nebula film also, enterobiasis.The stimulation of the employing hot plates such as Sun Xiaoping, glacial acetic acid stimulation mouse writhing, glacial acetic acid cause the methods such as the mouse peritoneal capillary permeability increases, carrageenin causes rat paw edema and make inflammatory model, the result shows that adopting Borneolum Syntheticum to treat can obviously suppress the rat paw edema degree, reduces the mouse writhing number of times; Under the dosage condition, the analgesic effect of Borneolum Syntheticum is more more obvious than anti-inflammatory effect.
Assistant is with Fructus Gleditsia, Rhizoma Menispermi heat-clearing and toxic substances removing, and wind-expelling pain-stopping is had one's ideas straightened out to lead to and closed; Strengthen except the rheumatic arthralgia effect.The Fructus Gleditsia temperature; Hot, salty; Mild toxicity (controlling minimum topical dose).Has expelling phlegm for arresting cough; Have one's ideas straightened out and lead to the effect of closing.Be used for apoplexy locked mouth, accumulation and obstruction of sputum, carbuncle scabies etc.Rhizoma Menispermi is cold in nature, bitter in the mouth.Has heat-clearing and toxic substances removing, wind-expelling pain-stopping.Be used for rheumatic arthralgia etc.
Make with Herba Asari, Fructus Anisi Stellati, cold expelling dispels the wind, and regulates the flow of vital energy, the pain relieving of inducing sweat; Strengthen exterior syndrome due to wind-cold, rheumatic arthralgia, chills and pain of the waist and kness pain relieving effect.Herba Asari is hot, temperature.Slightly poisonous (controlling minimum topical dose).Have cold expelling and dispel the wind, pain relieving, warming the lung to resolve fluid-retention, sensible, the effect of inducing sweat.Be used for exterior syndrome due to wind-cold; Rheumatic arthralgia; Headache, toothache etc.Herba Asari volatile oil has obvious central inhibitory action, and low dose can make animal peace and quiet, taming, autonomic activities minimizing; Heavy dose can make animal sleep, and obvious anticonvulsant action is arranged.The Herba Asari decoct gavages also analgesic activity.Its stronger analgesic activity is the valuable pharmacological basis of its treatment general pain, toothache etc.
Fructus Anisi Stellati is hot, temperature.Have cold expelling, regulate the flow of vital energy, analgesic effect.Be used for colic of cold type stomachache; Chills and pain of the waist and kness etc.Fang Yuzhen adopts hot plate method, boiling hot tail method, writhing method and electrostimulation to test, the result shows: extract shihimic acid and flow to mice (the remarkable analgesic activity of 50 ~ 100mg/kg) tools, and confirm that site of action is at cental system and without addiction from the Flos Carthami anise.The shikimic acid that extracts from Fructus Anisi Stellati also can reduce the number of times of mouse writhing, and reaction has significant inhibitory action to mice pain.
Requirement and pertinent literature report according to the preparation preparation, we select following adjuvant: rubber, Oleum Cinnamomi, diphhydramine hydrochloride, methyl salicylate, zinc oxide, Colophonium, lanoline, vaseline, liquid Paraffin etc., more suitable infiltration rate is arranged, absorbed medicine has the nonspecific stimulation effect to teleneuron, reflexively cause vasodilation, make metabolism vigorous, effectively bring into play the local action of medicine.The selection of substrate is take rubber as main.Above-mentioned adjuvant mixes with substrate, makes rubber-emplastrum have an adhibit quality good, and hardness is suitable, and permeability is good, the tool armaticity, and the absorption of medicine is abundant, the characteristics such as long shelf-life.
This product can actively be prevented and treated generation and the development of various pain that prolapse of lumbar intervertebral disc causes effectively, and this is for the health of the existence that improves patient with quality of life, protection patient, and then the raising productivity, significant and higher practical value.Because the primary disease sickness rate is high, the morbidity crowd is wide, estimate to use once marketing, will produce good Social benefit and economic benefit.
The specific embodiment
Embodiment 1
Each needs the raw material medicaments in part by weight number to count: 1800 parts of Radix Clematidis, 800 parts of Rhizoma Corydalis, 800 parts of Fructus Anisi Stellatis, 800 parts of Rhizoma Menispermis, 310 parts of Fructus Gleditsiae Abnormalis, 310 parts of Herba Asaris, 280 parts of rubber, 25 parts of Oleum Cinnamomi, 25 parts of Borneolum Syntheticums, 10 parts of diphhydramine hydrochlorides, 12 parts of methyl salicylate, 430 parts of zinc oxide, 100 parts of Colophonium, 15 parts of lanolines, 15 parts in vaseline, 5 parts of liquid Paraffin.
[Preparation Example 1]
Take by weighing Herba Asari 310g, Fructus Anisi Stellati 800g and add 16 times of water gagings extraction volatile oil, extracted the volatile oil beta-cyclodextrin inclusion compound at every turn 8 hours; Adopt polishing (β-CD: volatile oil 6:1, water: β-CD 6:1) ground 2 hours at every turn, Radix Clematidis 1800g, Fructus Gleditsiae Abnormalis 310g, Rhizoma Corydalis 800g, Rhizoma Menispermi 800g, with Herba Asari, the Fructus Anisi Stellati medicinal residues add 6 times of amount 60% ethanol extractions three times, it is 2 hours at every turn, merging filtrate, be concentrated to the extractum (70 ℃) of relative density 1.10～1.20, add Borneolum Syntheticum 25g, diphhydramine hydrochloride 10g, Oleum Cinnamomi 25g, liquid Paraffin 5g, methyl salicylate 12g, mix and make it molten altogether, then with recipe quantity zinc oxide 430g, Colophonium 100g after the pulverizing, lanoline 15g, vaseline 15g is respectively among the even mixed rubber 280g, puts in the bubble glue basin static 15～20 hours.The substrate such as the volatile oil of medicinal material extract concentrated extract, beta-cyclodextrin inclusion compound and rubber are mixed, and the hot pressing mixing is made and is coated with cream, coating, and the lid lining, section, both.
Embodiment 2
Each needs the raw material medicaments in part by weight number to count: 2000 parts of Radix Clematidis, 1000 parts of Rhizoma Corydalis, 1000 parts of Fructus Anisi Stellatis, 1000 parts of Rhizoma Menispermis, 333 parts of Fructus Gleditsiae Abnormalis, 333 parts of Herba Asaris, 300 parts of rubber, 28 parts of Oleum Cinnamomi, 28 parts of Borneolum Syntheticums, 12.6 parts of diphhydramine hydrochlorides, 14 parts of methyl salicylate, 451 parts of zinc oxide, 120 parts of Colophonium, 20 parts of lanolines, 20 parts in vaseline, 10 parts of liquid Paraffin.
[Preparation Example 2]
Take by weighing Herba Asari 333g, Fructus Anisi Stellati 1000g and add 16 times of water gagings extraction volatile oil, extracted the volatile oil beta-cyclodextrin inclusion compound at every turn 8 hours; Adopt polishing (β-CD: volatile oil 6:1, water: β-CD 6:1) to grind 2 hours at every turn; Take by weighing Radix Clematidis 2000g, Fructus Gleditsiae Abnormalis 333g, Rhizoma Corydalis 1000g, Rhizoma Menispermi 1000g, with Herba Asari, the Fructus Anisi Stellati medicinal residues add 6 times of amount 60% ethanol extractions three times, it is 2 hours at every turn, merging filtrate, be concentrated to the extractum (70 ℃) of relative density 1.10～1.20, add Borneolum Syntheticum 28g, diphhydramine hydrochloride 12.6g, Oleum Cinnamomi 28g, liquid Paraffin 10g, methyl salicylate 14g, mix and make it molten altogether, then with recipe quantity zinc oxide 451g, Colophonium 120g after the pulverizing, lanoline 20g, vaseline 20g is respectively among the even mixed rubber 300g, puts in the bubble glue basin static 15～20 hours.The substrate such as the volatile oil of medicinal material extract concentrated extract, beta-cyclodextrin inclusion compound and rubber are mixed, and the hot pressing mixing is made and is coated with cream, coating, and the lid lining, section, both.
Embodiment 3
Each needs the raw material medicaments in part by weight number to count: 2200 parts of Radix Clematidis, 1200 parts of Rhizoma Corydalis, 1200 parts of Fructus Anisi Stellatis, 1200 parts of Rhizoma Menispermis, 350 parts of Fructus Gleditsiae Abnormalis, 350 parts of Herba Asaris, 320 parts of rubber, 30 parts of Oleum Cinnamomi, 30 parts of Borneolum Syntheticums, 14 parts of diphhydramine hydrochlorides, 16 parts of methyl salicylate, 470 parts of zinc oxide, 140 parts of Colophonium, 25 parts of lanolines, 25 parts in vaseline, 15 parts of liquid Paraffin.
[Preparation Example 3]
Take by weighing Herba Asari 350g, Fructus Anisi Stellati 1200g and add 16 times of water gagings extraction volatile oil, extracted the volatile oil beta-cyclodextrin inclusion compound at every turn 8 hours; Adopt polishing (β-CD: volatile oil 6:1, water: β-CD 6:1) to grind 2 hours at every turn; Take by weighing Radix Clematidis 2200g, Fructus Gleditsiae Abnormalis 350g, Rhizoma Corydalis 1200g, Rhizoma Menispermi 1200g, with Herba Asari, the Fructus Anisi Stellati medicinal residues add 6 times of amount 60% ethanol extractions three times, it is 2 hours at every turn, merging filtrate, be concentrated to the extractum (70 ℃) of relative density 1.10～1.20, add Borneolum Syntheticum 30g, diphhydramine hydrochloride 14g, Oleum Cinnamomi 30g, liquid Paraffin 15g, methyl salicylate 16g, mix and make it molten altogether, then with recipe quantity zinc oxide 470g, Colophonium 140g after the pulverizing, lanoline 25g, vaseline 25g is respectively among the even mixed rubber 320g, puts in the bubble glue basin static 15～20 hours.The substrate such as the volatile oil of medicinal material extract concentrated extract, beta-cyclodextrin inclusion compound and rubber are mixed, and the hot pressing mixing is made and is coated with cream, coating, and the lid lining, section, both.
Claims (2)
1. preparation method for the treatment of the prolapse of lumbar intervertebral disc unguentum, it is characterized in that: prepare the raw material medicaments in part by weight number that this unguentum adopts and count 1800 parts～2200 parts of Radix Clematidis, 800 parts～1200 parts of Rhizoma Corydalis, 800 parts～1200 parts of Fructus Anisi Stellatis, 800 parts～1200 parts of Rhizoma Menispermis, 310 parts～350 parts of Fructus Gleditsiae Abnormalis, 310 parts～350 parts of Herba Asaris, 280 parts～320 parts of rubber, 25 parts～30 parts of Oleum Cinnamomi, 25 parts～30 parts of Borneolum Syntheticums, 10 parts～14 parts of diphhydramine hydrochlorides, 12 parts～16 parts of methyl salicylate, 430 parts～470 parts of zinc oxide, 100 parts～140 parts of Colophonium, 15 parts～25 parts of lanolines, 15 parts～25 parts in vaseline, 5 parts～15 parts of liquid Paraffin, the step of its preparation method is:
Step 1, take by weighing Herba Asari, Fructus Anisi Stellati according to aforementioned proportion, add weight and be 16 times the water yield, extract volatile oil, the each extraction 8 hours, the volatile oil beta-cyclodextrin inclusion compound adopts polishing, beta-schardinger dextrin-: volatile oil=6:1 wherein, water: beta-schardinger dextrin-=6:1 ground 2 hours at every turn;
Step 2, according to aforementioned proportion take by weighing Radix Clematidis, Fructus Gleditsiae Abnormalis, Rhizoma Corydalis, Rhizoma Menispermi, with step 1 in Herba Asari, Fructus Anisi Stellati medicinal residues, be that 6 times of amount concentration are 60% ethanol with weight, extract three times, it is 2 hours at every turn, merging filtrate is concentrated to relative density and is 1.10～1.20 extractum under 70 ℃ of temperature;
Step 3, take by weighing Borneolum Syntheticum, diphhydramine hydrochloride, Oleum Cinnamomi, liquid Paraffin, methyl salicylate according to aforementioned proportion, mix and make it to reach altogether molten state, continuation takes by weighing Colophonium, lanoline, vaseline, zinc oxide and rubber according to aforementioned proportion, wherein Colophonium is the Colophonium after pulverizing, mix uniformly respectively, then place bubble glue basin to leave standstill 15 hours～20 hours;
Step 4, the rubber mass for preparing in the medicinal material extract concentrated extract for preparing in the volatile oil of the beta-cyclodextrin inclusion compound for preparing in the step 1, the step 2 and the step 3 is mixed, and hot pressing mixing, then make and be coated with cream, the technical process that is coated with, covers lining, section namely prepares complete.
2. a kind of preparation method for the treatment of the prolapse of lumbar intervertebral disc unguentum according to claim 1, it is characterized in that: the dosage form of described unguentum is plaster.
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| WO2002013840A1 (en) * | 2000-08-18 | 2002-02-21 | University Of Bern | Essential oils and chemically related species for the treatment of increased bone resorption |
| US6939571B2 (en) * | 2002-07-16 | 2005-09-06 | Xiao-Feng Zuo | Process of making an osteopathy solution |
| CN1788770A (en) * | 2004-12-13 | 2006-06-21 | 王令喜 | Numbness relieving and pain relieving ointment |
| KR20080105825A (en) * | 2007-06-01 | 2008-12-04 | 김선정 | Herb composition useful for arthritis treatment or prevention and preparation thereof |
| CN101361819A (en) * | 2008-10-10 | 2009-02-11 | 大连蓝德奥科技有限公司 | Novel external traditional Chinese medicine liniment capable of relaxing muscles and alleviating pain |
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